Elena Shagisultanova, MD, PhD
Assistant Professor, Medicine-Medical Oncology

Medical School:
  • MD, Bashkir State Medical University, Russia (1997)
Graduate School :
  • PhD, Institute of Biochemistry and Genetics, Russia (2002)
  • St Mary's Hospital and Medical Center Program (2010)
  • St Mary's Hospital and Medical Center Program, Chief Resident, Internal Medicine (2012)
  • Fox Chase Cancer Center Program, Hematology and Oncology (2015)
Languages: English, Russian
Department: Medicine-Medical Oncology

Research Interests

My research interests focus on developing new and improved therapies for patients with breast cancer.


  • E. Shagisultanova, L.S. Crump, M. Borakove, J.K. Hall, A.R. Rasti, B.A. Harrison, P. Kabos, T.R. Lyons and V.F. Borges "Triple targeting of breast tumors driven by hormonal receptors and HER2"
  • E Shagisultanova, W Gradishar, U Brown-Glaberman, P Chalasani, AJ Brenner, A Stopeck, J Mayordomo, J R. Diamond, P Kabos, VF. Borges. "Interim safety and efficacy analysis of phase IB / II clinical trial of tucatinib, palbociclib and letrozole in patients with hormone receptor and HER2-positive metastatic breast cancer". Proceedings of SABCS December 2020.
  • West AH, Knollman H, Dugan J, Hedeker D, Handorf EA, Nielsen SM, Bealin LC, Goldblatt LG, Willems H, Daly MB, Afghahi A, Olopade OI, Hulick PJ, Shagisultanova E, Huo D, Obeid E, Churpek JE. Hematologic toxicity in BRCA1 and BRCA2 mutation carriers during chemotherapy: A retrospective matched cohort study. Cancer Med. 2019 Sep;8(12):5609-5618. PubMed PMID: 31407530
  • Korobeynikov V, Borakove M, Feng Y, Wuest WM, Koval AB, Nikonova AS, Serebriiskii I, Chernoff J, Borges VF, Golemis EA, Shagisultanova E. Combined inhibition of Aurora A and p21-activated kinase 1 as a new treatment strategy in breast cancer. Breast Cancer Res Treat. 2019 Sep;177(2):369-382. PubMed PMID: 31254157
  • Shagisultanova E, Mayordomo J, Elias AD. Triple-negative breast cancer in the elderly. Breast J. 2017 Nov;23(6):627-629. PubMed PMID: 29112794
  • Lev A, Deihimi S, Shagisultanova E, Xiu J, Lulla AR, Dicker DT, El-Deiry WS. Preclinical rationale for combination of crizotinib with mitomycin C for the treatment of advanced colorectal cancer. Cancer Biol Ther. 2017 Sep 2;18(9):694-704. PubMed PMID: 28886275
  • Deihimi S, Lev A, Slifker M, Shagisultanova E, Xu Q, Jung K, Vijayvergia N, Ross EA, Xiu J, Swensen J, Gatalica Z, Andrake M, Dunbrack RL, El-Deiry WS. BRCA2, EGFR, and NTRK mutations in mismatch repair-deficient colorectal cancers with MSH2 or MLH1 mutations. Oncotarget. 2017 Jun 20;8(25):39945-39962. PubMed PMID: 28591715
  • Jasem J, Fisher CM, Amini A, Shagisultanova E, Rabinovitch R, Borges VF, Elias A, Kabos P. The 21-Gene Recurrence Score Assay for Node-Positive, Early-Stage Breast Cancer and Impact of RxPONDER Trial on Chemotherapy Decision-Making: Have Clinicians Already Decided?. J Natl Compr Canc Netw. 2017 Apr;15(4):494-503. PubMed PMID: 28404760
  • Overholser L, Shagisultanova E, Rabinovitch RA, Kounalakis N, Diamond J, Finlayson CA, Fisher CM, Kabos P, Elias AD, Borges VF, Mayordomo J. Breast Cancer Following Radiation for Hodgkin Lymphoma: Clinical Scenarios and Risk-Reducing Strategies. Oncology (Williston Park). 2016 Dec 15;30(12). PubMed PMID: 27987198
  • Beck TN, Georgopoulos R, Shagisultanova EI, Sarcu D, Handorf EA, Dubyk C, Lango MN, Ridge JA, Astsaturov I, Serebriiskii IG, Burtness BA, Mehra R, Golemis EA. EGFR and RB1 as Dual Biomarkers in HPV-Negative Head and Neck Cancer. Mol Cancer Ther. 2016 Oct;15(10):2486-2497. PubMed PMID: 27507850
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Professional Memberships

  • American Society of Clinical Oncology (ASCO), Member
  • American Society of Hematology (ASH), Member

Practice Locations

Diane O'Connor Thompson Breast Center - Anschutz
1635 Aurora Ct
3rd Floor
Aurora, CO 80045

UCH - Cancer Center
1665 Aurora Ct
Aurora, CO 80045

University of Colorado Hospital (UCH)
12605 E. 16th Ave
Aurora, CO 80045

Hospital Affiliation
  • University of Colorado Hospital
Center Affiliations

Specialty Information

  • Internal Medicine, Board Certification (2012)
  • Hematology and Oncology
Conditions & Treatments
  • Cancers - Breast Cancer
  • Cancers
Clinical Interests
Breast cancer

Care Philosophy
Being diagnosed with cancer is a life-changing event, affecting both patients and their families. No one should walk this path alone. It is my honor and privilege to accompany my patients on their cancer journey, and to become a part of their lives in a very special way. In my clinical practice, I focus on the care of patients with breast cancer. I strive to provide expert, prompt, individualized and compassionate care for every patient and family. My philosophy in taking care of patients is, first of all, to listen to them and keep in very close communication throughout the course of treatment. We work together as a team. I help my patient in understanding their diagnosis, and together we design the best plan of action. By working with each patient, their family, and a group of my expert colleagues (surgeons, radiation oncologists, radiologists, pathologists), we can design the most comprehensive treatment plan, that could include both standard treatments and emerging therapies in the form of clinical trials. We live in an exciting time of many outstanding scientific discoveries in cancer diagnostics and therapy. My goal is to bring together all the scientific advances and resources of a cutting-edge cancer center to my patients.

Personal Interests
In my spare time, I enjoy reading books and being outdoors. I love skiing, hiking, biking and backpacking with my husband and three children.

Public Speaking

General Information

Medical Schools:
  • MD, Bashkir State Medical University, Russia (1997)
Graduate Schools:
  • PhD, Institute of Biochemistry and Genetics, Russia (2002)
  • St Mary's Hospital and Medical Center Program (2010)
Residency Programs:
  • St Mary's Hospital and Medical Center Program, Chief Resident, Internal Medicine (2012)
  • Fox Chase Cancer Center Program, Hematology and Oncology (2015)
Languages: English, Russian
Department: Medicine-Medical Oncology