Elena Hsieh, MD
Assistant Professor, Pediatrics-Allergy/Immunology

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Medical School:
  • MD, University of California, San Francisco, School of Medicine (2008)
Undergraduate School:
  • BA/BS, University of California–Los Angeles (CA) (2002)
Internship:
  • UCLA Medical Center Program (2008)
Residency:
  • UCLA Medical Center Program, Pediatrics (2011)
Fellowships:
  • Stanford Hospital and Clinics Program, Allergy and Immunology (2014)
Languages: English, Mandarin, Spanish
Department: Pediatrics-Allergy/Immunology

Professional Titles

  • Assistant Professor

Recognition & Awards

  • NIH K23 Mentored Patient-Oriented Research Career Development Award, NIH (2017)
    To provide support for the career development of clinically trained professionals who have made a commitment to patient-oriented research, and who have the potential to develop into productive, clinical investigators.
  • Boettcher Foundation Webb-Waring Biomedical Research Award, Boettcher Foundation (2016)
    Supports early career investigators whose research has a direct impact on human health. The biomedical research supported pursuant to this grant program will be designed to find ways to prevent disease and improve human health through basic and applied biomedical research. The intent of the program is to fund meritorious research that has the potential for new discoveries or advances a discovery to the proof of its potential value as an application to improve human health. This research will improve the understanding, treatment and prevention of human disease.
  • Pediatric Scientist Development Program Award, Cincinnati Children's Medical Center (2011)
  • American Academy of Pediatrics Research Resident Award, American Academy of Pediatrics (2010)

Research Interests

My research interests are primarily focused on investigating the cellular and molecular mechanisms underlying innate immune dysregulation in inflammatory disorders. My research program at UCD combines (i) multi-parameter technologies such as mass cytometry, and (ii) basic immunology molecular and biochemical methods, which enable mechanistic follow up studies to initial findings from “systems biology” approaches. This combination of “systems approach” and focused mechanistic studies allow characterization of mechanisms that govern the human immune perturbations in inflammatory disease, at the level of the single-cell and in the context of the entire immune system. The ultimate goal of my research is to identify immune parameters that predict and determine disease flare/relapse and prognosis in individual patients, and to devise immune-modulatory strategies that can decrease flare/relapse rate and prevent end-organ damage.

Teaching

  • Assistant Professor (2015)
    School of Medicine, Immunology and Microbiology
    Primary immunodeficiency, autoimmunity, inflammatory disorders

Publications

  • Shaker MS, Oppenheimer J, Grayson M, Stukus D, Hartog N, Hsieh EWY, Rider N, Dutmer CM, Vander Leek TK, Kim H, Chan ES, Mack D, Ellis AK, Lang D, Lieberman J, Fleischer D, Golden DBK, Wallace D, Portnoy J, Mosnaim G, Greenhawt M. COVID-19: Pandemic Contingency Planning for the Allergy and Immunology Clinic. J Allergy Clin Immunol Pract. 2020 May;8(5):1477-1488.e5. PubMed PMID: 32224232
  • Searing DA, Dutmer CM, Fleischer DM, Shaker MS, Oppenheimer J, Grayson MH, Stukus D, Hartog N, Hsieh EWY, Rider NL, Vander Leek TK, Kim H, Chan ES, Mack D, Ellis AK, Abrams EM, Bansal P, Lang DM, Lieberman J, Golden DB, Wallace D, Portnoy J, Mosnaim G, Greenhawt M. A Phased Approach to Resuming Suspended Allergy/Immunology Clinical Services. J Allergy Clin Immunol Pract. 2020 Jul - Aug;8(7):2125-2134. PubMed PMID: 32450236
  • Coughlan C, Bruce KD, Burgy O, Boyd TD, Michel CR, Garcia-Perez JE, Adame V, Anton P, Bettcher BM, Chial HJ, Königshoff M, Hsieh EWY, Graner M, Potter H. Exosome Isolation by Ultracentrifugation and Precipitation and Techniques for Downstream Analyses. Curr Protoc Cell Biol. 2020 Sep;88(1):e110. PubMed PMID: 32633898
  • Frank BS, Khailova L, Silveira L, Mitchell MB, Morgan GJ, Hsieh EWY, DiMaria MV, Twite M, Klawitter J, Davidson JA. Proteomic profiling identifies key differences between inter-stage infants with single ventricle heart disease and healthy controls. Transl Res. 2020 Oct 9. [Epub ahead of print] PubMed PMID: 33045409
  • Fernandez IZ, Baxter RM, Garcia-Perez JE, Vendrame E, Ranganath T, Kong DS, Lundquist K, Nguyen T, Ogolla S, Black J, Galambos C, Gumbart JC, Dawany N, Kelsen JR, de Zoeten EF, Quinones R, Eissa H, Verneris MR, Sullivan KE, Rochford R, Blish CA, Kedl RM, Dutmer CM, Hsieh EWY. A novel human IL2RB mutation results in T and NK cell-driven immune dysregulation. J Exp Med. 2019 Jun 3;216(6):1255-1267. PubMed PMID: 31040184
  • Garcia-Perez JE, Baxter RM, Kong DS, Tobin R, McCarter M, Routes JM, Verbsky J, Jordan MB, Dutmer CM, Hsieh EWY. CTLA4 Message Reflects Pathway Disruption in Monogenic Disorders and Under Therapeutic Blockade. Front Immunol. 2019;10:998. PubMed PMID: 31156616
  • Schuyler RP, Jackson C, Garcia-Perez JE, Baxter RM, Ogolla S, Rochford R, Ghosh D, Rudra P, Hsieh EWY. Minimizing Batch Effects in Mass Cytometry Data. Front Immunol. 2019;10:2367. PubMed PMID: 31681275
  • Waugh KA, Araya P, Pandey A, Jordan KR, Smith KP, Granrath RE, Khanal S, Butcher ET, Estrada BE, Rachubinski AL, McWilliams JA, Minter R, Dimasi T, Colvin KL, Baturin D, Pham AT, Galbraith MD, Bartsch KW, Yeager ME, Porter CC, Sullivan KD, Hsieh EW, Espinosa JM. Mass Cytometry Reveals Global Immune Remodeling with Multi-lineage Hypersensitivity to Type I Interferon in Down Syndrome. Cell Rep. 2019 Nov 12;29(7):1893-1908.e4. PubMed PMID: 31722205
  • Waugh KA, Araya P, Pandey A, Jordan KR, Smith KP, Granrath RE, Khanal S, Butcher ET, Estrada BE, Rachubinski AL, McWilliams JA, Minter R, Dimasi T, Colvin KL, Baturin D, Pham AT, Galbraith MD, Bartsch KW, Yeager ME, Porter CC, Sullivan KD, Hsieh EW, Espinosa JM. Mass Cytometry Reveals Global Immune Remodeling with Multi-lineage Hypersensitivity to Type I Interferon in Down Syndrome. Cell Rep. 2019 Nov 12;29(7):1893-1908.e4. PubMed PMID: 31722205
  • Schuyler RP, Jackson C, Garcia-Perez JE, Baxter RM, Ogolla S, Rochford R, Ghosh D, Rudra P, Hsieh EWY. Minimizing Batch Effects in Mass Cytometry Data. Front Immunol. 2019;10:2367. PubMed PMID: 31681275
  • Czechowska K, Lannigan J, Aghaeepour N, Back JB, Begum J, Behbehani G, Bispo C, Bitoun D, Fernández AB, Boova ST, Brinkman RR, Ciccolella CO, Cotleur B, Davies D, Dela Cruz GV, Del Rio-Guerra R, Des Lauriers-Cox AM, Douagi I, Dumrese C, Bonilla Escobar DL, Estevam J, Ewald C, Fossum A, Gaudillière B, Green C, Groves C, Hall C, Haque Y, Hedrick MN, Hogg K, Hsieh EWY, Irish J, Lederer J, Leipold M, Lewis-Tuffin LJ, Litwin V, Lopez P, Nasdala I, Nedbal J, Ohlsson-Wilhelm BM, Price KM, Rahman AH, Rayanki R, Rieger AM, Robinson JP, Shapiro H, Sun YS, Tang VA, Tesfa L, Telford WG, Walker R, Welsh JA, Wheeler P, Tárnok A. Cyt-Geist: Current and Future Challenges in Cytometry: Reports of the CYTO 2019 Conference Workshops. Cytometry A. 2019 Dec;95(12):1236-1274. PubMed PMID: 31833655
  • Baxter RM, Kong DS, Garcia-Perez JE, O'Gorman WE, Hsieh EWY. Single-cell Analysis of Immunophenotype and Cytokine Production in Peripheral Whole Blood via Mass Cytometry. J Vis Exp. 2018 Jun 26;(136). PubMed PMID: 30010641
  • Heimall JR, Hagin D, Hajjar J, Henrickson SE, Hernandez-Trujillo HS, Tan Y, Kobrynski L, Paris K, Torgerson TR, Verbsky JW, Wasserman RL, Hsieh EWY, Blessing JJ, Chou JS, Lawrence MG, Marsh RA, Rosenzweig SD, Orange JS, Abraham RS. Use of Genetic Testing for Primary Immunodeficiency Patients. J Clin Immunol. 2018 Apr;38(3):320-329. PubMed PMID: 29675737
  • O'Gorman WE, Kong DS, Balboni IM, Rudra P, Bolen CR, Ghosh D, Davis MM, Nolan GP, Hsieh EW. Mass cytometry identifies a distinct monocyte cytokine signature shared by clinically heterogeneous pediatric SLE patients. J Autoimmun. 2017 Apr 4. [Epub ahead of print] PubMed PMID: 28389038
  • Bousfiha AA, Duff C, Hsieh E. Ensuring Access to Immunoglobulin Therapies for People with Primary Immunodeficiency: A Need to Improve Individuals' Quality of Life and the Sustainability of Health-care Systems. Front Immunol. 2017;8:1165. PubMed PMID: 28974952
  • Hsieh EW, Hernandez JD. Novel tools for primary immunodeficiency diagnosis: making a case for deep profiling. Curr Opin Allergy Clin Immunol. 2016 Dec;16(6):549-556. PubMed PMID: 27749361
  • Frei AP, Bava FA, Zunder ER, Hsieh EW, Chen SY, Nolan GP, Gherardini PF. Highly multiplexed simultaneous detection of RNAs and proteins in single cells. Nat Methods. 2016 Mar;13(3):269-75. PubMed PMID: 26808670
  • Subjects at-risk for future development of rheumatoid arthritis demonstrate a PAD4- and TLR-dependent enhanced histone H3 citrullination and proinflammatory cytokine production in CD14hi monocytes
  • Brief Report: Prospective observational study showing early pulmonary function changes associated with brigatinib initiation
View All (19 Total) View Less

Professional Memberships

  • Clinical Immunology Society (CIS), Member
  • American Academy of Asthma, Allergy and Immunology (AAAAI), Member
  • European Society for Immunodeficiencies (ESID), Member

Practice Locations

Children's Hospital Colorado Anschutz Medical Campus
13123 East 16th Ave
Aurora, CO 80045
720-777-1234

Hospital Affiliation
  • Children's Hospital Colorado

Specialty Information

Specialties
  • Allergy and Immunology, Board Certification (2014)
  • Pediatrics, Board Certification (2011)
Conditions & Treatments
  • Genetic Conditions and Testing
  • Immune System - Allergies
  • Immune System - Anaphylaxis
  • Immune System - Angioedema
  • Immune System - Autoimmune Disorders
  • Immune System - Immunodeficiency
  • Immune System - Rhinitis
  • Immune System - Urticaria (Hives)
  • Immune System - Sinusitis
  • Immune System
Clinical Interests
My many clinical interests include diagnosis and treatment of primary immunodeficiency, autoimmune and chronic inflammatory disorders.

Care Philosophy
I strive to provide the best care for my patients. I believe in treating patients and their families, taking into account every aspect of the patient's body and health, empowering them with knowledge regarding their disease. In both the clinical and research environments, I consider myself a “hands on” teacher. History and physical exam skills are best exemplified at the patient’s bedside, and it is there that I prefer to teach clinical medicine to students, residents and fellows. Clues obtained from the history and physical exam lead to the formation of possible hypothesis that explain the current disease process (differential diagnosis), and the formulation of tests needed to test this hypothesis (laboratory and/or imaging evaluation). Similarly, for graduate students, I find that working side-by-side at the bench is the best way to obtain clues from failed experiments, to hypothesize the conceptual or technical errors, and design modifications to the experiment to best troubleshoot the issues at hand.

Personal Interests
In my spare time, I enjoy hiking, running, lifting, and cooking with my husband and daughter.

General Information

Medical Schools:
  • MD, University of California, San Francisco, School of Medicine (2008)
Undergraduate Schools:
  • BA/BS, University of California–Los Angeles (CA) (2002)
Internships:
  • UCLA Medical Center Program (2008)
Residency Programs:
  • UCLA Medical Center Program, Pediatrics (2011)
Fellowships:
  • Stanford Hospital and Clinics Program, Allergy and Immunology (2014)
Download CV
Languages: English, Mandarin, Spanish
Department: Pediatrics-Allergy/Immunology
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