Joyce Lee, MD
Associate Professor, Medicine-Pulmonary Sciences & Critical Care

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Medical School:
  • MD, Northwestern University The Feinberg School of Medicine (2003)
Undergraduate School:
  • BS, Northwestern University (IL) (2001)
Internship:
  • McGaw Medical Center of Northwestern University Program (2004)
Residency:
  • McGaw Medical Center of Northwestern University Program, Internal Medicine (2006)
Fellowships:
  • University of California (San Francisco) Program, Pulmonary Disease and Critical Care Medicine (2010)
Department: Medicine-Pulmonary Sciences & Critical Care

Professional Titles

  • Director, ILD Program

Research Interests

Research in my group focuses on advancing the clinical and translational understanding of scarring lung diseases, in particular idiopathic pulmonary fibrosis (IPF) and connective tissue associated interstitial lung disease (ILD). Work in our group encompasses risk factor identification and modification, risk prediction modeling and survival, diagnostic tests, genetics, biomarkers, and quality of life, for both patients and their caregivers. Through our research, I hope to better understand the biological mechanisms and clinical behavior of ILD, and ultimately translate that knowledge into improving patients’ quality of life.

Publications

  • Lee JS, La J, Aziz S, Dobrinskikh E, Brownell R, Jones KD, Achtar-Zadeh N, Green G, Elicker BM, Golden JA, Matthay MA, Kukreja J, Schwartz DA, Wolters PJ. Molecular Markers of Telomere Dysfunction and Senescence are Common Findings in the Usual Interstitial Pneumonia Pattern of Lung Fibrosis. Histopathology. 2021 Jan 11. [Epub ahead of print] PubMed PMID: 33432658
  • Kreuter M, Bradley SJ, Lee JS, Tzouvelekis A, Oldham JM, Molyneaux PL, Weycker D, Atwood M, Kirchgaessler KU, Maher TM. Monocyte Count as a Prognostic Biomarker in Patients with Idiopathic Pulmonary Fibrosis. Am J Respir Crit Care Med. 2021 Jan 12. [Epub ahead of print] PubMed PMID: 33434107
  • Dugger DT, Fung M, Hays SR, Singer JP, Kleinhenz ME, Leard LE, Golden JA, Shah RJ, Lee JS, Deiter F, Greenland NY, Jones KD, Langelier CR, Greenland JR. Chronic lung allograft dysfunction small airways reveal a lymphocytic inflammation gene signature. Am J Transplant. 2021 Jan;21(1):362-371. PubMed PMID: 32885581
  • Spagnolo P, Distler O, Ryerson CJ, Tzouvelekis A, Lee JS, Bonella F, Bouros D, Hoffmann-Vold AM, Crestani B, Matteson EL. Mechanisms of progressive fibrosis in connective tissue disease (CTD)-associated interstitial lung diseases (ILDs). Ann Rheum Dis. 2021 Feb;80(2):143-150. PubMed PMID: 33037004
  • Iasella CJ, Hoji A, Popescu I, Wei J, Snyder ME, Zhang Y, Xu W, Iouchmanov V, Koshy R, Brown M, Fung M, Langelier C, Lendermon EA, Dugger D, Shah R, Lee J, Johnson B, Golden J, Leard LE, Ellen Kleinhenz M, Kilaru S, Hays SR, Singer JP, Sanchez PG, Morrell MR, Pilewski JM, Greenland JR, Chen K, McDyer JF. Type-1 immunity and endogenous immune regulators predominate in the airway transcriptome during chronic lung allograft dysfunction. Am J Transplant. 2020 Oct 20. [Epub ahead of print] PubMed PMID: 33078555
  • Graney BA, He C, Marll M, Matson S, Bianchi P, Cosgrove GP, Lee JS. Essential Components of an Interstitial Lung Disease Clinic: Results From a Delphi Survey and Patient Focus Group Analysis. Chest. 2020 Oct 5. [Epub ahead of print] PubMed PMID: 33031832
  • Juge PA, Lee JS, Lau J, Kawano-Dourado L, Rojas Serrano J, Sebastiani M, Koduri G, Matteson E, Bonfiglioli K, Sawamura M, Kairalla R, Cavagna L, Bozzalla Cassione E, Manfredi A, Mejia M, Rodríguez-Henriquez P, González-Pérez MI, Falfán-Valencia R, Buendia-Roldán I, Pérez-Rubio G, Ebstein E, Gazal S, Borie R, Ottaviani S, Kannengiesser C, Wallaert B, Uzunhan Y, Nunes H, Valeyre D, Saidenberg-Kermanac'h N, Boissier MC, Wemeau-Stervinou L, Flipo RM, Marchand-Adam S, Richette P, Allanore Y, Dromer C, Truchetet ME, Richez C, Schaeverbeke T, Lioté H, Thabut G, Deane KD, Solomon J, Doyle T, Ryu JH, Rosas I, Holers VM, Boileau C, Debray MP, Porcher R, Schwartz DA, Vassallo R, Crestani B, Dieudé P. Methotrexate and rheumatoid arthritis associated interstitial lung disease. Eur Respir J. 2020 Jul 9. [Epub ahead of print] PubMed PMID: 32646919
  • Furusawa H, Cardwell JH, Okamoto T, Walts AD, Konigsberg IR, Kurche JS, Bang TJ, Schwarz MI, Brown KK, Kropski JA, Rojas M, Cool CD, Lee JS, Wolters PJ, Yang IV, Schwartz DA. Chronic Hypersensitivity Pneumonitis, an Interstitial Lung Disease with Distinct Molecular Signatures. Am J Respir Crit Care Med. 2020 Nov 15;202(10):1430-1444. PubMed PMID: 32602730
  • Zaman T, Moua T, Vittinghoff E, Ryu JH, Collard HR, Lee JS. Differences in Clinical Characteristics and Outcomes Between Men and Women With Idiopathic Pulmonary Fibrosis: A Multicenter Retrospective Cohort Study. Chest. 2020 Jul;158(1):245-251. PubMed PMID: 32084394
  • Spagnolo P, Kropski JA, Jones MG, Lee JS, Rossi G, Karampitsakos T, Maher TM, Tzouvelekis A, Ryerson CJ. Idiopathic pulmonary fibrosis: Disease mechanisms and drug development. Pharmacol Ther. 2020 Dec 24;222:107798. [Epub ahead of print] PubMed PMID: 33359599
  • Matson S, Lee J, Eickelberg O. Two sides of the same coin? A review of the similarities and differences between idiopathic pulmonary fibrosis and rheumatoid arthritis associated interstitial lung disease. Eur Respir J. 2020 Dec 10. [Epub ahead of print] PubMed PMID: 33303554
  • Lee JS, Fischer A. POINT: Does Interstitial Pneumonia With Autoimmune Features Represent a Distinct Class of Patients With Idiopathic Interstitial Pneumonia? Yes. Chest. 2019 Feb;155(2):258-260. PubMed PMID: 30732687
  • Fischer A, Strek ME, Cottin V, Dellaripa PF, Bernstein EJ, Brown KK, Danoff SK, Distler O, Hirani N, Jones KD, Khanna D, Lee JS, Lynch DA, Maher TM, Millar AB, Raghu G, Silver RM, Steen VD, Volkmann ER, Mullan RH, O'Dwyer DN, Donnelly SC. Proceedings of the American College of Rheumatology/Association of Physicians of Great Britain and Ireland Connective Tissue Disease-Associated Interstitial Lung Disease Summit: A Multidisciplinary Approach to Address Challenges and Opportunities. Arthritis Rheumatol. 2019 Feb;71(2):182-195. PubMed PMID: 30604506
  • Ryerson CJ, Kolb M, Richeldi L, Lee J, Wachtlin D, Stowasser S, Poletti V. Effects of nintedanib in patients with idiopathic pulmonary fibrosis by GAP stage. ERJ Open Res. 2019 Apr;5(2). PubMed PMID: 31044139
  • Jhajj A, Gill HP, Hague CJ, Murphy D, Elicker B, Soon J, Sulaiman N, Castillo-Saldana D, Wilcox PG, Dunne J, Lee JS, Wolters PJ, Ley B, Jones KD, Morisset J, Ryerson CJ. Pulmonary physiology is poorly associated with radiological extent of disease in systemic sclerosis-associated interstitial lung disease. Eur Respir J. 2019 May;53(5). PubMed PMID: 30846470
  • He C, Lee JS, Cool CD, Wicklund MP, Fischer A. Development of Autoimmune Interstitial Lung Disease in a Patient with Inclusion Body Myositis. Am J Med. 2019 Dec;132(12):e854-e855. PubMed PMID: 31310746
  • Mira-Avendano I, Abril A, Burger CD, Dellaripa PF, Fischer A, Gotway MB, Lee AS, Lee JS, Matteson EL, Yi ES, Ryu JH. Interstitial Lung Disease and Other Pulmonary Manifestations in Connective Tissue Diseases. Mayo Clin Proc. 2019 Feb;94(2):309-325. PubMed PMID: 30558827
  • Morisset J, Lee JS. New trajectories in the treatment of interstitial lung disease: treat the disease or treat the underlying pattern?. Curr Opin Pulm Med. 2019 Jun 28. [Epub ahead of print] PubMed PMID: 31261211
  • Greiffo FR, Viteri-Alvarez V, Frankenberger M, Dietel D, Ortega-Gomez A, Lee JS, Hilgendorff A, Behr J, Soehnlein O, Eickelberg O, Fernandez IE. CX3CR1-fractalkine axis drives kinetic changes of monocytes in fibrotic interstitial lung diseases. Eur Respir J. 2019 Nov 19. [Epub ahead of print] PubMed PMID: 31744836
  • Lee AS, Lee JS, He Z, Ryu JH. Reflux-Aspiration in Chronic Lung Disease. Ann Am Thorac Soc. 2019 Nov 7. [Epub ahead of print] PubMed PMID: 31697575
  • Chartrand S, Lee JS, Swigris JJ, Stanchev L, Fischer A. Clinical Characteristics and Natural History of Autoimmune Forms of Interstitial Lung Disease: A Single-Center Experience. Lung. 2019 Dec;197(6):709-713. PubMed PMID: 31583453
  • Raghu G, Pellegrini CA, Yow E, Flaherty KR, Meyer K, Noth I, Scholand MB, Cello J, Ho LA, Pipavath S, Lee JS, Lin J, Maloney J, Martinez FJ, Morrow E, Patti MG, Rogers S, Wolters PJ, Yates R, Anstrom KJ, Collard HR. Laparoscopic anti-reflux surgery for the treatment of idiopathic pulmonary fibrosis (WRAP-IPF): a multicentre, randomised, controlled phase 2 trial. Lancet Respir Med. 2018 Sep;6(9):707-714. PubMed PMID: 30100404
  • Martin-Medina A, Lehmann M, Burgy O, Hermann S, Baarsma HA, Wagner DE, De Santis MM, Ciolek F, Hofer TP, Frankenberger M, Aichler M, Lindner M, Gesierich W, Guenther A, Walch A, Coughlan C, Wolters P, Lee JS, Behr J, Königshoff M. Increased Extracellular Vesicles Mediate WNT-5A Signaling in Idiopathic Pulmonary Fibrosis. Am J Respir Crit Care Med. 2018 Jul 25. [Epub ahead of print] PubMed PMID: 30044642
  • Han MK, Arteaga-Solis E, Blenis J, Bourjeily G, Clegg DJ, DeMeo D, Duffy J, Gaston B, Heller NM, Hemnes A, Henske EP, Jain R, Lahm T, Lancaster LH, Lee J, Legato MJ, McKee S, Mehra R, Morris A, Prakash YS, Stampfli MR, Gopal-Srivastava R, Laposky AD, Punturieri A, Reineck L, Tigno X, Clayton J. Female Sex and Gender in Lung/Sleep Health and Disease. Increased Understanding of Basic Biological, Pathophysiological, and Behavioral Mechanisms Leading to Better Health for Female Patients with Lung Disease. Am J Respir Crit Care Med. 2018 Oct 1;198(7):850-858. PubMed PMID: 29746147
  • Mira-Avendano I, Abril A, Burger CD, Dellaripa PF, Fischer A, Gotway MB, Lee AS, Lee JS, Matteson EL, Yi ES, Ryu JH. Interstitial Lung Disease and Other Pulmonary Manifestations in Connective Tissue Diseases. Mayo Clin Proc. 2018 Dec 14. [Epub ahead of print] PubMed PMID: 30558827
  • Zaman T, Lee JS. Risk factors for the development of idiopathic pulmonary fibrosis: A review. Curr Pulmonol Rep. 2018 Dec;7(4):118-125. PubMed PMID: 31588408
  • Wang P, Jones KD, Urisman A, Elicker BM, Urbania T, Johannson KA, Assayag D, Lee J, Wolters PJ, Collard HR, Koth LL. Pathologic Findings and Prognosis in a Large Prospective Cohort of Chronic Hypersensitivity Pneumonitis. Chest. 2017 Sep;152(3):502-509. PubMed PMID: 28223152
  • Johannson KA, Vittinghoff E, Morisset J, Lee JS, Balmes JR, Collard HR. Home monitoring improves endpoint efficiency in idiopathic pulmonary fibrosis. Eur Respir J. 2017 Jul;50(1). PubMed PMID: 28679608
  • Natalini JG, Swigris JJ, Morisset J, Elicker BM, Jones KD, Fischer A, Collard HR, Lee JS. Understanding the determinants of health-related quality of life in rheumatoid arthritis-associated interstitial lung disease. Respir Med. 2017 Jun;127:1-6. PubMed PMID: 28502413
  • Ryerson CJ, Corte TJ, Lee JS, Richeldi L, Walsh SLF, Myers JL, Behr J, Cottin V, Danoff SK, Flaherty KR, Lederer DJ, Lynch DA, Martinez FJ, Raghu G, Travis WD, Udwadia Z, Wells AU, Collard HR. A Standardized Diagnostic Ontology for Fibrotic Interstitial Lung Disease. An International Working Group Perspective. Am J Respir Crit Care Med. 2017 Nov 15;196(10):1249-1254. PubMed PMID: 28414524
  • Morisset J, Vittinghoff E, Lee BY, Tonelli R, Hu X, Elicker BM, Ryu JH, Jones KD, Cerri S, Manfredi A, Sebastiani M, Gross AJ, Ley B, Wolters PJ, King TE Jr, Kim DS, Collard HR, Lee JS. The performance of the GAP model in patients with rheumatoid arthritis associated interstitial lung disease. Respir Med. 2017 Jun;127:51-56. PubMed PMID: 28502419
  • Morisset J, Vittinghoff E, Elicker BM, Hu X, Le S, Ryu JH, Jones KD, Haemel A, Golden JA, Boin F, Ley B, Wolters PJ, King TE Jr, Collard HR, Lee JS. Mortality Risk Prediction in Scleroderma-Related Interstitial Lung Disease: The SADL Model. Chest. 2017 Nov;152(5):999-1007. PubMed PMID: 28629914
  • Spagnolo P, Oldham JM, Jones MG, Lee JS. Personalized medicine in interstitial lung diseases. Curr Opin Pulm Med. 2017 May;23(3):231-236. PubMed PMID: 28198728
  • Lee JS. "An Ounce of Prevention . . . ": Will This Be the Future for Idiopathic Pulmonary Fibrosis?. Am J Respir Crit Care Med. 2017 Nov 15;196(10):1240-1241. PubMed PMID: 28628389
  • Chartrand S, Swigris JJ, Stanchev L, Lee JS, Brown KK, Fischer A. Clinical features and natural history of interstitial pneumonia with autoimmune features: A single center experience. Respir Med. 2016 Oct;119:150-154. PubMed PMID: 27692137
  • Collard HR, Ryerson CJ, Corte TJ, Jenkins G, Kondoh Y, Lederer DJ, Lee JS, Maher TM, Wells AU, Antoniou KM, Behr J, Brown KK, Cottin V, Flaherty KR, Fukuoka J, Hansell DM, Johkoh T, Kaminski N, Kim DS, Kolb M, Lynch DA, Myers JL, Raghu G, Richeldi L, Taniguchi H, Martinez FJ. Acute Exacerbation of Idiopathic Pulmonary Fibrosis. An International Working Group Report. Am J Respir Crit Care Med. 2016 Aug 1;194(3):265-75. PubMed PMID: 27299520
  • Johannson KA, Elicker BM, Vittinghoff E, Assayag D, de Boer K, Golden JA, Jones KD, King TE Jr, Koth LL, Lee JS, Ley B, Wolters PJ, Collard HR. A diagnostic model for chronic hypersensitivity pneumonitis. Thorax. 2016 Oct;71(10):951-4. PubMed PMID: 27245779
  • Morisset J, Dubé BP, Garvey C, Bourbeau J, Collard HR, Swigris JJ, Lee JS. The Unmet Educational Needs of Patients with Interstitial Lung Disease. Setting the Stage for Tailored Pulmonary Rehabilitation. Ann Am Thorac Soc. 2016 Jul;13(7):1026-33. PubMed PMID: 27064659
  • Lee JS, Fischer A. Current and emerging treatment options for interstitial lung disease in patients with rheumatic disease. Expert Rev Clin Immunol. 2016;12(5):509-20. PubMed PMID: 26752397
  • Morisset J, Johnson C, Rich E, Collard HR, Lee JS. Management of Myositis-Related Interstitial Lung Disease. Chest. 2016 Nov;150(5):1118-1128. PubMed PMID: 27102182
  • Aparicio IJ, Lee JS. Connective Tissue Disease-Associated Interstitial Lung Diseases: Unresolved Issues. Semin Respir Crit Care Med. 2016 Jun;37(3):468-76. PubMed PMID: 27231868
  • Assayag D, Kim EJ, Elicker BM, Jones KD, Golden JA, King TE Jr, Koth LL, Shum AK, Wolters PJ, Collard HR, Lee JS. Survival in interstitial pneumonia with features of autoimmune disease: a comparison of proposed criteria. Respir Med. 2015 Oct;109(10):1326-31. PubMed PMID: 26303338
  • Fischer A, Antoniou KM, Brown KK, Cadranel J, Corte TJ, du Bois RM, Lee JS, Leslie KO, Lynch DA, Matteson EL, Mosca M, Noth I, Richeldi L, Strek ME, Swigris JJ, Wells AU, West SG, Collard HR, Cottin V. An official European Respiratory Society/American Thoracic Society research statement: interstitial pneumonia with autoimmune features. Eur Respir J. 2015 Oct;46(4):976-87. PubMed PMID: 26160873
  • Tokman S, Singer JP, Devine MS, Westall GP, Aubert JD, Tamm M, Snell GI, Lee JS, Goldberg HJ, Kukreja J, Golden JA, Leard LE, Garcia CK, Hays SR. Clinical outcomes of lung transplant recipients with telomerase mutations. J Heart Lung Transplant. 2015 Oct;34(10):1318-24. PubMed PMID: 26169663
  • Fischer A, Lee JS, Cottin V. Interstitial lung disease evaluation: detecting connective tissue disease. Respiration. 2015;90(3):177-84. PubMed PMID: 26343272
  • de Boer K, Lee JS. Under-recognised co-morbidities in idiopathic pulmonary fibrosis: A review. Respirology. 2015 Sep 13. [Epub ahead of print] PubMed PMID: 26365251
  • Hu X, Lee JS, Pianosi PT, Ryu JH. Aspiration-related pulmonary syndromes. Chest. 2015 Mar;147(3):815-23. PubMed PMID: 25732447
  • Assayag D, Vittinghoff E, Ryerson CJ, Cocconcelli E, Tonelli R, Hu X, Elicker BM, Golden JA, Jones KD, King TE Jr, Koth LL, Lee JS, Ley B, Shum AK, Wolters PJ, Ryu JH, Collard HR. The effect of bronchodilators on forced vital capacity measurement in patients with idiopathic pulmonary fibrosis. Respir Med. 2015 Aug;109(8):1058-62. PubMed PMID: 26140806
  • Lee JS, Collard HR. Idiopathic pulmonary fibrosis: continuing to make progress. Lancet Respir Med. 2015 Dec;3(12):921-3. PubMed PMID: 26679021
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Professional Memberships

  • American Thoracic Society (ATS), Member
  • American College of Chest Physicians (CHEST), Member

Practice Locations

UCHealth Interstitial Lung Disease Clinic - Anschutz Medical Campus
1635 Aurora Ct
Anschutz Outpatient Pavilion, 7th Fl
Aurora, CO 80045
720-848-0748

Hospital Affiliation
  • University of Colorado Hospital

Specialty Information

Specialties
  • Internal Medicine, Board Certification (2006)
  • Pulmonary Disease, Board Certification (2009)
  • Critical Care Medicine, Board Certification (2010)
Conditions & Treatments
  • Lungs and Breathing - Interstitial Lung Disease
  • Lungs and Breathing
Care Philosophy
Our team is focused on providing comprehensive care for patients with ILD by using a multi-disciplinary and multi-dimensional approach to care and research. Interstitial lung diseases are complex group of more than 100 rare disorders that are often associated with significant morbidity and mortality. Examples of conditions include idiopathic pulmonary fibrosis, rheumatoid arthritis associated ILD and other forms of autoimmune related ILD, and chronic hypersensitivity pneumonitis. Our team has framed our approach to this important patient population by addressing the 4 key areas of clinical care, education of trainees, community outreach, and research.

Public Speaking
Yes

General Information

Medical Schools:
  • MD, Northwestern University The Feinberg School of Medicine (2003)
Undergraduate Schools:
  • BS, Northwestern University (IL) (2001)
Internships:
  • McGaw Medical Center of Northwestern University Program (2004)
Residency Programs:
  • McGaw Medical Center of Northwestern University Program, Internal Medicine (2006)
Fellowships:
  • University of California (San Francisco) Program, Pulmonary Disease and Critical Care Medicine (2010)
Department: Medicine-Pulmonary Sciences & Critical Care
Contact Us
CU Anschutz
Fitzsimons Building

13001 East 17th Place
Campus Box C290
Aurora, CO 80045

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