Lauren Fishbein, MD, PhD
Associate Professor, Medicine-Endocrinology/Metabolism/Diabetes

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Medical School:
  • MD, University of Florida College of Medicine (2006)
Graduate School :
  • PhD, University of Florida (2004)
Undergraduate School:
  • BA, Vassar College (NY) (1997)
Internship:
  • Beth Israel Deaconess Medical Center/Harvard Medical School Program (2007)
Residency:
  • Beth Israel Deaconess Medical Center/Harvard Medical School Program, Internal Medicine (2009)
Fellowships:
  • Hospital of the University of Pennsylvania, Endocrinology, Diabetes and Metabolism (2012)
Languages: English
Department: Medicine-Endocrinology/Metabolism/Diabetes

Research Interests

My research interests are to understand what causes neuroendocrine tumors to form (pheochromocytomas, paragangliomas, gastrointestinal and pancreatic neuroendocrine tumors). I am particularly interested in studying the inherited and tumor specific genetic changes that lead to tumor formation. The long terms goals of my research are to identify markers to predict aggressive or metastatic disease which can ultimately be used to develop therapies for prevention and/or treatment of these tumors.

Publications

  • Bancos I, Atkinson E, Eng C, Young WF Jr, Neumann HPH. Maternal and fetal outcomes in phaeochromocytoma and pregnancy: a multicentre retrospective cohort study and systematic review of literature. Lancet Diabetes Endocrinol. 2021 Jan;9(1):13-21. PubMed PMID: 33248478
  • Armaiz-Pena G, Flores SK, Cheng ZM, Zhang X, Esquivel E, Poullard N, Vaidyanathan A, Liu Q, Michalek J, Santillan-Gomez AA, Liss M, Ahmadi S, Katselnik D, Maldonado E, Salgado SA, Jimenez C, Fishbein L, Hamidi O, Else T, Lechan R, Tischler AS, Benn DE, Dwight T, Clifton-Bligh R, Sanso G, Barontini M, Vincent D, Aronin N, Biondi B, Koops M, Bowhay-Carnes E, Gimenez-Roqueplo AP, Alvarez-Eslava A, Bruder JM, Kitano M, Burnichon N, Ding Y, Dahia PLM. Genotype-Phenotype Features of Germline Variants of the TMEM127 Pheochromocytoma Susceptibility Gene: A 10-Year Update. J Clin Endocrinol Metab. 2021 Jan 1;106(1):e350-e364. PubMed PMID: 33051659
  • Haag J, Hardie L, Berning A, Fishbein L, Corr BR. Case report of a paraganglioma arising from a mature cystic teratoma of the ovary. Gynecol Oncol Rep. 2020 May;32:100537. PubMed PMID: 32042879
  • Greenberg SE, Jacobs MF, Wachtel H, Anson A, Buchmann L, Cohen DL, Bonanni M, Bennett B, Naumer A, Schaefer AM, Kohlmann W, Nathanson KL, Else T, Fishbein L. Tumor detection rates in screening of individuals with SDHx-related hereditary paraganglioma-pheochromocytoma syndrome. Genet Med. 2020 Dec;22(12):2101-2107. PubMed PMID: 32741965
  • Wachtel H, Hutchens T, Baraban E, Schwartz LE, Montone K, Baloch Z, LiVolsi V, Krumeich L, Fraker DL, Nathanson KL, Cohen DL, Fishbein L. Predicting Metastatic Potential in Pheochromocytoma and Paraganglioma: A Comparison of PASS and GAPP Scoring Systems. J Clin Endocrinol Metab. 2020 Dec 1;105(12). PubMed PMID: 32877928
  • Halfdanarson TR, Strosberg JR, Tang L, Bellizzi AM, Bergsland EK, O'Dorisio TM, Halperin DM, Fishbein L, Eads J, Hope TA, Singh S, Salem R, Metz DC, Naraev BG, Reidy-Lagunes DL, Howe JR, Pommier RF, Menda Y, Chan JA. The North American Neuroendocrine Tumor Society Consensus Guidelines for Surveillance and Medical Management of Pancreatic Neuroendocrine Tumors. Pancreas. 2020 Aug;49(7):863-881. PubMed PMID: 32675783
  • Berends AMA, Eisenhofer G, Fishbein L, Horst-Schrivers ANAVD, Kema IP, Links TP, Lenders JWM, Kerstens MN. Intricacies of the Molecular Machinery of Catecholamine Biosynthesis and Secretion by Chromaffin Cells of the Normal Adrenal Medulla and in Pheochromocytoma and Paraganglioma. Cancers (Basel). 2019 Aug 6;11(8). PubMed PMID: 31390824
  • Fishbein L. Pheochromocytoma/Paraganglioma: Is This a Genetic Disorder?. Curr Cardiol Rep. 2019 Jul 31;21(9):104. PubMed PMID: 31367972
  • Kiseljak-Vassiliades K, Zhang Y, Bagby SM, Kar A, Pozdeyev N, Xu M, Gowan K, Sharma V, Raeburn CD, Albuja-Cruz M, Jones KL, Fishbein L, Schweppe RE, Somerset H, Pitts TM, Leong S, Wierman ME. Development of new preclinical models to advance adrenocortical carcinoma research. Endocr Relat Cancer. 2018 Apr;25(4):437-451. PubMed PMID: 29371329
  • Pozdeyev N, Gay LM, Sokol ES, Hartmaier R, Deaver KE, Davis S, French JD, Borre PV, LaBarbera DV, Tan AC, Schweppe RE, Fishbein L, Ross JS, Haugen BR, Bowles DW. Genetic Analysis of 779 Advanced Differentiated and Anaplastic Thyroid Cancers. Clin Cancer Res. 2018 Jul 1;24(13):3059-3068. PubMed PMID: 29615459
  • Kiseljak-Vassiliades K, Zhang Y, Kar A, Razzaghi R, Xu M, Gowan K, Raeburn CD, Albuja-Cruz M, Jones KL, Somerset H, Fishbein L, Leong S, Wierman ME. Elucidating the Role of the Maternal Embryonic Leucine Zipper Kinase in Adrenocortical Carcinoma. Endocrinology. 2018 Jul 1;159(7):2532-2544. PubMed PMID: 29790920
  • Fishbein L, Wilkerson MD. Chromaffin cell biology: inferences from The Cancer Genome Atlas. Cell Tissue Res. 2018 May;372(2):339-346. PubMed PMID: 29450724
  • Else T, Fishbein L. Discovery of new susceptibility genes: proceed cautiously. Genet Med. 2018 Dec;20(12):1512-1514. PubMed PMID: 30100611
  • Jean S, Li J, Katsaros D, Wubbenhorst B, Maxwell KN, Fishbein L, McLane MW, Benedetto C, Canuto EM, Mitra N, Zhang L, Nathanson KL, Tanyi JL. Paclitaxel is necessary for improved survival in epithelial ovarian cancers with homologous recombination gene mutations. Oncotarget. 2016 Jul 26;7(30):48577-48585. PubMed PMID: 27191893
  • DeBrosse C, Nanga RP, Wilson N, D'Aquilla K, Elliott M, Hariharan H, Yan F, Wade K, Nguyen S, Worsley D, Parris-Skeete C, McCormick E, Xiao R, Cunningham ZZ, Fishbein L, Nathanson KL, Lynch DR, Stallings VA, Yudkoff M, Falk MJ, Reddy R, McCormack SE. Muscle oxidative phosphorylation quantitation using creatine chemical exchange saturation transfer (CrCEST) MRI in mitochondrial disorders. JCI Insight. 2016 Nov 3;1(18):e88207. PubMed PMID: 27812541
  • Santen RJ, Joham A, Fishbein L, Vella KR, Ebeling PR, Gibson-Helm M, Teede H. Career Advancement: Meeting the Challenges Confronting the Next Generation of Endocrinologists and Endocrine Researchers. J Clin Endocrinol Metab. 2016 Dec;101(12):4512-4520. PubMed PMID: 27691051
  • Fishbein L. Pheochromocytoma and Paraganglioma: Genetics, Diagnosis, and Treatment. Hematol Oncol Clin North Am. 2016 Feb;30(1):135-50. PubMed PMID: 26614373
  • Wachtel H, Kennedy EH, Zaheer S, Bartlett EK, Fishbein L, Roses RE, Fraker DL, Cohen DL. Preoperative Metyrosine Improves Cardiovascular Outcomes for Patients Undergoing Surgery for Pheochromocytoma and Paraganglioma. Ann Surg Oncol. 2015 Dec;22 Suppl 3:646-54. PubMed PMID: 26374407
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Professional Memberships

  • Endocrine Society, Member
  • American Association of Clinical Endocrinologists (AACE), Member
  • North American Neuroendocrine Tumor Society (NANETS), Member
  • American Association for Cancer Research (AACR), Member
  • Women in Endocrinology (WE), Member

Practice Locations

UCH - Anschutz Outpatient Pavilion
1635 Aurora Ct
Aurora, CO 80045
720-848-0000

Endocrinology/Diabetes/Metabolism - Anschutz
1635 Aurora Ct
6th Floor
Aurora, CO 80045
720-848-2650

Rocky Mountain Regional Veterans Administration Medical Center
1700 Wheeling St
Aurora, CO 80045
303-399-8020

Specialty Information

Specialties
  • Internal Medicine, Board Certification
  • Endocrinology, Diabetes and Metabolism, Board Certification
Conditions & Treatments
  • Endocrine System (Hormones) - Endocrine Cancer (Parathyroid, Adrenal, Carcinoid)
  • Endocrine System (Hormones) - Thyroid Cancer
  • Endocrine System (Hormones) - Adrenal Diseases
  • Brain and Nervous System - Pituitary Disorders
  • Brain and Nervous System
  • Endocrine System (Hormones)
Clinical Interests
Pheochromocytoma/Paraganglioma

General Information

Medical Schools:
  • MD, University of Florida College of Medicine (2006)
Graduate Schools:
  • PhD, University of Florida (2004)
Undergraduate Schools:
  • BA, Vassar College (NY) (1997)
Internships:
  • Beth Israel Deaconess Medical Center/Harvard Medical School Program (2007)
Residency Programs:
  • Beth Israel Deaconess Medical Center/Harvard Medical School Program, Internal Medicine (2009)
Fellowships:
  • Hospital of the University of Pennsylvania, Endocrinology, Diabetes and Metabolism (2012)
Languages: English
Department: Medicine-Endocrinology/Metabolism/Diabetes
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