Frank I. Scott, MD
Assistant Professor, Medicine-Gastroenterology

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Medical School:
  • MD, Temple University School of Medicine (2006)
Graduate School :
  • MSCE, University of Pennsylvania (2012)
Undergraduate School:
  • BA, University of Pennsylvania (Philadelphia, PA) (2000)
Residency:
  • New York Presbyterian Hospital (Cornell Campus) Program, Internal Medicine (2009)
Fellowships:
  • Hospital of the University of Pennsylvania, Gastroenterology (2012)
  • Hospital of the University of Pennsylvania, Advanced fellowship in Inflammatory Bowel Diseases (2013)
Languages: English
Department: Medicine-Gastroenterology

Recognition & Awards

  • Edward Raffensperger Award for Excellence in GI Fellow Teaching, Division of Gastroenterology, University of Pennsylvania (2012)
  • Assistant Chief Resident, Department of Medicine, New York-Presbyterian/Weill Cornell Medical College (2008)
  • Alpha Omega Alpha, Temple University School of Medicine, Epsilon Chapter (2006)
  • Emmanuel M. Weinberger Award in Infectious Diseases, Temple University School of Medicine (2006)

Publications

  • Osterman MT, Scott FI, Fogt FF, Gilroy ED, Parrott S, Galanko J, Cross R, Moss A, Herfarth HH, Higgins PDR. Endoscopic and Histological Assessment, Correlation, and Relapse in Clinically Quiescent Ulcerative Colitis (MARQUEE). Inflamm Bowel Dis. 2021 Jan 19;27(2):207-214. PubMed PMID: 32170946
  • Wang L, Scott FI, Boursi B, Reiss KA, Williams S, Glick H, Yang YX. Cost-Effectiveness of a Risk-Tailored Pancreatic Cancer Early Detection Strategy Among Patients With New-Onset Diabetes. Clin Gastroenterol Hepatol. 2021 Nov 2. [Epub ahead of print] PubMed PMID: 34737092
  • Almario CV, Kogan L, van Deen WK, Scott FI, Singh S, Hou JK, Lum D, Aguilar H, Betteridge J, Flynn A, Gerich M, Kaufman L, Mattar MC, Mize C, Ostrov A, Shah SA, Younes Z, Weaver SA, Heller C, Siegel CA, Melmed GY. Health Economic Impact of a Multicenter Quality-of-Care Initiative for Reducing Unplanned Healthcare Utilization Among Patients With Inflammatory Bowel Disease. Am J Gastroenterol. 2021 Nov 3. [Epub ahead of print] PubMed PMID: 34730561
  • Chu BK, Scott FI, Bewtra M. Optimal Placement of Colectomy in the Treatment of Ulcerative Colitis: a Markov Model Analysis. J Gastrointest Surg. 2021 Dec;25(12):3208-3217. PubMed PMID: 34725785
  • Haydek JP, Scott FI. Editorial: infliximab or adalimumab as first- or second-line anti-TNF-conflicting evidence. Aliment Pharmacol Ther. 2021 Sep;54(6):846-847. PubMed PMID: 34425006
  • Singh S, Proctor D, Scott FI, Falck-Ytter Y, Feuerstein JD. AGA Technical Review on the Medical Management of Moderate to Severe Luminal and Perianal Fistulizing Crohn's Disease. Gastroenterology. 2021 Jun;160(7):2512-2556.e9. PubMed PMID: 34051985
  • Lefferts AR, Regner EH, Stahly A, O'Rourke B, Gerich ME, Fennimore BP, Scott FI, Freeman AE, Jones K, Kuhn KA. Circulating mature granzyme B T cells distinguish Crohn's disease-associated axial spondyloarthritis from axial spondyloarthritis and Crohn's disease. Arthritis Res Ther. 2021 May 22;23(1):147. PubMed PMID: 34022940
  • Ahmed W, Scott FI. Closing the Gap: the Real-World Risk of Serious Infections With Vedolizumab in Comparison With Anti-TNF Therapy in Inflammatory Bowel Disease. Clin Gastroenterol Hepatol. 2021 May 20. [Epub ahead of print] PubMed PMID: 34022455
  • Han S, Kolb JM, Hosokawa P, Friedman C, Fox C, Scott FI, Lieu CH, Vajravelu RK, McCarter M, Murphy CC, Cook MB, Gleisner A, Falk GW, Katzka DA, Wani S. The Volume-Outcome Effect Calls for Centralization of Care in Esophageal Adenocarcinoma: Results From a Large National Cancer Registry. Am J Gastroenterol. 2021 Apr;116(4):811-815. PubMed PMID: 33982952
  • Kriss M, Te HS, Verna EC, VanWagner LB, Scott FI, Lai JC. National Early Career Transplant Hepatologist Survey: Compensation, Burnout, and Job Satisfaction. Hepatol Commun. 2021 Apr;5(4):701-712. PubMed PMID: 33860127
  • Berlinberg AJ, Regner EH, Stahly A, Brar A, Reisz JA, Gerich ME, Fennimore BP, Scott FI, Freeman AE, Kuhn KA. Multi 'Omics Analysis of Intestinal Tissue in Ankylosing Spondylitis Identifies Alterations in the Tryptophan Metabolism Pathway. Front Immunol. 2021;12:587119. PubMed PMID: 33746944
  • Vajravelu RK, Kolb JM, Thanawala SU, Scott FI, Han S, Singal AG, Falk GW, Katzka DA, Wani S. Characterization of Prevalent, Post-Endoscopy, and Incident Esophageal Cancer in the United States: A Large Retrospective Cohort Study. Clin Gastroenterol Hepatol. 2021 Feb 5. [Epub ahead of print] PubMed PMID: 33549872
  • Scott FI, Vajravelu RK, Mamtani R, Bianchina N, Mahmoud N, Hou JK, Wu Q, Wang X, Haynes K, Lewis JD. Association Between Statin Use at the Time of Intra-abdominal Surgery and Postoperative Adhesion-Related Complications and Small-Bowel Obstruction. JAMA Netw Open. 2021 Feb 1;4(2):e2036315. PubMed PMID: 33533930
  • Scott FI, Hans AK, Gerich ME, Fennimore B, Mamtani R, Vajravelu RK, Lewis JD. Identification of the Most Effective Position for Ustekinumab in Treatment Algorithms for Crohn's Disease. Clin Gastroenterol Hepatol. 2021 Oct;19(10):2082-2092.e10. PubMed PMID: 32801006
  • Osterman MT, Scott FI, Fogt FF, Gilroy ED, Parrott S, Galanko J, Cross R, Moss A, Herfarth HH, Higgins PDR. Endoscopic and Histological Assessment, Correlation, and Relapse in Clinically Quiescent Ulcerative Colitis (MARQUEE). Inflamm Bowel Dis. 2021 Jan 19;27(2):207-214. PubMed PMID: 32170946
  • Scott FI, Luo M, Shah Y, Lasch K, Vajravelu RK, Mamtani R, Fennimore B, Gerich ME, Lewis JD. Identification of the most cost effective position of vedolizumab among the available biologic drugs for the treatment of ulcerative colitis. J Crohns Colitis. 2020 Jan 4. [Epub ahead of print] PubMed PMID: 31901085
  • Bewtra M, Reed SD, Johnson FR, Scott FI, Gilroy E, Sandler RS, Chen W, Lewis JD. Variation Among Patients With Crohn's Disease in Benefit vs Risk Preferences and Remission Time Equivalents. Clin Gastroenterol Hepatol. 2020 Feb;18(2):406-414.e7. PubMed PMID: 31100456
  • Han S, Kolb JM, Hosokawa P, Friedman C, Fox C, Scott FI, Lieu CH, Vajravelu RK, McCarter M, Murphy CC, Cook MB, Gleisner A, Falk GW, Katzka DA, Wani S. The Volume-Outcome Effect Calls for Centralization of Care in Esophageal Adenocarcinoma: Results From a Large National Cancer Registry. Am J Gastroenterol. 2020 Nov 23. [Epub ahead of print] PubMed PMID: 33229980
  • Scott FI, Hans AK, Gerich ME, Fennimore B, Mamtani R, Vajravelu RK, Lewis JD. Identification of the Most Effective Position for Ustekinumab in Treatment Algorithms for Crohn's Disease. Clin Gastroenterol Hepatol. 2020 Aug 12. [Epub ahead of print] PubMed PMID: 32801006
  • Kolb JM, Han S, Scott FI, Murphy CC, Hosokawa P, Wani S. Early-Onset Esophageal Adenocarcinoma Presents With Advanced-Stage Disease But Has Improved Survival Compared With Older Individuals. Gastroenterology. 2020 Dec;159(6):2238-2240.e4. PubMed PMID: 32777286
  • Mittal C, Dang D, Stoffel E, Menees S, Scott FI, Ahnen D, Patel SG. Underutilization of Lynch Syndrome Screening at Two Large Veterans Affairs Medical Centers. Dig Dis Sci. 2020 Nov;65(11):3305-3315. PubMed PMID: 32500284
  • Vachon A, Scott FI. The treatment approach to inflammatory bowel disease in 2020. Curr Opin Gastroenterol. 2020 Jul;36(4):247-256. PubMed PMID: 32452863
  • Scott FI. Marijuana Use in Inflammatory Bowel Disease: Understanding the Prevalence and the Potential Pitfalls. Crohns Colitis 360. 2020 Apr;2(2):otaa016. PubMed PMID: 32363340
  • Scott FI. Infliximab Versus Biosimilars for IBD: Is It Better to Fight Than Switch?. Dig Dis Sci. 2020 Aug;65(8):2158-2160. PubMed PMID: 32338328
  • Scott FI, Luo M, Shah Y, Lasch K, Vajravelu RK, Mamtani R, Fennimore B, Gerich ME, Lewis JD. Identification of the Most Cost-effective Position of Vedolizumab Among the Available Biologic Drugs for the Treatment of Ulcerative Colitis. J Crohns Colitis. 2020 Jun 19;14(5):575-587. PubMed PMID: 31901085
  • Vajravelu RK, Copelovitch L, Osterman MT, Scott FI, Mamtani R, Lewis JD, Denburg MR. Inflammatory Bowel Diseases Are Associated With an Increased Risk for Chronic Kidney Disease, Which Decreases With Age. Clin Gastroenterol Hepatol. 2020 Sep;18(10):2262-2268. PubMed PMID: 31683056
  • Bewtra M, Reed SD, Johnson FR, Scott FI, Gilroy E, Sandler RS, Chen W, Lewis JD. Variation Among Patients With Crohn's Disease in Benefit vs Risk Preferences and Remission Time Equivalents. Clin Gastroenterol Hepatol. 2020 Feb;18(2):406-414.e7. PubMed PMID: 31100456
  • Scott FI, Singh S. Bridging Gaps in Evidence-based Clinical Practice in Inflammatory Bowel Diseases: Observational Comparative Effectiveness Research for the Win. Clin Gastroenterol Hepatol. 2019 Jan 7. [Epub ahead of print] PubMed PMID: 30630101
  • Vajravelu RK, Copelovitch L, Osterman MT, Scott FI, Mamtani R, Lewis JD, Denburg MR. Risk for Chronic Kidney Disease in Patients with Inflammatory Bowel Diseases Increases with Age but is not Associated with 5-aminosalicylate Use. Clin Gastroenterol Hepatol. 2019 Nov 1. [Epub ahead of print] PubMed PMID: 31683056
  • Johnson FR, Scott FI, Reed SD, Lewis JD, Bewtra M. Comparing the Noncomparable: The Need for Equivalence Measures That Make Sense in Health-Economic Evaluations. Value Health. 2019 Jun;22(6):684-692. PubMed PMID: 31198186
  • Scott FI, Rubin DT, Kugathasan S, Bousvaros A, Elson CO, Newberry RD, Melmed GY, Pekow J, Fleshman JW, Boyle BM, Mahadevan U, Cannon LM, Long MD, Cross RK, Ha CY, Lasch KL, Robinson AM, Rafferty JF, Lee JJ, Dahl KDC, Weaver A, Shtraizent N, Honig G, Hurtado-Lorenzo A, Heller CA. Challenges in IBD Research: Pragmatic Clinical Research. Inflamm Bowel Dis. 2019 May 16;25(Suppl 2):S40-S47. PubMed PMID: 31095704
  • Kinnucan J, Binion D, Cross R, Evans E, Harlen K, Matarese L, Mullins A, O'Neal B, Reiss M, Scott FI, Weaver A, Rosenberg J. Inflammatory Bowel Disease Care Referral Pathway. Gastroenterology. 2019 Jul;157(1):242-254.e6. PubMed PMID: 30980795
  • Scott FI, Singh S. Bridging Gaps in Evidence-based Clinical Practice in Inflammatory Bowel Diseases: Observational Comparative Effectiveness Research for the Win. Clin Gastroenterol Hepatol. 2019 Aug;17(9):1726-1728. PubMed PMID: 30630101
  • Scott FI, Johnson FR, Bewtra M, Brensinger CM, Roy JA, Reed SD, Osterman MT, Mamtani R, Chen L, Yun H, Xie F, Curtis JR, Lewis JD. Improved Quality of Life With Anti-TNF Therapy Compared With Continued Corticosteroid Utilization in Crohn's Disease. Inflamm Bowel Dis. 2019 Apr 11;25(5):925-936. PubMed PMID: 30535149
  • Vajravelu RK, Scott FI, Mamtani R, Li H, Moore JH, Lewis JD. Medication class enrichment analysis: a novel algorithm to analyze multiple pharmacologic exposures simultaneously using electronic health record data. J Am Med Inform Assoc. 2018 Jan 25. [Epub ahead of print] PubMed PMID: 29378062
  • Lewis JD, Scott FI, Brensinger CM, Roy JA, Osterman MT, Mamtani R, Bewtra M, Chen L, Yun H, Xie F, Curtis JR. Increased Mortality Rates With Prolonged Corticosteroid Therapy When Compared With Antitumor Necrosis Factor-a-Directed Therapy for Inflammatory Bowel Disease. Am J Gastroenterol. 2018 Jan 16. [Epub ahead of print] PubMed PMID: 29336432
  • Scott FI, Johnson FR, Bewtra M, Brensinger CM, Roy JA, Reed SD, Osterman MT, Mamtani R, Chen L, Yun H, Xie F, Curtis JR, Lewis JD. Improved Quality of Life With Anti-TNF Therapy Compared With Continued Corticosteroid Utilization in Crohn's Disease. Inflamm Bowel Dis. 2018 Dec 9. [Epub ahead of print] PubMed PMID: 30535149
  • Hans AK, Scott FI. Editorial: which inflammatory bowel disease patients should be screened for Epstein-Barr virus infection?. Aliment Pharmacol Ther. 2018 Nov;48(10):1158-1159. PubMed PMID: 30375692
  • Vajravelu RK, Mamtani R, Scott FI, Waxman A, Lewis JD. Incidence, Risk Factors, and Clinical Effects of Recurrent Diverticular Hemorrhage: A Large Cohort Study. Gastroenterology. 2018 Nov;155(5):1416-1427. PubMed PMID: 30056095
  • Han S, Brauer BC, Scott FI. A Heart-Stopping Cause of Upper Gastrointestinal Bleeding. Gastroenterology. 2018 Oct;155(4):983-984. PubMed PMID: 29614298
  • Vajravelu RK, Scott FI, Mamtani R, Li H, Moore JH, Lewis JD. Medication class enrichment analysis: a novel algorithm to analyze multiple pharmacologic exposures simultaneously using electronic health record data. J Am Med Inform Assoc. 2018 Jul 1;25(7):780-789. PubMed PMID: 29378062
  • Scott FI, Lichtenstein GR. Biosimilars in the Treatment of Inflammatory Bowel Disease: Supporting Evidence in 2017. Curr Treat Options Gastroenterol. 2018 Mar;16(1):147-164. PubMed PMID: 29492747
  • Scott FI, Shah Y, Lasch K, Luo M, Lewis JD. Assessing the Optimal Position for Vedolizumab in the Treatment of Ulcerative Colitis: A Simulation Model. Inflamm Bowel Dis. 2018 Jan 18;24(2):286-295. PubMed PMID: 29361100
  • Lewis JD, Scott FI, Brensinger CM, Roy JA, Osterman MT, Mamtani R, Bewtra M, Chen L, Yun H, Xie F, Curtis JR. Increased Mortality Rates With Prolonged Corticosteroid Therapy When Compared With Antitumor Necrosis Factor-a-Directed Therapy for Inflammatory Bowel Disease. Am J Gastroenterol. 2018 Mar;113(3):405-417. PubMed PMID: 29336432
  • Osterman CK, Alanzi J, Lewis JD, Kaufman EL, Narayan V, Boursi B, Vajravelu RK, Scott FI, Malkowicz SB, Mamtani R. Association Between Symptomatic Versus Asymptomatic Recurrence and Survival in Bladder Cancer. Clin Genitourin Cancer. 2018 Jun;16(3):235-239. PubMed PMID: 29287969
  • Agarwal A, Garimall S, Scott FI, Ahmad NA, Kochman ML, Ginsberg GG, Chandrasekhara V. En bloc endoscopic mucosal resection is equally effective for sessile serrated polyps and conventional adenomas. Surg Endosc. 2018 Apr;32(4):1871-1878. PubMed PMID: 28940106
  • Scott FI, Mamtani R. Antibiotics and Obesity-A Burgeoning or Thinning Argument?. JAMA Pediatr. 2017 Feb 1;171(2):118-120. PubMed PMID: 28027341
  • Osterman CK, Alanzi J, Lewis JD, Kaufman EL, Narayan V, Boursi B, Vajravelu RK, Scott FI, Malkowicz SB, Mamtani R. Association Between Symptomatic Versus Asymptomatic Recurrence and Survival in Bladder Cancer. Clin Genitourin Cancer. 2017 Dec 6. [Epub ahead of print] PubMed PMID: 29287969
  • Agarwal A, Garimall S, Scott FI, Ahmad NA, Kochman ML, Ginsberg GG, Chandrasekhara V. En bloc endoscopic mucosal resection is equally effective for sessile serrated polyps and conventional adenomas. Surg Endosc. 2017 Sep 22. [Epub ahead of print] PubMed PMID: 28940106
  • Scott FI, Lichtenstein GR. Approach to the Patient with Mild Crohn's Disease: a 2016 Update. Curr Gastroenterol Rep. 2016 Sep;18(9):50. PubMed PMID: 27448619
  • Agarwal A, Scott FI, Ahmad NA, Chandrasekhara V. Chronic immunosuppression does not potentiate the malignant progression of mucinous pancreatic cystic lesions. Pancreatology. 2016 Sep-Oct;16(5):900-4. PubMed PMID: 27424477
  • Mamtani R, Clark AS, Scott FI, Brensinger CM, Boursi B, Chen L, Xie F, Yun H, Osterman MT, Curtis JR, Lewis JD. Association Between Breast Cancer Recurrence and Immunosuppression in Rheumatoid Arthritis and Inflammatory Bowel Disease: A Cohort Study. Arthritis Rheumatol. 2016 Oct;68(10):2403-11. PubMed PMID: 27159030
  • Mamtani R, Lewis JD, Scott FI, Ahmad T, Goldberg DS, Datta J, Yang YX, Boursi B. Disentangling the Association between Statins, Cholesterol, and Colorectal Cancer: A Nested Case-Control Study. PLoS Med. 2016 Apr 26;13(4):e1002007. PubMed PMID: 27116322
  • Shelton E, Laharie D, Scott FI, Mamtani R, Lewis JD, Colombel JF, Ananthakrishnan AN. Cancer Recurrence Following Immune-Suppressive Therapies in Patients With Immune-Mediated Diseases: A Systematic Review and Meta-analysis. Gastroenterology. 2016 Jul;151(1):97-109.e4. PubMed PMID: 27039969
  • Scott FI, Horton DB, Mamtani R, Haynes K, Goldberg DS, Lee DY, Lewis JD. Administration of Antibiotics to Children Before Age 2 Years Increases Risk for Childhood Obesity. Gastroenterology. 2016 Jul;151(1):120-129.e5. PubMed PMID: 27003602
  • Scott FI, Mamtani R, Haynes K, Goldberg DS, Mahmoud NN, Lewis JD. Validation of a coding algorithm for intra-abdominal surgeries and adhesion-related complications in an electronic medical records database. Pharmacoepidemiol Drug Saf. 2016 Apr;25(4):405-12. PubMed PMID: 26860870
  • Scott FI, Lichtenstein GR. Advances in Therapeutic Drug Monitoring of Biologic Therapies in Inflammatory Bowel Disease: 2015 in Review. Curr Treat Options Gastroenterol. 2016 Mar;14(1):91-102. PubMed PMID: 26847358
  • Mamtani R, Yang YX, Scott FI, Lewis JD, Boursi B. Association of Itraconazole, a Hedgehog Inhibitor, and Bladder Cancer. J Urol. 2016 Aug;196(2):343-8. PubMed PMID: 26812305
  • Zhang F, Mamtani R, Scott FI, Goldberg DS, Haynes K, Lewis JD. Increasing use of prescription drugs in the United Kingdom. Pharmacoepidemiol Drug Saf. 2016 Jun;25(6):628-36. PubMed PMID: 26710965
  • Goldberg DS, French B, Lewis JD, Scott FI, Mamtani R, Gilroy R, Halpern SD, Abt PL. Liver transplant center variability in accepting organ offers and its impact on patient survival. J Hepatol. 2016 Apr;64(4):843-51. PubMed PMID: 26626495
  • Horton DB, Scott FI, Haynes K, Putt ME, Rose CD, Lewis JD, Strom BL. Antibiotic Exposure, Infection, and the Development of Pediatric Psoriasis: A Nested Case-Control Study. JAMA Dermatol. 2016 Feb;152(2):191-9. PubMed PMID: 26560335
  • Scott FI, Mamtani R, Brensinger CM, Haynes K, Chiesa-Fuxench ZC, Zhang J, Chen L, Xie F, Yun H, Osterman MT, Beukelman T, Margolis DJ, Curtis JR, Lewis JD. Risk of Nonmelanoma Skin Cancer Associated With the Use of Immunosuppressant and Biologic Agents in Patients With a History of Autoimmune Disease and Nonmelanoma Skin Cancer. JAMA Dermatol. 2016 Feb;152(2):164-72. PubMed PMID: 26510126
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Professional Memberships

  • American College of Gastroenterology (ACG), Member
  • Crohn's and Colitis Foundation of America (CCFA), Member, Research Initiatives Committee
  • American Gastroenterological Association (AGA), Member

Practice Locations

Digestive Health Center - Anschutz
1635 Aurora Ct
5th Floor
Aurora, CO 80045
720-848-2777

Crohn's and Colitis Center - Anschutz
1635 Aurora Ct
6th Floor
Aurora, CO 80045
720-848-2777

Hospital Affiliation
  • University of Colorado Hospital

Specialty Information

Specialties
  • Internal Medicine, Board Certification (2009)
  • Gastroenterology, Board Certification (2012)
Conditions & Treatments
  • Digestive System - Inflammatory Bowel Disease (IBD): Crohn’s disease, ulcerative colitis, microscopic colitis
  • Digestive System
Care Philosophy
I strive to provide the best possible care for patients with inflammatory bowel disease, combining state-of-the-art medical therapy and diagnostic techniques to achieve the most personalized therapy for my patients.

Personal Interests
In my free time, I am an avid cyclist, runner, and relatively poor swimmer. I also enjoy taking advantage of some of the best skiing terrain in North America.

Public Speaking
Yes

General Information

Medical Schools:
  • MD, Temple University School of Medicine (2006)
Graduate Schools:
  • MSCE, University of Pennsylvania (2012)
Undergraduate Schools:
  • BA, University of Pennsylvania (Philadelphia, PA) (2000)
Residency Programs:
  • New York Presbyterian Hospital (Cornell Campus) Program, Internal Medicine (2009)
Fellowships:
  • Hospital of the University of Pennsylvania, Gastroenterology (2012)
  • Hospital of the University of Pennsylvania, Advanced fellowship in Inflammatory Bowel Diseases (2013)
Download CV
Languages: English
Department: Medicine-Gastroenterology
Contact Us
CU Anschutz
Fitzsimons Building

13001 East 17th Place
Campus Box C290
Aurora, CO 80045

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