Slobodan Todorovic, MD, PhD
Professor, Anesthesiology

Photo
Download CV
Graduate Schools :
  • PhD, University of Illinois At Chicago (1990)
  • MD, University of Belgrade (1982)
Internship:
  • McGaw Medical Center of Northwestern University Program (1992)
Residencies:
  • Washington University in St. Louis, Anesthesiology (1996)
  • Washington University/Barnes-Jewish Hospital/St. Louis Children's Hospital, Neurology (1993)
Fellowships:
  • Washington University in St. Louis, Anesthesiology (1998)
Languages: English, Serbian
Department: Anesthesiology

Professional Titles

  • Professor of Anesthesiology

Research Interests

I am interested in mechanism of action and safety of general anesthetics

Teaching

  • Professor (2016)
    School of Medicine, Anesthesiology
    Ion channels and neuronal excitability, molecular mechanisms of anesthesia and analgesia

Publications

  • Hoffmann T, Kistner K, Joksimovic SLJ, Todorovic SM, Reeh PW, Sauer SK. Painful diabetic neuropathy leads to functional Ca(V)3.2 expression and spontaneous activity in skin nociceptors of mice. Exp Neurol. 2021 Dec;346:113838. PubMed PMID: 34450183
  • Coulter I, Timic Stamenic T, Eggan P, Fine BR, Corrigan T, Covey DF, Yang L, Pan JQ, Todorovic SM. Different roles of T-type calcium channel isoforms in hypnosis induced by an endogenous neurosteroid epipregnanolone. Neuropharmacology. 2021 Oct 1;197:108739. PubMed PMID: 34339750
  • Joksimovic SM, Sampath D, Krishnan K, Covey DF, Jevtovic-Todorovic V, Raol YH, Todorovic SM. Differential effects of the novel neurosteroid hypnotic (3ß,5ß,17ß)-3-hydroxyandrostane-17-carbonitrile on electroencephalogram activity in male and female rats. Br J Anaesth. 2021 Sep;127(3):435-446. PubMed PMID: 33972091
  • Joksimovic SL, Lamborn N, Jevtovic-Todorovic V, Todorovic SM. Alpha lipoic acid attenuates evoked and spontaneous pain following surgical skin incision in rats. Channels (Austin). 2021 Dec;15(1):398-407. PubMed PMID: 33843451
  • Timic Stamenic T, Feseha S, Manzella FM, Wallace D, Wilkey D, Corrigan T, Fiedler H, Doerr P, Krishnan K, Raol YH, Covey DF, Jevtovic-Todorovic V, Todorovic SM. The T-type calcium channel isoform Ca(v)3.1 is a target for the hypnotic effect of the anaesthetic neurosteroid (3ß,5ß,17ß)-3-hydroxyandrostane-17-carbonitrile. Br J Anaesth. 2021 Jan;126(1):245-255. PubMed PMID: 32859366
  • Tat QL, Joksimovic SM, Krishnan K, Covey DF, Todorovic SM, Jevtovic-Todorovic V. Preemptive Analgesic Effect of Intrathecal Applications of Neuroactive Steroids in a Rodent Model of Post-Surgical Pain: Evidence for the Role of T-Type Calcium Channels. Cells. 2020 Dec 12;9(12). PubMed PMID: 33322727
  • Feseha S, Timic Stamenic T, Wallace D, Tamag C, Yang L, Pan JQ, Todorovic SM. Global genetic deletion of Ca(V)3.3 channels facilitates anaesthetic induction and enhances isoflurane-sparing effects of T-type calcium channel blockers. Sci Rep. 2020 Dec 9;10(1):21510. PubMed PMID: 33299036
  • Raol YH, Joksimovic SM, Sampath D, Matter BA, Lam PM, Kompella UB, Todorovic SM, González MI. The role of KCC2 in hyperexcitability of the neonatal brain. Neurosci Lett. 2020 Nov 1;738:135324. PubMed PMID: 32860887
  • Manzella FM, Joksimovic SM, Orfila JE, Fine BR, Dietz RM, Sampath D, Fiedler HK, Tesic V, Atluri N, Raol YH, Jevtovic-Todorovic V, Herson PS, Todorovic SM. Neonatal Ketamine Alters High-Frequency Oscillations and Synaptic Plasticity in the Subiculum But Does not Affect Sleep Macrostructure in Adolescent Rats. Front Syst Neurosci. 2020;14:26. PubMed PMID: 32528257
  • Timic Stamenic T, Feseha S, Manzella FM, Wallace D, Wilkey D, Corrigan T, Fiedler H, Doerr P, Krishnan K, Raol YH, Covey DF, Jevtovic-Todorovic V, Todorovic SM. The T-type calcium channel isoform Ca(v)3.1 is a target for the hypnotic effect of the anaesthetic neurosteroid (3ß,5ß,17ß)-3-hydroxyandrostane-17-carbonitrile. Br J Anaesth. 2020 Aug 25. [Epub ahead of print] PubMed PMID: 32859366
  • Tesic V, Joksimovic SM, Quillinan N, Krishnan K, Covey DF, Todorovic SM, Jevtovic-Todorovic V. Neuroactive steroids alphaxalone and CDNC24 are effective hypnotics and potentiators of GABA(A) currents, but are not neurotoxic to the developing rat brain. Br J Anaesth. 2020 May;124(5):603-613. PubMed PMID: 32151384
  • Joksimovic SL, Joksimovic SM, Manzella FM, Asnake B, Orestes P, Raol YH, Krishnan K, Covey DF, Jevtovic-Todorovic V, Todorovic SM. Novel neuroactive steroid with hypnotic and T-type calcium channel blocking properties exerts effective analgesia in a rodent model of post-surgical pain. Br J Pharmacol. 2020 Apr;177(8):1735-1753. PubMed PMID: 31732978
  • Joksimovic SM, DiGruccio MR, Boscolo A, Jevtovic-Todorovic V, Todorovic SM. The Role of Free Oxygen Radicals in Lasting Hyperexcitability of Rat Subicular Neurons After Exposure to General Anesthesia During Brain Development. Mol Neurobiol. 2020 Jan;57(1):208-216. PubMed PMID: 31493241
  • Joksimovic SL, Evans JG, McIntire WE, Orestes P, Barrett PQ, Jevtovic-Todorovic V, Todorovic SM. Glycosylation of Ca(V)3.2 Channels Contributes to the Hyperalgesia in Peripheral Neuropathy of Type 1 Diabetes. Front Cell Neurosci. 2020;14:605312. PubMed PMID: 33384586
  • Woodward TJ, Tesic V, Stamenic TT, Jevtovic-Todorovic V, Todorovic SM. Pharmacological Antagonism of T-Type Calcium Channels Constrains Rebound Burst Firing in Two Distinct Subpopulations of GABA Neurons in the Rat Ventral Tegmental Area: Implications for a-Lipoic Acid. Front Pharmacol. 2019;10:1402. PubMed PMID: 31849661
  • Joksimovic SL, Joksimovic SM, Manzella FM, Asnake B, Orestes P, Raol YH, Krishnan K, Covey DF, Jevtovic-Todorovic V, Todorovic SM. Novel neuroactive steroid with hypnotic and T-channel blocking properties exerts effective analgesia in a rodent model of post-surgical pain. Br J Pharmacol. 2019 Nov 15. [Epub ahead of print] PubMed PMID: 31732978
  • Chemin J, Stamenic TT, Cazade M, Llinares J, Blesneac I, Todorovic SM, Lory P. A novel phospho-modulatory mechanism contributes to the calcium-dependent regulation of T-type Ca(2 ) channels. Sci Rep. 2019 Oct 30;9(1):15642. PubMed PMID: 31666636
  • Joksimovic SM, DiGruccio MR, Boscolo A, Jevtovic-Todorovic V, Todorovic SM. The Role of Free Oxygen Radicals in Lasting Hyperexcitability of Rat Subicular Neurons After Exposure to General Anesthesia During Brain Development. Mol Neurobiol. 2019 Sep 6. [Epub ahead of print] PubMed PMID: 31493241
  • Joksimovic SM, Izumi Y, Joksimovic SL, Tesic V, Krishnan K, Asnake B, Jevtovic-Todorovic V, Covey DF, Zorumski CF, Todorovic SM. Novel neurosteroid hypnotic blocks T-type calcium channel-dependent rebound burst firing and suppresses long-term potentiation in the rat subiculum. Br J Anaesth. 2019 May;122(5):643-651. PubMed PMID: 30916017
  • Woodward TJ, Timic Stamenic T, Todorovic SM. Neonatal general anesthesia causes lasting alterations in excitatory and inhibitory synaptic transmission in the ventrobasal thalamus of adolescent female rats. Neurobiol Dis. 2019 Jul;127:472-481. PubMed PMID: 30825640
  • Timic Stamenic T, Feseha S, Valdez R, Zhao W, Klawitter J, Todorovic SM. Alterations in Oscillatory Behavior of Central Medial Thalamic Neurons Demonstrate a Key Role of CaV3.1 Isoform of T-Channels During Isoflurane-Induced Anesthesia. Cereb Cortex. 2019 Dec 17;29(11):4679-4696. PubMed PMID: 30715245
  • Joksimovic SL, Donald RR, Park JY, Todorovic SM. Inhibition of multiple voltage-gated calcium channels may contribute to spinally mediated analgesia by epipregnanolone in a rat model of surgical paw incision. Channels (Austin). 2019 Dec;13(1):48-61. PubMed PMID: 30672394
  • Joksimovic SL, Covey DF, Jevtovic-Todorovic V, Todorovic SM. Neurosteroids in Pain Management: A New Perspective on an Old Player. Front Pharmacol. 2018;9:1127. PubMed PMID: 30333753
  • Joksimovic SL, Joksimovic SM, Tesic V, García-Caballero A, Feseha S, Zamponi GW, Jevtovic-Todorovic V, Todorovic SM. Selective inhibition of Ca(V)3.2 channels reverses hyperexcitability of peripheral nociceptors and alleviates postsurgical pain. Sci Signal. 2018 Aug 28;11(545). PubMed PMID: 30154101
  • Tracy ME, Tesic V, Stamenic TT, Joksimovic SM, Busquet N, Jevtovic-Todorovic V, Todorovic SM. Ca(V)3.1 isoform of T-type calcium channels supports excitability of rat and mouse ventral tegmental area neurons. Neuropharmacology. 2018 Jun;135:343-354. PubMed PMID: 29578032
  • Atluri N, Joksimovic SM, Oklopcic A, Milanovic D, Klawitter J, Eggan P, Krishnan K, Covey DF, Todorovic SM, Jevtovic-Todorovic V. A neurosteroid analogue with T-type calcium channel blocking properties is an effective hypnotic, but is not harmful to neonatal rat brain. Br J Anaesth. 2018 Apr;120(4):768-778. PubMed PMID: 29576117
  • Stamenic TT, Todorovic SM. Cytosolic ATP Relieves Voltage-Dependent Inactivation of T-Type Calcium Channels and Facilitates Excitability of Neurons in the Rat Central Medial Thalamus. eNeuro. 2018 Jan-Feb;5(1). PubMed PMID: 29468189
  • Joksimovic SM, Osuru HP, Oklopcic A, Beenhakker MP, Jevtovic-Todorovic V, Todorovic SM. Histone Deacetylase Inhibitor Entinostat (MS-275) Restores Anesthesia-induced Alteration of Inhibitory Synaptic Transmission in the Developing Rat Hippocampus. Mol Neurobiol. 2018 Jan;55(1):222-228. PubMed PMID: 28840475
  • Joksimovic SJ, Eggan P, Izumi Y, Joksimovic SLj, Tesic V, Dietz RM, Orfila JE, DiGruccio MR, Herson PS, Jevtovic-Todorovic V, Zorumski CF, Todorovic SM. The role of T-type calcium channels in the subiculum: to burst or not to burst? J Physiol, 2017, 000.00:1-22.
  • Todorovic SM. Painful Diabetic Neuropathy: Prevention or Suppression?. Int Rev Neurobiol. 2016;127:211-25. PubMed PMID: 27133151
  • Dalla Massara L, Osuru HP, Oklopcic A, Milanovic D, Joksimovic SM, Caputo V, DiGruccio MR, Ori C, Wang G, Todorovic SM, Jevtovic-Todorovic V. General Anesthesia Causes Epigenetic Histone Modulation of c-Fos and Brain-derived Neurotrophic Factor, Target Genes Important for Neuronal Development in the Immature Rat Hippocampus. Anesthesiology. 2016 Jun;124(6):1311-27. PubMed PMID: 27028464
  • Todorovic SM. Is Diabetic Nerve Pain Caused by Dysregulated Ion Channels in Sensory Neurons?. Diabetes. 2015 Dec;64(12):3987-9. PubMed PMID: 26604173
View All (32 Total) View Less

Professional Memberships

  • Society For Neuroscience, member
  • American Society of Anesthesiologists, member
  • Colorado Society of Anesthesiologists, member
  • Association of University Anesthesiologists, member
  • American Society for Biophysics, member

Practice Locations

Hospital Affiliation
  • Veterans Affairs Medical Center

Specialty Information

Specialties
  • Anesthesiology, Board Certification
Personal Interests
In my spare time I enjoy running, cycling and reading novels

General Information

Graduate Schools:
  • PhD, University of Illinois At Chicago (1990)
  • MD, University of Belgrade (1982)
Internships:
  • McGaw Medical Center of Northwestern University Program (1992)
Residency Programs:
  • Washington University in St. Louis, Anesthesiology (1996)
  • Washington University/Barnes-Jewish Hospital/St. Louis Children's Hospital, Neurology (1993)
Fellowships:
  • Washington University in St. Louis, Anesthesiology (1998)
Download CV
Languages: English, Serbian
Department: Anesthesiology
;