Vesna Jevtovic-Todorovic, MD, PhD
Professor, Anesthesiology

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Graduate Schools :
  • MD, University of Belgrade (1985)
  • PhD, University of Illinois At Chicago (1990)
  • MBA, University of Virginia - Charlottesville (2010)
Internship:
  • Loyola University Program (1992)
Residency:
  • Washington University/Barnes-Jewish Hospital/St. Louis Children's Hospital, Anesthesiology (1995)
Languages: English, Serbian, Russian
Department: Anesthesiology

Professional Titles

  • Professor

Research Interests

Developmental Neurotoxicity Pharmacology and mechanisms of chronic pain

Teaching

  • Chair (2016)
    School of Medicine, Anesthesiology
    General anesthesiology Developmental neuroscience and chronic pain research

Publications

  • Jevtovic-Todorovic V, Vutskits L. Beyond Anesthesia Apoptosis: Wiring and Communication Matter!. Anesthesiology. 2020 Sep;133(3):495-496. PubMed PMID: 32788555
  • Tesic V, Joksimovic SM, Quillinan N, Krishnan K, Covey DF, Todorovic SM, Jevtovic-Todorovic V. Neuroactive steroids alphaxalone and CDNC24 are effective hypnotics and potentiators of GABA(A) currents, but are not neurotoxic to the developing rat brain. Br J Anaesth. 2020 May;124(5):603-613. PubMed PMID: 32151384
  • Chinn GA, Pearn ML, Vutskits L, Mintz CD, Loepke AW, Lee JJ, Chen J, Bosnjak ZJ, Brambrink AM, Jevtovic-Todorovic V, Sun LS, Sall JW. Standards for preclinical research and publications in developmental anaesthetic neurotoxicity: expert opinion statement from the SmartTots preclinical working group. Br J Anaesth. 2020 May;124(5):585-593. PubMed PMID: 32145876
  • Cabrera OH, Gulvezan T, Symmes B, Quillinan N, Jevtovic-Todorovic V. Sex differences in neurodevelopmental abnormalities caused by early-life anaesthesia exposure: a narrative review. Br J Anaesth. 2020 Mar;124(3):e81-e91. PubMed PMID: 31980157
  • Chastain-Potts SE, Tesic V, Tat QL, Cabrera OH, Quillinan N, Jevtovic-Todorovic V. Sevoflurane Exposure Results in Sex-Specific Transgenerational Upregulation of Target IEGs in the Subiculum. Mol Neurobiol. 2020 Jan;57(1):11-22. PubMed PMID: 31512116
  • Diana P, Joksimovic SM, Faisant A, Jevtovic-Todorovic V. Early exposure to general anesthesia impairs social and emotional development in rats. Mol Neurobiol. 2020 Jan;57(1):41-50. PubMed PMID: 31494825
  • Cabrera OH, Tesic V, Tat QL, Chastain S, Quillinan N, Jevtovic-Todorovic V. Sevoflurane-Induced Dysregulation of Cation-Chloride Cotransporters NKCC1 and KCC2 in Neonatal Mouse Brain. Mol Neurobiol. 2020 Jan;57(1):1-10. PubMed PMID: 31493242
  • Joksimovic SM, DiGruccio MR, Boscolo A, Jevtovic-Todorovic V, Todorovic SM. The Role of Free Oxygen Radicals in Lasting Hyperexcitability of Rat Subicular Neurons After Exposure to General Anesthesia During Brain Development. Mol Neurobiol. 2020 Jan;57(1):208-216. PubMed PMID: 31493241
  • Joksimovic SL, Joksimovic SM, Manzella FM, Asnake B, Orestes P, Raol YH, Krishnan K, Covey DF, Jevtovic-Todorovic V, Todorovic SM. Novel neuroactive steroid with hypnotic and T-type calcium channel blocking properties exerts effective analgesia in a rodent model of post-surgical pain. Br J Pharmacol. 2020 Apr;177(8):1735-1753. PubMed PMID: 31732978
  • Manzella FM, Joksimovic SM, Orfila JE, Fine BR, Dietz RM, Sampath D, Fiedler HK, Tesic V, Atluri N, Raol YH, Jevtovic-Todorovic V, Herson PS, Todorovic SM. Neonatal Ketamine Alters High-Frequency Oscillations and Synaptic Plasticity in the Subiculum But Does not Affect Sleep Macrostructure in Adolescent Rats. Front Syst Neurosci. 2020;14:26. PubMed PMID: 32528257
  • Tat QL, Joksimovic SM, Krishnan K, Covey DF, Todorovic SM, Jevtovic-Todorovic V. Preemptive Analgesic Effect of Intrathecal Applications of Neuroactive Steroids in a Rodent Model of Post-Surgical Pain: Evidence for the Role of T-Type Calcium Channels. Cells. 2020 Dec 12;9(12). PubMed PMID: 33322727
  • Timic Stamenic T, Feseha S, Manzella FM, Wallace D, Wilkey D, Corrigan T, Fiedler H, Doerr P, Krishnan K, Raol YH, Covey DF, Jevtovic-Todorovic V, Todorovic SM. The T-type calcium channel isoform Ca(v)3.1 is a target for the hypnotic effect of the anaesthetic neurosteroid (3ß,5ß,17ß)-3-hydroxyandrostane-17-carbonitrile. Br J Anaesth. 2020 Aug 25. [Epub ahead of print] PubMed PMID: 32859366
  • Joksimovic SL, Evans JG, McIntire WE, Orestes P, Barrett PQ, Jevtovic-Todorovic V, Todorovic SM. Glycosylation of Ca(V)3.2 Channels Contributes to the Hyperalgesia in Peripheral Neuropathy of Type 1 Diabetes. Front Cell Neurosci. 2020;14:605312. PubMed PMID: 33384586
  • 1. Tat QL, Joksimovic SM, Krishnan K, Covey DF, Todorovic SM, Jevtovic-Todorovic V. Preemptive Analgesic Effect of Intrathecal Applications of Neuroactive Steroids in a Rodent Model of Post-Surgical Pain: Evidence for the Role of T-Type Calcium Channels. Cells 2020, 9: 2674-2686.
  • 2. Joksimovic SL, Evans JG, McIntire WE, Orestes P, Barrett PQ, Jevtovic-Todorovic V, Todorovic SM. Glycosylation of CaV3.2 Channels Contributes to the Hyperalgesia in Peripheral Neuropathy of Type 1 Diabetes. Front Cell Neurosci. 2020 15;14:605312.
  • 3. Timic Stamenic T, Feseha S, Manzella FM, Wallace D, Wilkey D, Corrigan T, Fiedler H, Doerr P, Krishnan K, Raol YH, Covey DF, Jevtovic-Todorovic V, Todorovic SM. The T-type calcium channel isoform Cav3.1 is a target for the hypnotic effect of the anaesthetic neurosteroid (3ß,5ß,17ß)-3-hydroxyandrostane-17-carbonitrile. Br J Anaesth. 2020, S0007-0912 (20)30611-5.
  • 5. Manzella FM, Joksimovic SM, Orfila JE, Fine BR, Dietz RM, Sampath D, Fiedler HK, *Tesic V, *Atluri N, Raol YH, Jevtovic-Todorovic V, Herson PS, Todorovic SM. Neonatal Ketamine Alters High-Frequency Oscillations and Synaptic Plasticity in the Subiculum But Does not Affect Sleep Macrostructure in Adolescent Rats. Front Syst Neurosci. 2020, 14:26.
  • 6. *Tesic V, Joksimovic SM, Quillinan N, Krishnan K, Covey DF, Todorovic SM, Jevtovic-Todorovic V. Neuroactive steroids alphaxalone and CDNC24 are effective hypnotics and potentiators of GABAA currents, but are not neurotoxic to the developing rat brain. Br J Anaesth. 2020, 124(5): 603-613.
  • 7. Chinn GA, Pearn ML, Vutskits L, Mintz CD, Loepke AW, Lee JJ, Chen J, Bosnjak ZJ, Brambrink AM, Jevtovic-Todorovic V, Sun LS, Sall JW. Standards for preclinical research and publications in developmental anaesthetic neurotoxicity: expert opinion statement from the SmartTots preclinical working group. Br J Anaesth. 2020, 124(5): 585-593.
  • 8. *Cabrera OH, *Gulvezan T, *Symmes B, Quillinan N, Jevtovic-Todorovic V. Sex differences in neurodevelopmental abnormalities caused by early-life anaesthesia exposure: a narrative review. Br J Anaesth. 2020;124(3): e81-e91.
  • Joksimovic SM, Izumi Y, Joksimovic SL, Tesic V, Krishnan K, Asnake B, Jevtovic-Todorovic V, Covey DF, Zorumski CF, Todorovic SM. Novel neurosteroid hypnotic blocks T-type calcium channel-dependent rebound burst firing and suppresses long-term potentiation in the rat subiculum. Br J Anaesth. 2019 May;122(5):643-651. PubMed PMID: 30916017
  • Woodward TJ, Tesic V, Stamenic TT, Jevtovic-Todorovic V, Todorovic SM. Pharmacological Antagonism of T-Type Calcium Channels Constrains Rebound Burst Firing in Two Distinct Subpopulations of GABA Neurons in the Rat Ventral Tegmental Area: Implications for a-Lipoic Acid. Front Pharmacol. 2019;10:1402. PubMed PMID: 31849661
  • Joksimovic SL, Covey DF, Jevtovic-Todorovic V, Todorovic SM. Neurosteroids in Pain Management: A New Perspective on an Old Player. Front Pharmacol. 2018;9:1127. PubMed PMID: 30333753
  • Joksimovic SL, Joksimovic SM, Tesic V, García-Caballero A, Feseha S, Zamponi GW, Jevtovic-Todorovic V, Todorovic SM. Selective inhibition of Ca(V)3.2 channels reverses hyperexcitability of peripheral nociceptors and alleviates postsurgical pain. Sci Signal. 2018 Aug 28;11(545). PubMed PMID: 30154101
  • Vutskits L, Sall JW, Jevtovic-Todorovic V. A poisoned chalice: the heritage of parental anaesthesia exposure. Br J Anaesth. 2018 Aug;121(2):337-339. PubMed PMID: 30032869
  • Tracy ME, Tesic V, Stamenic TT, Joksimovic SM, Busquet N, Jevtovic-Todorovic V, Todorovic SM. Ca(V)3.1 isoform of T-type calcium channels supports excitability of rat and mouse ventral tegmental area neurons. Neuropharmacology. 2018 Jun;135:343-354. PubMed PMID: 29578032
  • Atluri N, Joksimovic SM, Oklopcic A, Milanovic D, Klawitter J, Eggan P, Krishnan K, Covey DF, Todorovic SM, Jevtovic-Todorovic V. A neurosteroid analogue with T-type calcium channel blocking properties is an effective hypnotic, but is not harmful to neonatal rat brain. Br J Anaesth. 2018 Apr;120(4):768-778. PubMed PMID: 29576117
  • Jevtovic-Todorovic V. Monkey business: the importance of mounting behavioural evidence for anaesthesia-induced developmental neurotoxicity. Br J Anaesth. 2018 Apr;120(4):617-619. PubMed PMID: 29576100
  • Maloney SE, Creeley CE, Hartman RE, Yuede CM, Zorumski CF, Jevtovic-Todorovic V, Dikranian K, Noguchi KK, Farber NB, Wozniak DF. Using animal models to evaluate the functional consequences of anesthesia during early neurodevelopment. Neurobiol Learn Mem. 2018 Mar 14. [Epub ahead of print] PubMed PMID: 29550366
  • Jevtovic-Todorovic V. Exposure of Developing Brain to General Anesthesia: What Is the Animal Evidence?. Anesthesiology. 2018 Apr;128(4):832-839. PubMed PMID: 29271804
  • Joksimovic SM, Osuru HP, Oklopcic A, Beenhakker MP, Jevtovic-Todorovic V, Todorovic SM. Histone Deacetylase Inhibitor Entinostat (MS-275) Restores Anesthesia-induced Alteration of Inhibitory Synaptic Transmission in the Developing Rat Hippocampus. Mol Neurobiol. 2018 Jan;55(1):222-228. PubMed PMID: 28840475
  • Obradovic AL, Atluri N, Dalla Massara L, Oklopcic A, Todorovic NS, Katta G, Osuru HP, Jevtovic-Todorovic V. Early Exposure to Ketamine Impairs Axonal Pruning in Developing Mouse Hippocampus. Mol Neurobiol. 2018 Jan;55(1):164-172. PubMed PMID: 28840469
  • Jevtovic-Todorovic V, Brambrick A. General Anesthesia and Young Brain: What is New?. J Neurosurg Anesthesiol. 2018 Jul;30(3):217-222. PubMed PMID: 28622158
  • Jevtovic-Todorovic V. Anesthetics and Cognitive Impairments in Developing Children: What is Our Responsibility? JAMA Pediatr. 171: 1135-1136, 2017.
  • Soriano SG, Vutskits L, Jevtovic-Todorovic V, Hemmings HC. Thinking, fast and slow: highlights from the 2016 BJA seminar on anaesthetic neurotoxicity and neutoplasticity. Br J Anaesth. 119(3):443-447, 2017.
  • Jevotovic-Todorovic V. Anaesthesia-induced developmental neurotoxicity: reality or fiction? Br J Anaesth. 119(3):455-457, 2017.
  • Jin L, Ding M, Oklopcic A, Aghdasi B, Xiao L, Li Z, Jevtovic-Todorovic V. Nanoparticle fullerol alleviates radiculopathy via NLRP3 inflammasome and neuropeptides. Nanomedicine: Nanotechnology, Biology, and Medicine. 13(6):2049-2059, 2017.
  • *Milanovic D, Pesic V, Loncarevic-Vasiljkovic N, Avramovic V, Tesic V, Jevtovic-Todorovic V, Kanazir S, Ruzdijic S. Neonatal Propofol Anesthesia Changes Expression of Synaptic Plasticity Proteins and Increases Stereotypic and Anxyolitic Behavior in Adult Rats. Neurotoxicity Research, 32(2):247-263, 2017.
  • Joksimovic SM, Eggan P, Izumi Y, Joksimovic SLj, Tesic V, *Osuru HP, DiGruccio MR, Jevtovic-Todorovic V, Zorumski CF, TodorovicSM. The role of T-channels in the subiculum: to burst or not to burst? J Physiology, 595(19):6327-6348, 2017.
  • Jevtovic-Todorovic V, Paule MG. Introduction to the Special Issue "Developmental Neurotoxicity Associated with Pediatric General Anesthesia: Preclinical Findings". Neurotoxicol Teratol, 2017.
  • *Weaver J, Arandjelovic S, Brown G, Mendu S, Schappe M, Buckley M, Chiu Y-H, Shu S, Kim J, Chung J, Krupa J, Jevtovic-Todorovic V, Desai B, Ravichandran K, Bayliss DA. Hematopoietic pannexin 1 function is critical for neuropathic pain. Sci Rep. 7: 42550, 2017.
  • *Zanghi CN, Jevtovic-Todorovic V. A holistic approach to anesthesia-induced neurotoxicity and its implications for future mechanistic studies. Neurotoxicol Teratol. 60:24-32, 2017.
  • Jevtovic-Todorovic V. General Anesthetics and Neurotoxicity: How Much Do We Know? Anesthesiol Clin. 2016, 34(3):439-51.
  • Milanovic D, Pesic V, Loncarevic-Vasiljkovic N, Pavkovic Z, Popic J, Kanazir S, Jevtovic-Todorovic V, Ruzdijic S. The Fas Ligand/Fas Death Receptor Pathways Contribute to Propofol-Induced Apoptosis and Neuroinflammation in the Brain of Neonatal Rats. Neurotox Res. 2016, 30(3):434-52.
  • Dalla Massara L, Osuru HP, Oklopcic A, Milanovic D, Joksimovic SM, Caputo V, DiGruccio MR, Ori C, Wang G, Todorovic SM, Jevtovic-Todorovic V. General Anesthesia Causes Epigenetic Histone Modulation of c-Fos and Brain-derived Neurotrophic Factor, Target Genes Important for Neuronal Development in the Immature Rat Hippocampus. Anesthesiology 2016; 124(6):1311-27.
  • 4. Jevtovic-Todorovic V, Vutskits L. Beyond Anesthesia Apoptosis: Wiring and Communication Matter! Anesthesiology 2020, 133(3):495-496.
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Practice Locations

University of Colorado Hospital (UCH)
12605 E. 16th Ave
Aurora, CO 80045
720-848-0000

Hospital Affiliation
  • University of Colorado Hospital
Center Affiliations

Specialty Information

Specialties
  • Anesthesiology, Board Certification
Personal Interests
In my spare time I enjoy playing piano, doing needle work and crafts, and reading financial literature.

General Information

Graduate Schools:
  • MD, University of Belgrade (1985)
  • PhD, University of Illinois At Chicago (1990)
  • MBA, University of Virginia - Charlottesville (2010)
Internships:
  • Loyola University Program (1992)
Residency Programs:
  • Washington University/Barnes-Jewish Hospital/St. Louis Children's Hospital, Anesthesiology (1995)
Languages: English, Serbian, Russian
Department: Anesthesiology
Contact Us
CU Anschutz
Fitzsimons Building

13001 East 17th Place
Campus Box C290
Aurora, CO 80045

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