Zhiying You, MD, PhD
Associate Research Professor, Medicine-Renal Med Diseases/Hypertension

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Languages: English, Mandarin
Department: Medicine-Renal Med Diseases/Hypertension

Publications

  • Gitomer BY, Wang W, George D, Coleman E, Nowak KL, Struemph T, Cadnapaphornchai MA, Patel NU, Jovanovich A, Klawitter J, Farmer B, Ostrow A, You Z, Chonchol M. Statin therapy in patients with early-stage autosomal dominant polycystic kidney disease: Design and baseline characteristics. Contemp Clin Trials. 2023 Dec 25;137:107423. [Epub ahead of print] PubMed PMID: 38151173
  • Lai J, Furgeson S, Bjornstad P, You Z, Tommerdahl KL, Kendrick J. Leukotriene Antagonist Use is Associated With Lower Systolic Blood Pressure in Adults. Kidney Int Rep. 2023 Feb;8(2):373-375. PubMed PMID: 36815112
  • Stenson EK, Edelstein CL, You Z, Miyazaki-Anzai S, Thurman JM, Dixon BP, Zappitelli M, Goldstein SL, Akcan Arikan A, Kendrick J. Urine Complement Factor Ba Is Associated with AKI in Critically Ill Children. Kidney360. 2023 Mar 1;4(3):326-332. PubMed PMID: 36758197
  • Kendrick J, You Z, Andrews E, Farmer-Bailey H, Moreau K, Chonchol M, Steele C, Wang W, Nowak KL, Patel N. Sodium Bicarbonate Treatment and Vascular Function in CKD: A Randomized, Double-Blind, Placebo-Controlled Trial. J Am Soc Nephrol. 2023 Aug 1;34(8):1433-1444. PubMed PMID: 37228030
  • Oh ES, You Z, Nowak KL, Jovanovich AJ. Sex Differences in Cardiovascular and All-Cause Mortality in Adults with and without CKD: NHANES 1999-2018. Kidney360. 2023 Oct 1;4(10):1467-1471. PubMed PMID: 37548954
  • Perez L, You Z, Kendrick J. Association of Plant-Based Protein Intake with Cognitive Function in Adults with CKD. Kidney360. 2023 Nov 1;4(11):1554-1561. PubMed PMID: 37889573
  • Steele C, You Z, Gitomer BY, Brosnahan GM, Abebe KZ, Braun WE, Chapman AB, Harris PC, Perrone RD, Steinman TI, Torres VE, Yu ASL, Chonchol M, Nowak KL. PKD1 Compared With PK D2 Genotype and Cardiac Hospitalizations in the Halt Progression of Polycystic Kidney Disease Studies. Kidney Int Rep. 2022 Jan;7(1):117-120. PubMed PMID: 35005320
  • Nowak KL, Farmer-Bailey H, Wang W, You Z, Steele C, Cadnapaphornchai MA, Klawitter J, Patel N, George D, Jovanovich A, Soranno DE, Gitomer B, Chonchol M. Curcumin Therapy to Treat Vascular Dysfunction in Children and Young Adults with ADPKD: A Randomized Controlled Trial. Clin J Am Soc Nephrol. 2022 Feb;17(2):240-250. PubMed PMID: 34907021
  • Brosnahan GM, Wang W, Gitomer B, Struemph T, George D, You Z, Nowak KL, Klawitter J, Chonchol MB. Metformin Therapy in Autosomal Dominant Polycystic Kidney Disease: A Feasibility Study. Am J Kidney Dis. 2022 Apr;79(4):518-526. PubMed PMID: 34391872
  • Freeberg KA, Craighead DH, Martens CR, You Z, Chonchol M, Seals DR. Nicotinamide Riboside Supplementation for Treating Elevated Systolic Blood Pressure and Arterial Stiffness in Midlife and Older Adults. Front Cardiovasc Med. 2022;9:881703. PubMed PMID: 35620522
  • Paudel S, Raina K, Tiku VR, Maurya A, Orlicky DJ, You Z, Rigby CM, Deep G, Kant R, Raina B, Agarwal C, Agarwal R. Chemopreventive efficacy of silibinin against basal cell carcinoma growth and progression in UVB-irradiated Ptch /- mice. Carcinogenesis. 2022 Jun 27;43(6):557-570. PubMed PMID: 35184170
  • Perez L, You Z, Teitelbaum I, Andrews ES, Reddin R, Ramirez-Renteria L, Wilson G, Kendrick J. A 6-Month clinical practice pilot study of sucroferric oxyhydroxide on nutritional status in patients on peritoneal dialysis. BMC Nephrol. 2022 Jul 9;23(1):245. PubMed PMID: 35810296
  • Craighead DH, Freeberg KA, McCarty NP, Rossman MJ, Moreau KL, You Z, Chonchol M, Seals DR. Inspiratory muscle strength training for lowering blood pressure and improving endothelial function in postmenopausal women: comparison with "standard of care" aerobic exercise. Front Physiol. 2022;13:967478. PubMed PMID: 36105300
  • Murray KO, Berryman-Maciel M, Darvish S, Coppock ME, You Z, Chonchol M, Seals DR, Rossman MJ. Mitochondrial-targeted antioxidant supplementation for improving age-related vascular dysfunction in humans: A study protocol. Front Physiol. 2022;13:980783. PubMed PMID: 36187760
  • Oh ES, Steele CN, You Z, Nowak KL, Jovanovich AJ. Sex hormones and the risk of cardiovascular disease and mortality in male and female patients with chronic kidney disease: A systematic review and meta-analysis. Physiol Rep. 2022 Nov;10(22):e15490. PubMed PMID: 36394074
  • Renner B, Laskowski J, Poppelaars F, Ferreira VP, Blaine J, Antonioli AH, Hannan JP, Kovacs JM, van Kooten C, You Z, Pickering MC, Holers VM, Thurman JM. Factor H related proteins modulate complement activation on kidney cells. Kidney Int. 2022 Dec;102(6):1331-1344. PubMed PMID: 36063874
  • Nowak K, Farmer-Bailey H, Wang W, You Z, Steele C, Cadnapaphornchai M, Klawitter J, Patel N, George D, Jovanovich A, Soranno D, Gitomer B, Chonchol M. Curcumin Therapy to Treat Vascular Dysfunction in Children and Young Adults with ADPKD. Clin J Am Soc Nephrol. 2021 Dec 14. [Epub ahead of print] PubMed PMID: 34907021
  • Trachtman H, Laskowski J, Lee C, Renner B, Feemster A, Parikh S, Panzer SE, Zhong W, Cravedi P, Cantarelli C, Kulik L, You Z, Satchell S, Rovin B, Liu F, Kalled SL, Holers VM, Jalal D, Thurman JM. Natural antibody and complement activation characterize patients with idiopathic nephrotic syndrome. Am J Physiol Renal Physiol. 2021 Oct 1;321(4):F505-F516. PubMed PMID: 34459222
  • Pengshung MH, Bispham NZ, You Z, Oh E, Supiano MA, Chonchol MB, Nowak KL, Jovanovich AJ. Arterial Stiffness Is Independently Associated with Acute Kidney Injury in SPRINT. Clin J Am Soc Nephrol. 2021 Oct;16(10):1560-1561. PubMed PMID: 34452880
  • Nowak KL, Murray K, You Z, Gitomer B, Brosnahan G, Abebe KZ, Braun W, Chapman A, Harris PC, Miskulin D, Perrone R, Torres V, Steinman T, Yu A, Chonchol M. Pain and Obesity in Autosomal Dominant Polycystic Kidney Disease: A Post Hoc Analysis of the Halt Progression of Polycystic Kidney Disease (HALT-PKD) Studies. Kidney Med. 2021 Jul-Aug;3(4):536-545.e1. PubMed PMID: 34401721
  • Brosnahan GM, Wang W, Gitomer B, Struemph T, George D, You Z, Nowak KL, Klawitter J, Chonchol MB. Metformin Therapy in Autosomal Dominant Polycystic Kidney Disease: A Feasibility Study. Am J Kidney Dis. 2021 Aug 12. [Epub ahead of print] PubMed PMID: 34391872
  • Brosnahan GM, You Z, Wang W, Gitomer BY, Chonchol M. Serum Uric Acid and Progression of Autosomal Dominant Polycystic Kidney Disease: Results from the HALT PKD Trials. Curr Hypertens Rev. 2021;17(3):228-237. PubMed PMID: 32807060
  • Jovanovich A, Ginsberg C, You Z, Katz R, Ambrosius WT, Berlowitz D, Cheung AK, Cho M, Lee AK, Punzi H, Rehman S, Roumie C, Supiano MA, Wright CB, Shlipak M, Ix JH, Chonchol M. FGF23, Frailty, and Falls in SPRINT. J Am Geriatr Soc. 2021 Feb;69(2):467-473. PubMed PMID: 33289072
  • Kendrick J, Chonchol M, You Z, Jovanovich A. Lower serum bicarbonate is associated with an increased risk of acute kidney injury. J Nephrol. 2021 Apr;34(2):433-439. PubMed PMID: 32436182
  • Gitomer B, Pereira R, Salusky IB, Stoneback JW, Isakova T, Cai X, Dalrymple LS, Ofsthun N, You Z, Malluche HH, Maddux F, George D, Torres V, Chapman A, Steinman TI, Wolf M, Chonchol M. Mineral bone disease in autosomal dominant polycystic kidney disease. Kidney Int. 2021 Apr;99(4):977-985. PubMed PMID: 32926884
  • Craighead DH, Heinbockel TC, Freeberg KA, Rossman MJ, Jackman RA, Jankowski LR, Hamilton MN, Ziemba BP, Reisz JA, D'Alessandro A, Brewster LM, DeSouza CA, You Z, Chonchol M, Bailey EF, Seals DR. Time-Efficient Inspiratory Muscle Strength Training Lowers Blood Pressure and Improves Endothelial Function, NO Bioavailability, and Oxidative Stress in Midlife/Older Adults With Above-Normal Blood Pressure. J Am Heart Assoc. 2021 Jul 6;10(13):e020980. PubMed PMID: 34184544
  • Bohling R, Grafals M, Moreau K, You Z, Tommerdahl KL, Bjornstad P, Stenson EK, Andrews E, Ramirez-Renteria L, Kendrick J. A Pilot Study of the Safety and Efficacy of Alkali Therapy on Vascular Function in Kidney Transplant Recipients. Kidney Int Rep. 2021 Sep;6(9):2323-2330. PubMed PMID: 34514193
  • Aslan G, Afsar B, Sag AA, Camkiran V, Erden N, Yilmaz S, Siriopol D, Incir S, You Z, Garcia ML, Covic A, Cherney DZI, Johnson RJ, Kanbay M. The Effect of Urine pH and Urinary Uric Acid Levels on the Development of Contrast Nephropathy. Kidney Blood Press Res. 2020;45(1):131-141. PubMed PMID: 31865342
  • Stites E, Renner B, Laskowski J, Le Quintrec M, You Z, Freed B, Cooper J, Jalal D, Thurman JM. Complement fragments are biomarkers of antibody-mediated endothelial injury. Mol Immunol. 2020 Feb;118:142-152. PubMed PMID: 31884386
  • Perrenoud L, Kruse NT, Andrews E, You Z, Chonchol M, Wu C, Ten Eyck P, Zepeda-Orozco D, Jalal D. Uric Acid Lowering and Biomarkers of Kidney Damage in CKD Stage 3: A Post Hoc Analysis of a Randomized Clinical Trial. Kidney Med. 2020 Mar-Apr;2(2):155-161. PubMed PMID: 32964203
  • Skrypnyk NI, Gist KM, Okamura K, Montford JR, You Z, Yang H, Moldovan R, Bodoni E, Blaine JT, Edelstein CL, Soranno DE, Kirkbride-Romeo LA, Griffin BR, Altmann C, Faubel S. IL-6-mediated hepatocyte production is the primary source of plasma and urine neutrophil gelatinase-associated lipocalin during acute kidney injury. Kidney Int. 2020 May;97(5):966-979. PubMed PMID: 32081304
  • Kruse NT, You Z, Moreau K, Kendrick J, Jalal D. Sex differences in endothelial function in chronic kidney disease. Am J Physiol Renal Physiol. 2020 Jul 1;319(1):F33-F40. PubMed PMID: 32421350
  • Kendrick J, Chonchol M, You Z, Jovanovich A. Lower serum bicarbonate is associated with an increased risk of acute kidney injury. J Nephrol. 2020 May 20. [Epub ahead of print] PubMed PMID: 32436182
  • Griffin BR, You Z, Noureddine L, Gitomer B, Perrenoud L, Wang W, Chonchol M, Jalal D. KIM-1 and Kidney Disease Progression in Autosomal Dominant Polycystic Kidney Disease: HALT-PKD Results. Am J Nephrol. 2020;51(6):473-479. PubMed PMID: 32541154
  • Nowak KL, Farmer-Bailey H, Cadnapaphornchai MA, You Z, George D, Wang W, Jovanovich A, Soranno DE, Gitomer B, Chonchol M. Curcumin therapy to treat vascular dysfunction in children and young adults with autosomal dominant polycystic kidney disease: Design and baseline characteristics of participants. Contemp Clin Trials Commun. 2020 Sep;19:100635. PubMed PMID: 33294724
  • Brosnahan GM, You Z, Wang W, Gitomer BY, Chonchol M. Serum Uric Acid and Progression of Autosomal Dominant Polycystic Kidney Disease: Results from the HALT PKD Trials. Curr Hypertens Rev. 2020 Aug 17. [Epub ahead of print] PubMed PMID: 32807060
  • Gitomer B, Pereira R, Salusky IB, Stoneback JW, Isakova T, Cai X, Dalrymple LS, Ofsthun N, You Z, Malluche HH, Maddux F, George D, Torres V, Chapman A, Steinman TI, Wolf M, Chonchol M. Mineral bone disease in autosomal dominant polycystic kidney disease. Kidney Int. 2020 Sep 11. [Epub ahead of print] PubMed PMID: 32926884
  • Jovanovich A, Ginsberg C, You Z, Katz R, Ambrosius WT, Berlowitz D, Cheung AK, Cho M, Lee AK, Punzi H, Rehman S, Roumie C, Supiano MA, Wright CB, Shlipak M, Ix JH, Chonchol M. FGF23, Frailty, and Falls in SPRINT. J Am Geriatr Soc. 2020 Dec 1. [Epub ahead of print] PubMed PMID: 33289072
  • Davis S, Dylewski J, Shah PB, Holmen J, You Z, Chonchol M, Kendrick J. Risk of adverse maternal and fetal outcomes during pregnancy in living kidney donors: A matched cohort study. Clin Transplant. 2018 Nov 25;:e13453. [Epub ahead of print] PubMed PMID: 30472740
  • Liu Z, Che P, Mercado JJ, Hackney JR, Friedman GK, Zhang C, You Z, Zhao X, Ding Q, Kim K, Li H, Liu X, Markert JM, Nabors B, Gillespie GY, Zhao R, Han X. Characterization of iPSCs derived from low grade gliomas revealed early regional chromosomal amplifications during gliomagenesis. J Neurooncol. 2018 Nov 20. [Epub ahead of print] PubMed PMID: 30460631
  • Villegas LR, Rivard CJ, Hunter B, You Z, Roncal C, Joy MS, Le MT. Effects of fructose-containing sweeteners on fructose intestinal, hepatic, and oral bioavailability in dual-catheterized rats. PLoS One. 2018;13(11):e0207024. PubMed PMID: 30408104
  • Andrews ES, Perrenoud L, Nowak KL, You Z, Pasch A, Chonchol M, Kendrick J, Jalal D. Examining the effects of uric acid-lowering on markers vascular of calcification and CKD-MBD; A post-hoc analysis of a randomized clinical trial. PLoS One. 2018;13(10):e0205831. PubMed PMID: 30356327
  • Kendrick J, Shah P, Andrews E, You Z, Nowak K, Pasch A, Chonchol M. Effect of Treatment of Metabolic Acidosis on Vascular Endothelial Function in Patients with CKD: A Pilot Randomized Cross-Over Study. Clin J Am Soc Nephrol. 2018 Oct 8;13(10):1463-1470. PubMed PMID: 30237219
  • Jalal D, Renner B, Laskowski J, Stites E, Cooper J, Valente K, You Z, Perrenoud L, Le Quintrec M, Muhamed I, Christians U, Klawitter J, Lindorfer MA, Taylor RP, Holers VM, Thurman JM. Endothelial Microparticles and Systemic Complement Activation in Patients With Chronic Kidney Disease. J Am Heart Assoc. 2018 Jul 13;7(14). PubMed PMID: 30006493
  • Nowak KL, Fried L, Jovanovich A, Ix J, Yaffe K, You Z, Chonchol M. Dietary Sodium/Potassium Intake Does Not Affect Cognitive Function or Brain Imaging Indices. Am J Nephrol. 2018;47(1):57-65. PubMed PMID: 29393090
  • Nowak KL, Yaffe K, Orwoll ES, Ix JH, You Z, Barrett-Connor E, Hoffman AR, Chonchol M. Serum Sodium and Cognition in Older Community-Dwelling Men. Clin J Am Soc Nephrol. 2018 Mar 7;13(3):366-374. PubMed PMID: 29439092
  • Jones D, You Z, Kendrick JB. Racial/Ethnic Differences in Barriers to Kidney Transplant Evaluation among Hemodialysis Patients. Am J Nephrol. 2018;47(1):1-7. PubMed PMID: 29258094
  • Nowak KL, Chonchol M, You Z, Gupta M, Gitomer B. Affected parent sex and severity of autosomal dominant polycystic kidney disease: a retrospective cohort study?. Clin Nephrol. 2018 Mar;89(3):196-204. PubMed PMID: 29035198
  • Nowak KL, You Z, Gitomer B, Brosnahan G, Torres VE, Chapman AB, Perrone RD, Steinman TI, Abebe KZ, Rahbari-Oskoui FF, Yu ASL, Harris PC, Bae KT, Hogan M, Miskulin D, Chonchol M. Overweight and Obesity Are Predictors of Progression in Early Autosomal Dominant Polycystic Kidney Disease. J Am Soc Nephrol. 2018 Feb;29(2):571-578. PubMed PMID: 29118087
  • Griffin BR, Jovanovich A, You Z, Palevsky P, Faubel S, Jalal D. Effects of Baseline Thrombocytopenia and Platelet Decrease Following Renal Replacement Therapy Initiation in Patients With Severe Acute Kidney Injury. Crit Care Med. 2018 Dec 21. [Epub ahead of print] PubMed PMID: 30585829
  • Jalal DI, Decker E, Perrenoud L, Nowak KL, Bispham N, Mehta T, Smits G, You Z, Seals D, Chonchol M, Johnson RJ. Vascular Function and Uric Acid-Lowering in Stage 3 CKD. J Am Soc Nephrol. 2017 Mar;28(3):943-952. PubMed PMID: 27620990
  • Nowak KL, Hung A, Ikizler TA, Farmer-Bailey H, Salas-Cruz N, Sarkar S, Hoofnagle A, You Z, Chonchol M. Interleukin-1 inhibition, chronic kidney disease-mineral and bone disorder, and physical function?. Clin Nephrol. 2017 Sep;88(9):132-143. PubMed PMID: 28699886
  • Kendrick J, Andrews E, You Z, Moreau K, Nowak KL, Farmer-Bailey H, Seals DR, Chonchol M. Cholecalciferol, Calcitriol, and Vascular Function in CKD: A Randomized, Double-Blind Trial. Clin J Am Soc Nephrol. 2017 Sep 7;12(9):1438-1446. PubMed PMID: 28784657
  • Kendrick J, Holmen J, You Z, Smits G, Chonchol M. Association of Unilateral Renal Agenesis With Adverse Outcomes in Pregnancy: A Matched Cohort Study. Am J Kidney Dis. 2017 Oct;70(4):506-511. PubMed PMID: 28396109
  • Sukits SF, Erman JE, Satterlee JD. Proton NMR assignments and magnetic axes orientations for wild-type yeast iso-1-ferricytochrome c free in solution and bound to cytochrome c peroxidase. Biochemistry. 1997 Apr 29;36(17):5251-9. PubMed PMID: 9136887
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Professional Memberships

  • American Statistical Association (ASA), member
  • American Heart Association (AHA), member
  • Society for Clinical Trials (SCT), member
  • International Chinese Statistical Association (ICSA), Permanent Member

General Information

Languages: English, Mandarin
Department: Medicine-Renal Med Diseases/Hypertension
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Fitzsimons Building
13001 East 17th Place
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