James Pomposelli, MD, PhD
Professor, Surgery-Transplant

Photo
Medical Schools:
  • PhD, Boston University School of Medicine (1990)
  • MD, Boston University School of Medicine (1990)
Undergraduate School:
  • BS, University of Rhode Island (RI) (1982)
Internship:
  • Beth Israel Deaconess Medical Center/Harvard Medical School Program (1991)
Residency:
  • Beth Israel Deaconess Medical Center/Harvard Medical School Program, Chief Resident, Surgery (1995)
Fellowships:
  • Beth Israel Deaconess Medical Center/Harvard Medical School Program, Multiorgan Organ Transplantation (1999)
Languages: English
Department: Surgery-Transplant

Professional Titles

  • Professor of Surgery
  • Surgical Director of Liver Transplantation

Recognition & Awards

  • Guide to Americas Best Surgeons, Consumers' Research Council of America (2016)
  • Outstanding Teacher Award, Third Year Medical Students, Tufts Medical School (2015)
  • Outstanding Teacher Award, Third Year Medical Students, Tufts Medical School (2014)
  • Visiting Professor in Transplantation, Department of Transplantation, University of Pennsylvania (2014)
  • Guide to Americas Best Surgeons, Consumers' Research Council of America (2013)
  • America’s Best Doctors, U.S. News (2011)
  • Outstanding Teacher Award, Third Year Medical Students, Tufts Medical School (2008)
  • Outstanding Teacher Award, Third Year Medical Students, Tufts Medical School (2007)
  • Selected to Vanguard Committee, American Society of Transplant Surgeons (2006)
  • Outstanding Teacher Award, Third Year Medical Students, Tufts Medical School (2006)
  • Selected to Vanguard Committee, American Society of Transplant Surgeons (2005)
  • Selected to Vanguard Committee, American Society of Transplant Surgeons (2004)
  • Distinguished Visiting Professor, Division of Vascular Surgery, Washington Hospital Center (2004)
  • Selected to Vanguard Committee, American Society of Transplant Surgeons (2003)
  • Young Surgeon Travel Award, 96th Annual Congress, Japan Surgical Society (1996)
    Paper Presentation “Work of breathing as a criteria for weaning ventilator dependent patients.”
  • Stanley Dudrick Research Scholar Award Finalist, American Society of Enteral and Parenteral Nutrition (1992)
  • Charles E. Culpepper Research Fellow, Charles E. Culpepper Foundation (1990)
  • Stanley Dudrick Research Scholar Award Finalist, American Society of Enteral and Parenteral Nutrition. (1990)
  • Harry M. Vars Research Award Finalist, American Society of Enteral and Parenteral Nutrition (1989)
  • Charles E. Culpepper Research Fellow, Charles E. Culpepper Foundation (1989)
  • Alpha Omega Alpha, Boston University School of Medicine (1989)
  • Harry M. Vars Research Award Finalist, American Society of Enteral and Parenteral Nutrition (1988)
  • American Institute of Nutrition (FASEB/AIN) Graduate Student Research Award, Federation of American Societies for Experimental Biology (1988)
  • Charles E. Culpepper Research Fellow, Charles E. Culpepper Foundation (1988)
  • Harry M. Vars Research Award Finalist, American Society of Enteral and Parenteral Nutrition (1987)

Research Interests

I am interested in improving outcomes for live donor liver transplantation through surgical innovations. I was co-investigator in the NIH funded A2ALL study surgical innovation work-group. I am also interested in new surgical approaches to metastatic cancer to the liver using the ALPPS procedure.

Publications

  • Moore HB, Saben J, Rodriguez I, Bababekov YJ, Pomposelli JJ, Yoeli D, Ferrell T, Adams MA, Pshak TJ, Kaplan B, Pomfret EA, Nydam TL. Postoperative fibrinolytic resistance is associated with early allograft dysfunction in liver transplantation: A prospective observational study. Liver Transpl. 2023 Jul 1;29(7):724-734. PubMed PMID: 36749288
  • Malamon JS, Jackson WE, Saben JL, Conzen K, Schold JD, Pomposelli JJ, Pomfret EA, Kaplan B. A model for calculating the long-term estimated post-transplant survival of deceased donor liver transplant patients. EBioMedicine. 2023 Apr;90:104505. PubMed PMID: 36870199
  • Sawinski D, Lai JC, Pinney S, Gray AL, Jackson AM, Stewart D, Levine DJ, Locke JE, Pomposelli JJ, Hartwig MG, Hall SA, Dadhania DM, Cogswell R, Perez RV, Schold JD, Turgeon NA, Kobashigawa J, Kukreja J, Magee JC, Friedewald J, Gill JS, Loor G, Heimbach JK, Verna EC, Walsh MN, Terrault N, Testa G, Diamond JM, Reese PP, Brown K, Orloff S, Farr MA, Olthoff KM, Siegler M, Ascher N, Feng S, Kaplan B, Pomfret E. Addressing sex-based disparities in solid organ transplantation in the United States - a conference report. Am J Transplant. 2023 Mar;23(3):316-325. PubMed PMID: 36906294
  • Malamon JS, Kaplan B, Jackson WE, Saben JL, Schold JD, Pomfret EA, Pomposelli JJ. Reassessing the survival benefit of deceased donor liver transplantation: retrospective cohort study. Int J Surg. 2023 Sep 1;109(9):2714-2720. PubMed PMID: 37226874
  • Saben JL, Kaplan B, Burton JR Jr, Cooper JE, Pomposelli JJ, Schold JD, Pomfret EA. Highlights From Controversies in Transplantation 2023 Conference. Transplantation. 2023 Jun 14. [Epub ahead of print] PubMed PMID: 37314449
  • Ivanics T, Claasen MP, Samstein B, Emond JC, Fox AN, Pomfret E, Pomposelli J, Tabrizian P, Florman SS, Mehta N, Roberts JP, Emamaullee JA, Genyk Y, Hernandez-Alejandro R, Tomiyama K, Sasaki K, Quintini C, Nagai S, Abouljoud M, Olthoff KM, Hoteit MA, Heimbach J, Taner T, Liapakis AH, Mulligan DC, Sapisochin G, Halazun KJ. Living Donor Liver Transplantation (LDLT) for Hepatocellular Carcinoma (HCC) within and Outside Traditional Selection Criteria: A Multicentric North American Experience. Ann Surg. 2023 Jul 31. [Epub ahead of print] PubMed PMID: 37522174
  • Moore HB, LaRiviere W, Rodriguez I, Brown K, Hadley K, Pomposelli JJ, Adams MA, Wachs ME, Conzen KD, Kennealey PT, Kaplan B, Pomfret EA, Nydam TL. Early predictors of prolonged intensive care utilization following liver transplantation. Am J Surg. 2023 Dec;226(6):829-834. PubMed PMID: 37604748
  • Hakeem AR, Mathew JS, Aunés CV, Mazzola A, Alconchel F, Yoon YI, Testa G, Selzner N, Sarin SK, Lee KW, Soin A, Pomposelli J, Menon K, Goyal N, Kota V, Abu-Gazala S, Rodriguez-Davalos M, Rajalingam R, Kapoor D, Durand F, Kamath P, Jothimani D, Sudhindran S, Vij V, Yoshizumi T, Egawa H, Lerut J, Broering D, Berenguer M, Cattral M, Clavien PA, Chen CL, Shah S, Zhu ZJ, Ascher N, Bhangui P, Rammohan A, Emond J, Rela M. Preventing Small-for-size Syndrome in Living Donor Liver Transplantation: Guidelines From the ILTS-iLDLT-LTSI Consensus Conference. Transplantation. 2023 Oct 1;107(10):2203-2215. PubMed PMID: 37635285
  • Kwong AJ, Foutz J, Cafarella M, Biggins SW, Shah ND, Eason J, Perito ER, Pomposelli J, Trotter J. Implementation of a National Liver Review Board for exception requests in the United States: A 2-year monitoring report. Liver Transpl. 2023 Aug 29. [Epub ahead of print] PubMed PMID: 37639285
  • Schold JD, Mohan S, Jackson WE, Stites E, Burton JR, Bababekov YJ, Saben JL, Pomposelli JJ, Pomfret EA, Kaplan B. Differential in Kidney Graft Years Based on Solitary Kidney, Simultaneous Liver-Kidney, and Kidney after Liver Transplants. Clin J Am Soc Nephrol. 2023 Nov 14. [Epub ahead of print] PubMed PMID: 37962880
  • Jonica ER, Han S, Burton JR Jr, Pomposelli JJ, Shah RJ. Choledochoduodenostomy is associated with fewer post-transplant biliary complications compared to Roux-en-Y in primary sclerosing cholangitis patients. Clin Transplant. 2022 Jan 19;:e14597. [Epub ahead of print] PubMed PMID: 35043996
  • Jonica ER, Han S, Burton JR Jr, Pomposelli JJ, Shah RJ. Choledochoduodenostomy is associated with fewer post-transplant biliary complications compared to Roux-en-Y in primary sclerosing cholangitis patients. Clin Transplant. 2022 May;36(5):e14597. PubMed PMID: 35043996
  • Moore HB, Bababekov YJ, Pomposelli JJ, Adams MA, Crouch C, Yoeli D, Choudhury RA, Ferrell T, Burton JR, Pomfret EA, Nydam TL. The vexing triad of obesity, alcohol, and coagulopathy predicts the need for multiple operations in liver transplantation. Am J Surg. 2022 Jul;224(1 Pt A):69-74. PubMed PMID: 35227491
  • Cheah YL, Heimbach J, Kwon CHD, Pomposelli J, Rudow DL, Broering D, Spiro M, Raptis DA, Roberts JP. Influence of surgical technique in donor hepatectomy on immediate and short-term living donor outcomes - A systematic review of the literature, meta-analysis, and expert panel recommendations. Clin Transplant. 2022 Oct;36(10):e14703. PubMed PMID: 35538019
  • Jackson WE, Malamon JS, Kaplan B, Saben JL, Schold JD, Pomposelli JJ, Pomfret EA. Survival Benefit of Living-Donor Liver Transplant. JAMA Surg. 2022 Oct 1;157(10):926-932. PubMed PMID: 35921119
  • Jiang JG, Ferrell T, Sauaia A, Rodriguez IE, Yoeli D, Nydam TL, Kennealey PT, Pomposelli JJ, Pomfret EA, Moore HB. Low viscoelastic clot strength, platelet transfusions, and graft dysfunction are associated with persistent postoperative ascites following liver transplantation. Am J Surg. 2022 Dec;224(6):1432-1437. PubMed PMID: 36216610
  • Stewart E, Nydam TL, Hendrickse A, Pomposelli JJ, Pomfret EA, Moore HB. Viscoelastic Management of Coagulopathy during the Perioperative Period of Liver Transplantation. Semin Thromb Hemost. 2022 Nov 1. [Epub ahead of print] PubMed PMID: 36318962
  • Truong R, Moore HB, Sauaia A, Kam I, Pshak T, Adams M, Conzen K, Zimmerman MA, Wachs M, Bak T, Pomposelli J, Pomfret E, Nydam TL. Choledochoduodenostomy continues to be a safe alternative for biliary reconstruction in deceased-donor liver transplantation. Am J Surg. 2022 Dec;224(6):1398-1402. PubMed PMID: 36400602
  • Heimbach JK, Trotter JF, Pomposelli J, Cafarella M, Noreen SM. A Tale Full of Sound and Fury. Liver Transpl. 2021 Jan 18. [Epub ahead of print] PubMed PMID: 33458925
  • Jackson WE, Kriss MS, Burton JR Jr, Nydam TL, Conzen KD, Pomposelli JJ, Pomfret EA. Reply to "Living liver donation in previous kidney donors: A single-center experience". Am J Transplant. 2021 Jan;21(1):435-437. PubMed PMID: 32558135
  • Yoeli D, Jackson WE, Adams MA, Wachs ME, Sundaram SS, Sater A, Cisek JR, Choudhury RA, Nydam TL, Pomposelli JJ, Conzen KD, Kriss MS, Burton JR Jr, Pomfret EA. Challenging the Traditional Paradigm of Supply and Demand in Pediatric Liver Transplantation Through Nondirected Living Donation: A Case Series. Liver Transpl. 2021 Oct;27(10):1392-1400. PubMed PMID: 34048131
  • Heimbach JK, Trotter JF, Pomposelli J, Cafarella M, Noreen SM. A Tale Full of Sound and Fury. Liver Transpl. 2021 May;27(5):624-626. PubMed PMID: 33458925
  • Yoeli D, Choudhury RA, Nydam TL, Pomposelli JJ, Goss JA, Pomfret EA, Wachs ME, Adams MA. The Surge in Deceased Liver Donors Due to the Opioid Epidemic: Is It Time to Split the Difference?. Transplantation. 2021 Oct 1;105(10):2239-2244. PubMed PMID: 33065726
  • Jackson WE, Kriss MS, Burton JR Jr, Nydam TL, Conzen KD, Pomposelli JJ, Pomfret EA. Reply to "Living liver donation in previous kidney donors: A single-center experience". Am J Transplant. 2021 Jan;21(1):435-437. PubMed PMID: 32558135
  • Choudhury RA, Foster M, Hoeltzel G, Moore HB, Yaffe H, Yoeli D, Prins K, Ghincea C, Vigneshwar N, Dumon KR, Rame JE, Conzen KD, Pomposelli JJ, Pomfret EA, Nydam TL. Bariatric Surgery for Congestive Heart Failure Patients Improves Access to Transplantation and Long-term Survival. J Gastrointest Surg. 2021 Apr;25(4):926-931. PubMed PMID: 32323251
  • Yoeli D, Choudhury RA, Nydam TL, Pomposelli JJ, Goss JA, Pomfret EA, Wachs ME, Adams MA. The Surge in Deceased Liver Donors Due to the Opioid Epidemic: Is it Time to Split the Difference?. Transplantation. 2020 Oct 12. [Epub ahead of print] PubMed PMID: 33065726
  • Choudhury RA, Yoeli D, Dagan A, Yaffe H, Moore HB, Conzen KD, Adams M, Wachs M, Pomposelli JJ, Pomfret EA, Nydam TL. Offspring to Parent LDLT: Narrowing the Gap Between Theory and Evidence. Transplantation. 2020 Oct;104(10):e307. PubMed PMID: 32969991
  • Hughes DL, Rice JD, Burton JR, Jin Y, Peterson RA, Ambardekar AV, Pomposelli JJ, Pomfret EA, Kriss MS. Presence of any degree of coronary artery disease among liver transplant candidates is associated with increased rate of post-transplant major adverse cardiac events. Clin Transplant. 2020 Nov;34(11):e14077. PubMed PMID: 32939833
  • Schulick AC, Moore HB, Walker CB, Yaffe H, Pomposelli JJ, Azam F, Wachs M, Bak T, Kennealey P, Conzen K, Adams M, Pshak T, Choudhury R, Chapman MP, Pomfret EA, Nydam TL. A clinical coagulopathy score concurrent with viscoelastic testing defines opportunities to improve hemostatic resuscitation and enhance blood product utilization during liver transplantation. Am J Surg. 2020 Dec;220(6):1379-1386. PubMed PMID: 32907709
  • Moore HB, Yaffe H, Pomposelli JJ, Wachs M, Bak T, Kennealey P, Conzen K, Adams M, Pshak T, Choudhury R, Walker C, Schulick A, Ferrell T, Chapman MP, Pomfret EA, Nydam TL. Detection of early allograft dysfunction at 30 min of reperfusion in liver transplantation: An intraoperative diagnostic tool with real time assessment of graft function. Am J Surg. 2020 Dec;220(6):1518-1525. PubMed PMID: 32907708
  • Walker CB, Moore HB, Nydam TL, Schulick AC, Yaffe H, Pomposelli JJ, Wachs M, Bak T, Conzen K, Adams M, Pshak T, Choudhury R, Chapman MP, Pomfret EA, Kennealey P. The use of thromboelastography to assess post-operative changes in coagulation and predict graft function in renal transplantation. Am J Surg. 2020 Dec;220(6):1511-1517. PubMed PMID: 32878689
  • Choudhury RA, Foster M, Hoeltzel G, Moore HB, Yaffe H, Yoeli D, Prins K, Ghincea C, Vigneshwar N, Dumon KR, Rame JE, Conzen KD, Pomposelli JJ, Pomfret EA, Nydam TL. Bariatric Surgery for Congestive Heart Failure Patients Improves Access to Transplantation and Long-term Survival. J Gastrointest Surg. 2020 Apr 22. [Epub ahead of print] PubMed PMID: 32323251
  • Bababekov YJ, Hung YC, Chang DC, Rickert CG, Adler JT, Bethea E, Pomfret EA, Pomposelli JJ, Yeh H. Do Social Determinants Define "Too Sick" to Transplant in Patients With End-stage Liver Disease?. Transplantation. 2020 Feb;104(2):280-284. PubMed PMID: 31335769
  • Dagan A, Choudhury RA, Yaffe H, Yoeli D, Moore HB, Conzen KD, Adams M, Wachs M, Pomposelli JJ, Pomfret EA, Nydam TL. Offspring Versus Nonoffspring to Parent Living Donor Liver Transplantation: Does Donor Relationship Matter?. Transplantation. 2020 May;104(5):996-1002. PubMed PMID: 31568397
  • Kim D, Bolus C, Iqbal S, Pomposelli J, Flacke S. Percutaneous Creation of Intrahepatic Biliary Tract for Treatment of Posthepatectomy Excluded Segmental Bile Duct Leak. J Vasc Interv Radiol. 2018 Dec;29(12):1770-1772. PubMed PMID: 30502880
  • Bababekov YJ, Hung YC, Rickert CG, Njoku FC, Cao B, Adler JT, Brega AG, Pomposelli JJ, Chang DC, Yeh H. Health Literacy Burden Is Associated with Access to Liver Transplantation. Transplantation. 2018 Nov 13. [Epub ahead of print] PubMed PMID: 30431496
  • Leppard W, Pomposelli T, Chang EI, Suliman A, Herrera F. Internal mammary usability as recipient vessels in DIEP breast reconstruction in the setting of previous radiation. J Plast Reconstr Aesthet Surg. 2018 Aug;71(8):1123-1128. PubMed PMID: 29933915
  • Rivard CJ, Tanabe T, Lanaspa MA, Watanabe H, Nomura S, Andres-Hernando A, Garth K, Sekijima M, Ishimoto T, Ariyoshi Y, Garcia GE, Shah J, Lennan B, Tasaki M, Pomposelli T, Shimizu A, Sachs DH, Johnson RJ, Yamada K. Upregulation of CD80 on glomerular podocytes plays an important role in development of proteinuria following pig-to-baboon xeno-renal transplantation - an experimental study. Transpl Int. 2018 Oct;31(10):1164-1177. PubMed PMID: 29722117
  • Bababekov YJ, Nydam TL, Pomposelli JJ, Moore HB. Goal-directed Management of Coagulation: The Right Treatment, the Right Patient, the Right Time. Transplantation. 2018 Jun;102(6):e303-e304. PubMed PMID: 29557909
  • Fiz F, Villa G, Ferrari E, Pomposelli E, Morbelli S, Alloisio A, Pende D, Meazza R, Gereloni C, Marini C, Ratto GB, Sambuceti G. Prevention of systemic toxicity in hyperthermic isolated lung perfusion using radioisotopic leakage monitoring. Int J Hyperthermia. 2018 Jun;34(4):469-478. PubMed PMID: 28705098
  • Bababekov YJ, Ven Fong Z, Chang DC, Simpson MA, Yeh H, Pomposelli JJ. Is liver transplant education patient-centered?. Liver Transpl. 2017 Aug;23(8):1070-1072. PubMed PMID: 28618164
  • Baker TB, Zimmerman MA, Goodrich NP, Samstein B, Pomfret EA, Pomposelli JJ, Gillespie BW, Berg CL, Emond JC, Merion RM. Biliary reconstructive techniques and associated anatomic variants in adult living donor liver transplantations: The adult-to-adult living donor liver transplantation cohort study experience. Liver Transpl. 2017 Dec;23(12):1519-1530. PubMed PMID: 28926171
  • Emond JC, Goodrich NP, Pomposelli JJ, Baker TB, Humar A, Grant DR, Abt P, Friese CE, Fisher RA, Kam I, Sherker AH, Gillespie BW, Merion RM. Hepatic Hemodynamics and Portal Flow Modulation: The A2ALL Experience. Transplantation. 2017 Oct;101(10):2375-2384. PubMed PMID: 28514251
  • Bababekov YJ, Pomposelli JJ, Yeh H, Rudd RE, Chang DC. Surgical Outcomes: Shifting the Focus From Measurement to Improvement. Ann Surg. 2017 Dec;266(6):e103-e104. PubMed PMID: 27043741
  • Pomposelli JJ. Hepatic Artery Thrombosis After Liver Transplant: Not A Surgical Problem?. Transplantation. 2016 Nov;100(11):2251. PubMed PMID: 27547869
  • Pomposelli JJ, Goodrich NP, Emond JC, Humar A, Baker TB, Grant DR, Fisher RA, Roberts JP, Olthoff KM, Gillespie BW, Merion RM. Patterns of Early Allograft Dysfunction in Adult Live Donor Liver Transplantation: The A2ALL Experience. Transplantation. 2016 Jul;100(7):1490-9. PubMed PMID: 27326811
  • Bababekov YJ, Pomposelli JJ, Yeh H, Rudd RE, Chang DC. Surgical Outcomes: Shifting the Focus From Measurement to Improvement. Ann Surg. 2016 Mar 31. [Epub ahead of print] PubMed PMID: 27043741
  • Genyk Y, Kato T, Pomposelli JJ, Wright JK Jr, Sher LS, Tetens V, Chapman WC. Fibrin Sealant Patch (TachoSil) vs Oxidized Regenerated Cellulose Patch (Surgicel Original) for the Secondary Treatment of Local Bleeding in Patients Undergoing Hepatic Resection: A Randomized Controlled Trial. J Am Coll Surg. 2016 Mar;222(3):261-8. PubMed PMID: 26776356
View All (48 Total) View Less

Professional Memberships

  • American Society of Transplant Surgeons, Co-Chair Legislative and Regulatory Committee
  • Massachusetts Medical Society, Member
  • Alpha Omega Alpha, Boston Chapter, Member
  • American College of Surgeons, Member
  • New England Surgical Society, Member
  • Boston Surgical Society, Member
  • American Liver Foundation, Member
  • American Society of Transplant Surgeons, Member
  • International Liver Transplant Society, Member

Practice Locations

UCHealth Transplant Surgery - Anschutz Medical Campus
1635 Aurora Ct
7th Floor
Aurora, CO 80045
720-848-0833

Hospital Affiliation
  • University of Colorado Hospital
  • Children's Hospital Colorado

Specialty Information

Specialties
  • Surgery, Board Certification (1998, 2008)
  • Robotic Surgery, Certificate (2015)
  • American Society of Transplant Surgeons, Certificate (1999)
Conditions & Treatments
  • Surgery - Kidney Transplant Surgery
  • Surgery
  • Surgery - Laparoscopic Surgery
  • Surgery - Liver Transplant Surgery
  • Surgery - Pancreas Transplant Surgery
  • Surgery - Transplant Surgery
  • Cancers - Biliary Cancer
  • Cancers
  • Cancers - Pancreatic Cancer
  • Digestive System - Hepatology (Liver Disorders)
  • Digestive System
  • Digestive System - Pancreas Surgery
  • Digestive System - Biliary Surgery
Clinical Interests
My many clinical interests include: live donor liver and kidney transplantation and liver cancer surgery.

Care Philosophy
I strive to provide the best care for my patients by treating them as I would want my parents treated.

General Information

Medical Schools:
  • PhD, Boston University School of Medicine (1990)
  • MD, Boston University School of Medicine (1990)
Undergraduate Schools:
  • BS, University of Rhode Island (RI) (1982)
Internships:
  • Beth Israel Deaconess Medical Center/Harvard Medical School Program (1991)
Residency Programs:
  • Beth Israel Deaconess Medical Center/Harvard Medical School Program, Chief Resident, Surgery (1995)
Fellowships:
  • Beth Israel Deaconess Medical Center/Harvard Medical School Program, Multiorgan Organ Transplantation (1999)
Languages: English
Department: Surgery-Transplant
Contact Us
CU Anschutz
Fitzsimons Building

13001 East 17th Place
Campus Box C290
Aurora, CO 80045

Update My Profile
;