Fernando Holguin, MD
Professor, Medicine-Pulmonary Sciences & Critical Care

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Medical School:
  • MD, Universidad La Salle-Facultad Mexicana de Medicina, Mexico City, Mexico (1991)
Internship:
  • Emory University School of Medicine Program (1992)
Residency:
  • Emory University School of Medicine Program, Chief Resident, Internal Medicine (1996)
Fellowships:
  • Emory University School of Medicine Program, Pulmonary Disease and Critical Care Medicine (1999)
Languages: Spanish
Department: Medicine-Pulmonary Sciences & Critical Care

Professional Titles

  • Professor, Medicine-Pulmonary Sciences & Critical Care
  • Director Asthma Clinical and Research Programs

Recognition & Awards

  • Chair, American Thoracic Society and European Respiratory Society Task Force for Severe Asthma, ATS/ERS (2018)
    Developing guidelines/recommendations for managing severe asthma

Publications

  • Holguin F, Cardet JC, Chung KF, Diver S, Ferreira DS, Fitzpatrick A, Gaga M, Kellermeyer L, Khurana S, Knight S, McDonald VM, Morgan RL, Ortega VE, Rigau D, Subbarao P, Tonia T, Adcock IM, Bleecker ER, Brightling C, Boulet LP, Cabana M, Castro M, Chanez P, Custovic A, Djukanovic R, Frey U, Frankemölle B, Gibson P, Hamerlijnck D, Jarjour N, Konno S, Shen H, Vitary C, Bush A. Management of severe asthma: a European Respiratory Society/American Thoracic Society guideline. Eur Respir J. 2020 Jan;55(1). PubMed PMID: 31558662
  • Althoff M, Holguin F. Contemporary management techniques of asthma in obese patients. Expert Rev Respir Med. 2019 Dec 25;:1-9. [Epub ahead of print] PubMed PMID: 31852311
  • Thalanayar Muthukrishnan P, Nouraie M, Parikh A, Holguin F. Zileuton use and phenotypic features in asthma. Pulm Pharmacol Ther. 2019 Dec 10;60:101872. [Epub ahead of print] PubMed PMID: 31841698
  • Holguin F, Grasemann H, Sharma S, Winnica D, Wasil K, Smith V, Cruse MH, Perez N, Coleman E, Scialla TJ, Que LG. L-Citrulline increases nitric oxide and improves control in obese asthmatics. JCI Insight. 2019 Dec 19;4(24). PubMed PMID: 31714895
  • Holguin F. Sex Hormones and Asthma. Am J Respir Crit Care Med. 2019 Oct 29. [Epub ahead of print] PubMed PMID: 31661291
  • Wechsler ME, Szefler SJ, Ortega VE, Pongracic JA, Chinchilli V, Lima JJ, Krishnan JA, Kunselman SJ, Mauger D, Bleecker ER, Bacharier LB, Beigelman A, Benson M, Blake KV, Cabana MD, Cardet JC, Castro M, Chmiel JF, Covar R, Denlinger L, DiMango E, Fitzpatrick AM, Gentile D, Grossman N, Holguin F, Jackson DJ, Kumar H, Kraft M, LaForce CF, Lang J, Lazarus SC, Lemanske RF Jr, Long D, Lugogo N, Martinez F, Meyers DA, Moore WC, Moy J, Naureckas E, Olin JT, Peters SP, Phipatanakul W, Que L, Raissy H, Robison RG, Ross K, Sheehan W, Smith LJ, Solway J, Sorkness CA, Sullivan-Vedder L, Wenzel S, White S, Israel E. Step-Up Therapy in Black Children and Adults with Poorly Controlled Asthma. N Engl J Med. 2019 Sep 26;381(13):1227-1239. PubMed PMID: 31553835
  • Grossman NL, Ortega VE, King TS, Bleecker ER, Ampleford EA, Bacharier LB, Cabana MD, Cardet JC, Carr TF, Castro M, Denlinger LC, Denson JL, Fandino N, Fitzpatrick AM, Hawkins GA, Holguin F, Krishnan JA, Lazarus SC, Nyenhuis SM, Phipatanakul W, Ramratnam SK, Wenzel S, Peters SP, Meyers DA, Wechsler ME, Israel E. Exacerbation-prone asthma in the context of race and ancestry in Asthma Clinical Research Network trials. J Allergy Clin Immunol. 2019 Dec;144(6):1524-1533. PubMed PMID: 31520679
  • Cardet JC, Jiang X, Lu Q, Gerard N, McIntire K, Boushey HA, Castro M, Chinchilli VM, Codispoti CD, Dyer AM, Holguin F, Kraft M, Lazarus S, Lemanske RF, Lugogo N, Mauger D, Moore WC, Moy J, Ortega VE, Peters SP, Smith LJ, Solway J, Sorkness CA, Sumino K, Wechsler ME, Wenzel S, Israel E. Reply. J Allergy Clin Immunol. 2019 Sep;144(3):873-874. PubMed PMID: 31300279
  • Lazarus SC, Krishnan JA, King TS, Lang JE, Blake KV, Covar R, Lugogo N, Wenzel S, Chinchilli VM, Mauger DT, Dyer AM, Boushey HA, Fahy JV, Woodruff PG, Bacharier LB, Cabana MD, Cardet JC, Castro M, Chmiel J, Denlinger L, DiMango E, Fitzpatrick AM, Gentile D, Hastie A, Holguin F, Israel E, Jackson D, Kraft M, LaForce C, Lemanske RF Jr, Martinez FD, Moore W, Morgan WJ, Moy JN, Myers R, Peters SP, Phipatanakul W, Pongracic JA, Que L, Ross K, Smith L, Szefler SJ, Wechsler ME, Sorkness CA. Mometasone or Tiotropium in Mild Asthma with a Low Sputum Eosinophil Level. N Engl J Med. 2019 May 23;380(21):2009-2019. PubMed PMID: 31112384
  • Forno E, Zhang P, Nouraie M, Courcoulas A, Mitchell JE, Wolfe BM, Strain G, Khandelwal S, Holguin F. The impact of bariatric surgery on asthma control differs among obese individuals with reported prior or current asthma, with or without metabolic syndrome. PLoS One. 2019;14(4):e0214730. PubMed PMID: 30964910
  • Laje K, Seger M, Dungan B, Cooke P, Polle J, Holguin FO. Phytoene Accumulation in the Novel Microalga Chlorococcum sp. Using the Pigment Synthesis Inhibitor Fluridone. Mar Drugs. 2019 Mar 22;17(3). PubMed PMID: 30909380
  • Khalid F, Holguin F. Idiopathic Hypereosinophilic Syndrome in an Elderly Female: A Case Report. Am J Case Rep. 2019 Mar 23;20:381-384. PubMed PMID: 30902963
  • Cardet JC, Jiang X, Lu Q, Gerard N, McIntire K, Boushey HA, Castro M, Chinchilli VM, Codispoti CD, Dyer AM, Holguin F, Kraft M, Lazarus S, Lemanske RF, Lugogo N, Mauger D, Moore WC, Moy J, Ortega VE, Peters SP, Smith LJ, Solway J, Sorkness CA, Sumino K, Wechsler ME, Wenzel S, Israel E. Loss of bronchoprotection with ICS plus LABA treatment, ß-receptor dynamics, and the effect of alendronate. J Allergy Clin Immunol. 2019 Aug;144(2):416-425.e7. PubMed PMID: 30872116
  • Lurbet MF, Rojano B, Whittaker Brown SA, Busse P, Holguin F, Federman AD, Wisnivesky JP. Obesity Trends among Asthma Patients in the United States: A Population-based Study. Ann Glob Health. 2019 Jan 22;85(1). PubMed PMID: 30741512
  • Zhou X, Kinlough CL, Hughey RP, Jin M, Inoue H, Etling E, Modena BD, Kaminski N, Bleecker ER, Meyers DA, Jarjour NN, Trudeau JB, Holguin F, Ray A, Wenzel SE. Sialylation of MUC4ß N-glycans by ST6GAL1 orchestrates human airway epithelial cell differentiation associated with type-2 inflammation. JCI Insight. 2019 Mar 7;4(5). PubMed PMID: 30730306
  • Dixon AE, Holguin F. Diet and Metabolism in the Evolution of Asthma and Obesity. Clin Chest Med. 2019 Mar;40(1):97-106. PubMed PMID: 30691720
  • Guilbert TW, Bacharier LB, Mauger DT, Phipatanakul W, Szefler SJ, Boehmer S, Beigelman A, Fitzpatrick AM, Jackson DJ, Baxi SN, Benson M, Burnham CD, Cabana MD, Castro M, Chmiel JF, Covar R, Daines M, Gaffin JM, Gentile DA, Holguin F, Israel E, Kelly HW, Lazarus SC, Lemanske RF Jr, Ly N, Meade K, Morgan W, Moy J, Olin JT, Peters SP, Pongracic JA, Raissy HH, Ross K, Sheehan WJ, Sorkness C, Teague WG, Thyne S, Martinez FD. Challenges in assessing the efficacy of systemic corticosteroids for severe wheezing episodes in preschool children. J Allergy Clin Immunol. 2019 May;143(5):1934-1937.e4. PubMed PMID: 30660645
  • Inoue H, Hattori T, Zhou X, Etling EB, Modena BD, Trudeau JB, Holguin F, Wenzel SE. Dysfunctional ErbB2, an EGF receptor family member, hinders repair of airway epithelial cells from asthmatic patients. J Allergy Clin Immunol. 2019 Jun;143(6):2075-2085.e10. PubMed PMID: 30639343
  • Winnica D, Corey C, Mullett S, Reynolds M, Hill G, Wendell S, Que L, Holguin F, Shiva S. Bioenergetic Differences in the Airway Epithelium of Lean Versus Obese Asthmatics Are Driven by Nitric Oxide and Reflected in Circulating Platelets. Antioxid Redox Signal. 2019 Oct 1;31(10):673-686. PubMed PMID: 30608004
  • Khan NA, Johnson MD, Kubicki JD, Holguin FO, Dungan B, Carroll KC. Cyclodextrin-enhanced 1,4-dioxane treatment kinetics with TCE and 1,1,1-TCA using aqueous ozone. Chemosphere. 2019 Mar;219:335-344. PubMed PMID: 30551099
  • Brusseau ML, Yan N, Van Glubt S, Wang Y, Chen W, Lyu Y, Dungan B, Carroll KC, Holguin FO. Comprehensive retention model for PFAS transport in subsurface systems. Water Res. 2019 Jan 1;148:41-50. PubMed PMID: 30343197
  • Fitzpatrick AM, Bacharier LB, Guilbert TW, Jackson DJ, Szefler SJ, Beigelman A, Cabana MD, Covar R, Holguin F, Lemanske RF Jr, Martinez FD, Morgan W, Phipatanakul W, Pongracic JA, Zeiger RS, Mauger DT. Phenotypes of Recurrent Wheezing in Preschool Children: Identification by Latent Class Analysis and Utility in Prediction of Future Exacerbation. J Allergy Clin Immunol Pract. 2019 Mar;7(3):915-924.e7. PubMed PMID: 30267890
  • Khalid F, Holguin F. A review of obesity and asthma across the life span. J Asthma. 2018 Feb 8;:1-15. [Epub ahead of print] PubMed PMID: 29420086
  • Dabass A, Talbott EO, Rager JR, Marsh GM, Venkat A, Holguin F, Sharma RK. Systemic inflammatory markers associated with cardiovascular disease and acute and chronic exposure to fine particulate matter air pollution (PM(2.5)) among US NHANES adults with metabolic syndrome. Environ Res. 2018 Feb;161:485-491. PubMed PMID: 29223110
  • Sharma S, Holguin F. IFN-stimulated Genes and Non-Type 2 Inflammation. New Pathway or Red Herring?. Am J Respir Crit Care Med. 2018 Feb 1;197(3):277-278. PubMed PMID: 29120663
  • Cardet JC, Louisias M, King TS, Castro M, Codispoti CD, Dunn R, Engle L, Giles BL, Holguin F, Lima JJ, Long D, Lugogo N, Nyenhuis S, Ortega VE, Ramratnam S, Wechsler ME, Israel E, Phipatanakul W. Income is an independent risk factor for worse asthma outcomes. J Allergy Clin Immunol. 2018 Feb;141(2):754-760.e3. PubMed PMID: 28535964
  • Roman J, Viegi G, Schenker M, Ojeda VD, Pérez-Stable EJ, Nemery B, Annesi-Maesano I, Patel SR, La Grutta S, Holguin F, Moughrabieh A, Bime C, Lindberg A, Migliori GB, de Vries G, Ramírez J, Aliberti S, Feldman C, Celedón JC. Research Needs on Respiratory Health in Migrant and Refugee Populations. An Official American Thoracic Society and European Respiratory Society Workshop Report. Ann Am Thorac Soc. 2018 Nov;15(11):1247-1255. PubMed PMID: 30382778
  • Holguin F. Triple CFTR Modulator Therapy for Cystic Fibrosis. N Engl J Med. 2018 Oct 25;379(17):1671-1672. PubMed PMID: 30334694
  • Fitzpatrick AM, Bacharier LB, Guilbert TW, Jackson DJ, Szefler SJ, Beigelman A, Cabana MD, Covar R, Holguin F, Lemanske RF Jr, Martinez FD, Morgan W, Phipatanakul W, Pongracic JA, Zeiger RS, Mauger DT. Phenotypes of Recurrent Wheezing in Preschool Children: Identification by Latent Class Analysis and Utility in Prediction of Future Exacerbation. J Allergy Clin Immunol Pract. 2018 Sep 26. [Epub ahead of print] PubMed PMID: 30267890
  • Holguin F. Biological Treatments for Eosinophilic Asthma Enter the Airways. Am J Respir Crit Care Med. 2018 Sep 1;198(5):551-552. PubMed PMID: 29993268
  • Durack J, Huang YJ, Nariya S, Christian LS, Ansel KM, Beigelman A, Castro M, Dyer AM, Israel E, Kraft M, Martin RJ, Mauger DT, Rosenberg SR, King TS, White SR, Denlinger LC, Holguin F, Lazarus SC, Lugogo N, Peters SP, Smith LJ, Wechsler ME, Lynch SV, Boushey HA. Bacterial biogeography of adult airways in atopic asthma. Microbiome. 2018 Jun 9;6(1):104. PubMed PMID: 29885665
  • DeBoer MD, Phillips BR, Mauger DT, Zein J, Erzurum SC, Fitzpatrick AM, Gaston BM, Myers R, Ross KR, Chmiel J, Lee MJ, Fahy JV, Peters M, Ly NP, Wenzel SE, Fajt ML, Holguin F, Moore WC, Peters SP, Meyers D, Bleecker ER, Castro M, Coverstone AM, Bacharier LB, Jarjour NN, Sorkness RL, Ramratnam S, Irani AM, Israel E, Levy B, Phipatanakul W, Gaffin JM, Gerald Teague W. Effects of endogenous sex hormones on lung function and symptom control in adolescents with asthma. BMC Pulm Med. 2018 Apr 10;18(1):58. PubMed PMID: 29631584
  • Jackson DJ, Bacharier LB, Mauger DT, Boehmer S, Beigelman A, Chmiel JF, Fitzpatrick AM, Gaffin JM, Morgan WJ, Peters SP, Phipatanakul W, Sheehan WJ, Cabana MD, Holguin F, Martinez FD, Pongracic JA, Baxi SN, Benson M, Blake K, Covar R, Gentile DA, Israel E, Krishnan JA, Kumar HV, Lang JE, Lazarus SC, Lima JJ, Long D, Ly N, Marbin J, Moy JN, Myers RE, Olin JT, Raissy HH, Robison RG, Ross K, Sorkness CA, Lemanske RF Jr. Quintupling Inhaled Glucocorticoids to Prevent Childhood Asthma Exacerbations. N Engl J Med. 2018 Mar 8;378(10):891-901. PubMed PMID: 29504498
  • Khalid F, Holguin F. A review of obesity and asthma across the life span. J Asthma. 2018 Feb 8;:1-15. [Epub ahead of print] PubMed PMID: 29420086
  • Lang JE, Fitzpatrick AM, Mauger DT, Guilbert TW, Jackson DJ, Lemanske RF Jr, Martinez FD, Strunk RC, Zeiger RS, Phipatanakul W, Bacharier LB, Pongracic JA, Holguin F, Cabana MD, Covar RA, Raissy HH, Tang M, Szefler SJ. Overweight/obesity status in preschool children associates with worse asthma but robust improvement on inhaled corticosteroids. J Allergy Clin Immunol. 2018 Apr;141(4):1459-1467.e2. PubMed PMID: 29273557
  • Dabass A, Talbott EO, Rager JR, Marsh GM, Venkat A, Holguin F, Sharma RK. Systemic inflammatory markers associated with cardiovascular disease and acute and chronic exposure to fine particulate matter air pollution (PM(2.5)) among US NHANES adults with metabolic syndrome. Environ Res. 2018 Feb;161:485-491. PubMed PMID: 29223110
  • Sharma S, Holguin F. IFN-stimulated Genes and Non-Type 2 Inflammation. New Pathway or Red Herring?. Am J Respir Crit Care Med. 2018 Feb 1;197(3):277-278. PubMed PMID: 29120663
  • Teague WG, Phillips BR, Fahy JV, Wenzel SE, Fitzpatrick AM, Moore WC, Hastie AT, Bleecker ER, Meyers DA, Peters SP, Castro M, Coverstone AM, Bacharier LB, Ly NP, Peters MC, Denlinger LC, Ramratnam S, Sorkness RL, Gaston BM, Erzurum SC, Comhair SAA, Myers RE, Zein J, DeBoer MD, Irani AM, Israel E, Levy B, Cardet JC, Phipatanakul W, Gaffin JM, Holguin F, Fajt ML, Aujla SJ, Mauger DT, Jarjour NN. Baseline Features of the Severe Asthma Research Program (SARP III) Cohort: Differences with Age. J Allergy Clin Immunol Pract. 2018 Mar - Apr;6(2):545-554.e4. PubMed PMID: 28866107
  • Cardet JC, Louisias M, King TS, Castro M, Codispoti CD, Dunn R, Engle L, Giles BL, Holguin F, Lima JJ, Long D, Lugogo N, Nyenhuis S, Ortega VE, Ramratnam S, Wechsler ME, Israel E, Phipatanakul W. Income is an independent risk factor for worse asthma outcomes. J Allergy Clin Immunol. 2018 Feb;141(2):754-760.e3. PubMed PMID: 28535964
  • Lang JE, Fitzpatrick AM, Mauger DT, Guilbert TW, Jackson DJ, Lemanske RF Jr, Martinez FD, Strunk RC, Zeiger RS, Phipatanakul W, Bacharier LB, Pongracic JA, Holguin F, Cabana MD, Covar RA, Raissy HH, Tang M, Szefler SJ. Overweight/obesity status in preschool children associates with worse asthma but robust improvement on inhaled corticosteroids. J Allergy Clin Immunol. 2017 Dec 8. [Epub ahead of print] PubMed PMID: 29273557
  • Rastogi D, Holguin F. Metabolic Dysregulation, Systemic Inflammation, and Pediatric Obesity-related Asthma. Ann Am Thorac Soc. 2017 Nov;14(Supplement_5):S363-S367. PubMed PMID: 29161075
  • Teague WG, Phillips BR, Fahy JV, Wenzel SE, Fitzpatrick AM, Moore WC, Hastie AT, Bleecker ER, Meyers DA, Peters SP, Castro M, Coverstone AM, Bacharier LB, Ly NP, Peters MC, Denlinger LC, Ramratnam S, Sorkness RL, Gaston BM, Erzurum SC, Comhair SAA, Myers RE, Zein J, DeBoer MD, Irani AM, Israel E, Levy B, Cardet JC, Phipatanakul W, Gaffin JM, Holguin F, Fajt ML, Aujla SJ, Mauger DT, Jarjour NN. Baseline Features of the Severe Asthma Research Program (SARP III) Cohort: Differences with Age. J Allergy Clin Immunol Pract. 2017 Aug 31. [Epub ahead of print] PubMed PMID: 28866107
  • Raysoni AU, Stock TH, Sarnat JA, Chavez MC, Sarnat SE, Montoya T, Holguin F, Li WW. Evaluation of VOC concentrations in indoor and outdoor microenvironments at near-road schools. Environ Pollut. 2017 Dec;231(Pt 1):681-693. PubMed PMID: 28850936
  • Suratt BT, Ubags NDJ, Rastogi D, Tantisira KG, Marsland BJ, Petrache I, Allen JB, Bates JHT, Holguin F, McCormack MC, Michelakis ED, Black SM, Jain M, Mora AL, Natarajan V, Miller YI, Fessler MB, Birukov KG, Summer RS, Shore SA, Dixon AE. An Official American Thoracic Society Workshop Report: Obesity and Metabolism. An Emerging Frontier in Lung Health and Disease. Ann Am Thorac Soc. 2017 Jun;14(6):1050-1059. PubMed PMID: 28570148
  • Celedón JC, Burchard EG, Schraufnagel D, Castillo-Salgado C, Schenker M, Balmes J, Neptune E, Cummings KJ, Holguin F, Riekert KA, Wisnivesky JP, Garcia JGN, Roman J, Kittles R, Ortega VE, Redline S, Mathias R, Thomas A, Samet J, Ford JG. An American Thoracic Society/National Heart, Lung, and Blood Institute Workshop Report: Addressing Respiratory Health Equality in the United States. Ann Am Thorac Soc. 2017 May;14(5):814-826. PubMed PMID: 28459618
  • Holguin F, Moughrabieh MA, Ojeda V, Patel SR, Peyrani P, Pinedo M, Celedón JC, Douglas IS, Upson DJ, Roman J. Respiratory Health in Migrant Populations: A Crisis Overlooked. Ann Am Thorac Soc. 2017 Feb;14(2):153-159. PubMed PMID: 28146384
  • Nyenhuis SM, Krishnan JA, Berry A, Calhoun WJ, Chinchilli VM, Engle L, Grossman N, Holguin F, Israel E, Kittles RA, Kraft M, Lazarus SC, Lehman EB, Mauger DT, Moy JN, Peters SP, Phipatanakul W, Smith LJ, Sumino K, Szefler SJ, Wechsler ME, Wenzel S, White SR, Ackerman SJ. Race is associated with differences in airway inflammation in patients with asthma. J Allergy Clin Immunol. 2017 Jul;140(1):257-265.e11. PubMed PMID: 28069248
  • Phipatanakul W, Mauger DT, Sorkness RL, Gaffin JM, Holguin F, Woodruff PG, Ly NP, Bacharier LB, Bhakta NR, Moore WC, Bleecker ER, Hastie AT, Meyers DA, Castro M, Fahy JV, Fitzpatrick AM, Gaston BM, Jarjour NN, Levy BD, Peters SP, Teague WG, Fajt M, Wenzel SE, Erzurum SC, Israel E. Effects of Age and Disease Severity on Systemic Corticosteroid Responses in Asthma. Am J Respir Crit Care Med. 2017 Jun 1;195(11):1439-1448. PubMed PMID: 27967215
  • Durack J, Lynch SV, Nariya S, Bhakta NR, Beigelman A, Castro M, Dyer AM, Israel E, Kraft M, Martin RJ, Mauger DT, Rosenberg SR, Sharp-King T, White SR, Woodruff PG, Avila PC, Denlinger LC, Holguin F, Lazarus SC, Lugogo N, Moore WC, Peters SP, Que L, Smith LJ, Sorkness CA, Wechsler ME, Wenzel SE, Boushey HA, Huang YJ. Features of the bronchial bacterial microbiome associated with atopy, asthma, and responsiveness to inhaled corticosteroid treatment. J Allergy Clin Immunol. 2017 Jul;140(1):63-75. PubMed PMID: 27838347
  • Ye J, Nouraie M, Holguin F, Gillespie AI. The Ability of Patient-Symptom Questionnaires to Differentiate PVFMD From Asthma. J Voice. 2017 May;31(3):382.e1-382.e8. PubMed PMID: 27697409
  • Winnica D, Que LG, Baffi C, Grasemann H, Fiedler K, Yang Z, Etling E, Wasil K, Wenzel SE, Freeman B, Holguin F. l-citrulline prevents asymmetric dimethylarginine-mediated reductions in nitric oxide and nitrosative stress in primary human airway epithelial cells. Clin Exp Allergy. 2017 Feb;47(2):190-199. PubMed PMID: 27562295
  • Denlinger LC, Phillips BR, Ramratnam S, Ross K, Bhakta NR, Cardet JC, Castro M, Peters SP, Phipatanakul W, Aujla S, Bacharier LB, Bleecker ER, Comhair SA, Coverstone A, DeBoer M, Erzurum SC, Fain SB, Fajt M, Fitzpatrick AM, Gaffin J, Gaston B, Hastie AT, Hawkins GA, Holguin F, Irani AM, Israel E, Levy BD, Ly N, Meyers DA, Moore WC, Myers R, Opina MT, Peters MC, Schiebler ML, Sorkness RL, Teague WG, Wenzel SE, Woodruff PG, Mauger DT, Fahy JV, Jarjour NN. Inflammatory and Comorbid Features of Patients with Severe Asthma and Frequent Exacerbations. Am J Respir Crit Care Med. 2017 Feb 1;195(3):302-313. PubMed PMID: 27556234
  • Holguin F, Rubió-Casadevall J, Saigi M, Marruecos J, Taberna M, Tobed M, Maños M, Mesía R. Cetuximab as treatment for head and neck cancer patients with a previous liver transplant: report of two cases. J Chemother. 2017 Oct;29(5):310-313. PubMed PMID: 27380218
  • Rastogi D, Holguin F. Metabolic Dysregulation, Systemic Inflammation, and Pediatric Obesity-related Asthma. Ann Am Thorac Soc. 2017 Nov;14(Supplement_5):S363-S367. PubMed PMID: 29161075
  • Raysoni AU, Stock TH, Sarnat JA, Chavez MC, Sarnat SE, Montoya T, Holguin F, Li WW. Evaluation of VOC concentrations in indoor and outdoor microenvironments at near-road schools. Environ Pollut. 2017 Dec;231(Pt 1):681-693. PubMed PMID: 28850936
  • Suratt BT, Ubags NDJ, Rastogi D, Tantisira KG, Marsland BJ, Petrache I, Allen JB, Bates JHT, Holguin F, McCormack MC, Michelakis ED, Black SM, Jain M, Mora AL, Natarajan V, Miller YI, Fessler MB, Birukov KG, Summer RS, Shore SA, Dixon AE. An Official American Thoracic Society Workshop Report: Obesity and Metabolism. An Emerging Frontier in Lung Health and Disease. Ann Am Thorac Soc. 2017 Jun;14(6):1050-1059. PubMed PMID: 28570148
  • Celedón JC, Burchard EG, Schraufnagel D, Castillo-Salgado C, Schenker M, Balmes J, Neptune E, Cummings KJ, Holguin F, Riekert KA, Wisnivesky JP, Garcia JGN, Roman J, Kittles R, Ortega VE, Redline S, Mathias R, Thomas A, Samet J, Ford JG. An American Thoracic Society/National Heart, Lung, and Blood Institute Workshop Report: Addressing Respiratory Health Equality in the United States. Ann Am Thorac Soc. 2017 May;14(5):814-826. PubMed PMID: 28459618
  • Holguin F, Moughrabieh MA, Ojeda V, Patel SR, Peyrani P, Pinedo M, Celedón JC, Douglas IS, Upson DJ, Roman J. Respiratory Health in Migrant Populations: A Crisis Overlooked. Ann Am Thorac Soc. 2017 Feb;14(2):153-159. PubMed PMID: 28146384
  • Nyenhuis SM, Krishnan JA, Berry A, Calhoun WJ, Chinchilli VM, Engle L, Grossman N, Holguin F, Israel E, Kittles RA, Kraft M, Lazarus SC, Lehman EB, Mauger DT, Moy JN, Peters SP, Phipatanakul W, Smith LJ, Sumino K, Szefler SJ, Wechsler ME, Wenzel S, White SR, Ackerman SJ. Race is associated with differences in airway inflammation in patients with asthma. J Allergy Clin Immunol. 2017 Jul;140(1):257-265.e11. PubMed PMID: 28069248
  • Phipatanakul W, Mauger DT, Sorkness RL, Gaffin JM, Holguin F, Woodruff PG, Ly NP, Bacharier LB, Bhakta NR, Moore WC, Bleecker ER, Hastie AT, Meyers DA, Castro M, Fahy JV, Fitzpatrick AM, Gaston BM, Jarjour NN, Levy BD, Peters SP, Teague WG, Fajt M, Wenzel SE, Erzurum SC, Israel E. Effects of Age and Disease Severity on Systemic Corticosteroid Responses in Asthma. Am J Respir Crit Care Med. 2017 Jun 1;195(11):1439-1448. PubMed PMID: 27967215
  • Durack J, Lynch SV, Nariya S, Bhakta NR, Beigelman A, Castro M, Dyer AM, Israel E, Kraft M, Martin RJ, Mauger DT, Rosenberg SR, Sharp-King T, White SR, Woodruff PG, Avila PC, Denlinger LC, Holguin F, Lazarus SC, Lugogo N, Moore WC, Peters SP, Que L, Smith LJ, Sorkness CA, Wechsler ME, Wenzel SE, Boushey HA, Huang YJ. Features of the bronchial bacterial microbiome associated with atopy, asthma, and responsiveness to inhaled corticosteroid treatment. J Allergy Clin Immunol. 2017 Jul;140(1):63-75. PubMed PMID: 27838347
  • Ye J, Nouraie M, Holguin F, Gillespie AI. The Ability of Patient-Symptom Questionnaires to Differentiate PVFMD From Asthma. J Voice. 2017 May;31(3):382.e1-382.e8. PubMed PMID: 27697409
  • Winnica D, Que LG, Baffi C, Grasemann H, Fiedler K, Yang Z, Etling E, Wasil K, Wenzel SE, Freeman B, Holguin F. l-citrulline prevents asymmetric dimethylarginine-mediated reductions in nitric oxide and nitrosative stress in primary human airway epithelial cells. Clin Exp Allergy. 2017 Feb;47(2):190-199. PubMed PMID: 27562295
  • Denlinger LC, Phillips BR, Ramratnam S, Ross K, Bhakta NR, Cardet JC, Castro M, Peters SP, Phipatanakul W, Aujla S, Bacharier LB, Bleecker ER, Comhair SA, Coverstone A, DeBoer M, Erzurum SC, Fain SB, Fajt M, Fitzpatrick AM, Gaffin J, Gaston B, Hastie AT, Hawkins GA, Holguin F, Irani AM, Israel E, Levy BD, Ly N, Meyers DA, Moore WC, Myers R, Opina MT, Peters MC, Schiebler ML, Sorkness RL, Teague WG, Wenzel SE, Woodruff PG, Mauger DT, Fahy JV, Jarjour NN. Inflammatory and Comorbid Features of Patients with Severe Asthma and Frequent Exacerbations. Am J Respir Crit Care Med. 2017 Feb 1;195(3):302-313. PubMed PMID: 27556234
  • Holguin F, Rubió-Casadevall J, Saigi M, Marruecos J, Taberna M, Tobed M, Maños M, Mesía R. Cetuximab as treatment for head and neck cancer patients with a previous liver transplant: report of two cases. J Chemother. 2017 Oct;29(5):310-313. PubMed PMID: 27380218
  • Nyenhuis SM, Krishnan JA, Berry A, Calhoun WJ, Chinchilli VM, Engle L, Grossman N, Holguin F, Israel E, Kittles RA, Kraft M, Lazarus SC, Lehman EB, Mauger DT, Moy JN, Peters SP, Phipatanakul W, Smith LJ, Sumino K, Szefler SJ, Wechsler ME, Wenzel S, White SR, Ackerman SJ. Race is associated with differences in airway inflammation in patients with asthma. J Allergy Clin Immunol. 2016 Dec 31. [Epub ahead of print] PubMed PMID: 28069248
  • Phipatanakul W, Mauger DT, Sorkness RL, Gaffin JM, Holguin F, Woodruff PG, Ly NP, Bacharier LB, Bhakta NR, Moore WC, Bleecker ER, Hastie AT, Meyers DA, Castro M, Fahy J, Fitzpatrick A, Gaston BM, Jarjour NN, Levy BD, Peters SP, Teague WG, Fajt M, Wenzel SE, Erzurum SC, Israel E. Effects of Age and Disease Severity on Systemic Corticosteroid Responses in Asthma. Am J Respir Crit Care Med. 2016 Dec 14. [Epub ahead of print] PubMed PMID: 27967215
  • Durack J, Lynch SV, Nariya S, Bhakta NR, Beigelman A, Castro M, Dyer AM, Israel E, Kraft M, Martin RJ, Mauger DT, Rosenberg SR, Sharp-King T, White SR, Woodruff PG, Avila PC, Denlinger LC, Holguin F, Lazarus SC, Lugogo N, Moore WC, Peters SP, Que L, Smith LJ, Sorkness CA, Wechsler ME, Wenzel SE, Boushey HA, Huang YJ. Features of the bronchial bacterial microbiome associated with atopy, asthma, and responsiveness to inhaled corticosteroid treatment. J Allergy Clin Immunol. 2016 Nov 10. [Epub ahead of print] PubMed PMID: 27838347
  • Fitzpatrick AM, Jackson DJ, Mauger DT, Boehmer SJ, Phipatanakul W, Sheehan WJ, Moy JN, Paul IM, Bacharier LB, Cabana MD, Covar R, Holguin F, Lemanske RF Jr, Martinez FD, Pongracic JA, Beigelman A, Baxi SN, Benson M, Blake K, Chmiel JF, Daines CL, Daines MO, Gaffin JM, Gentile DA, Gower WA, Israel E, Kumar HV, Lang JE, Lazarus SC, Lima JJ, Ly N, Marbin J, Morgan W, Myers RE, Olin JT, Peters SP, Raissy HH, Robison RG, Ross K, Sorkness CA, Thyne SM, Szefler SJ. Individualized therapy for persistent asthma in young children. J Allergy Clin Immunol. 2016 Dec;138(6):1608-1618.e12. PubMed PMID: 27777180
  • Luyster FS, Strollo PJ Jr, Holguin F, Castro M, Dunican EM, Fahy J, Gaston B, Israel E, Jarjour NN, Mauger DT, Moore WC, Wenzel SE. Association Between Insomnia and Asthma Burden in the Severe Asthma Research Program (SARP) III. Chest. 2016 Dec;150(6):1242-1250. PubMed PMID: 27720882
  • Ye J, Nouraie M, Holguin F, Gillespie AI. The Ability of Patient-Symptom Questionnaires to Differentiate PVFMD From Asthma. J Voice. 2016 Sep 30. [Epub ahead of print] PubMed PMID: 27697409
  • Winnica D, Que LG, Baffi C, Grasemann H, Fiedler K, Yang Z, Etling E, Wasil K, Wenzel SE, Freeman B, Holguin F. l-citrulline prevents asymmetric dimethylarginine-mediated reductions in nitric oxide and nitrosative stress in primary human airway epithelial cells. Clin Exp Allergy. 2016 Aug 26. [Epub ahead of print] PubMed PMID: 27562295
  • Sheehan WJ, Mauger DT, Paul IM, Moy JN, Boehmer SJ, Szefler SJ, Fitzpatrick AM, Jackson DJ, Bacharier LB, Cabana MD, Covar R, Holguin F, Lemanske RF Jr, Martinez FD, Pongracic JA, Beigelman A, Baxi SN, Benson M, Blake K, Chmiel JF, Daines CL, Daines MO, Gaffin JM, Gentile DA, Gower WA, Israel E, Kumar HV, Lang JE, Lazarus SC, Lima JJ, Ly N, Marbin J, Morgan WJ, Myers RE, Olin JT, Peters SP, Raissy HH, Robison RG, Ross K, Sorkness CA, Thyne SM, Wechsler ME, Phipatanakul W. Acetaminophen versus Ibuprofen in Young Children with Mild Persistent Asthma. N Engl J Med. 2016 Aug 18;375(7):619-30. PubMed PMID: 27532828
  • Barton JH, Ireland A, Fitzpatrick M, Kessinger C, Camp D, Weinman R, McMahon D, Leader JK, Holguin F, Wenzel SE, Morris A, Gingo MR. Adiposity influences airway wall thickness and the asthma phenotype of HIV-associated obstructive lung disease: a cross-sectional study. BMC Pulm Med. 2016 Aug 4;16(1):111. PubMed PMID: 27488495
  • Holguin F, Rubió-Casadevall J, Saigi M, Marruecos J, Taberna M, Tobed M, Maños M, Mesía R. Cetuximab as treatment for head and neck cancer patients with a previous liver transplant: report of two cases. J Chemother. 2016 Jul 5;:1-4. [Epub ahead of print] PubMed PMID: 27380218
  • Zein JG, Udeh BL, Teague WG, Koroukian SM, Schlitz NK, Bleecker ER, Busse WB, Calhoun WJ, Castro M, Comhair SA, Fitzpatrick AM, Israel E, Wenzel SE, Holguin F, Gaston BM, Erzurum SC. Impact of Age and Sex on Outcomes and Hospital Cost of Acute Asthma in the United States, 2011-2012. PLoS One. 2016 Jun 13;11(6):e0157301. PubMed PMID: 27294365
  • Peters MC, McGrath KW, Hawkins GA, Hastie AT, Levy BD, Israel E, Phillips BR, Mauger DT, Comhair SA, Erzurum SC, Johansson MW, Jarjour NN, Coverstone AM, Castro M, Holguin F, Wenzel SE, Woodruff PG, Bleecker ER, Fahy JV. Plasma interleukin-6 concentrations, metabolic dysfunction, and asthma severity: a cross-sectional analysis of two cohorts. Lancet Respir Med. 2016 Jul;4(7):574-84. PubMed PMID: 27283230
  • Xu KY, Wisnivesky JP, Martynenko M, Mhango G, Busse PJ, Wolf MS, Holguin F, Federman AD. Assessing the association of obesity and asthma morbidity in older adults. Ann Allergy Asthma Immunol. 2016 Jul;117(1):33-7. PubMed PMID: 27234936
  • Baffi CW, Wood L, Winnica D, Strollo PJ Jr, Gladwin MT, Que LG, Holguin F. Metabolic Syndrome and the Lung. Chest. 2016 Jun;149(6):1525-34. PubMed PMID: 26836925
  • Khan NA, Engle M, Dungan B, Holguin FO, Xu P, Carroll KC. Volatile-organic molecular characterization of shale-oil produced water from the Permian Basin. Chemosphere. 2016 Apr;148:126-36. PubMed PMID: 26802271
  • Dabass A, Talbott EO, Venkat A, Rager J, Marsh GM, Sharma RK, Holguin F. Association of exposure to particulate matter (PM2.5) air pollution and biomarkers of cardiovascular disease risk in adult NHANES participants (2001-2008). Int J Hyg Environ Health. 2016 May;219(3):301-10. PubMed PMID: 26725170
  • Denlinger LC, King TS, Cardet JC, Craig T, Holguin F, Jackson DJ, Kraft M, Peters SP, Ross K, Sumino K, Boushey HA, Jarjour NN, Wechsler ME, Wenzel SE, Castro M, Avila PC. Vitamin D Supplementation and the Risk of Colds in Patients with Asthma. Am J Respir Crit Care Med. 2016 Mar 15;193(6):634-41. PubMed PMID: 26540136
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Professional Memberships

  • American Thoracic Society, member
  • European Respiratory Society, Member
  • Chest, member

Practice Locations

Allergy & Asthma Clinic - Anschutz
1635 Aurora Ct
6th floor
Aurora, CO 80045
720-848-7600

Hospital Affiliation
  • University of Colorado Hospital

Specialty Information

Specialties
  • Pulmonary Disease, Board Certification (1999, 2010)
  • Critical Care Medicine, Board Certification (1999, 2010)
  • Masters in Public Health, Other (2008)
Conditions & Treatments
  • Lungs and Breathing - Asthma
  • Lungs and Breathing
  • Lungs and Breathing - Lung Disease
  • Lungs and Breathing - Respiratory Disease
Clinical Interests
My many clinical interests include asthma, asthma that is difficult to treat or severe asthma

Care Philosophy
I strive to provide the best possible care and to treat each patient with compassion and respect.

Personal Interests
I enjoy skiing, reading, spending time with family and friends

Volunteer Activities
I direct the Latino Center for Research and Policy Center, focusing on Latino Health Disparities

Public Speaking
Yes
I regularly speak on matters related to asthma clinical and translational research

General Information

Medical Schools:
  • MD, Universidad La Salle-Facultad Mexicana de Medicina, Mexico City, Mexico (1991)
Internships:
  • Emory University School of Medicine Program (1992)
Residency Programs:
  • Emory University School of Medicine Program, Chief Resident, Internal Medicine (1996)
Fellowships:
  • Emory University School of Medicine Program, Pulmonary Disease and Critical Care Medicine (1999)
Download CV
Languages: Spanish
Department: Medicine-Pulmonary Sciences & Critical Care
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