Ken Tyler, MD
Professor, Neurology

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Medical School:
  • MD, Johns Hopkins University School of Medicine (1978)
Undergraduate School:
  • AB, Harvard University (MA) (1974)
Internship:
  • Brigham and Women's Hospital/Harvard Medical School Program (1979)
Residencies:
  • Massachusetts General Hospital Program, Chief Resident, Neurology (1983)
  • Brigham and Women's Hospital/Harvard Medical School Program, Internal Medicine (1980)
Languages: English
Department: Neurology

Professional Titles

  • Louise Baum Endowed Chair of Neurology
  • Chair, Department of Neurology

Recognition & Awards

  • Inaugural H. Richard Tyler Lecturer, Brigham & Women’s Hospital (2018)
  • Richard Paine Lecturer, Children’s National Medical Center (2018)
  • 4th Visiting Professor, University of Texas Medical Branch, Galveston (2017)
  • Elected, Henry Kunkel Society, Rockefeller University (2014)
  • Editorial Board, Annals of Neurology (2013)
  • Editorial Board, Journal of Infectious Disease (2013)
  • Editorial Board, Experimental Neurology (2013)
  • Associate Editor, Neurology Today (2013)
  • Associate Editor, Journal of Neurovirology (2013)
  • Editorial Board, Virology (2013)
  • Edittorial Board, Archives of Neurology (2013)
  • Robert Aird Professor, UCSF (2012)
  • Top Doctor, US News & World Report (2012)
  • Lippard Lecturer, Columbia University (2010)

Teaching

  • Professor (1995)
    School of Medicine, Immunology and Microbiology
  • Professor (1995)
    School of Medicine, Medicine
  • Professor (1995)
    School of Medicine, Neurology

Publications

  • Tyler KL. A Message from the Editor-in-Chief. Ann Neurol. 2022 Jan;91(1):1-3. PubMed PMID: 34820891
  • Anderson CA, Tyler KL, Prion Diseases in: Schaechter's Mechanisms of Microbial Disease (6th ed). Engleberg NC, DiRita VJ, Imperiale MJ (Eds). Wolters Kluwer, 2021:544-550.
  • DeBiasi RL, Tyler KL. Infections of the Central Nervous System. In: Schaechter's Mechanisms of Microbial Disease (6th ed). Enfleberg NC, DiRita VJ, Imperiale MJ (Eds). Wolters Kluwer, 2022:603-618.
  • Tyler KL. The Link Between Alzheimer Disease and Herpes Simplex Virus Infection: Better Late Than Never, or Better Never Than Late?. Neurotherapeutics. 2021 Sep 3. [Epub ahead of print] PubMed PMID: 34480291
  • Kapadia RK, Gill CM, Baca C, McMenamin C, Kannappan A, Niehaus WN, Tyler KL, Pastula DM, Piquet AL. Enterovirus A71 causing meningoencephalitis and acute flaccid myelitis in a patient receiving rituximab. J Neuroimmunol. 2021 Sep 15;358:577639. PubMed PMID: 34214953
  • Clarke P, Leser JS, Tyler KL. Intrinsic Innate Immune Responses Control Viral Growth and Protect against Neuronal Death in an Ex Vivo Model of West Nile Virus-Induced Central Nervous System Disease. J Virol. 2021 Aug 25;95(18):e0083521. PubMed PMID: 34190599
  • Coleman KJ, Chauhan L, Piquet AL, Tyler KL, Pastula DM. An Overview of Jamestown Canyon Virus Disease. Neurohospitalist. 2021 Jul;11(3):277-278. PubMed PMID: 34163560
  • Dionne KR, Tyler KL, Clarke P. Slice Culture Modeling of CNS Viral Infection. Methods Mol Biol. 2021;2311:109-130. PubMed PMID: 34033080
  • High B, Hixon AM, Tyler KL, Piquet AL, Pelak VS. Neurology and the COVID-19 Pandemic: Gathering Data for an Informed Response. Neurol Clin Pract. 2021 Apr;11(2):e48-e63. PubMed PMID: 33842072
  • Rozental AJ, McGrath S, Mooney AP, Hinson SR, McKeon A, Pittock SJ, Gross CC, Tyler KL. Evaluation of cell-based and tissue-based immunofluorescent assays for detection of glial fibrillary acidic protein autoantibodies in the cerebrospinal fluid of dogs with meningoencephalitis of unknown origin and other central nervous system disorders. Am J Vet Res. 2021 Feb;82(2):132-137. PubMed PMID: 33480282
  • Beckham JD, Solbrig MV, Tyler KL. Viral encephalitis and meningitis. In: Jankovic J, Mazziotta J, Pomeroy S, Daroff R (Eds): Bradley’s Neurology in Clinical Practice (8th ed). Elsevier, Philadelphia, 2022.
  • Piquet AL, Pastula DM, Beckham JD, Tyler KL. Infections, immunodeficiency and complications of immunomodulatory therapies in neuroimmunolog. In: Piquet AL, Alvarez E (Eds). Neuroimmunology. Springer Nature, 2021:405-415.
  • Smith DE, Beckham JD, Pastula D, Tyler KL. Neurological manifestations of West Nile virus. Nath A, Berger J (Eds): Clinical Neurovirology, 2nd ed. CRC Press, Boca Raton, FL 2020:225- 236.
  • Stonedahl S, Clarke P, Tyler KL. The Role of Microglia during West Nile Virus Infection of the Central Nervous System. Vaccines (Basel). 2020 Aug 28;8(3). PubMed PMID: 32872152
  • Kapadia RK, Tyler KL, Pastula DM. Encephalitis in adults caused by herpes simplex virus. CMAJ. 2020 Aug 10;192(32):E919. PubMed PMID: 32778604
  • Potter H, Boyd TD, Clarke P, Pelak VS, Tyler KL. Recruiting the innate immune system with GM-CSF to fight viral diseases, including West Nile Virus encephalitis and COVID-19. F1000Res. 2020;9:345. PubMed PMID: 32704352
  • Messacar K, Gaensbauer JT, Birkholz M, Palmer C, Todd JK, Tyler KL, Dominguez SR. Impact of FilmArray meningitis encephalitis panel on HSV testing and empiric acyclovir use in children beyond the neonatal period. Diagn Microbiol Infect Dis. 2020 Aug;97(4):115085. PubMed PMID: 32559588
  • Kapadia RK, Chauhan L, Piquet AL, Tyler KL, Pastula DM. An Overview of Eastern Equine Encephalitis (EEE). Neurohospitalist. 2020 Jul;10(3):161-162. PubMed PMID: 32549937
  • Koralnik IJ, Tyler KL. COVID-19: A Global Threat to the Nervous System. Ann Neurol. 2020 Jul;88(1):1-11. PubMed PMID: 32506549
  • Kuczynski AM, Wallace CJ, Wada R, Tyler KL, Kapadia RK. Crossed Zoster Syndrome: A Rare Clinical Presentation Following Herpes Zoster Ophthalmicus. Can J Neurol Sci. 2020 Sep;47(5):711-713. PubMed PMID: 32389129
  • Tyler KL, Rüegg S. The neuromythology of Hashimoto encephalopathy: The emperor has no clothes. Neurology. 2020 Jan 14;94(2):55-56. PubMed PMID: 31882524
  • Messacar K, Spence-Davizon E, Osborne C, Press C, Schreiner TL, Martin J, Messer R, Maloney J, Burakoff A, Barnes M, Rogers S, Lopez AS, Routh J, Gerber SI, Oberste MS, Nix WA, Abzug MJ, Tyler KL, Herlihy R, Dominguez SR. Clinical characteristics of enterovirus A71 neurological disease during an outbreak in children in Colorado, USA, in 2018: an observational cohort study. Lancet Infect Dis. 2020 Feb;20(2):230-239. PubMed PMID: 31859216
  • Gill CM, Kapadia RK, Beckham JD, Piquet AL, Tyler KL, Pastula DM. Usutu virus disease: a potential problem for North America?. J Neurovirol. 2020 Apr;26(2):149-154. PubMed PMID: 31858483
  • Messacar K, Spence-Davizon E, Osborne C, Press C, Schreiner TL, Martin J, Messer R, Maloney J, Burakoff A, Barnes M, Rogers S, Lopez AS, Routh J, Gerber SI, Oberste MS, Nix WA, Abzug MJ, Tyler KL, Herlihy R, Dominguez SR. Clinical characteristics of enterovirus A71 neurological disease during an outbreak in children in Colorado, USA, in 2018: an observational cohort study. Lancet Infect Dis. 2019 Dec 16. [Epub ahead of print] PubMed PMID: 31859216
  • Tyler KL, Rüegg S. The neuromythology of Hashimoto encephalopathy: The emperor has no clothes. Neurology. 2019 Dec 27. [Epub ahead of print] PubMed PMID: 31882524
  • Gill CM, Kapadia RK, Beckham JD, Piquet AL, Tyler KL, Pastula DM. Usutu virus disease: a potential problem for North America?. J Neurovirol. 2019 Dec 19. [Epub ahead of print] PubMed PMID: 31858483
  • Gnann JW Jr, Agrawal A, Hart J, Buitrago M, Carson P, Hanfelt-Goade D, Tyler K, Spotkov J, Freifeld A, Moore T, Reyno J, Masur H, Jester P, Dale I, Li Y, Aban I, Lakeman FD, Whitley RJ. Lack of Efficacy of High-Titered Immunoglobulin in Patients with West Nile Virus Central Nervous System Disease. Emerg Infect Dis. 2019 Nov;25(11):2064-2073. PubMed PMID: 31625835
  • Khan M, Beckham JD, Piquet AL, Tyler KL, Pastula DM. An Overview of Powassan Virus Disease. Neurohospitalist. 2019 Oct;9(4):181-182. PubMed PMID: 31534605
  • Gill CM, Beckham JD, Piquet AL, Tyler KL, Pastula DM. Five Emerging Neuroinvasive Arboviral Diseases: Cache Valley, Eastern Equine Encephalitis, Jamestown Canyon, Powassan, and Usutu. Semin Neurol. 2019 Aug;39(4):419-427. PubMed PMID: 31533182
  • Clifford DB, Tyler KL. Dosing interval of natalizumab in MS: Do good things come to those who wait?. Neurology. 2019 Oct 8;93(15):655-656. PubMed PMID: 31515289
  • Hixon AM, Frost J, Rudy MJ, Messacar K, Clarke P, Tyler KL. Understanding Enterovirus D68-Induced Neurologic Disease: A Basic Science Review. Viruses. 2019 Sep 4;11(9). PubMed PMID: 31487952
  • Bonney S, Seitz S, Ryan CA, Jones KL, Clarke P, Tyler KL, Siegenthaler JA. Gamma Interferon Alters Junctional Integrity via Rho Kinase, Resulting in Blood-Brain Barrier Leakage in Experimental Viral Encephalitis. mBio. 2019 Aug 6;10(4). PubMed PMID: 31387911
  • Hixon AM, Clarke P, Tyler KL. Contemporary Circulating Enterovirus D68 Strains Infect and Undergo Retrograde Axonal Transport in Spinal Motor Neurons Independent of Sialic Acid. J Virol. 2019 Aug 15;93(16). PubMed PMID: 31167912
  • Clarke P, Zhuang Y, Berens HM, Leser JS, Tyler KL. Interferon Beta Contributes to Astrocyte Activation in the Brain following Reovirus Infection. J Virol. 2019 May 15;93(10). PubMed PMID: 30814290
  • Messacar K, Tyler KL. Enterovirus D68-Associated Acute Flaccid Myelitis: Rising to the Clinical and Research Challenges. JAMA. 2019 Mar 5;321(9):831-832. PubMed PMID: 30768149
  • Dubey D, Pittock SJ, Krecke KN, Morris PP, Sechi E, Zalewski NL, Weinshenker BG, Shosha E, Lucchinetti CF, Fryer JP, Lopez-Chiriboga AS, Chen JC, Jitprapaikulsan J, McKeon A, Gadoth A, Keegan BM, Tillema JM, Naddaf E, Patterson MC, Messacar K, Tyler KL, Flanagan EP. Clinical, Radiologic, and Prognostic Features of Myelitis Associated With Myelin Oligodendrocyte Glycoprotein Autoantibody. JAMA Neurol. 2019 Mar 1;76(3):301-309. PubMed PMID: 30575890
  • Messacar K, Sillau S, Hopkins SE, Otten C, Wilson-Murphy M, Wong B, Santoro JD, Treister A, Bains HK, Torres A, Zabrocki L, Glanternik JR, Hurst AL, Martin JA, Schreiner T, Makhani N, DeBiasi RL, Kruer MC, Tremoulet AH, Van Haren K, Desai J, Benson LA, Gorman MP, Abzug MJ, Tyler KL, Dominguez SR. Safety, tolerability, and efficacy of fluoxetine as an antiviral for acute flaccid myelitis. Neurology. 2019 Apr 30;92(18):e2118-e2126. PubMed PMID: 30413631
  • Gnann JW Jr, Agrawal A, Hart J, Buitrago M, Carson P, Hanfelt-Goade D, Tyler K, Spotkov J, Freifeld A, Moore T, Reyno J, Masur H, Jester P, Dale I, Li Y, Aban I, Lakeman FD, Whitley RJ. Lack of Efficacy of High-Titered Immunoglobulin in Patients with West Nile Virus Central Nervous System Disease. Emerg Infect Dis. 2019 Nov;25(11):2064-2073. PubMed PMID: 31625835
  • Khan M, Beckham JD, Piquet AL, Tyler KL, Pastula DM. An Overview of Powassan Virus Disease. Neurohospitalist. 2019 Oct;9(4):181-182. PubMed PMID: 31534605
  • Gill CM, Beckham JD, Piquet AL, Tyler KL, Pastula DM. Five Emerging Neuroinvasive Arboviral Diseases: Cache Valley, Eastern Equine Encephalitis, Jamestown Canyon, Powassan, and Usutu. Semin Neurol. 2019 Aug;39(4):419-427. PubMed PMID: 31533182
  • Clifford DB, Tyler KL. Dosing interval of natalizumab in MS: Do good things come to those who wait?. Neurology. 2019 Oct 8;93(15):655-656. PubMed PMID: 31515289
  • Hixon AM, Frost J, Rudy MJ, Messacar K, Clarke P, Tyler KL. Understanding Enterovirus D68-Induced Neurologic Disease: A Basic Science Review. Viruses. 2019 Sep 4;11(9). PubMed PMID: 31487952
  • Bonney S, Seitz S, Ryan CA, Jones KL, Clarke P, Tyler KL, Siegenthaler JA. Gamma Interferon Alters Junctional Integrity via Rho Kinase, Resulting in Blood-Brain Barrier Leakage in Experimental Viral Encephalitis. mBio. 2019 Aug 6;10(4). PubMed PMID: 31387911
  • Hixon AM, Clarke P, Tyler KL. Contemporary Circulating Enterovirus D68 Strains Infect and Undergo Retrograde Axonal Transport in Spinal Motor Neurons Independent of Sialic Acid. J Virol. 2019 Aug 15;93(16). PubMed PMID: 31167912
  • Clarke P, Zhuang Y, Berens HM, Leser JS, Tyler KL. Interferon Beta Contributes to Astrocyte Activation in the Brain following Reovirus Infection. J Virol. 2019 May 15;93(10). PubMed PMID: 30814290
  • Messacar K, Tyler KL. Enterovirus D68-Associated Acute Flaccid Myelitis: Rising to the Clinical and Research Challenges. JAMA. 2019 Mar 5;321(9):831-832. PubMed PMID: 30768149
  • Dubey D, Pittock SJ, Krecke KN, Morris PP, Sechi E, Zalewski NL, Weinshenker BG, Shosha E, Lucchinetti CF, Fryer JP, Lopez-Chiriboga AS, Chen JC, Jitprapaikulsan J, McKeon A, Gadoth A, Keegan BM, Tillema JM, Naddaf E, Patterson MC, Messacar K, Tyler KL, Flanagan EP. Clinical, Radiologic, and Prognostic Features of Myelitis Associated With Myelin Oligodendrocyte Glycoprotein Autoantibody. JAMA Neurol. 2019 Mar 1;76(3):301-309. PubMed PMID: 30575890
  • Messacar K, Sillau S, Hopkins SE, Otten C, Wilson-Murphy M, Wong B, Santoro JD, Treister A, Bains HK, Torres A, Zabrocki L, Glanternik JR, Hurst AL, Martin JA, Schreiner T, Makhani N, DeBiasi RL, Kruer MC, Tremoulet AH, Van Haren K, Desai J, Benson LA, Gorman MP, Abzug MJ, Tyler KL, Dominguez SR. Safety, tolerability, and efficacy of fluoxetine as an antiviral for acute flaccid myelitis. Neurology. 2019 Apr 30;92(18):e2118-e2126. PubMed PMID: 30413631
  • Dubey D, Pittock SJ, Krecke KN, Morris PP, Sechi E, Zalewski NL, Weinshenker BG, Shosha E, Lucchinetti CF, Fryer JP, Lopez-Chiriboga AS, Chen JC, Jitprapaikulsan J, McKeon A, Gadoth A, Keegan BM, Tillema JM, Naddaf E, Patterson MC, Messacar K, Tyler KL, Flanagan EP. Clinical, Radiologic, and Prognostic Features of Myelitis Associated With Myelin Oligodendrocyte Glycoprotein Autoantibody. JAMA Neurol. 2018 Dec 21. [Epub ahead of print] PubMed PMID: 30575890
  • Messacar K, Sillau S, Hopkins SE, Otten C, Wilson-Murphy M, Wong B, Santoro JD, Treister A, Bains HK, Torres A, Zabrocki L, Glanternik JR, Hurst AL, Martin JA, Schreiner T, Makhani N, DeBiasi RL, Kruer MC, Tremoulet AH, Van Haren K, Desai J, Benson LA, Gorman MP, Abzug MJ, Tyler KL, Dominguez SR. Safety, tolerability, and efficacy of fluoxetine as an antiviral for acute flaccid myelitis. Neurology. 2018 Nov 9. [Epub ahead of print] PubMed PMID: 30413631
  • Brown DM, Hixon AM, Oldfield LM, Zhang Y, Novotny M, Wang W, Das SR, Shabman RS, Tyler KL, Scheuermann RH. Contemporary Circulating Enterovirus D68 Strains Have Acquired the Capacity for Viral Entry and Replication in Human Neuronal Cells. MBio. 2018 Oct 16;9(5). PubMed PMID: 30327438
  • Tyler KL. Acute Viral Encephalitis. N Engl J Med. 2018 Aug 9;379(6):557-566. PubMed PMID: 30089069
  • Seitz S, Clarke P, Tyler KL. Pharmacologic Depletion of Microglia Increases Viral Load in the Brain and Enhances Mortality in Murine Models of Flavivirus-Induced Encephalitis. J Virol. 2018 Aug 15;92(16). PubMed PMID: 29899084
  • Tyler KL. What's Next (Generation) for the Diagnosis of Chronic Meningitis?. JAMA Neurol. 2018 Aug 1;75(8):915-917. PubMed PMID: 29710076
  • Messacar K, Asturias EJ, Hixon AM, Van Leer-Buter C, Niesters HGM, Tyler KL, Abzug MJ, Dominguez SR. Enterovirus D68 and acute flaccid myelitis-evaluating the evidence for causality. Lancet Infect Dis. 2018 Aug;18(8):e239-e247. PubMed PMID: 29482893
  • Messacar K, Fischer M, Dominguez SR, Tyler KL, Abzug MJ. Encephalitis in US Children. Infect Dis Clin North Am. 2018 Mar;32(1):145-162. PubMed PMID: 29224854
  • Hoon-Hanks LL, McGrath S, Tyler KL, Owen C, Stenglein MD. Metagenomic Investigation of Idiopathic Meningoencephalomyelitis in Dogs. J Vet Intern Med. 2018 Jan;32(1):324-330. PubMed PMID: 29197179
  • Brown DM, Hixon AM, Oldfield LM, Zhang Y, Novotny M, Wang W, Das SR, Shabman RS, Tyler KL, Scheuermann RH. Contemporary Circulating Enterovirus D68 Strains Have Acquired the Capacity for Viral Entry and Replication in Human Neuronal Cells. mBio. 2018 Oct 16;9(5). PubMed PMID: 30327438
  • Tyler KL. Acute Viral Encephalitis. N Engl J Med. 2018 Aug 9;379(6):557-566. PubMed PMID: 30089069
  • Seitz S, Clarke P, Tyler KL. Pharmacologic Depletion of Microglia Increases Viral Load in the Brain and Enhances Mortality in Murine Models of Flavivirus-Induced Encephalitis. J Virol. 2018 Aug 15;92(16). PubMed PMID: 29899084
  • Tyler KL. What's Next (Generation) for the Diagnosis of Chronic Meningitis?. JAMA Neurol. 2018 Aug 1;75(8):915-917. PubMed PMID: 29710076
  • Hoon-Hanks LL, McGrath S, Tyler KL, Owen C, Stenglein MD. Metagenomic Investigation of Idiopathic Meningoencephalomyelitis in Dogs. J Vet Intern Med. 2018 Jan;32(1):324-330. PubMed PMID: 29197179
  • Messacar K, Fischer M, Dominguez SR, Tyler KL, Abzug MJ. Encephalitis in US Children. Infect Dis Clin North Am. 2018 Mar;32(1):145-162. PubMed PMID: 29224854
  • Messacar K, Asturias EJ, Hixon AM, Van Leer-Buter C, Niesters HGM, Tyler KL, Abzug MJ, Dominguez SR. Enterovirus D68 and acute flaccid myelitis-evaluating the evidence for causality. Lancet Infect Dis. 2018 Aug;18(8):e239-e247. PubMed PMID: 29482893
  • Tyler KL, Nagel M. In Memoriam: Donald H. Gilden, MD (1937-2016). JAMA Neurol. 2017 Jan 1;74(1):132-133. PubMed PMID: 28030726
  • Tyler KL, Pastula DM. Hepatitis E Virus and Guillain-Barré Syndrome. JAMA Neurol. 2017 Jan 1;74(1):13-15. PubMed PMID: 27820625
  • Messacar K, Fischer M, Dominguez SR, Tyler KL, Abzug MJ. Encephalitis in US Children. Infect Dis Clin North Am. 2017 Dec 7. [Epub ahead of print] PubMed PMID: 29224854
  • Hoon-Hanks LL, McGrath S, Tyler KL, Owen C, Stenglein MD. Metagenomic Investigation of Idiopathic Meningoencephalomyelitis in Dogs. J Vet Intern Med. 2017 Dec 2. [Epub ahead of print] PubMed PMID: 29197179
  • McGuinness I, Beckham JD, Tyler KL, Pastula DM. An Overview of Yellow Fever Virus Disease. Neurohospitalist. 2017 Oct;7(4):157-158. PubMed PMID: 28974992
  • Hixon AM, Clarke P, Tyler KL. Evaluating Treatment Efficacy in a Mouse Model of Enterovirus D68-Associated Paralytic Myelitis. J Infect Dis. 2017 Dec 5;216(10):1245-1253. PubMed PMID: 28968718
  • Quick ED, Seitz S, Clarke P, Tyler KL. Minocycline Has Anti-inflammatory Effects and Reduces Cytotoxicity in an Ex Vivo Spinal Cord Slice Culture Model of West Nile Virus Infection. J Virol. 2017 Nov 15;91(22). PubMed PMID: 28878079
  • Tyler KL, Roos KL. The Expanding Spectrum of Zika Virus Infections of the Nervous System. JAMA Neurol. 2017 Oct 1;74(10):1169-1171. PubMed PMID: 28806454
  • Martin JA, Messacar K, Yang ML, Maloney JA, Lindwall J, Carry T, Kenyon P, Sillau SH, Oleszek J, Tyler KL, Dominguez SR, Schreiner TL. Outcomes of Colorado children with acute flaccid myelitis at 1 year. Neurology. 2017 Jul 11;89(2):129-137. PubMed PMID: 28615421
  • Shives KD, Tyler KL, Beckham JD. Molecular mechanisms of neuroinflammation and injury during acute viral encephalitis. J Neuroimmunol. 2017 Jul 15;308:102-111. PubMed PMID: 28291542
  • Hixon AM, Yu G, Leser JS, Yagi S, Clarke P, Chiu CY, Tyler KL. A mouse model of paralytic myelitis caused by enterovirus D68. PLoS Pathog. 2017 Feb;13(2):e1006199. PubMed PMID: 28231269
  • Tyler KL, Vollmer TL. To PLEX or not to PLEX in natalizumab-associated PML. Neurology. 2017 Mar 21;88(12):1108-1109. PubMed PMID: 28228561
  • Duca LM, Beckham JD, Tyler KL, Pastula DM. Zika Virus Disease and Associated Neurologic Complications. Curr Infect Dis Rep. 2017 Jan;19(1):4. PubMed PMID: 28220392
  • Tyler KL, Nagel M. In Memoriam: Donald H. Gilden, MD (1937-2016). JAMA Neurol. 2017 Jan 1;74(1):132-133. PubMed PMID: 28030726
  • Pastula DM, Durrant JC, Smith DE, Beckham JD, Tyler KL. Zika Virus Disease for the Neurointensivist. Neurocrit Care. 2017 Jun;26(3):457-463. PubMed PMID: 27995511
  • Tyler KL, Pastula DM. Hepatitis E Virus and Guillain-Barré Syndrome. JAMA Neurol. 2017 Jan 1;74(1):13-15. PubMed PMID: 27820625
  • Pastula DM, Durrant JC, Smith DE, Beckham JD, Tyler KL. Zika Virus Disease for the Neurointensivist. Neurocrit Care. 2016 Dec 19. [Epub ahead of print] PubMed PMID: 27995511
  • Tyler KL, Lipton HL. Donald H. Gilden, MD (1937-2016). Neurology. 2016 Nov 22;87(21):2182-2183. PubMed PMID: 27872221
  • Tyler KL, Samuels MA. In Memoriam: H. Richard Tyler, MD (1927-2016). JAMA Neurol. 2016 Nov 1;73(11):1378-1380. PubMed PMID: 27842155
  • Wilson M, Tyler KL. Emerging Diagnostic and Therapeutic Tools for Central Nervous System Infections. JAMA Neurol. 2016 Dec 1;73(12):1389-1390. PubMed PMID: 27695862
  • Lipton HL, Tyler K. In memoriam: Donald H. Gilden, M.D. J Neurovirol. 2016 Oct;22(5):551-552. PubMed PMID: 27683234
  • White MK, Wollebo HS, David Beckham J, Tyler KL, Khalili K. Zika virus: An emergent neuropathological agent. Ann Neurol. 2016 Oct;80(4):479-89. PubMed PMID: 27464346
  • Messacar K, Schreiner TL, Van Haren K, Yang M, Glaser CA, Tyler KL, Dominguez SR. Acute flaccid myelitis: A clinical review of US cases 2012-2015. Ann Neurol. 2016 Sep;80(3):326-38. PubMed PMID: 27422805
  • Pastula DM, Smith DE, Beckham JD, Tyler KL. An Overview of Zika Virus Disease. Neurohospitalist. 2016 Jul;6(3):93-4. PubMed PMID: 27366289
  • Vasek MJ, Garber C, Dorsey D, Durrant DM, Bollman B, Soung A, Yu J, Perez-Torres C, Frouin A, Wilton DK, Funk K, DeMasters BK, Jiang X, Bowen JR, Mennerick S, Robinson JK, Garbow JR, Tyler KL, Suthar MS, Schmidt RE, Stevens B, Klein RS. A complement-microglial axis drives synapse loss during virus-induced memory impairment. Nature. 2016 Jun 23;534(7608):538-43. PubMed PMID: 27337340
  • Zhuang Y, Berens-Norman HM, Leser JS, Clarke P, Tyler KL. Mitochondrial p53 Contributes to Reovirus-Induced Neuronal Apoptosis and Central Nervous System Injury in a Mouse Model of Viral Encephalitis. J Virol. 2016 Sep 1;90(17):7684-91. PubMed PMID: 27307572
  • Beckham JD, Pastula DM, Massey A, Tyler KL. Zika Virus as an Emerging Global Pathogen: Neurological Complications of Zika Virus. JAMA Neurol. 2016 Jul 1;73(7):875-9. PubMed PMID: 27183312
  • Pastula DM, Smith DE, Beckham JD, Tyler KL. Four emerging arboviral diseases in North America: Jamestown Canyon, Powassan, chikungunya, and Zika virus diseases. J Neurovirol. 2016 Jun;22(3):257-60. PubMed PMID: 26903031
  • Smith DE, Beckham JD, Tyler KL, Pastula DM. Zika virus disease for neurologists. Neurol Clin Pract. 2016 Dec;6(6):515-522. PubMed PMID: 28058206
  • Smith DE, Beckham JD, Tyler KL, Pastula DM. Zika virus disease for neurologists. Neurol Clin Pract. 2016 Dec;6(6):515-522. PubMed PMID: 28058206
  • Tyler KL, Lipton HL. Donald H. Gilden, MD (1937-2016). Neurology. 2016 Nov 22;87(21):2182-2183. PubMed PMID: 27872221
  • Tyler KL, Samuels MA. In Memoriam: H. Richard Tyler, MD (1927-2016). JAMA Neurol. 2016 Nov 1;73(11):1378-1380. PubMed PMID: 27842155
  • Wilson M, Tyler KL. Emerging Diagnostic and Therapeutic Tools for Central Nervous System Infections. JAMA Neurol. 2016 Dec 1;73(12):1389-1390. PubMed PMID: 27695862
  • Lipton HL, Tyler K. In memoriam: Donald H. Gilden, M.D. J Neurovirol. 2016 Oct;22(5):551-552. PubMed PMID: 27683234
  • White MK, Wollebo HS, David Beckham J, Tyler KL, Khalili K. Zika virus: An emergent neuropathological agent. Ann Neurol. 2016 Oct;80(4):479-89. PubMed PMID: 27464346
  • Messacar K, Schreiner TL, Van Haren K, Yang M, Glaser CA, Tyler KL, Dominguez SR. Acute flaccid myelitis: A clinical review of US cases 2012-2015. Ann Neurol. 2016 Sep;80(3):326-38. PubMed PMID: 27422805
  • Pastula DM, Smith DE, Beckham JD, Tyler KL. An Overview of Zika Virus Disease. Neurohospitalist. 2016 Jul;6(3):93-4. PubMed PMID: 27366289
  • Zhuang Y, Berens-Norman HM, Leser JS, Clarke P, Tyler KL. Mitochondrial p53 Contributes to Reovirus-Induced Neuronal Apoptosis and Central Nervous System Injury in a Mouse Model of Viral Encephalitis. J Virol. 2016 Sep 1;90(17):7684-91. PubMed PMID: 27307572
  • Vasek MJ, Garber C, Dorsey D, Durrant DM, Bollman B, Soung A, Yu J, Perez-Torres C, Frouin A, Wilton DK, Funk K, DeMasters BK, Jiang X, Bowen JR, Mennerick S, Robinson JK, Garbow JR, Tyler KL, Suthar MS, Schmidt RE, Stevens B, Klein RS. A complement-microglial axis drives synapse loss during virus-induced memory impairment. Nature. 2016 Jun 23;534(7608):538-43. PubMed PMID: 27337340
  • Beckham JD, Pastula DM, Massey A, Tyler KL. Zika Virus as an Emerging Global Pathogen: Neurological Complications of Zika Virus. JAMA Neurol. 2016 Jul 1;73(7):875-9. PubMed PMID: 27183312
  • Pastula DM, Smith DE, Beckham JD, Tyler KL. Four emerging arboviral diseases in North America: Jamestown Canyon, Powassan, chikungunya, and Zika virus diseases. J Neurovirol. 2016 Jun;22(3):257-60. PubMed PMID: 26903031
  • Tyler KL. Fingolimod and risk of varicella-zoster virus infection: back to the future with an old infection and a new drug. JAMA Neurol. 2015 Jan 1;72(1):10-3. PubMed PMID: 25420159
  • Beckham JD, Tyler KL. Arbovirus Infections. Continuum (Minneap Minn). 2015 Dec;21(6 Neuroinfectious Disease):1599-611. PubMed PMID: 26633778
  • Patera AC, Butler SL, Cinque P, Clifford DB, Elston R, Garcea RL, Major EO, Pavlovic D, Peterson IS, Ryan AM, Tyler KL, Weber T. 2nd International Conference on Progressive Multifocal Leukoencephalopathy (PML) 2015: JCV virology, progressive multifocal leukoencephalopathy pathogenesis, diagnosis and risk stratification, and new approaches to prevention and treatment. J Neurovirol. 2015 Oct 26. [Epub ahead of print] PubMed PMID: 26501778
  • Tyler KL. Editorial Commentary: Failure of Adjunctive Valacyclovir to Improve Outcomes in Herpes Simplex Encephalitis. Clin Infect Dis. 2015 Sep 1;61(5):692-4. PubMed PMID: 25956893
  • Tyler KL. Rationale for the evaluation of fluoxetine in the treatment of enterovirus D68-associated acute flaccid myelitis. JAMA Neurol. 2015 May;72(5):493-4. PubMed PMID: 25775436
  • Tyler KL. Fingolimod and risk of varicella-zoster virus infection: back to the future with an old infection and a new drug. JAMA Neurol. 2015 Jan;72(1):10-3. PubMed PMID: 25420159
  • Clarke P, Leser JS, Quick ED, Dionne KR, Beckham JD, Tyler KL. Death Receptor-Mediated Apoptotic Signaling Is Activated in the Brain following Infection with West Nile Virus in the Absence of a Peripheral Immune Response. J Virol. 2014 Jan;88(2):1080-9. PubMed PMID: 24198425
  • Steiner I, Tyler KL. The toll (like receptor 3) to the pathogenesis of herpes simplex encephalitis. Neurology. 2014 Nov 18;83(21):1882-3. PubMed PMID: 25339218
  • Quick ED, Leser JS, Clarke P, Tyler KL. Activation of intrinsic immune responses and microglial phagocytosis in an ex vivo spinal cord slice culture model of West Nile virus infection. J Virol. 2014 Nov;88(22):13005-14. PubMed PMID: 25165111
  • Oyer RJ, David Beckham J, Tyler KL. West Nile and St. Louis encephalitis viruses. Handb Clin Neurol. 2014;123:433-47. PubMed PMID: 25015498
  • Tyler KL. Current developments in understanding of West Nile virus central nervous system disease. Curr Opin Neurol. 2014 Jun;27(3):342-8. PubMed PMID: 24722324
  • Clarke P, Leser JS, Bowen RA, Tyler KL. Virus-induced transcriptional changes in the brain include the differential expression of genes associated with interferon, apoptosis, interleukin 17 receptor A, and glutamate signaling as well as flavivirus-specific upregulation of tRNA synthetases. MBio. 2014 Mar 11;5(2):e00902-14. PubMed PMID: 24618253
  • Clarke P, Leser JS, Quick ED, Dionne KR, Beckham JD, Tyler KL. Death receptor-mediated apoptotic signaling is activated in the brain following infection with West Nile virus in the absence of a peripheral immune response. J Virol. 2014 Jan;88(2):1080-9. PubMed PMID: 24198425
  • Tyler KL, Johnson EC, Cantu DS, Haller BL. A 20-year-old woman with headache and transient numbness. Neurohospitalist. 2013 Apr;3(2):101-10. PubMed PMID: 23983894
  • Dionne KR, Tyler KL. Slice culture modeling of central nervous system (CNS) viral infection. Methods Mol Biol. 2013;1078:97-117. PubMed PMID: 23975824
  • Nath A, Tyler KL. Novel approaches and challenges to treatment of central nervous system viral infections. Ann Neurol. 2013 Sep;74(3):412-22. PubMed PMID: 23913580
  • Tyler KL. PML therapy: "It's Déjà vu all over again". J Neurovirol. 2013 Aug;19(4):311-3. PubMed PMID: 23913113
  • Davis LE, Oyer R, Beckham JD, Tyler KL. Elevated CSF cytokines in the Jarisch-Herxheimer reaction of general paresis. JAMA Neurol. 2013 Aug;70(8):1060-4. PubMed PMID: 23732875
  • Dionne KR, Zhuang Y, Leser JS, Tyler KL, Clarke P. Daxx upregulation within the cytoplasm of reovirus-infected cells is mediated by interferon and contributes to apoptosis. J Virol. 2013 Mar;87(6):3447-60. PubMed PMID: 23302889
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Professional Memberships

  • American College of Physicians (ACP), Fellow
  • American Academy of Neurology, Fellow
  • American Neurological Association, Fellow
  • Infectious Disease Society of America, Fellow
  • American Association for the Advancement of Science, Fellow
  • Association of American Physicians, Member
  • American Society for Clinical Investigation, Member
  • American Academy of Microbiology, Fellow
  • American Society for Virology, Member
  • Society for Neuroscience, Member

Practice Locations

Neurosciences Center - Anschutz
1635 Aurora Ct
4th Floor
Aurora, CO 80045
720-848-2080

Rocky Mountain Regional Veterans Administration Medical Center
1700 Wheeling St
Aurora, CO 80045
303-399-8020

Hospital Affiliation
  • Veterans Affairs Medical Center
  • University of Colorado Hospital

Specialty Information

Specialties
  • Internal Medicine, Board Certification (1983)
  • Neurology, Board Certification (1984)
  • Microbiology & Molecular Genetics, Specialized Training (1983)
Conditions & Treatments
  • Brain and Nervous System
  • Infections

General Information

Medical Schools:
  • MD, Johns Hopkins University School of Medicine (1978)
Undergraduate Schools:
  • AB, Harvard University (MA) (1974)
Internships:
  • Brigham and Women's Hospital/Harvard Medical School Program (1979)
Residency Programs:
  • Massachusetts General Hospital Program, Chief Resident, Neurology (1983)
  • Brigham and Women's Hospital/Harvard Medical School Program, Internal Medicine (1980)
Languages: English
Department: Neurology
Contact Us
CU Anschutz
Fitzsimons Building

13001 East 17th Place
Campus Box C290
Aurora, CO 80045

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