Kambez H. Benam, PhD
Assistant Professor, Medicine-Pulmonary Sciences & Critical Care

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Graduate School :
  • D.Phil., University of Oxford (2012)
Undergraduate School:
  • BSc (Hons), Newcastle University (2007)
Department: Medicine-Pulmonary Sciences & Critical Care

Professional Titles

  • Assistant Professor, Medicine-Pulmonary Sciences & Critical Care
  • Assistant Professor of Bioengineering
  • Director, Lung Microengineering Lab at University of Colorado

Recognition & Awards

  • Science and Innovation Center Rising Star Award, American Thoracic Society Respiratory Structure & Function Assembly (2019)
  • Assembly Recognition of Early Academic Achievement (REAAch) Award, American Thoracic Society Respiratory Cell & Molecular Biology Assembly (2019)
  • Finalist, Science-to-Startup (S2S) (2019)
    S2S is an invitation-only symposium featuring the most innovative therapeutics startup ideas from the world’s top research institutions.
  • Young Investigator Award, Society of Toxicology Inhalation and Respiratory Specialty Section (2018)
  • Young Researcher Award, Lush (2016)
  • Young Investigator Award, Baxter’s (2016)

Research Interests

My lab applies a multidisciplinary approach to design and develop bio-inspired technologies that enable us to elucidate cellular and molecular mechanisms that govern tissue pathology or offer protection during lung injury. My research program lies at the intersection of respiratory medicine, immuno-microbiology, tissue engineering, and systems and synthetic biology. Ultimately, my goal is to discover novel druggable targets and personalized diagnostics using microengineered systems that recreate complex human organ pathophysiology in vitro.

Publications

  • Benam KH, Novak R, Ferrante TC, Choe Y, Ingber DE. Biomimetic smoking robot for in vitro inhalation exposure compatible with microfluidic organ chips. Nat Protoc. 2020 Jan 10. [Epub ahead of print] PubMed PMID: 31925401
  • Benam KH, Gilchrist S, Kleensang A, Satz AB, Willett C, Zhang Q. Exploring new technologies in biomedical research. Drug Discov Today. 2019 Jun;24(6):1242-1247. PubMed PMID: 30953865
  • Benam KH, Denney L, Ho LP. How the Respiratory Epithelium Senses and Reacts to Influenza Virus. Am J Respir Cell Mol Biol. 2019 Mar;60(3):259-268. PubMed PMID: 30372120
  • Benam KH, Vladar EK, Janssen WJ, Evans CM. Mucociliary Defense: Emerging Cellular, Molecular, and Animal Models. Ann Am Thorac Soc. 2018 Nov;15(Supplement_3):S210-S215. PubMed PMID: 30431350
  • Benam KH, Denney L, Ho LP. How the Respiratory Epithelium Senses and Reacts to Influenza Virus. Am J Respir Cell Mol Biol. 2018 Oct 29. [Epub ahead of print] PubMed PMID: 30372120
  • Niemeyer BF, Zhao P, Tuder RM, Benam KH. Advanced Microengineered Lung Models for Translational Drug Discovery. SLAS Discov. 2018 Sep;23(8):777-789. PubMed PMID: 29447055
  • Benam KH, Königshoff M, Eickelberg O. Breaking the In Vitro Barrier in Respiratory Medicine. Engineered Microphysiological Systems for Chronic Obstructive Pulmonary Disease and Beyond. Am J Respir Crit Care Med. 2018 Apr 1;197(7):869-875. PubMed PMID: 29262260
  • Benam KH, Königshoff M, Eickelberg O. Breaking the In Vitro Barrier in Respiratory Medicine: Engineered Microphysiological Systems for COPD and Beyond. Am J Respir Crit Care Med. 2017 Dec 20. [Epub ahead of print] PubMed PMID: 29262260
  • Benam KH, Mazur M, Choe Y, Ferrante TC, Novak R, Ingber DE. Human Lung Small Airway-on-a-Chip Protocol. Methods Mol Biol. 2017;1612:345-365. PubMed PMID: 28634955
  • Benam KH, Novak R, Nawroth J, Hirano-Kobayashi M, Ferrante TC, Choe Y, Prantil-Baun R, Weaver JC, Bahinski A, Parker KK, Ingber DE. Matched-Comparative Modeling of Normal and Diseased Human Airway Responses Using a Microengineered Breathing Lung Chip. Cell Syst. 2016 Nov 23;3(5):456-466.e4. PubMed PMID: 27894999
  • Benam KH, Ingber DE. Commendation for Exposing Key Advantage of Organ Chip Approach. Cell Syst. 2016 Nov 23;3(5):411. PubMed PMID: 27883885
  • Benam KH, Villenave R, Lucchesi C, Varone A, Hubeau C, Lee HH, Alves SE, Salmon M, Ferrante TC, Weaver JC, Bahinski A, Hamilton GA, Ingber DE. Small airway-on-a-chip enables analysis of human lung inflammation and drug responses in vitro. Nat Methods. 2016 Feb;13(2):151-7. PubMed PMID: 26689262
  • Benam KH, Dauth S, Hassell B, Herland A, Jain A, Jang KJ, Karalis K, Kim HJ, MacQueen L, Mahmoodian R, Musah S, Torisawa YS, van der Meer AD, Villenave R, Yadid M, Parker KK, Ingber DE. Engineered in vitro disease models. Annu Rev Pathol. 2015;10:195-262. PubMed PMID: 25621660
  • Cole SL, Benam KH, McMichael AJ, Ho LP. Involvement of the 4-1BB/4-1BBL pathway in control of monocyte numbers by invariant NKT cells. J Immunol. 2014 Apr 15;192(8):3898-907. PubMed PMID: 24639347
  • Kok WL, Denney L, Benam K, Cole S, Clelland C, McMichael AJ, Ho LP. Pivotal Advance: Invariant NKT cells reduce accumulation of inflammatory monocytes in the lungs and decrease immune-pathology during severe influenza A virus infection. J Leukoc Biol. 2012 Mar;91(3):357-68. PubMed PMID: 22003207
  • Benam KH, Kok WL, McMichael AJ, Ho LP. Alternative spliced CD1d transcripts in human bronchial epithelial cells. PLoS One. 2011;6(8):e22726. PubMed PMID: 21853044
View All (16 Total) View Less

Professional Memberships

  • American Thoracic Society, Member
  • American Association of Immunologists, Member
  • Society of Toxicology, Member
Public Speaking
Yes
I enjoy sharing ideas that can make people think, and learning from questions I get asked. I commonly present our scientific discoveries and translational science to diverse audience.

General Information

Graduate Schools:
  • D.Phil., University of Oxford (2012)
Undergraduate Schools:
  • BSc (Hons), Newcastle University (2007)
Department: Medicine-Pulmonary Sciences & Critical Care
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