Holly Frost, MD
Assistant Professor, Pediatrics

Medical School:
  • MD, Medical College of Wisconsin (2010)
Undergraduate School:
  • BS, Michigan Technological University (MI) (2004)
  • University of Colorado (Children's Hospital Colorado) Program (2011)
  • University of Colorado (Children's Hospital Colorado) Program, Pediatrics (2013)
Languages: English
Department: Pediatrics

Professional Titles

  • Assistant Professor, Pediatrics
  • Assistant Professor Pediatrics

Recognition & Awards

  • Days of Celebration Poster Award, Denver Health Medical Center, (2018)
  • Shining Star Award, Marshfield Clinic, (2016)
  • Kass Award, Infectious Disease Society of America, (2013)


  • Assistant Professor (2019)
    School of Medicine, Pediatrics
    General academic pediatrics; infectious diseases; clinical and translational research


  • Frost HM, Gerber JS, Hersh AL. Antibiotic Recommendations for Acute Otitis Media and Acute Bacterial Sinusitis. Pediatr Infect Dis J. 2019 Feb;38(2):217. PubMed PMID: 30640191
  • Frost HM, Fritsche TR, Hall MC. Beta-Hemolytic Nongroup A Streptococcal Pharyngitis in Children. J Pediatr. 2018 Dec 6. [Epub ahead of print] PubMed PMID: 30528760
  • Frost HM, McLean HQ, Chow BDW. Variability in Antibiotic Prescribing for Upper Respiratory Illnesses by Provider Specialty. J Pediatr. 2018 Dec;203:76-85.e8. PubMed PMID: 30195553
  • Koester TM, Meece JK, Fritsche TR, Frost HM. Infectious Mononucleosis and Lyme Disease as Confounding Diagnoses: A Report of 2 Cases. Clin Med Res. 2018 Dec;16(3-4):66-68. PubMed PMID: 30166498
  • Thomm AM, Schotthoefer AM, Dupuis AP 2nd, Kramer LD, Frost HM, Fritsche TR, Harrington YA, Knox KK, Kehl SC. Development and Validation of a Serologic Test Panel for Detection of Powassan Virus Infection in U.S. Patients Residing in Regions Where Lyme Disease Is Endemic. mSphere. 2018 Jan-Feb;3(1). PubMed PMID: 29359181
  • Schotthoefer AM, Hall MC, Vittala S, Bajwa R, Frost HM. Clinical Presentation and Outcomes of Children With Human Granulocytic Anaplasmosis. J Pediatric Infect Dis Soc. 2018 May 15;7(2):e9-e15. PubMed PMID: 28520981
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Professional Memberships

  • American Academy of Pediatrics, FAAP
  • Society for Healthcare Epidemiology of America, Member

Practice Locations

Denver Health
777 Bannock St
Denver, CO 80204

Hospital Affiliation
  • University of Colorado Hospital
  • Denver Health Medical Center

Specialty Information

  • Pediatrics, Board Certification (2013, 2019)
  • Neonatal Rescucitation Program, Certificate (2018)
  • Pediatric Advanced Life Support, Certificate (2017)
  • Fellowship Government and Community Service-Pediatric Obesity Prevention, Specialized Training (2007)
Care Philosophy
Dr. Frost is a board-certified pediatrician at Denver Health and an Assistant Professor of Pediatrics at the University of Colorado School of Medicine. She completed her medical education at the Medical College of Wisconsin and pediatric residency at the University of Colorado and Children’s Hospital Colorado. Dr. Frost has been in practice for more than 7 years and sees patients of all ages for primary care. Her research and clinical interests focus on infectious diseases in children, including the development of new tests to rapidly diagnose infections and improved treatment options for common infections of childhood. When not in clinic, Dr. Frost enjoys spending time with her two young boys and hiking in the mountains. Dr. Frost strives to provide compassionate, evidence-based care for children and to treat every child in the way she would want others to care for her own children.

General Information

Medical Schools:
  • MD, Medical College of Wisconsin (2010)
Undergraduate Schools:
  • BS, Michigan Technological University (MI) (2004)
  • University of Colorado (Children's Hospital Colorado) Program (2011)
Residency Programs:
  • University of Colorado (Children's Hospital Colorado) Program, Pediatrics (2013)
Languages: English
Department: Pediatrics