In my current role as the Director of the Ocular Development and Translational Technologies Laboratory within CellSight, the Ocular Stem Cell and Regeneration Program at the Sue Anschutz-Rodgers Eye Center, my research program focuses on two key areas:
I). Understanding the cellular and molecular mechanisms of human retina development and degeneration.
II). Engineering stem cell-based disease models and technologies that facilitate the application of human retinal organoids to the development of novel therapeutic drugs for retinal degenerative diseases.
To support these goals, I have established fruitful partnerships with industry and academic stakeholders. I am leading a project aimed at developing innovative functional assays that will improve the application of retinal organoid disease models to the pre-clinical validation of drugs with therapeutic potential for retinal degenerative diseases. And through productive collaborations with the Crnic Institute for Down Syndrome and the University of Colorado Alzheimer's and Cognition Center (CUACC), I am advancing exciting research into the ocular manifestations of Down syndrome and Alzheimer’s disease.