Sujatha Jagannathan, PhD
Assistant Professor, Biochemistry & Molecular Genetics
Professional Titles
- Assistant Professor
Publications
- Kolakada D, Fu R, Biziaev N, Shuvalov A, Lore M, Campbell AE, Cortázar MA, Sajek MP, Hesselberth JR, Mukherjee N, Alkalaeva E, Jagannathan S. Peptidyl-tRNA hydrolysis rate influences the efficiency of nonsense-mediated mRNA decay. bioRxiv. 2024 Jan 11. PubMed PMID: 38260612
- Sherlock ME, Baquero Galvis L, Vicens Q, Kieft JS, Jagannathan S. Principles, mechanisms, and biological implications of translation termination-reinitiation. RNA. 2023 Jul;29(7):865-884. PubMed PMID: 37024263
- Muñoz O, Lore M, Jagannathan S. The long and short of EJC-independent nonsense-mediated RNA decay. Biochem Soc Trans. 2023 Jun 28;51(3):1121-1129. PubMed PMID: 37145092
- Campbell AE, Dyle MC, Albanese R, Matheny T, Sudheendran K, Cortázar MA, Forman T, Fu R, Gillen AE, Caruthers MH, Floor SN, Calviello L, Jagannathan S. Compromised nonsense-mediated RNA decay results in truncated RNA-binding protein production upon DUX4 expression. Cell Rep. 2023 Jun 27;42(6):112642. PubMed PMID: 37314931
- Hamm DC, Paatela EM, Bennett SR, Wong CJ, Campbell AE, Wladyka CL, Smith AA, Jagannathan S, Hsieh AC, Tapscott SJ. The transcription factor DUX4 orchestrates translational reprogramming by broadly suppressing translation efficiency and promoting expression of DUX4-induced mRNAs. PLoS Biol. 2023 Sep;21(9):e3002317. PubMed PMID: 37747887
- Campbell AE, Arjomand J, King OD, Tawil R, Jagannathan S. A Targeted Approach for Evaluating DUX4-Regulated Proteins as Potential Serum Biomarkers for Facioscapulohumeral Muscular Dystrophy Using Immunoassay Proteomics. J Neuromuscul Dis. 2023;10(6):1031-1040. PubMed PMID: 37899061
- Kolakada D, Campbell AE, Baquero Galvis L, Li Z, Lore M, Jagannathan S. A system of reporters for comparative investigation of EJC-independent and EJC-enhanced nonsense-mediated mRNA decay. bioRxiv. 2023 Nov 15. PubMed PMID: 38014198
- Jagannathan S. The evolution of DUX4 gene regulation and its implication for facioscapulohumeral muscular dystrophy. Biochim Biophys Acta Mol Basis Dis. 2022 May 1;1868(5):166367. PubMed PMID: 35158020
- Jagannathan S, de Greef JC, Hayward LJ, Yokomori K, Gabellini D, Mul K, Sacconi S, Arjomand J, Kinoshita J, Harper SQ. Meeting report: the 2021 FSHD International Research Congress. Skelet Muscle. 2022 Jan 17;12(1):1. PubMed PMID: 35039091
- Campbell AE, Arjomand J, King OD, Tawil R, and Jagannathan S. Targeted Identification of Serum Biomarkers for Facioscapulohumeral Muscular Dystrophy Using Immunoassay Proteomics. medRxiv. 2022 https://doi.org/10.1101/2022.07.25.22276982
- Child JR, Chen Q, Reid DW, Jagannathan S, Nicchitta CV. Recruitment of endoplasmic reticulum-targeted and cytosolic mRNAs into membrane-associated stress granules. RNA. 2021 Oct;27(10):1241-1256. PubMed PMID: 34244458
- Campbell AE, Dyle MC, Calviello L, Matheny T, Cortazar MA, Forman T, Fu R, Gillen AE, Floor SN, and Jagannathan S. The myopathic transcription factor DUX4 induces the production of truncated RNA-binding proteins in human muscle cells. Preprint. 2021; bioRxiv https://doi.org/10.1101/2021.06.28.450189
- Dyle MC, Kolakada D, Cortazar MA, Jagannathan S. How to get away with nonsense: Mechanisms and consequences of escape from nonsense-mediated RNA decay. Wiley Interdiscip Rev RNA. 2020 Jan;11(1):e1560. PubMed PMID: 31359616
- Jagannathan S, Ramachandran S, Rissland OS. Slow Down to Catch Up. Cell. 2019 Aug 8;178(4):774-776. PubMed PMID: 31398334
- Jagannathan S, Ogata Y, Gafken PR, Tapscott SJ, Bradley RK. Quantitative proteomics reveals key roles for post-transcriptional gene regulation in the molecular pathology of facioscapulohumeral muscular dystrophy. Elife. 2019 Jan 15;8. PubMed PMID: 30644821
- Campbell AE, Shadle SC, Jagannathan S, Lim JW, Resnick R, Tawil R, van der Maarel SM, Tapscott SJ. NuRD and CAF-1-mediated silencing of the D4Z4 array is modulated by DUX4-induced MBD3L proteins. Elife. 2018 Mar 13;7. PubMed PMID: 29533181
General Information
Graduate Schools:
- PhD, Duke University (2013)