Masanori Hayashi, MD
Assistant Professor, Pediatrics-Heme/Onc and Bone Marrow Transplantation

Recognition & Awards

• SARC Sarcoma Spore Career Development Award, SARC (2015)
  The SARC Sarcoma Spore Career Development Award is awarded to two sarcoma translational researchers every year, to ensure the continual renewal of high-quality scientific endeavors in sarcoma research.
• Duke Pediatrics Deborah Kredich Memorial Award for the most influential resident of the year for house staff education, Duke University Department of Pediatrics (2010)
  Selected by peers through voting, this award is awarded to the resident recognized as the most influential in resident education.

Teaching

Publications

• Weiser DA, Hayashi M, Applebaum MA. Breaking Up Isn't Hard to Do: Isolating Cell-free DNA Fragments in Osteosarcoma. Clin Cancer Res. 2023 Jun 1;29(11):2017-2019. PubMed PMID: 36976253
• Ligon JA, Hayashi M, Ciampa D, Kramer C, Guastella A, Fuchs RJ, Herati AS, Christianson MS, Chen AR. A multidisciplinary pediatric oncofertility team improves fertility preservation and counseling across 7?years. Cancer Rep (Hoboken). 2023 Feb;6(2):e1753. PubMed PMID: 36346013
• Taylor AM, Ng P, Kumar PM, Harder J, George JM, Robson P, Hayashi M, Isakoff M, Toledo S, Hoang B, Lau CC. IMMUNOSUPPRESSIVE TUMOR MICROENVIRONMENT OF OSTEOSARCOMA. Poster Presentation P329 CTOS Annual Meeting 2023
• Setty B, Mullinax J, Hayashi M, Fridley BL, Isakoff M, Wagner LM, Metts J, Trucco M, Reed D, Lee D. TGFß IMPRINTED, EX VIVO EXPANDED UNIVERSAL DONOR NATURAL KILLER CELLS WITH CHEMOTHERAPY FOR RELAPSED BONE AND SOFT TISSUE SARCOMA - NCT05634369, REPORT FROM THE NATIONAL PEDIATRIC CANCER FOUNDATION. Poster presentation P537 CTOS Annual meeting 2023
• Dhir A, Oesterheld J, Thompson P, Badgett T, Pratilas CA, Setty B, Hayashi M, Trucco M, Metts J, Reed D, Wagner LM. PHASE II TRIAL OF GEMCITABINE AND NAB-PACLITAXEL IN PATIENTS WITH RECURRENT RHABDOMYOSARCOMA: A CLINICAL TRIAL IN PROGRESS FROM THE NATIONAL PEDIATRIC CANCER FOUNDATION. Poster presentation P551. CTOS Annual meeting 2023
• Grohar PJ, Ballman KV, Heise R,Surrey L, Wedekind MF, Glod J, Mascarenhas L, Gedminas J, Dubois SG, Maki RG, Crompton BD, Hayashi M, Peer C, Figg WD, Lindenberg L, Menagonzalez E, Bagatell R, Overman L, Roberts RD, Laetsch TW, Widemann B, Kaufman R, Reinke D, Chugh R. TRABECTEDIN ADMINISTERED AS A 1-HOUR INFUSION IN COMBINATION WITH LOW DOSE IRINOTECAN IN PATIENTS WITH EWING SARCOMA: ANTI-TUMOR ACTIVITY AND REVERSAL OF THE EWS-FLI1 TRANSCRIPTOME. Oral presentation 37. CTOS Annual Meeting 2023
• Shulman DS, Whittle SB, Surdez D, Bailey KM, de Álava E, Yustein JT, Shlien A, Hayashi M, Bishop AJR, Crompton BD, DuBois SG, Shukla N, Leavey PJ, Lessnick SL, Kovar H, Delattre O, Grünewald TGP, Antonescu CR, Roberts RD, Toretsky JA, Tirode F, Gorlick R, Janeway KA, Reed D, Lawlor ER, Grohar PJ. An international working group consensus report for the prioritization of molecular biomarkers for Ewing sarcoma. NPJ Precis Oncol. 2022 Sep 17;6(1):65. PubMed PMID: 36115869
• Abstract 1681: Single cell RNA sequencing of primary Ewing sarcoma tumors and identification of circulating tumor cells in patient-matched peripheral blood samples Sarah K. Nelson-Taylor; Avery Bodlack; Andrew Goodspeed; Amy Treece; Nathan Donaldson; Carrye Cost; Tim Garrington; Brian Greffe; Sandra Luna-Fineman; Jenna Sopfe; Masanori Hayashi
• Abstract 957: Cadherin-11 contributes to the heterogenous and dynamic Wnt-ß-catenin pathway activation in Ewing sarcoma. Cancer Res 15 June 2022; 82 (12_Supplement): 957. Ryota Shirai; Tyler Biebighauser; Sarah Nelson-Taylor; Avery Bodlak; Timothy Porfilio; Deandra Walker; Naoki Oike; Masanori Hayashi
• High-Throughput Drug Screening Identifies GSK3b Inhibition as a Therapeutic Target to Enhance Allogeneic NK Cell Cytotoxicity in Ewing Sarcoma. Naoki Oike, Ryota Shirai, Taylor Gillis, Deandra Walker, Avery Bodlak, Timothy Porfilio, Michael Verneris, Masanori Hayashi
• Bodlak A, Chang K, Channel J, Treece AL, Donaldson N, Cost CR, Garrington TP, Greffe B, Luna-Fineman S, Sopfe J, Loeb DM, Hayashi M. Circulating Plasma Tumor DNA Is Superior to Plasma Tumor RNA Detection in Ewing Sarcoma Patients: ptDNA and ptRNA in Ewing Sarcoma. J Mol Diagn. 2021 Jul;23(7):872-881. PubMed PMID: 33887462
• Oike N, Kawashima H, Ogose A, Hatano H, Ariizumi T, Yamagishi T, Murayama Y, Umezu H, Imai C, Hayashi M, Endo N. Human leukocyte antigen I is significantly downregulated in patients with myxoid liposarcomas. Cancer Immunol Immunother. 2021 Apr 24. [Epub ahead of print] PubMed PMID: 33893830
• Brechbuhl HM, Vinod-Paul K, Gillen AE, Kopin EG, Gibney K, Elias AD, Hayashi M, Sartorius CA, Kabos P. Analysis of circulating breast cancer cell heterogeneity and interactions with peripheral blood mononuclear cells. Mol Carcinog. 2020 Oct;59(10):1129-1139. PubMed PMID: 32822091
• Oesterheld JE, Reed DR, Setty BA, Isakoff MS, Thompson P, Yin H, Hayashi M, Loeb DM, Smith T, Makanji R, Fridley BL, Wagner LM. Phase II trial of gemcitabine and nab-paclitaxel in patients with recurrent Ewing sarcoma: A report from the National Pediatric Cancer Foundation. Pediatr Blood Cancer. 2020 Jul;67(7):e28370. PubMed PMID: 32386107
• Nellan A, Bodlak A, Mirsky DM, Mulcahy Levy J, Garrington TP, Foreman NK, Gilani A, Hayashi M. ddPCR Analysis Reveals BRAF V600E Mutations Are Infrequent in Isolated Pituitary Langerhans Cell Histiocytosis Patients. J Neuropathol Exp Neurol. 2020 Sep 15:nlaa091. doi: 10.1093/jnen/nlaa091. Epub ahead of print. PMID: 32930721.
• Reed DR, Metts J, Pressley M, Fridley BL, Hayashi M, Isakoff MS, Loeb DM, Makanji R, Roberts RD, Trucco M, Wagner LM, Alexandrow MG, Gatenby RA, Brown JS. An evolutionary framework for treating pediatric sarcomas. Cancer. 2020 Jun 1;126(11):2577-2587. PubMed PMID: 32176331
• AACR oral presentation A CRISPR drop-out screen combined with high-throughput drug screening identifies genetic and therapeutic vulnerabilities of BCOR-CCNB3 fusion positive sarcomas. Naoki Oike, Hiroyuki Kawashima, Akira Ogose, Takashi Ariizumi, Yudai Murayama, Hajime Umezu, Molishree Joshi, Colin Sempeck, Bridget Samford, Deandra Walker, Avery Bodlak, Naoto Endo, Masanori Hayashi
• Borinstein SC, Steppan D, Hayashi M, Loeb DM, Isakoff MS, Binitie O, Brohl AS, Bridge JA, Stavas M, Shinohara ET, Meyer WH, Reed DR, Wagner LM. Consensus and controversies regarding the treatment of rhabdomyosarcoma. Pediatr Blood Cancer. 2018 Feb;65(2). PubMed PMID: 28905489
• Reed DR, Hayashi M, Wagner L, Binitie O, Steppan DA, Brohl AS, Shinohara ET, Bridge JA, Loeb DM, Borinstein SC, Isakoff MS. Treatment pathway of bone sarcoma in children, adolescents, and young adults. Cancer. 2017 Jun 15;123(12):2206-2218. PubMed PMID: 28323337
• Llosa NJ, Cooke KR, Chen AR, Gamper CJ, Klein OR, Zambidis ET, Luber B, Rosner G, Siegel N, Holuba MJ, Robey N, Hayashi M, Jones RJ, Fuchs E, Holdhoff M, Loeb DM, Symons HJ. Reduced-Intensity Haploidentical Bone Marrow Transplantation with Post-Transplant Cyclophosphamide for Solid Tumors in Pediatric and Young Adult Patients. Biol Blood Marrow Transplant. 2017 Aug 12. [Epub ahead of print] PubMed PMID: 28807769
• Borinstein SC, Steppan D, Hayashi M, Loeb DM, Isakoff MS, Binitie O, Brohl AS, Bridge JA, Stavas M, Shinohara ET, Meyer WH, Reed DR, Wagner LM. Consensus and controversies regarding the treatment of rhabdomyosarcoma. Pediatr Blood Cancer. 2017 Sep 14. [Epub ahead of print] PubMed PMID: 28905489
• Hayashi M, Zhu P, McCarty G, Meyer CF, Pratilas CA, Levin A, Morris CD, Albert CM, Jackson KW, Tang CM, Loeb DM. Size-based detection of sarcoma circulating tumor cells and cell clusters. Oncotarget. 2017 Oct 3;8(45):78965-78977. PubMed PMID: 29108279
• Hayashi M, Baker A, Goldstein SD, Albert CM, Jackson KW, McCarty G, Kahlert UD, Loeb DM. Inhibition of porcupine prolongs metastasis free survival in a mouse xenograft model of Ewing sarcoma. Oncotarget. 2017 Oct 3;8(45):78265-78276. PubMed PMID: 29108227
• Hayashi M, Zhu P, McCarty G, Meyer CF, Pratilas CA, Levin A, Morris CD, Albert CM, Jackson KW, Tang CM, Loeb DM. Size-based detection of sarcoma circulating tumor cells and cell clusters. Oncotarget. 2017 Oct 3;8(45):78965-78977. PubMed PMID: 29108279
• Hayashi M, Baker A, Goldstein SD, Albert CM, Jackson KW, McCarty G, Kahlert UD, Loeb DM. Inhibition of porcupine prolongs metastasis free survival in a mouse xenograft model of Ewing sarcoma. Oncotarget. 2017 Oct 3;8(45):78265-78276. PubMed PMID: 29108227
• Llosa NJ, Cooke KR, Chen AR, Gamper CJ, Klein OR, Zambidis ET, Luber B, Rosner G, Siegel N, Holuba MJ, Robey N, Hayashi M, Jones RJ, Fuchs E, Holdhoff M, Loeb DM, Symons HJ. Reduced-Intensity Haploidentical Bone Marrow Transplantation with Post-Transplant Cyclophosphamide for Solid Tumors in Pediatric and Young Adult Patients. Biol Blood Marrow Transplant. 2017 Dec;23(12):2127-2136. PubMed PMID: 28807769
• Reed DR, Hayashi M, Wagner L, Binitie O, Steppan DA, Brohl AS, Shinohara ET, Bridge JA, Loeb DM, Borinstein SC, Isakoff MS. Treatment pathway of bone sarcoma in children, adolescents, and young adults. Cancer. 2017 Jun 15;123(12):2206-2218. PubMed PMID: 28323337

Professional Memberships

• Children's Oncology Group, Member, Ewing Sarcoma biology committee
• Connective Tissue Oncology Society, Member
• American Association for Cancer Research, Member
• American Society of Clinical Oncology, Member