Joshua Thurman, MD
Professor, Medicine-Renal Med Diseases/Hypertension

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Medical School:
  • MD, University of Chicago Division of the Biological Sciences The Pritzker School of Medicine (1997)
Undergraduate School:
  • AB, Harvard University (MA) (1988)
Internship:
  • Beth Israel Deaconess Medical Center Program (1998)
Residency:
  • Beth Israel Deaconess Medical Center Program, Internal Medicine (2000)
Fellowships:
  • University of Colorado (University Hospital) Program, Nephrology (2002)
Languages: English
Department: Medicine-Renal Med Diseases/Hypertension

Professional Titles

  • Professor, Medicine-Renal Med Diseases/Hypertension
  • Professor of Medicine

Publications

  • Stites E, Renner B, Laskowski J, Le Quintrec M, You Z, Freed B, Cooper J, Jalal D, Thurman JM. Complement fragments are biomarkers of antibody-mediated endothelial injury. Mol Immunol. 2020 Feb;118:142-152. PubMed PMID: 31884386
  • Kulik L, Laskowski J, Renner B, Woolaver R, Zhang L, Lyubchenko T, You Z, Thurman JM, Holers VM. Targeting the Immune Complex-Bound Complement C3d Ligand as a Novel Therapy for Lupus. J Immunol. 2019 Nov 15. [Epub ahead of print] PubMed PMID: 31732528
  • Grafals M, Thurman JM. The Role of Complement in Organ Transplantation. Front Immunol. 2019;10:2380. PubMed PMID: 31636644
  • Frid MG, McKeon BA, Thurman JM, Maron BA, Li M, Zhang H, Kumar S, Sullivan T, Laskowsky J, Fini MA, Hu S, Tuder RM, Gandjeva A, Wilkins MR, Rhodes CJ, Ghataorhe P, Leopold JA, Wang RS, Holers VM, Stenmark KR. Immunoglobulin-Driven Complement Activation Regulates Pro-Inflammatory Remodeling in Pulmonary Hypertension. Am J Respir Crit Care Med. 2019 Sep 23. [Epub ahead of print] PubMed PMID: 31545648
  • Laskowski J, Philbrook HT, Parikh CR, Thurman JM. Urine complement activation fragments are increased in patients with kidney injury after cardiac surgery. Am J Physiol Renal Physiol. 2019 Sep 1;317(3):F650-F657. PubMed PMID: 31313951
  • Thurman JM, Panzer SE, Le Quintrec M. The role of complement in antibody mediated transplant rejection. Mol Immunol. 2019 Aug;112:240-246. PubMed PMID: 31195225
  • Klawitter J, Klawitter J, Pennington A, Kirkpatrick B, Roda G, Kotecha NC, Thurman JM, Christians U. Cyclophilin D knockout protects the mouse kidney against cyclosporin A-induced oxidative stress. Am J Physiol Renal Physiol. 2019 Sep 1;317(3):F683-F694. PubMed PMID: 31188033
  • Thurman JM, Yapa R. Complement Therapeutics in Autoimmune Disease. Front Immunol. 2019;10:672. PubMed PMID: 31001274
  • Antonioli AH, White J, Crawford F, Renner B, Marchbank KJ, Hannan JP, Thurman JM, Marrack P, Holers VM. Modulation of the Alternative Pathway of Complement by Murine Factor H-Related Proteins. J Immunol. 2018 Jan 1;200(1):316-326. PubMed PMID: 29187587
  • Kwak JW, Laskowski J, Li HY, McSharry MV, Sippel TR, Bullock BL, Johnson AM, Poczobutt JM, Neuwelt AJ, Malkoski SP, Weiser-Evans MC, Lambris JD, Clambey ET, Thurman JM, Nemenoff RA. Complement Activation via a C3a Receptor Pathway Alters CD4( ) T Lymphocytes and Mediates Lung Cancer Progression. Cancer Res. 2018 Jan 1;78(1):143-156. PubMed PMID: 29118090
  • Thurman JM. Complement Biomarkers of Hemolytic Uremic Syndrome-If Not One Thing, Maybe Another. Mayo Clin Proc. 2018 Oct;93(10):1337-1339. PubMed PMID: 30286826
  • Tomlinson S, Thurman JM. Tissue-targeted complement therapeutics. Mol Immunol. 2018 Oct;102:120-128. PubMed PMID: 30220307
  • Jalal D, Renner B, Laskowski J, Stites E, Cooper J, Valente K, You Z, Perrenoud L, Le Quintrec M, Muhamed I, Christians U, Klawitter J, Lindorfer MA, Taylor RP, Holers VM, Thurman JM. Endothelial Microparticles and Systemic Complement Activation in Patients With Chronic Kidney Disease. J Am Heart Assoc. 2018 Jul 13;7(14). PubMed PMID: 30006493
  • Foss CA, Kulik L, Ordonez AA, Jain SK, Michael Holers V, Thurman JM, Pomper MG. SPECT/CT Imaging of Mycobacterium tuberculosis Infection with [(125)I]anti-C3d mAb. Mol Imaging Biol. 2018 Jul 11. [Epub ahead of print] PubMed PMID: 29998399
  • Luo W, Olaru F, Miner JH, Beck LH Jr, van der Vlag J, Thurman JM, Borza DB. Alternative Pathway Is Essential for Glomerular Complement Activation and Proteinuria in a Mouse Model of Membranous Nephropathy. Front Immunol. 2018;9:1433. PubMed PMID: 29988342
  • Mihai S, Hirose M, Wang Y, Thurman JM, Holers VM, Morgan BP, Köhl J, Zillikens D, Ludwig RJ, Nimmerjahn F. Specific Inhibition of Complement Activation Significantly Ameliorates Autoimmune Blistering Disease in Mice. Front Immunol. 2018;9:535. PubMed PMID: 29616034
  • Okamoto T, Mathai SK, Hennessy CE, Hancock LA, Walts AD, Stefanski AL, Brown KK, Lynch DA, Cosgrove GP, Groshong SD, Cool CD, Schwarz MI, Banda NK, Thurman JM, Yang IV, Holers VM, Schwartz DA. The relationship between complement C3 expression and the MUC5B genotype in pulmonary fibrosis. Am J Physiol Lung Cell Mol Physiol. 2018 Jul 1;315(1):L1-L10. PubMed PMID: 29565179
  • Thurman JM. A Patient with Hemolytic Uremic Syndrome and Kidney Failure. Clin J Am Soc Nephrol. 2018 Jun 7;13(6):933-936. PubMed PMID: 29459381
  • Goetz L, Laskowski J, Renner B, Pickering MC, Kulik L, Klawitter J, Stites E, Christians U, van der Vlag J, Ravichandran K, Holers VM, Thurman JM. Complement factor H protects mice from ischemic acute kidney injury but is not critical for controlling complement activation by glomerular IgM. Eur J Immunol. 2018 May;48(5):791-802. PubMed PMID: 29389016
  • Antonioli AH, White J, Crawford F, Renner B, Marchbank KJ, Hannan JP, Thurman JM, Marrack P, Holers VM. Modulation of the Alternative Pathway of Complement by Murine Factor H-Related Proteins. J Immunol. 2018 Jan 1;200(1):316-326. PubMed PMID: 29187587
  • Kwak JW, Laskowski J, Li HY, McSharry MV, Sippel TR, Bullock BL, Johnson AM, Poczobutt JM, Neuwelt AJ, Malkoski SP, Weiser-Evans MC, Lambris JD, Clambey ET, Thurman JM, Nemenoff RA. Complement Activation via a C3a Receptor Pathway Alters CD4( ) T Lymphocytes and Mediates Lung Cancer Progression. Cancer Res. 2018 Jan 1;78(1):143-156. PubMed PMID: 29118090
  • Thurman JM, Laskowski J. Complement factor H-related proteins in IgA nephropathy-sometimes a gentle nudge does the trick. Kidney Int. 2017 Oct;92(4):790-793. PubMed PMID: 28938951
  • Klawitter J, Pennington A, Klawitter J, Thurman JM, Christians U. Mitochondrial cyclophilin D ablation is associated with the activation of Akt/p70S6K pathway in the mouse kidney. Sci Rep. 2017 Sep 5;7(1):10540. PubMed PMID: 28874678
  • Thurman JM, Frazer-Abel A, Holers VM. The Evolving Landscape for Complement Therapeutics in Rheumatic and Autoimmune Diseases. Arthritis Rheumatol. 2017 Nov;69(11):2102-2113. PubMed PMID: 28732131
  • Thurman JM. Many drugs for many targets: novel treatments for complement-mediated glomerular disease. Nephrol Dial Transplant. 2017 Jan 1;32(suppl_1):i57-i64. PubMed PMID: 28391332
  • Casiraghi F, Azzollini N, Todeschini M, Fiori S, Cavinato RA, Cassis P, Solini S, Pezzuto F, Mister M, Thurman JM, Benigni A, Remuzzi G, Noris M. Complement Alternative Pathway Deficiency in Recipients Protects Kidney Allograft From Ischemia/Reperfusion Injury and Alloreactive T Cell Response. Am J Transplant. 2017 Sep;17(9):2312-2325. PubMed PMID: 28276660
  • Rubtsova K, Rubtsov AV, Thurman JM, Mennona JM, Kappler JW, Marrack P. B cells expressing the transcription factor T-bet drive lupus-like autoimmunity. J Clin Invest. 2017 Apr 3;127(4):1392-1404. PubMed PMID: 28240602
  • Kataria A, Levine D, Wertenteil S, Vento S, Xue J, Rajendiran K, Kannan K, Thurman JM, Morrison D, Brody R, Urbina E, Attina T, Trasande L, Trachtman H. Exposure to bisphenols and phthalates and association with oxidant stress, insulin resistance, and endothelial dysfunction in children. Pediatr Res. 2017 Jun;81(6):857-864. PubMed PMID: 28099427
  • Thurman JM. Getting over our Immune-Complex - C5a receptor blockade is the answer. Cell Mol Immunol. 2017 Mar;14(3):319-320. PubMed PMID: 26144251
  • Hannan JP, Laskowski J, Thurman JM, Hageman GS, Holers VM. Mapping the Complement Factor H-Related Protein 1 (CFHR1):C3b/C3d Interactions. PLoS One. 2016 Nov 4;11(11):e0166200. PubMed PMID: 27814381
  • Thurman JM, Nemenoff RA. Never make assumptions: the complicated role of complement in urinary tract infections. Kidney Int. 2016 Sep;90(3):469-71. PubMed PMID: 27521106
  • Thurman JM, Nester CM. All Things Complement. Clin J Am Soc Nephrol. 2016 Jun 23. [Epub ahead of print] PubMed PMID: 27340286
  • Thurman JM, Le Quintrec M. Targeting the complement cascade: novel treatments coming down the pike. Kidney Int. 2016 Oct;90(4):746-52. PubMed PMID: 27325183
  • Holers VM, Tomlinson S, Kulik L, Atkinson C, Rohrer B, Banda N, Thurman JM. New therapeutic and diagnostic opportunities for injured tissue-specific targeting of complement inhibitors and imaging modalities. Semin Immunol. 2016 Jun;28(3):260-7. PubMed PMID: 27282113
  • Blatt AZ, Saggu G, Kulkarni KV, Cortes C, Thurman JM, Ricklin D, Lambris JD, Valenzuela JG, Ferreira VP. Properdin-Mediated C5a Production Enhances Stable Binding of Platelets to Granulocytes in Human Whole Blood. J Immunol. 2016 Jun 1;196(11):4671-80. PubMed PMID: 27183616
  • Laskowski J, Renner B, Le Quintrec M, Panzer S, Hannan JP, Ljubanovic D, Ruseva MM, Borza DB, Antonioli AH, Pickering MC, Holers VM, Thurman JM. Distinct roles for the complement regulators factor H and Crry in protection of the kidney from injury. Kidney Int. 2016 Jul;90(1):109-22. PubMed PMID: 27165610
  • Li D, Zou L, Feng Y, Xu G, Gong Y, Zhao G, Ouyang W, Thurman JM, Chao W. Complement Factor B Production in Renal Tubular Cells and Its Role in Sodium Transporter Expression During Polymicrobial Sepsis. Crit Care Med. 2016 May;44(5):e289-99. PubMed PMID: 26757165
  • Renner B, Tong HH, Laskowski J, Jonscher K, Goetz L, Woolaver R, Hannan J, Li YX, Hourcade D, Pickering MC, Holers VM, Thurman JM. Annexin A2 Enhances Complement Activation by Inhibiting Factor H. J Immunol. 2016 Feb 1;196(3):1355-65. PubMed PMID: 26729803
  • Wehrmann F, Lavelle JC, Collins CB, Tinega AN, Thurman JM, Burnham EL, Simonian PL. ?d T cells protect against LPS-induced lung injury. J Leukoc Biol. 2016 Feb;99(2):373-86. PubMed PMID: 26428678
  • Panzer SE, Laskowski J, Renner B, Kulik L, Ljubanovic D, Huber KM, Zhong W, Pickering MC, Holers VM, Thurman JM. IgM exacerbates glomerular disease progression in complement-induced glomerulopathy. Kidney Int. 2015 Sep;88(3):528-37. PubMed PMID: 25945405
  • Klepacki J, Klawitter J, Klawitter J, Thurman JM, Christians U. A high-performance liquid chromatography-tandem mass spectrometry-based targeted metabolomics kidney dysfunction marker panel in human urine. Clin Chim Acta. 2015 Jun 15;446:43-53. PubMed PMID: 25871999
  • Evgin L, Acuna SA, Tanese de Souza C, Marguerie M, Lemay CG, Ilkow CS, Findlay CS, Falls T, Parato KA, Hanwell D, Goldstein A, Lopez R, Lafrance S, Breitbach CJ, Kirn D, Atkins H, Auer RC, Thurman JM, Stahl GL, Lambris JD, Bell JC, McCart JA. Complement inhibition prevents oncolytic vaccinia virus neutralization in immune humans and cynomolgus macaques. Mol Ther. 2015 Jun;23(6):1066-1076. PubMed PMID: 25807289
  • Thurman JM. Complement in kidney disease: core curriculum 2015. Am J Kidney Dis. 2015 Jan;65(1):156-68. PubMed PMID: 25441433
  • Stites E, Le Quintrec M, Thurman JM. The Complement System and Antibody-Mediated Transplant Rejection. J Immunol. 2015 Dec 15;195(12):5525-31. PubMed PMID: 26637661
  • Byrne SN, Hammond KJ, Chan CY, Rogers LJ, Beaugie C, Rana S, Marsh-Wakefield F, Thurman JM, Halliday GM. The alternative complement component factor B regulates UV-induced oedema, systemic suppression of contact and delayed hypersensitivity, and mast cell infiltration into the skin. Photochem Photobiol Sci. 2015 Apr;14(4):801-6. PubMed PMID: 25645888
  • Thurman JM, Wong M, Renner B, Frazer-Abel A, Giclas PC, Joy MS, Jalal D, Radeva MK, Gassman J, Gipson DS, Kaskel F, Friedman A, Trachtman H. Complement Activation in Patients with Focal Segmental Glomerulosclerosis. PLoS One. 2015;10(9):e0136558. PubMed PMID: 26335102
  • Thurman JM, Serkova NJ. Non-invasive imaging to monitor lupus nephritis and neuropsychiatric systemic lupus erythematosus. F1000Res. 2015;4:153. PubMed PMID: 26309728
  • Klawitter J, Klawitter J, Schmitz V, Shokati T, Epshtein E, Thurman JM, Christians U. Mycophenolate mofetil enhances the negative effects of sirolimus and tacrolimus on rat kidney cell metabolism. PLoS One. 2014 Jan 3;9(1):e86202. PubMed PMID: 24497939
  • Thurman JM. New anti-complement drugs: not so far away. Blood. 2014 Mar 27;123(13):1975-6. PubMed PMID: 24677397
  • Locatelli M, Buelli S, Pezzotta A, Corna D, Perico L, Tomasoni S, Rottoli D, Rizzo P, Conti D, Thurman JM, Remuzzi G, Zoja C, Morigi M. Shiga toxin promotes podocyte injury in experimental hemolytic uremic syndrome via activation of the alternative pathway of complement. J Am Soc Nephrol. 2014 Aug;25(8):1786-98. PubMed PMID: 24578132
  • Tong HH, Lambert G, Li YX, Thurman JM, Stahl GL, Douthitt K, Clancy C, He Y, Bowman AS. Deletion of the complement C5a receptor alleviates the severity of acute pneumococcal otitis media following influenza A virus infection in mice. PLoS One. 2014;9(4):e95160. PubMed PMID: 24740152
  • Thurman JM, Serkova NJ. Nanosized contrast agents to noninvasively detect kidney inflammation by magnetic resonance imaging. Adv Chronic Kidney Dis. 2013 Nov;20(6):488-99. PubMed PMID: 24206601
  • Pickering MC, D'Agati VD, Nester CM, Smith RJ, Haas M, Appel GB, Alpers CE, Bajema IM, Bedrosian C, Braun M, Doyle M, Fakhouri F, Fervenza FC, Fogo AB, Frémeaux-Bacchi V, Gale DP, Goicoechea de Jorge E, Griffin G, Harris CL, Holers VM, Johnson S, Lavin PJ, Medjeral-Thomas N, Paul Morgan B, Nast CC, Noel LH, Peters DK, Rodríguez de Córdoba S, Servais A, Sethi S, Song WC, Tamburini P, Thurman JM, Zavros M, Cook HT. C3 glomerulopathy: consensus report. Kidney Int. 2013 Dec;84(6):1079-89. PubMed PMID: 24172683
  • McCullough JW, Renner B, Thurman JM. The role of the complement system in acute kidney injury. Semin Nephrol. 2013 Nov;33(6):543-56. PubMed PMID: 24161039
  • Zou L, Feng Y, Li Y, Zhang M, Chen C, Cai J, Gong Y, Wang L, Thurman JM, Wu X, Atkinson JP, Chao W. Complement factor B is the downstream effector of TLRs and plays an important role in a mouse model of severe sepsis. J Immunol. 2013 Dec 1;191(11):5625-35. PubMed PMID: 24154627
  • Renner B, Klawitter J, Goldberg R, McCullough JW, Ferreira VP, Cooper JE, Christians U, Thurman JM. Cyclosporine induces endothelial cell release of complement-activating microparticles. J Am Soc Nephrol. 2013 Nov;24(11):1849-62. PubMed PMID: 24092930
  • Berman N, Lectura M, Thurman JM, Reinecke J, Raff AC, Melamed ML, Quan Z, Evans T, Meyer TW, Hostetter TH. A zebrafish model for uremic toxicity: role of the complement pathway. Blood Purif. 2013;35(4):265-9. PubMed PMID: 23689420
  • Fuquay R, Renner B, Kulik L, McCullough JW, Amura C, Strassheim D, Pelanda R, Torres R, Thurman JM. Renal ischemia-reperfusion injury amplifies the humoral immune response. J Am Soc Nephrol. 2013 Jun;24(7):1063-72. PubMed PMID: 23641055
  • Thurman JM, Kulik L, Orth H, Wong M, Renner B, Sargsyan SA, Mitchell LM, Hourcade DE, Hannan JP, Kovacs JM, Coughlin B, Woodell AS, Pickering MC, Rohrer B, Holers VM. Detection of complement activation using monoclonal antibodies against C3d. J Clin Invest. 2013 May 1;123(5):2218-30. PubMed PMID: 23619360
  • Thurman JM, Rohrer B. Noninvasive detection of complement activation through radiologic imaging. Adv Exp Med Biol. 2013;735:271-82. PubMed PMID: 23402034
  • Strassheim D, Renner B, Panzer S, Fuquay R, Kulik L, Ljubanovic D, Holers VM, Thurman JM. IgM contributes to glomerular injury in FSGS. J Am Soc Nephrol. 2013 Feb;24(3):393-406. PubMed PMID: 23393315
  • Bohra R, Klepacki J, Klawitter J, Klawitter J, Thurman JM, Christians U. Proteomics and metabolomics in renal transplantation-quo vadis?. Transpl Int. 2013 Mar;26(3):225-41. PubMed PMID: 23350848
  • Hu X, Holers VM, Thurman JM, Schoeb TR, Ramos TN, Barnum SR. Therapeutic inhibition of the alternative complement pathway attenuates chronic EAE. Mol Immunol. 2013 Jul;54(3-4):302-8. PubMed PMID: 23337717
  • Amura CR, Renner B, Lyubchenko T, Faubel S, Simonian PL, Thurman JM. Complement activation and toll-like receptor-2 signaling contribute to cytokine production after renal ischemia/reperfusion. Mol Immunol. 2012 Oct;52(3-4):249-57. PubMed PMID: 22750071
  • Klawitter J, Klawitter J, Schmitz V, Brunner N, Crunk A, Corby K, Bendrick-Peart J, Leibfritz D, Edelstein CL, Thurman JM, Christians U. Low-salt diet and cyclosporine nephrotoxicity: changes in kidney cell metabolism. J Proteome Res. 2012 Nov 2;11(11):5135-44. PubMed PMID: 23057591
  • Thurman JM. Factor friction: protective and pathogenic roles for complement factors in immune complex glomerulonephritis. Kidney Int. 2012 Nov;82(9):945-7. PubMed PMID: 23064186
  • Li Q, Li YX, Douthitt K, Stahl GL, Thurman JM, Tong HH. Role of the alternative and classical complement activation pathway in complement mediated killing against Streptococcus pneumoniae colony opacity variants during acute pneumococcal otitis media in mice. Microbes Infect. 2012 Nov;14(14):1308-18. PubMed PMID: 22975410
  • Larson JD, Thurman JM, Rubtsov AV, Claypool D, Marrack P, van Dyk LF, Torres RM, Pelanda R. Murine gammaherpesvirus 68 infection protects lupus-prone mice from the development of autoimmunity. Proc Natl Acad Sci U S A. 2012 May 1;109(18):E1092-100. PubMed PMID: 22474381
  • Thurman JM. Therapeutic regulation of complement in patients with renal disease - where is the promise?. Clin Nephrol. 2012 May;77(5):413-23. PubMed PMID: 22551888
  • Thurman JM, Tchepeleva SN, Haas M, Panzer S, Boackle SA, Glogowska MJ, Quigg RJ, Holers VM. Complement alternative pathway activation in the autologous phase of nephrotoxic serum nephritis. Am J Physiol Renal Physiol. 2012 Jun 15;302(12):F1529-36. PubMed PMID: 22492944
  • Sargsyan SA, Thurman JM. Molecular imaging of autoimmune diseases and inflammation. Mol Imaging. 2012 Jun;11(3):251-64. PubMed PMID: 22554489
  • Takeda K, Thurman JM, Tomlinson S, Okamoto M, Shiraishi Y, Ferreira VP, Cortes C, Pangburn MK, Holers VM, Gelfand EW. The critical role of complement alternative pathway regulator factor H in allergen-induced airway hyperresponsiveness and inflammation. J Immunol. 2012 Jan 15;188(2):661-7. PubMed PMID: 22174452
  • Sargsyan SA, Serkova NJ, Renner B, Hasebroock KM, Larsen B, Stoldt C, McFann K, Pickering MC, Thurman JM. Detection of glomerular complement C3 fragments by magnetic resonance imaging in murine lupus nephritis. Kidney Int. 2012 Jan;81(2):152-9. PubMed PMID: 21956190
  • Kunchithapautham K, Bandyopadhyay M, Dahrouj M, Thurman JM, Rohrer B. Sublytic membrane-attack-complex activation and VEGF secretion in retinal pigment epithelial cells. Adv Exp Med Biol. 2012;723:23-30. PubMed PMID: 22183311
  • Kenyon KD, Cole C, Crawford F, Kappler JW, Thurman JM, Bratton DL, Boackle SA, Henson PM. IgG autoantibodies against deposited C3 inhibit macrophage-mediated apoptotic cell engulfment in systemic autoimmunity. J Immunol. 2011 Sep 1;187(5):2101-11. PubMed PMID: 21813769
  • Renner B, Ferreira VP, Cortes C, Goldberg R, Ljubanovic D, Pangburn MK, Pickering MC, Tomlinson S, Holland-Neidermyer A, Strassheim D, Holers VM, Thurman JM. Binding of factor H to tubular epithelial cells limits interstitial complement activation in ischemic injury. Kidney Int. 2011 Jul;80(2):165-73. PubMed PMID: 21544060
  • Li Q, Li YX, Stahl GL, Thurman JM, He Y, Tong HH. Essential role of factor B of the alternative complement pathway in complement activation and opsonophagocytosis during acute pneumococcal otitis media in mice. Infect Immun. 2011 Jul;79(7):2578-85. PubMed PMID: 21502587
  • Thurman JM, Renner B. Dynamic control of the complement system by modulated expression of regulatory proteins. Lab Invest. 2011 Jan;91(1):4-11. PubMed PMID: 20921948
  • Renner B, Coleman K, Goldberg R, Amura C, Holland-Neidermyer A, Pierce K, Orth HN, Molina H, Ferreira VP, Cortes C, Pangburn MK, Holers VM, Thurman JM. The complement inhibitors Crry and factor H are critical for preventing autologous complement activation on renal tubular epithelial cells. J Immunol. 2010 Sep 1;185(5):3086-94. PubMed PMID: 20675597
  • Renner B, Strassheim D, Amura CR, Kulik L, Ljubanovic D, Glogowska MJ, Takahashi K, Carroll MC, Holers VM, Thurman JM. B cell subsets contribute to renal injury and renal protection after ischemia/reperfusion. J Immunol. 2010 Oct 1;185(7):4393-400. PubMed PMID: 20810984
  • Serkova NJ, Renner B, Larsen BA, Stoldt CR, Hasebroock KM, Bradshaw-Pierce EL, Holers VM, Thurman JM. Renal inflammation: targeted iron oxide nanoparticles for molecular MR imaging in mice. Radiology. 2010 May;255(2):517-26. PubMed PMID: 20332377
  • Tong HH, Li YX, Stahl GL, Thurman JM. Enhanced susceptibility to acute pneumococcal otitis media in mice deficient in complement C1qa, factor B, and factor B/C2. Infect Immun. 2010 Mar;78(3):976-83. PubMed PMID: 20065024
  • Shaw CD, Storek MJ, Young KA, Kovacs JM, Thurman JM, Holers VM, Hannan JP. Delineation of the complement receptor type 2-C3d complex by site-directed mutagenesis and molecular docking. J Mol Biol. 2010 Dec 10;404(4):697-710. PubMed PMID: 20951140
  • Goldberg RJ, Nakagawa T, Johnson RJ, Thurman JM. The role of endothelial cell injury in thrombotic microangiopathy. Am J Kidney Dis. 2010 Dec;56(6):1168-74. PubMed PMID: 20843591
  • Tchepeleva SN, Thurman JM, Ruff K, Perkins SJ, Morel L, Boackle SA. An allelic variant of Crry in the murine Sle1c lupus susceptibility interval is not impaired in its ability to regulate complement activation. J Immunol. 2010 Aug 15;185(4):2331-9. PubMed PMID: 20660348
  • Dalton K, Smith M, Thurman JM. The development of membranous lupus nephritis during treatment with mycophenolate mofetil for proliferative renal disease. NDT Plus. 2010 Aug;3(4):346-8. PubMed PMID: 25949427
  • Rohrer B, Long Q, Coughlin B, Renner B, Huang Y, Kunchithapautham K, Ferreira VP, Pangburn MK, Gilkeson GS, Thurman JM, Tomlinson S, Holers VM. A targeted inhibitor of the complement alternative pathway reduces RPE injury and angiogenesis in models of age-related macular degeneration. Adv Exp Med Biol. 2010;703:137-49. PubMed PMID: 20711712
  • Thurman JM, Renner B, Kunchithapautham K, Holers VM, Rohrer B. Aseptic injury to epithelial cells alters cell surface complement regulation in a tissue specific fashion. Adv Exp Med Biol. 2010;664:151-8. PubMed PMID: 20238013
  • Banda NK, Levitt B, Glogowska MJ, Thurman JM, Takahashi K, Stahl GL, Tomlinson S, Arend WP, Holers VM. Targeted inhibition of the complement alternative pathway with complement receptor 2 and factor H attenuates collagen antibody-induced arthritis in mice. J Immunol. 2009 Nov 1;183(9):5928-37. PubMed PMID: 19828624
  • Thurman JM, Renner B, Kunchithapautham K, Ferreira VP, Pangburn MK, Ablonczy Z, Tomlinson S, Holers VM, Rohrer B. Oxidative stress renders retinal pigment epithelial cells susceptible to complement-mediated injury. J Biol Chem. 2009 Jun 19;284(25):16939-47. PubMed PMID: 19386604
  • Thurman JM, Marians R, Emlen W, Wood S, Smith C, Akana H, Holers VM, Lesser M, Kline M, Hoffman C, Christen E, Trachtman H. Alternative pathway of complement in children with diarrhea-associated hemolytic uremic syndrome. Clin J Am Soc Nephrol. 2009 Dec;4(12):1920-4. PubMed PMID: 19820137
  • Singh MV, Kapoun A, Higgins L, Kutschke W, Thurman JM, Zhang R, Singh M, Yang J, Guan X, Lowe JS, Weiss RM, Zimmermann K, Yull FE, Blackwell TS, Mohler PJ, Anderson ME. Ca2+/calmodulin-dependent kinase II triggers cell membrane injury by inducing complement factor B gene expression in the mouse heart. J Clin Invest. 2009 Apr;119(4):986-96. PubMed PMID: 19273909
  • Sesarman A, Mihai S, Chiriac MT, Olaru F, Sitaru AG, Thurman JM, Zillikens D, Sitaru C. Binding of avian IgY to type VII collagen does not activate complement and leucocytes and fails to induce subepidermal blistering in mice. Br J Dermatol. 2008 Mar;158(3):463-71. PubMed PMID: 18205879
  • Clark A, Weymann A, Hartman E, Turmelle Y, Carroll M, Thurman JM, Holers VM, Hourcade DE, Rudnick DA. Evidence for non-traditional activation of complement factor C3 during murine liver regeneration. Mol Immunol. 2008 Jun;45(11):3125-32. PubMed PMID: 18452991
  • Thurman JM, Parikh CR. Peeking into the black box: new biomarkers for acute kidney injury. Kidney Int. 2008 Feb;73(4):379-81. PubMed PMID: 18235520
  • Smith RJ, Alexander J, Barlow PN, Botto M, Cassavant TL, Cook HT, de Córdoba SR, Hageman GS, Jokiranta TS, Kimberling WJ, Lambris JD, Lanning LD, Levidiotis V, Licht C, Lutz HU, Meri S, Pickering MC, Quigg RJ, Rops AL, Salant DJ, Sethi S, Thurman JM, Tully HF, Tully SP, van der Vlag J, Walker PD, Würzner R, Zipfel PF. New approaches to the treatment of dense deposit disease. J Am Soc Nephrol. 2007 Sep;18(9):2447-56. PubMed PMID: 17675665
  • Mihai S, Chiriac MT, Takahashi K, Thurman JM, Holers VM, Zillikens D, Botto M, Sitaru C. The alternative pathway of complement activation is critical for blister induction in experimental epidermolysis bullosa acquisita. J Immunol. 2007 May 15;178(10):6514-21. PubMed PMID: 17475881
  • Thorgersen EB, Ghebremariam YT, Thurman JM, Fung M, Nielsen EW, Holers VM, Kotwal GJ, Mollnes TE. Candidate inhibitors of porcine complement. Mol Immunol. 2007 Mar;44(8):1827-34. PubMed PMID: 17109963
  • Hoke TS, Douglas IS, Klein CL, He Z, Fang W, Thurman JM, Tao Y, Dursun B, Voelkel NF, Edelstein CL, Faubel S. Acute renal failure after bilateral nephrectomy is associated with cytokine-mediated pulmonary injury. J Am Soc Nephrol. 2007 Jan;18(1):155-64. PubMed PMID: 17167117
  • Thurman JM, Lenderink AM, Royer PA, Coleman KE, Zhou J, Lambris JD, Nemenoff RA, Quigg RJ, Holers VM. C3a is required for the production of CXC chemokines by tubular epithelial cells after renal ishemia/reperfusion. J Immunol. 2007 Feb 1;178(3):1819-28. PubMed PMID: 17237432
  • Babu AN, Murakawa T, Thurman JM, Miller EJ, Henson PM, Zamora MR, Voelkel NF, Nicolls MR. Microvascular destruction identifies murine allografts that cannot be rescued from airway fibrosis. J Clin Invest. 2007 Dec;117(12):3774-85. PubMed PMID: 18060031
  • Jørgensen TN, Roper E, Thurman JM, Marrack P, Kotzin BL. Type I interferon signaling is involved in the spontaneous development of lupus-like disease in B6.Nba2 and (B6.Nba2 x NZW)F(1) mice. Genes Immun. 2007 Dec;8(8):653-62. PubMed PMID: 17882225
  • Lenderink AM, Liegel K, Ljubanovic D, Coleman KE, Gilkeson GS, Holers VM, Thurman JM. The alternative pathway of complement is activated in the glomeruli and tubulointerstitium of mice with adriamycin nephropathy. Am J Physiol Renal Physiol. 2007 Aug;293(2):F555-64. PubMed PMID: 17522263
  • Thurman JM. Triggers of inflammation after renal ischemia/reperfusion. Clin Immunol. 2007 Apr;123(1):7-13. PubMed PMID: 17064966
  • Girardi G, Yarilin D, Thurman JM, Holers VM, Salmon JE. Complement activation induces dysregulation of angiogenic factors and causes fetal rejection and growth restriction. J Exp Med. 2006 Sep 4;203(9):2165-75. PubMed PMID: 16923853
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Professional Memberships

  • American Society of Nephrology, Member
  • American Association of Immunologists, Member

Practice Locations

UCH - Renal Clinic/Nephrology
1635 Aurora Ct
7th Floor
Aurora, CO 80045
720-848-0749

UCH - Anschutz Inpatient Pavilion
12605 E. 16th Ave
Aurora, CO 80045
720-848-0000

UCH - Anschutz Outpatient Pavilion
1635 Aurora Ct
Aurora, CO 80045
720-848-0000

Hospital Affiliation
  • University of Colorado Hospital

Specialty Information

Specialties
  • Internal Medicine, Board Certification (2000)
  • Nephrology, Board Certification (2002, 2012)
Conditions & Treatments
  • Kidneys and Urinary System - Kidney Disease
  • Kidneys and Urinary System
  • Kidneys and Urinary System - Kidney Failure
  • Kidneys and Urinary System - Nephrotic Syndrome
  • Kidneys and Urinary System - Proteinuria
  • Kidneys and Urinary System - Nephropathy (Nephrosis)
Care Philosophy
Since glomerulonephritis affects patients of all ages, the treatment plan should be tailored to match each patient's individual needs.

General Information

Medical Schools:
  • MD, University of Chicago Division of the Biological Sciences The Pritzker School of Medicine (1997)
Undergraduate Schools:
  • AB, Harvard University (MA) (1988)
Internships:
  • Beth Israel Deaconess Medical Center Program (1998)
Residency Programs:
  • Beth Israel Deaconess Medical Center Program, Internal Medicine (2000)
Fellowships:
  • University of Colorado (University Hospital) Program, Nephrology (2002)
Languages: English
Department: Medicine-Renal Med Diseases/Hypertension
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