KC Woulfe, PhD
Assistant Professor, Medicine-Cardiology

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Graduate School :
  • PhD, Thomas Jefferson University (2010)
Undergraduate School:
  • BS, Washington & Lee University (VA) (2004)
Department: Medicine-Cardiology

Professional Titles

  • Assistant Professor

Publications

  • Guo W, Zhu C, Yin Z, Zhang Y, Wang C, Walk AS, Lin YH, McKinsey TA, Woulfe KC, Ren J, Chew HG Jr. The ryanodine receptor stabilizer S107 ameliorates contractility of adult Rbm20 knockout rat cardiomyocytes. Physiol Rep. 2021 Sep;9(17):e15011. PubMed PMID: 34523260
  • Yusifov A, Chhatre VE, Koplin EK, Wilson CE, Schmitt EE, Woulfe KC, Bruns DR. Transcriptomic analysis of cardiac gene expression across the life course in male and female mice. Physiol Rep. 2021 Jul;9(13):e14940. PubMed PMID: 34245129
  • Woulfe KC, Jeffrey DA, Pires Da Silva J, Wilson CE, Mahaffey JH, Lau E, Slavov D, Hailu F, Karimpour-Fard A, Dockstader K, Bristow MR, Stauffer BL, Miyamoto SD, Sucharov CC. Serum response factor deletion 5 regulates phospholamban phosphorylation and calcium uptake. J Mol Cell Cardiol. 2021 Oct;159:28-37. PubMed PMID: 34139234
  • Woulfe KC, Walker LA. Physiology of the Right Ventricle Across the Lifespan. Front Physiol. 2021;12:642284. PubMed PMID: 33737888
  • Travers JG, Wennersten SA, Peña B, Bagchi RA, Smith HE, Hirsch RA, Vanderlinden LA, Lin YH, Dobrinskikh E, Demos-Davies KM, Cavasin MA, Mestroni L, Steinkühler C, Lin CY, Houser SR, Woulfe KC, Lam MPY, McKinsey TA. HDAC Inhibition Reverses Preexisting Diastolic Dysfunction and Blocks Covert Extracellular Matrix Remodeling. Circulation. 2021 May 11;143(19):1874-1890. PubMed PMID: 33682427
  • Yusifov A, Chhatre VE, Zumo JM, Cook RF, McNair BD, Schmitt EE, Woulfe KC, Bruns DR. Cardiac response to adrenergic stress differs by sex and across the lifespan. Geroscience. 2021 Aug;43(4):1799-1813. PubMed PMID: 33651247
  • Knight WE, Cao Y, Lin YH, Chi C, Bai B, Sparagna GC, Zhao Y, Du Y, Londono P, Reisz JA, Brown BC, Taylor MRG, Ambardekar AV, Cleveland JC Jr, McKinsey TA, Jeong MY, Walker LA, Woulfe KC, D'Alessandro A, Chatfield KC, Xu H, Bristow MR, Buttrick PM, Song K. Maturation of Pluripotent Stem Cell-Derived Cardiomyocytes Enables Modeling of Human Hypertrophic Cardiomyopathy. Stem Cell Reports. 2021 Mar 9;16(3):519-533. PubMed PMID: 33636116
  • Woulfe KC, Travers JG, McKinsey TA. A Phosphatase Anchor Weighs on the Heart. Circulation. 2020 Sep 8;142(10):963-966. PubMed PMID: 32897751
  • Lin YH, Schmidt W, Fritz KS, Jeong MY, Cammarato A, Foster DB, Biesiadecki BJ, McKinsey TA, Woulfe KC. Site-specific acetyl-mimetic modification of cardiac troponin I modulates myofilament relaxation and calcium sensitivity. J Mol Cell Cardiol. 2020 Feb;139:135-147. PubMed PMID: 31981571
  • Madan A, Viswanathan MC, Woulfe KC, Schmidt W, Sidor A, Liu T, Nguyen TH, Trinh B, Wilson C, Madathil S, Vogler G, O'Rourke B, Biesiadecki BJ, Tobacman LS, Cammarato A. TNNT2 mutations in the tropomyosin binding region of TNT1 disrupt its role in contractile inhibition and stimulate cardiac dysfunction. Proc Natl Acad Sci U S A. 2020 Aug 4;117(31):18822-18831. PubMed PMID: 32690703
  • Knight WE, Ali HR, Nakano SJ, Wilson CE, Walker LA, Woulfe KC. Ex vivo Methods for Measuring Cardiac Muscle Mechanical Properties. Front Physiol. 2020;11:616996. PubMed PMID: 33488406
  • Knight WE, Ali HR, Nakano SJ, Wilson CE, Walker LA, Woulfe KC. Ex vivo Methods for Measuring Cardiac Muscle Mechanical Properties. Front Physiol. 2020;11:616996. PubMed PMID: 33488406
  • Woulfe KC, Travers JG, McKinsey TA. A Phosphatase Anchor Weighs on the Heart. Circulation. 2020 Sep 8;142(10):963-966. PubMed PMID: 32897751
  • Madan A, Viswanathan MC, Woulfe KC, Schmidt W, Sidor A, Liu T, Nguyen TH, Trinh B, Wilson C, Madathil S, Vogler G, O'Rourke B, Biesiadecki BJ, Tobacman LS, Cammarato A. TNNT2 mutations in the tropomyosin binding region of TNT1 disrupt its role in contractile inhibition and stimulate cardiac dysfunction. Proc Natl Acad Sci U S A. 2020 Aug 4;117(31):18822-18831. PubMed PMID: 32690703
  • Lin YH, Schmidt W, Fritz KS, Jeong MY, Cammarato A, Foster DB, Biesiadecki BJ, McKinsey TA, Woulfe KC. Site-specific acetyl-mimetic modification of cardiac troponin I modulates myofilament relaxation and calcium sensitivity. J Mol Cell Cardiol. 2020 Feb;139:135-147. PubMed PMID: 31981571
  • Ali HR, Michel CR, Lin YH, McKinsey TA, Jeong MY, Ambardekar AV, Cleveland JC, Reisdorph R, Reisdorph N, Woulfe KC, Fritz KS. Defining decreased protein succinylation of failing human cardiac myofibrils in ischemic cardiomyopathy. J Mol Cell Cardiol. 2020 Jan;138:304-317. PubMed PMID: 31836543
  • Woulfe KC, Bruns DR. From pediatrics to geriatrics: Mechanisms of heart failure across the life-course. J Mol Cell Cardiol. 2019 Jan;126:70-76. PubMed PMID: 30458169
  • Ali HR, Michel CR, Lin YH, McKinsey TA, Jeong MY, Ambardekar AV, Cleveland JC, Reisdorph R, Reisdorph N, Woulfe KC, Fritz KS. Defining decreased protein succinylation of failing human cardiac myofibrils in ischemic cardiomyopathy. J Mol Cell Cardiol. 2019 Dec 10;138:304-317. [Epub ahead of print] PubMed PMID: 31836543
  • Woulfe KC, Ferrara C, Pioner JM, Mahaffey JH, Coppini R, Scellini B, Ferrantini C, Piroddi N, Tesi C, Poggesi C, Jeong M. A Novel Method of Isolating Myofibrils From Primary Cardiomyocyte Culture Suitable for Myofibril Mechanical Study. Front Cardiovasc Med. 2019;6:12. PubMed PMID: 30838216
  • Woulfe KC, Wilson CE, Nau S, Chau S, Phillips EK, Zang S, Tompkins C, Sucharov CC, Miyamoto SD, Stauffer BL. Acute isoproterenol leads to age-dependent arrhythmogenesis in guinea pigs. Am J Physiol Heart Circ Physiol. 2018 Oct 1;315(4):H1051-H1062. PubMed PMID: 30028197
  • Miyamoto SD, Sucharov CC, Woulfe KC. Differential Response to Heart Failure Medications in Children. Prog Pediatr Cardiol. 2018 Jun;49:27-30. PubMed PMID: 29962825
View All (21 Total) View Less

Professional Memberships

  • American Heart Association, Member
  • Biophysical Society, Member
  • International Heart Research Society, Early Career Investigator Communications Committee

Practice Locations

UCHealth University of Colorado Hospital (UCH)
12605 E. 16th Ave
Aurora, CO 80045
720-848-0000

General Information

Graduate Schools:
  • PhD, Thomas Jefferson University (2010)
Undergraduate Schools:
  • BS, Washington & Lee University (VA) (2004)
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Department: Medicine-Cardiology
Contact Us
CU Anschutz
Fitzsimons Building

13001 East 17th Place
Campus Box C290
Aurora, CO 80045

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