Carlos Zgheib, PhD
Assistant Professor, Surgery-Peds Surgery

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Graduate Schools :
  • MS, University of Mississippi Medical Center (2010)
  • PhD, University of Mississippi Medical Center (2012)
Languages: English, French, Arabic
Department: Surgery-Peds Surgery

Professional Titles

  • Assistant Professor, Surgery-Peds Surgery
  • Assistant Professor of Surgery

Recognition & Awards

  • The Owen H. Wangensteen Excellence in Research Award (Diabetic wound healing), The American College of Surgeons (2018)
  • The Wound Healing Society Junior Faculty Travel Award, The Wound Healing Society (2016)
  • Academic Excellence and Superior Scholarship Award, Honor Society of Phi Kappa Phi Award for Academic Excellence (2011)

Teaching

  • Assistant Professor of Surgery (2014)
    School of Medicine, Surgery
    Regenerative medicine, Biomaterials and Nanotechnology, Pharmacology and Pharmacotherapy, Stem Cell and Gene therapies

Publications

  • Hodges MM, Zgheib C, Xu J, Hu J, Dewberry LC, Hilton SA, Allukian MW, Gorman JH 3rd, Gorman RC, Liechty KW. Differential expression of TGFß1 is associated with fetal regeneration after myocardial infarction. Ann Thorac Surg. 2019 Jan 25. [Epub ahead of print] PubMed PMID: 30690019
  • Zgheib C, Hilton SA, Dewberry LC, Hodges MM, Ghatak S, Xu J, Singh S, Roy S, Sen CK, Seal S, Liechty KW. Use of Cerium Oxide Nanoparticles Conjugated with MicroRNA-146a to Correct the Diabetic Wound Healing Impairment. J Am Coll Surg. 2019 Jan;228(1):107-115. PubMed PMID: 30359833
  • Kurdi M, Zgheib C, Booz GW. Recent Developments on the Crosstalk Between STAT3 and Inflammation in Heart Function and Disease. Front Immunol. 2018;9:3029. PubMed PMID: 30619368
  • Xu J, Zgheib C, Hodges MM, Caskey RC, Hu J, Liechty KW. Mesenchymal stem cells correct impaired diabetic wound healing by decreasing ECM proteolysis. Physiol Genomics. 2017 Oct 1;49(10):541-548. PubMed PMID: 28842435
  • Zgheib C, Hodges MM, Allukian MW, Xu J, Spiller KL, Gorman JH 3rd, Gorman RC, Liechty KW. Cardiac Progenitor Cell Recruitment Drives Fetal Cardiac Regeneration by Enhanced Angiogenesis. Ann Thorac Surg. 2017 Dec;104(6):1968-1975. PubMed PMID: 28821329
  • Zgheib C, Hodges MM, Hu J, Liechty KW, Xu J. Long non-coding RNA Lethe regulates hyperglycemia-induced reactive oxygen species production in macrophages. PLoS One. 2017;12(5):e0177453. PubMed PMID: 28494015
  • Zgheib C, Liechty KW. Shedding light on miR-26a: Another key regulator of angiogenesis in diabetic wound healing. J Mol Cell Cardiol. 2016 Mar;92:203-5. PubMed PMID: 26906635
  • Zgheib C, Hodges M, Hu J, Beason DP, Soslowsky LJ, Liechty KW, Xu J. Mechanisms of mesenchymal stem cell correction of the impaired biomechanical properties of diabetic skin: the role of miR-29a. Wound Repair Regen. 2016 Jan 25. [Epub ahead of print] PubMed PMID: 26808714
  • Zgheib C, Xu J, Mallette AC, Caskey RC, Zhang L, Hu J, Liechty KW. SCF increases in utero-labeled stem cells migration and improves wound healing. Wound Repair Regen. 2015 Jul-Aug;23(4):583-90. PubMed PMID: 26032674
  • Gergi R, Osta N, Bourbouze G, Zgheib C, Arbab-Chirani R, Naaman A. Effects of three nickel titanium instrument systems on root canal geometry assessed by micro-computed tomography. Int Endod J. 2015 Feb;48(2):162-70. PubMed PMID: 24717063
  • Xu J, Zgheib C, Hu J, Wu W, Zhang L, Liechty KW. The role of microRNA-15b in the impaired angiogenesis in diabetic wounds. Wound Repair Regen. 2014 Sep-Oct;22(5):671-7. PubMed PMID: 25059098
  • Caskey RC, Zgheib C, Morris M, Allukian M, Dorsett-Martin W, Xu J, Wu W, Liechty KW. Dysregulation of collagen production in diabetes following recurrent skin injury: contribution to the development of a chronic wound. Wound Repair Regen. 2014 Jul-Aug;22(4):515-20. PubMed PMID: 24898050
  • Morris MW Jr, Allukian M 3rd, Herdrich BJ, Caskey RC, Zgheib C, Xu J, Dorsett-Martin W, Mitchell ME, Liechty KW. Modulation of the inflammatory response by increasing fetal wound size or interleukin-10 overexpression determines wound phenotype and scar formation. Wound Repair Regen. 2014 May-Jun;22(3):406-14. PubMed PMID: 24844340
  • Zgheib C, Allukian MW, Xu J, Morris MW Jr, Caskey RC, Herdrich BJ, Hu J, Gorman JH 3rd, Gorman RC, Liechty KW. Mammalian fetal cardiac regeneration after myocardial infarction is associated with differential gene expression compared with the adult. Ann Thorac Surg. 2014 May;97(5):1643-50. PubMed PMID: 24792251
  • Zgheib C, Xu J, Liechty KW. Targeting Inflammatory Cytokines and Extracellular Matrix Composition to Promote Wound Regeneration. Adv Wound Care (New Rochelle). 2014 Apr 1;3(4):344-355. PubMed PMID: 24757589
  • Werner T, Dombrowski SM, Zgheib C, Zouein FA, Keen HL, Kurdi M, Booz GW. Elucidating functional context within microarray data by integrated transcription factor-focused gene-interaction and regulatory network analysis. Eur Cytokine Netw. 2013 Jun;24(2):75-90. PubMed PMID: 23822978
  • Zouein FA, Zgheib C, Hamza S, Fuseler JW, Hall JE, Soljancic A, Lopez-Ruiz A, Kurdi M, Booz GW. Role of STAT3 in angiotensin II-induced hypertension and cardiac remodeling revealed by mice lacking STAT3 serine 727 phosphorylation. Hypertens Res. 2013 Jun;36(6):496-503. PubMed PMID: 23364341
  • Zgheib C, Zouein FA, Kurdi M, Booz GW. Chronic treatment of mice with leukemia inhibitory factor does not cause adverse cardiac remodeling but improves heart function. Eur Cytokine Netw. 2012 Oct-Dec;23(4):191-7. PubMed PMID: 23291613
  • Zgheib C, Kurdi M, Zouein FA, Gunter BW, Stanley BA, Zgheib J, Romero DG, King SB, Paolocci N, Booz GW. Acyloxy nitroso compounds inhibit LIF signaling in endothelial cells and cardiac myocytes: evidence that STAT3 signaling is redox-sensitive. PLoS One. 2012;7(8):e43313. PubMed PMID: 22905257
  • Zouein FA, Zgheib C, Liechty KW, Booz GW. Post-infarct biomaterials, left ventricular remodeling, and heart failure: is good good enough?. Congest Heart Fail. 2012 Sep-Oct;18(5):284-90. PubMed PMID: 22612796
  • Zgheib C, Zouein FA, Kurdi M, Booz GW. Differential STAT3 signaling in the heart: Impact of concurrent signals and oxidative stress. JAKSTAT. 2012 Apr 1;1(2):101-10. PubMed PMID: 23904970
  • Alturkmani HJ, Zgheib C, Zouein FA, Alshaaer NE, Kurdi M, Booz GW. Selenate enhances STAT3 transcriptional activity in endothelial cells: differential actions of selenate and selenite on LIF cytokine signaling and cell viability. J Inorg Biochem. 2012 Apr;109:9-15. PubMed PMID: 22366233
  • Zgheib C, Zouein FA, Chidiac R, Kurdi M, Booz GW. Calyculin A reveals serine/threonine phosphatase protein phosphatase 1 as a regulatory nodal point in canonical signal transducer and activator of transcription 3 signaling of human microvascular endothelial cells. J Interferon Cytokine Res. 2012 Feb;32(2):87-94. PubMed PMID: 22142222
  • Kurdi M, Chidiac R, Hoemann C, Zouein F, Zgheib C, Booz GW. Hydrogels as a platform for stem cell delivery to the heart. Congest Heart Fail. 2010 May-Jun;16(3):132-5. PubMed PMID: 20557335
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Professional Memberships

  • The Wound Healing Society, Member
  • The American Heart Association, Member
  • The International Society for Heart Research, Member
  • The Science Advisory Board, Member
  • The American Association for the Advancement of Science, Member
  • The Council of High Blood Pressure (AHA), Member
Care Philosophy
Dr. Zgheib is an innovative and highly driven clinical/scientific expert with a diverse scientific background that has: advanced knowledge of Pharmacology and Toxicology, years of experience in developing and maintaining professional relationships with key opinion leaders and healthcare professionals, effective managerial skills in both direct and matrix environments, and excellent verbal and written communication skills. Dr. Zgheib has experience in the following therapeutic areas: Pharmacology and Pharmacotherapy - Regenerative Medicine - Biomaterials and Nanotechnology - Non-healing Wounds (DFUs) - Inflammation and Inflammatory Diseases - Diabetes - Myocardial Infarction and Heart Failure - Acute Lung Injury - Tendon Injury - Fibrosis. Dr. Zgheib graduated with his BS degree in Biochemistry and a MS degree in Pharmacology and Cosmetology from the Holy Spirit University of Kaslik, Lebanon. He then obtained a MS degree in Biomedical Sciences and a PhD degree in Pharmacology and Toxicology from the University of Mississippi Medical Center. Dr. Zgheib completed his postdoctoral training at Nemours Children’s Hospital in Orlando, Florida. Currently Dr. Zgheib is an assistant professor in the Department of Surgery at the University of Colorado Denver - Anschutz Medical Campus. His research focuses on the discovery of novel therapies to promote tissue repair and regeneration. Dr. Zgheib is also knowledgeable about the FDA regulations and policies and possesses the following core competencies: Disease state education - Effective oral and written communication skills - Insight generation and gathering - Strong analytical and problem-solving skills - Outstanding interpersonal Skills - Project management - Strategic planning - Team building, mentoring, and coaching - Decision-making skills.

Volunteer Activities
President of the Sanford-Burnham Science Network Executive Committee (Sanford Burnham Prebys Medical Discovery Institute, 2013-2014) ; Member of the Center for Excellence in Cardiovascular and Renal Research (University of Mississippi Medical Center, 2009 - 2012)

Public Speaking
Yes
Dr. Zgheib has been invited to give talks at the following conferences, associations, and Institutions: The American College of Surgeons, The Academic Surgical Congress, The Wound Healing Society, The American Association of Pediatrics, The American Heart Association, Children's Hospital Colorado, Nemours Children's Hospital, Scott and White Hospital, Sanford Burnham Prebys Medical Discovery Institute, University of Mississippi Medical Center, University of Colorado Denver - Anschutz Medical Campus, and University of Central Florida.

General Information

Graduate Schools:
  • MS, University of Mississippi Medical Center (2010)
  • PhD, University of Mississippi Medical Center (2012)
Languages: English, French, Arabic
Department: Surgery-Peds Surgery
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