M. Eric Kohler, MD, PhD
Assistant Professor, Pediatrics-Heme/Onc and Bone Marrow Transplantation

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Medical School:
  • MD, Medical College of Wisconsin (2011)
Graduate School :
  • PhD, Medical College Of Wisconsin (2010)
Undergraduate School:
  • BS, Rockhurst University (MO) (2001)
Residency:
  • Johns Hopkins University School of Medicine Program, Pediatrics (2014)
Fellowships:
  • Johns Hopkins University Program, Pediatric Hematology / Oncology (2017)
  • National Cancer Institute, Pediatric Hematology / Oncology (2018)
Department: Pediatrics-Heme/Onc and Bone Marrow Transplantation

Professional Titles

  • Assistant Professor

Publications

  • Ishii et al. Perforin-deficient CAR T cells recapitulate late-onset inflammatory toxicities observed in patients. J Clin Invest. 2020 Oct 1;130(10): 5425-5443. doi: 10.1172/JCI130059.
  • Kohler ME, Fry TJ. Using erythrocyte tools to enhance CAR T cells. Blood. 2020 Feb 27;135(9):595-596. doi: 10.1182/blood.2019003944. PubMed PMID: 32106307.
  • Ishii K, Pouzolles M, Chien CD, Erwin-Cohen RA, Kohler ME, Qin H, Lei H, Kuhn S, Ombrello AK, Dulau-Florea A, Eckhaus MA, Shalabi H, Yates B, Lichtenstein DA, Zimmermann VS, Kondo T, Shern JF, Young HA, Taylor N, Shah NN, Fry TJ. Perforin-deficient CAR T cells recapitulate late-onset inflammatory toxicities observed in patients. J Clin Invest. 2020 Oct 1;130(10):5425-5443. PubMed PMID: 32925169
  • Kohler ME, Fry TJ. Using erythrocyte tools to enhance CAR T cells. Blood. 2020 Feb 27;135(9):595-596. PubMed PMID: 32106307
  • Walsh Z, Yang Y, Kohler ME. Immunobiology of chimeric antigen receptor T cells and novel designs. Immunol Rev. 2019 Jul;290(1):100-113. PubMed PMID: 31355496
  • Qin H, Ishii K, Nguyen S, Su PP, Burk CR, Kim BH, Duncan BB, Tarun S, Shah NN, Kohler ME, Fry TJ. Murine pre-B-cell ALL induces T-cell dysfunction not fully reversed by introduction of a chimeric antigen receptor. Blood. 2018 Nov 1;132(18):1899-1910. PubMed PMID: 30209120
  • Yang Y, Kohler ME, Chien CD, Sauter CT, Jacoby E, Yan C, Hu Y, Wanhainen K, Qin H, Fry TJ. TCR engagement negatively affects CD8 but not CD4 CAR T cell expansion and leukemic clearance. Sci Transl Med. 2017 Nov 22;9(417). PubMed PMID: 29167392
  • Long AH, Haso WM, Shern JF, Wanhainen KM, Murgai M, Ingaramo M, Smith JP, Walker AJ, Kohler ME, Venkateshwara VR, Kaplan RN, Patterson GH, Fry TJ, Orentas RJ, Mackall CL. 4-1BB costimulation ameliorates T cell exhaustion induced by tonic signaling of chimeric antigen receptors. Nat Med. 2015 Jun;21(6):581-90. PubMed PMID: 25939063
  • Shah NN, Baird K, Delbrook CP, Fleisher TA, Kohler ME, Rampertaap S, Lemberg K, Hurley CK, Kleiner DE, Merchant MS, Pittaluga S, Sabatino M, Stroncek DF, Wayne AS, Zhang H, Fry TJ, Mackall CL. Acute GVHD in patients receiving IL-15/4-1BBL activated NK cells following T-cell-depleted stem cell transplantation. Blood. 2015 Jan 29;125(5):784-92. PubMed PMID: 25452614
  • Kohler ME, Hallett WH, Chen QR, Khan J, Johnson BD, Orentas RJ. Early expression of stem cell-associated genes within the CD8 compartment after treatment with a tumor vaccine. Cell Immunol. 2010;265(1):65-73. PubMed PMID: 20692654
  • Kohler ME, Johnson BD, Palen K, Chen QR, Khan J, Orentas RJ. Tumor antigen analysis in neuroblastoma by serological interrogation of bioinformatic data. Cancer Sci. 2010 Nov;101(11):2316-24. PubMed PMID: 20718755
  • Orentas RJ, Kohler ME, Johnson BD. Suppression of anti-cancer immunity by regulatory T cells: back to the future. Semin Cancer Biol. 2006 Apr;16(2):137-49. PubMed PMID: 16376101
  • Stephens EB, Singh DK, Kohler ME, Jackson M, Pacyniak E, Berman NE. The primary phase of infection by pathogenic simian-human immunodeficiency virus results in disruption of the blood-brain barrier. AIDS Res Hum Retroviruses. 2003 Oct;19(10):837-46. PubMed PMID: 14585215
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Professional Memberships

  • American Society of Hematology, Member
  • Children's Oncology Group, Member
  • American Society of Gene & Cell Therapy, Member
  • American Society for Transplantation and Cellular Therapy, Member

Practice Locations

Children's Hospital Colorado Anschutz Medical Campus
13123 East 16th Ave
Aurora, CO 80045
720-777-1234

Hospital Affiliation
  • Children's Hospital Colorado
Center Affiliations

Specialty Information

Specialties
  • Pediatric Hematology / Oncology, Board Certification (2019)
  • Pediatrics, Board Certification (2015)
Conditions & Treatments
  • Cancers - Blood and Marrow Transplant
  • Cancers
  • Cancers - Leukemia (Childhood)
  • Cancers - Pediatric Cancer

General Information

Medical Schools:
  • MD, Medical College of Wisconsin (2011)
Graduate Schools:
  • PhD, Medical College Of Wisconsin (2010)
Undergraduate Schools:
  • BS, Rockhurst University (MO) (2001)
Residency Programs:
  • Johns Hopkins University School of Medicine Program, Pediatrics (2014)
Fellowships:
  • Johns Hopkins University Program, Pediatric Hematology / Oncology (2017)
  • National Cancer Institute, Pediatric Hematology / Oncology (2018)
Department: Pediatrics-Heme/Onc and Bone Marrow Transplantation
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