Cristina Sempio, PhD
Research Instructor, Anesthesiology

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Department: Anesthesiology

Publications

  • Gibson LP, Karoly HC, Ellingson JM, Klawitter J, Sempio C, Squeri JE, Bryan AD, Bidwell LC, Hutchison KE. Effects of cannabidiol in cannabis flower: Implications for harm reduction. Addict Biol. 2021 Aug 31;:e13092. [Epub ahead of print] PubMed PMID: 34467598
  • Gibson LP, Gust CJ, Ellingson JM, YorkWilliams SL, Sempio C, Klawitter J, Bryan AD, Hutchison KE, Cinnamon Bidwell L. Investigating sex differences in acute intoxication and verbal memory errors after ad libitum cannabis concentrate use. Drug Alcohol Depend. 2021 Jun 1;223:108718. PubMed PMID: 33866072
  • Gilman JM, Schmitt WA, Wheeler G, Schuster RM, Klawitter J, Sempio C, Evins AE. Variation in Cannabinoid Metabolites Present in the Urine of Adults Using Medical Cannabis Products in Massachusetts. JAMA Netw Open. 2021 Apr 1;4(4):e215490. PubMed PMID: 33844003
  • Sempio C, Klawitter J, Jackson M, Freni F, Shillingburg R, Hutchison K, Bidwell LC, Christians U, Klawitter J. Analysis of 14 endocannabinoids and endocannabinoid congeners in human plasma using column switching high-performance atmospheric pressure chemical ionization liquid chromatography-mass spectrometry. Anal Bioanal Chem. 2021 May;413(12):3381-3392. PubMed PMID: 33817753
  • Sempio C, Almaraz-Quinones N, Jackson M, Zhao W, Wang GS, Liu Y, Leehey M, Knupp K, Klawitter J, Christians U, Klawitter J. Simultaneous Quantification of 17 Cannabinoids bY LC-MS-MS in Human Plasma. J Anal Toxicol. 2021 Mar 23. [Epub ahead of print] PubMed PMID: 33754154
  • Wymore EM, Palmer C, Wang GS, Metz TD, Bourne DWA, Sempio C, Bunik M. Persistence of ?-9-Tetrahydrocannabinol in Human Breast Milk. JAMA Pediatr. 2021 Jun 1;175(6):632-634. PubMed PMID: 33683306
  • Sempio C, Bidwell LC, Hutchison K, Huestis MA, Klawitter J, Christians U, Henthorn TK. Using Population Pharmacokinetic Modeling to Estimate Exposure to ?9-Tetrahydrocannabinol in an Observational Study of Cannabis Smokers in Colorado. Ther Drug Monit. 2021 Aug 1;43(4):536-545. PubMed PMID: 33656464
  • Sempio C, Wymore E, Palmer C, Bunik M, Henthorn TK, Christians U, Klawitter J. Detection of Cannabinoids by LC-MS-MS and ELISA in Breast Milk. J Anal Toxicol. 2021 Aug 14;45(7):686-692. PubMed PMID: 33002141
  • Sempio C, Wymore E, Palmer C, Bunik M, Henthorn TK, Christians U, Klawitter J. Detection of Cannabinoids by LC-MS-MS and ELISA in Breast Milk. J Anal Toxicol. 2020 Oct 2. [Epub ahead of print] PubMed PMID: 33002141
  • Bidwell LC, Ellingson JM, Karoly HC, YorkWilliams SL, Hitchcock LN, Tracy BL, Klawitter J, Sempio C, Bryan AD, Hutchison KE. Association of Naturalistic Administration of Cannabis Flower and Concentrates With Intoxication and Impairment. JAMA Psychiatry. 2020 Aug 1;77(8):787-796. PubMed PMID: 32520316
  • Huestis MA, Sempio C, Newmeyer MN, Andersson M, Barnes AJ, Abulseoud OA, Blount BC, Schroeder J, Smith ML. Free and Glucuronide Urine Cannabinoids after Controlled Smoked, Vaporized and Oral Cannabis Administration in Frequent and Occasional Cannabis Users. J Anal Toxicol. 2020 Oct 12;44(7):651-660. PubMed PMID: 32369162
  • Wang GS, Bourne DWA, Klawitter J, Sempio C, Chapman K, Knupp K, Wempe MF, Borgelt L, Christians U, Leonard J, Heard K, Bajaj L. Disposition of Oral Cannabidiol-Rich Cannabis Extracts in Children with Epilepsy. Clin Pharmacokinet. 2020 Aug;59(8):1005-1012. PubMed PMID: 32048179
  • Sempio C, Huestis MA, Mikulich-Gilbertson SK, Klawitter J, Christians U, Henthorn TK. Population pharmacokinetic modeling of plasma ?9-tetrahydrocannabinol and an active and inactive metabolite following controlled smoked cannabis administration. Br J Clin Pharmacol. 2020 Mar;86(3):611-619. PubMed PMID: 31747464
  • Davari B, Kotecha N, Clavijo CF, Thomas JJ, Rzasa-Lynn R, Galinkin JL, Christians U, Sempio C. A Sensitive LC-MS/MS Assay for the Quantification of Methadone and its Metabolites in Dried Blood Spots: Comparison With Plasma. Ther Drug Monit. 2020 Feb;42(1):118-128. PubMed PMID: 31318842
  • Wang GS, Bourne DWA, Klawitter J, Sempio C, Chapman K, Knupp K, Wempe MF, Borgelt L, Christians U, Heard K, Bajaj L. Disposition of oral delta-9 tetrahydrocannabinol (THC) in children receiving cannabis extracts for epilepsy. Clin Toxicol (Phila). 2020 Feb;58(2):124-128. PubMed PMID: 31111749
  • Leehey MA, Liu Y, Hart F, Epstein C, Cook M, Sillau S, Klawitter J, Newman H, Sempio C, Forman L, Seeberger L, Klepitskaya O, Baud Z, Bainbridge J. Safety and Tolerability of Cannabidiol in Parkinson Disease: An Open Label, Dose-Escalation Study. Cannabis Cannabinoid Res. 2020;5(4):326-336. PubMed PMID: 33381646
  • Bidwell LC, Ellingson JM, Karoly HC, YorkWilliams SL, Hitchcock LN, Tracy BL, Klawitter J, Sempio C, Bryan AD, Hutchison KE. Association of Naturalistic Administration of Cannabis Flower and Concentrates With Intoxication and Impairment. JAMA Psychiatry. 2020 Aug 1;77(8):787-796. PubMed PMID: 32520316
  • Huestis MA, Sempio C, Newmeyer MN, Andersson M, Barnes AJ, Abulseoud OA, Blount BC, Schroeder J, Smith ML. Free and Glucuronide Urine Cannabinoids after Controlled Smoked, Vaporized and Oral Cannabis Administration in Frequent and Occasional Cannabis Users. J Anal Toxicol. 2020 Oct 12;44(7):651-660. PubMed PMID: 32369162
  • Wang GS, Bourne DWA, Klawitter J, Sempio C, Chapman K, Knupp K, Wempe MF, Borgelt L, Christians U, Leonard J, Heard K, Bajaj L. Disposition of Oral Cannabidiol-Rich Cannabis Extracts in Children with Epilepsy. Clin Pharmacokinet. 2020 Aug;59(8):1005-1012. PubMed PMID: 32048179
  • Sempio C, Huestis MA, Mikulich-Gilbertson SK, Klawitter J, Christians U, Henthorn TK. Population pharmacokinetic modeling of plasma ?9-tetrahydrocannabinol and an active and inactive metabolite following controlled smoked cannabis administration. Br J Clin Pharmacol. 2020 Mar;86(3):611-619. PubMed PMID: 31747464
  • Davari B, Kotecha N, Clavijo CF, Thomas JJ, Rzasa-Lynn R, Galinkin JL, Christians U, Sempio C. A Sensitive LC-MS/MS Assay for the Quantification of Methadone and its Metabolites in Dried Blood Spots: Comparison With Plasma. Ther Drug Monit. 2020 Feb;42(1):118-128. PubMed PMID: 31318842
  • Wang GS, Bourne DWA, Klawitter J, Sempio C, Chapman K, Knupp K, Wempe MF, Borgelt L, Christians U, Heard K, Bajaj L. Disposition of oral delta-9 tetrahydrocannabinol (THC) in children receiving cannabis extracts for epilepsy. Clin Toxicol (Phila). 2020 Feb;58(2):124-128. PubMed PMID: 31111749
  • Sempio C, Lindley E, Klawitter J, Christians U, Bowler RP, Adgate JL, Allshouse W, Awdziejczyk L, Fischer S, Bainbridge J, Vandyke M, Netsanet R, Crume T, Kinney GL. Surface Detection of THC Attributable to Vaporizer Use in the Indoor Environment. Sci Rep. 2019 Dec 9;9(1):18587. PubMed PMID: 31819131
  • Knupp KG, Rice JD, Helmkamp LJ, Galinkin J, Sempio C, Jost K, Chapman KE. Prospective evaluation of oral cannabis extracts in children with epilepsy. Seizure. 2019 Nov;72:23-27. PubMed PMID: 31550641
  • Fosen JT, Høiseth G, Sempio C, Giarratana N, Enger A, Mørland J, Morini L. Hair EtG: Alterations in segment levels accompanying hair growth. Drug Test Anal. 2019 Jan;11(1):112-118. PubMed PMID: 30084156
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General Information

Department: Anesthesiology
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