Amy Campbell, PhD
Research Instructor, Biochemistry & Molecular Genetics

Publications

• Kolakada D, Campbell AE, Baquero Galvis L, Li Z, Lore M, Jagannathan S. A system of reporters for comparative investigation of EJC-independent and EJC-enhanced nonsense-mediated mRNA decay. bioRxiv. 2023 Nov 15. PubMed PMID: 38014198
• Hamm DC, Paatela EM, Bennett SR, Wong CJ, Campbell AE, Wladyka CL, Smith AA, Jagannathan S, Hsieh AC, Tapscott SJ. The transcription factor DUX4 orchestrates translational reprogramming by broadly suppressing translation efficiency and promoting expression of DUX4-induced mRNAs. PLoS Biol. 2023 Sep;21(9):e3002317. PubMed PMID: 37747887
• Campbell AE, Arjomand J, King OD, Tawil R, Jagannathan S. A Targeted Approach for Evaluating DUX4-Regulated Proteins as Potential Serum Biomarkers for Facioscapulohumeral Muscular Dystrophy Using Immunoassay Proteomics. J Neuromuscul Dis. 2023;10(6):1031-1040. PubMed PMID: 37899061
• Campbell AE, Dyle MC, Albanese R, Matheny T, Sudheendran K, Cortázar MA, Forman T, Fu R, Gillen AE, Caruthers MH, Floor SN, Calviello L, Jagannathan S. Compromised nonsense-mediated RNA decay results in truncated RNA-binding protein production upon DUX4 expression. Cell Rep. 2023 Jun 27;42(6):112642. PubMed PMID: 37314931
• Spens AE, Sutliff NA, Bennett SR, Campbell AE, Tapscott SJ. Human DUX4 and mouse Dux interact with STAT1 and broadly inhibit interferon-stimulated gene induction. Elife. 2023 Apr 24;12. PubMed PMID: 37092726
• Leung DG, Kinoshita J, Arjomand J, Dumonceaux J. Meeting report: The 2022 FSHD International Research Congress. Neuromuscul Disord. 2023 Feb;33(2):196-198. PubMed PMID: 36682112
• Spens AE, Sutliff NA, Bennett SR, Campbell AE, Tapscott SJ. (2022) Human DUX4 and mouse Dux interact with STAT1 and broadly inhibit interferon-stimulated gene induction. bioRxiv. doi: https://doi.org/10.1101/2022.08.09.503314
• Campbell AE, Arjomand J, King OD, Tawil R, Jagannathan S. (2022) Targeted Identification of Serum Biomarkers for Facioscapulohumeral Muscular Dystrophy Using Immunoassay Proteomics. bioRxiv. doi: https://doi.org/10.1101/2022.07.25.22276982
• Campbell AE, Dyle MC, Calviello L, Matheny T, Cortazar MA, Forman T, Fu R, Gillen AE, Floor SN, Jagannathan S. (2021) The myopathic transcription factor DUX4 induces the production of truncated RNA-binding proteins in human muscle cells. bioRxiv. doi: https://doi.org/10.1101/2021.06.28.450189
• Wong CJ, Wang LH, Friedman SD, Shaw D, Campbell AE, Budech CB, Lewis LM, Lemmers RJFL, Statland JM, van der Maarel SM, Tawil RN, Tapscott SJ. (2020) Longitudinal measures of RNA expression and disease activity in FSHD muscle biopsies. Hum Mol Genet. 9(6):1030-1043. doi:10.1093/hmg/ddaa031.
• Shadle SC, Bennett SR, Wong CJ, Karreman NA, Campbell AE, van der Maarel SM, Bass BL, Tapscott SJ. DUX4-induced bidirectional HSATII satellite repeat transcripts form intranuclear double stranded RNA foci in human cell models of FSHD. Hum Mol Genet. 2019 Oct 19. [Epub ahead of print] PubMed PMID: 31630170
• Chew GL, Campbell AE, De Neef E, Sutliff NA, Shadle SC, Tapscott SJ, Bradley RK. DUX4 Suppresses MHC Class I to Promote Cancer Immune Evasion and Resistance to Checkpoint Blockade. Dev Cell. 2019 Sep 9;50(5):658-671.e7. PubMed PMID: 31327741
• Oliva J, Galasinski S, Richey A, Campbell AE, Meyers MJ, Modi N, Zhong JW, Tawil R, Tapscott SJ, Sverdrup FM. Clinically Advanced p38 Inhibitors Suppress DUX4 Expression in Cellular and Animal Models of Facioscapulohumeral Muscular Dystrophy. J Pharmacol Exp Ther. 2019 Aug;370(2):219-230. PubMed PMID: 31189728
• Wang LH, Friedman SD, Shaw D, Snider L, Wong CJ, Budech CB, Poliachik SL, Gove NE, Lewis LM, Campbell AE, Lemmers RJFL, Maarel SM, Tapscott SJ, Tawil RN. MRI-informed muscle biopsies correlate MRI with pathology and DUX4 target gene expression in FSHD. Hum Mol Genet. 2019 Feb 1;28(3):476-486. PubMed PMID: 30312408