Benjamin Frank, MD
Assistant Professor, Pediatrics-Cardiology

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Medical School:
  • MD, Weill Cornell Medical College (2012)
Undergraduate School:
  • ScB, Brown University (RI) (2007)
Residency:
  • University of Colorado (Children's Hospital Colorado) Program, Pediatrics
Fellowships:
  • University of Colorado (Children's Hospital Colorado) Program, Pediatric Cardiology
  • University of Colorado (Children's Hospital Colorado) Program, Advanced Cardiac Imaging and Pediatric Pulmonary Hypertension
Department: Pediatrics-Cardiology

Professional Titles

  • Assistant Professor of Pediatrics

Research Interests

My research interests center on improving care for children with pulmonary hypertension and abnormal pulmonary vascular development in its many forms, including in association with congenital heart disease and developmental lung disease. We are using a combined cardiac imaging and metabolomics approach to identify new treatment targets, improve prognostic accuracy, and personalize care for our patients.

Publications

  • Cooney SJ, Klawitter J, Khailova L, Robison J, Jaggers J, Ing RJ, Lawson S, Frank BS, Lujan SO, Davidson JA. Regional lung metabolic profile in a piglet model of cardiopulmonary bypass with circulatory arrest. Metabolomics. 2021 Sep 22;17(10):89. PubMed PMID: 34553313
  • Schäfer M, Ivy DD, Nguyen K, Boncella K, Frank BS, Morgan GJ, Miller-Reed K, Truong U, Colvin K, Yeager ME. Metalloproteinases and their inhibitors are associated with pulmonary arterial stiffness and ventricular function in pediatric pulmonary hypertension. Am J Physiol Heart Circ Physiol. 2021 Jul 1;321(1):H242-H252. PubMed PMID: 34085841
  • Oganesyan A, Hoffner-Heinike A, Barker AJ, Frank BS, Ivy DD, Hunter KS, Mitchell MB, Humphries SM, Fenster BE, Schäfer M. Abnormal pulmonary flow is associated with impaired right ventricular coupling in patients with COPD. Int J Cardiovasc Imaging. 2021 Oct;37(10):3039-3048. PubMed PMID: 34021434
  • Davidson JA, Frank BS, Urban TT, Twite M, Jaggers J, Khailova L, Klawitter J. Serum metabolic profile of postoperative acute kidney injury following infant cardiac surgery with cardiopulmonary bypass. Pediatr Nephrol. 2021 Oct;36(10):3259-3269. PubMed PMID: 33954809
  • Schäfer M, Frank BS, Ivy DD, Abman SH, Stenmark KR, Mitchell MB, Browne LP, Barker AJ, Hunter KS, Kheyfets V, Miller-Reed K, Ing R, Morgan GJ, Truong U. Short-Term Effects of Inhaled Nitric Oxide on Right Ventricular Flow Hemodynamics by 4-Dimensional-Flow Magnetic Resonance Imaging in Children With Pulmonary Arterial Hypertension. J Am Heart Assoc. 2021 Apr 20;10(8):e020548. PubMed PMID: 33821682
  • Frank BS, Schäfer M, Thomas TM, Ivy DD, Jone PN. Longitudinal assessment of right atrial conduit fraction provides additional insight to predict adverse events in pediatric pulmonary hypertension. Int J Cardiol. 2021 Apr 15;329:242-245. PubMed PMID: 33400972
  • Ivy D, Frank BS. Update on pediatric pulmonary arterial hypertension. Curr Opin Cardiol. 2021 Jan;36(1):67-79. PubMed PMID: 33136663
  • Frank BS, Khailova L, Silveira L, Mitchell MB, Morgan GJ, Hsieh EWY, DiMaria MV, Twite M, Klawitter J, Davidson JA. Proteomic profiling identifies key differences between inter-stage infants with single ventricle heart disease and healthy controls. Transl Res. 2021 Mar;229:24-37. PubMed PMID: 33045409
  • Schäfer M, Frank BS, Jacobsen R, Rausch CM, Mitchell MB, Jaggers J, Stone ML, Morgan GJ, Browne LP, Barker AJ, Hunter KS, Ivy DD, Younoszai A, Di Maria MV. Patients with Fontan circulation have abnormal aortic wave propagation patterns: A wave intensity analysis study. Int J Cardiol. 2021 Jan 1;322:158-167. PubMed PMID: 32853667
  • Bloom JL, Frank B, Weinman JP, Galambos C, O'Leary ST, Liptzin DR, Fuhlbrigge RC. Diffuse alveolar hemorrhage in children with trisomy 21. Pediatr Rheumatol Online J. 2021 Jul 17;19(1):114. PubMed PMID: 34273981
  • Ivy D, Frank BS. Update on pediatric pulmonary arterial hypertension. Curr Opin Cardiol. 2020 Oct 29. [Epub ahead of print] PubMed PMID: 33136663
  • Frank BS, Khailova L, Silveira L, Mitchell MB, Morgan GJ, Hsieh EWY, DiMaria MV, Twite M, Klawitter J, Davidson JA. Proteomic profiling identifies key differences between inter-stage infants with single ventricle heart disease and healthy controls. Transl Res. 2020 Oct 9. [Epub ahead of print] PubMed PMID: 33045409
  • Sabapathy D, Klawitter J, Silveira L, Khailova L, Mitchell MB, Morgan GJ, DiMaria MV, Twite M, Frank BS, Davidson JA. Activation of kynurenine pathway of tryptophan metabolism after infant cardiac surgery with cardiopulmonary bypass: a prospective cohort study. Metabolomics. 2020 Sep 5;16(9):93. PubMed PMID: 32889608
  • Frank BS, Ivy DD. Pediatric Pulmonary Arterial Hypertension. Pediatr Clin North Am. 2020 Oct;67(5):903-921. PubMed PMID: 32888689
  • Schäfer M, Frank BS, Jacobsen R, Rausch CM, Mitchell MB, Jaggers J, Stone ML, Morgan GJ, Browne LP, Barker AJ, Hunter KS, Ivy DD, Younoszai A, Di Maria MV. Patients with Fontan circulation have abnormal aortic wave propagation patterns: A wave intensity analysis study. Int J Cardiol. 2020 Aug 25. [Epub ahead of print] PubMed PMID: 32853667
  • Schäfer M, Bjornstad P, Frank BS, Baumgartner A, Truong U, Enge D, von Alvensleben JC, Mitchell MB, Ivy DD, Barker AJ, Reusch JEB, Nadeau KJ. Frequency of Reduced Left Ventricular Contractile Efficiency and Discoordinated Myocardial Relaxation in Patients Aged 16 to 21 Years With Type 1 Diabetes Mellitus (from the Emerald Study). Am J Cardiol. 2020 Aug 1;128:45-53. PubMed PMID: 32650923
  • Frank BS, Schafer M, Thomas TM, Haxel C, Ivy DD, Jone PN. Right Atrial Conduit Phase Emptying Predicts Risk of Adverse Events in Pediatric Pulmonary Arterial Hypertension. J Am Soc Echocardiogr. 2020 Aug;33(8):1006-1013. PubMed PMID: 32336608
  • Schäfer M, Frank BS, Humphries SM, Hunter KS, Carmody KL, Jacobsen R, Mitchell MB, Jaggers J, Stone ML, Morgan GJ, Barker AJ, Browne LP, Ivy DD, Younoszai A, Di Maria MV. Flow profile characteristics in Fontan circulation are associated with the single ventricle dilation and function: principal component analysis study. Am J Physiol Heart Circ Physiol. 2020 May 1;318(5):H1032-H1040. PubMed PMID: 32167782
  • Frank BS, Schäfer M, Douwes JM, Ivy DD, Abman SH, Davidson JA, Burzlaff S, Mitchell MB, Morgan GJ, Browne LP, Barker AJ, Truong U, von Alvensleben JC. Novel measures of left ventricular electromechanical discoordination predict clinical outcomes in children with pulmonary arterial hypertension. Am J Physiol Heart Circ Physiol. 2020 Feb 1;318(2):H401-H412. PubMed PMID: 31858817
  • Evan Pagano, Benjamin Frank, James Jaggers, et al, “Alterations in Metabolites Associated with Hypoxemia in Neonates and Infants with Congenital Heart Disease” Congenital Heart Disease, Vol 15 (4), 2020; 251-265
  • Frank B.S., Rashid A., Ivy D. (2020) Chronic Pulmonary Hypertension. In: Munoz R., Morell V., da Cruz E., Vetterly C., da Silva J. (eds) Critical Care of Children with Heart Disease. Springer, Cham
  • Frank BS, Schafer M, Thomas TM, Ivy DD, Jone PN, “Longitudinal Assessment of Right Atrial Conduit Fraction Provides Additional Insight to Predict Adverse Events in Pediatric Pulmonary Hypertension” American Society of Echocardiography Scientific Sessions, Virtual Experience, August, 2020.
  • Frank BS, Ivy DD. Pediatric Pulmonary Arterial Hypertension. Pediatr Clin North Am. 2020 Oct;67(5):903-921. PubMed PMID: 32888689
  • Frank BS, Schäfer M, Grenolds A, Ivy DD, Abman SH, Darst JR. Acute Vasoreactivity Testing during Cardiac Catheterization of Neonates with Bronchopulmonary Dysplasia-Associated Pulmonary Hypertension. J Pediatr. 2019 May;208:127-133. PubMed PMID: 30871795
  • Frank BS, Runciman M, Manning WA, Ivy DD, Abman SH, Howley L. Pulmonary Hypertension Secondary to Scurvy in a Developmentally Typical Child. J Pediatr. 2019 May;208:291-291.e2. PubMed PMID: 30738657
  • Frank BS, Urban TT, Lewis K, Tong S, Cassidy C, Mitchell MB, Nichols CS, Davidson JA. Circulating biomarkers of left ventricular hypertrophy in pediatric coarctation of the aorta. Congenit Heart Dis. 2019 May;14(3):446-453. PubMed PMID: 30650250
  • Schäfer M, Frank BS, Ivy DD, Wilson N, Morgan GJ, Barker AJ, Browne LP, Mitchell MB, Truong U. Close look at the Potts shunt flow hemodynamics in a patient with severe pulmonary hypertension: 4D-flow MRI evaluation. J Magn Reson Imaging. 2019 Jun;49(6):1800-1802. PubMed PMID: 30451346
  • Davidson JA, Urban TT, Tong S, Maddux A, Hill G, Frank BS, Watson JD, Jaggers J, Simões EAF, Wischmeyer P. Alkaline Phosphatase Activity and Endotoxemia After Infant Cardiothoracic Surgery. Shock. 2019 Mar;51(3):328-336. PubMed PMID: 29664834
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Practice Locations

Children's Hospital Colorado Anschutz Medical Campus
13123 East 16th Ave
Aurora, CO 80045
720-777-1234

Hospital Affiliation
  • Children's Hospital Colorado

Specialty Information

Specialties
  • Pediatric Cardiology, Board Certification (2018)
Clinical Interests
My clinical interests include advanced cardiac imaging, caring for children with pediatric pulmonary hypertension, and congenital heart disease.

General Information

Medical Schools:
  • MD, Weill Cornell Medical College (2012)
Undergraduate Schools:
  • ScB, Brown University (RI) (2007)
Residency Programs:
  • University of Colorado (Children's Hospital Colorado) Program, Pediatrics (0001)
Fellowships:
  • University of Colorado (Children's Hospital Colorado) Program, Pediatric Cardiology (0001)
  • University of Colorado (Children's Hospital Colorado) Program, Advanced Cardiac Imaging and Pediatric Pulmonary Hypertension (0001)
Department: Pediatrics-Cardiology
;