Colin Shearn, PhD
Assistant Research Professor, Pediatrics-Gastroenterology, Hepatology and Nutrition

Publications

• Shearn CT, Anderson AL, Devereaux MW, El Kasmi KC, Orlicky DJ, Sokol RJ. Expression of circadian regulatory genes is dysregulated by increased cytokine production in mice subjected to concomitant intestinal injury and parenteral nutrition. PLoS One. 2023;18(8):e0290385. PubMed PMID: 37647292
• Davidson EA, Chen Y, Singh S, Orlicky DJ, Thompson B, Wang Y, Charkoftaki G, Furnary TA, Cardone RL, Kibbey RG, Shearn CT, Nebert DW, Thompson DC, Vasiliou V. Endocrine pancreas-specific Gclc gene deletion causes a severe diabetes phenotype. bioRxiv. 2023 Jun 26. PubMed PMID: 37398356
• The autophagic protein p62 is a target of reactive aldehydes in human and murine cholestatic liver disease. Shearn CT, Anderson AL, Devereaux MW, Orlicky DJ, Michel C, Petersen DR, Miller CG, Harpavat S, Schmidt EE, Sokol RJ. PLoS One. 2022 Nov 15;17(11):e0276879. doi: 10.1371/journal.pone.0276879. eCollection 2022. PMID: 36378690
• El Kasmi KC, Anderson AL, Devereaux MW, Balasubramaniyan N, Suchy FJ, Orlicky DJ, Shearn CT, Sokol RJ. Interrupting tumor necrosis factor-alpha signaling prevents parenteral nutrition associated cholestasis in mice. JPEN J Parenter Enteral Nutr. 2021 Oct 19. [Epub ahead of print] PubMed PMID: 34664730
• El Kasmi KC, Ghosh S, Anderson AL, Devereaux MW, Balasubramaniyan N, D'Alessandro A, Orlicky DJ, Suchy FJ, Shearn CT, Sokol RJ. Pharmacologic Activation of Hepatic Farnesoid X Receptor Prevents Parenteral Nutrition Associated Cholestasis in Mice. Hepatology. 2021 Aug 13. [Epub ahead of print] PubMed PMID: 34387888
• Ghosh S, Devereaux MW, Anderson AL, Gehrke S, Reisz JA, D'Alessandro A, Orlicky DJ, Lovell M, El Kasmi KC, Shearn CT, Sokol RJ. NF-?B Regulation of LRH-1 and ABCG5/8 Potentiates Phytosterol Role in the Pathogenesis of Parenteral Nutrition-Associated Cholestasis. Hepatology. 2021 Jul 26. [Epub ahead of print] PubMed PMID: 34310734
• Charkoftaki G, Golla JP, Santos-Neto A, Orlicky DJ, Garcia-Milian R, Chen Y, Rattray NJW, Cai Y, Wang Y, Shearn CT, Mironova V, Wang Y, Johnson CH, Thompson DC, Vasiliou V. Identification of Dose-Dependent DNA Damage and Repair Responses From Subchronic Exposure to 1,4-Dioxane in Mice Using a Systems Analysis Approach. Toxicol Sci. 2021 Sep 28;183(2):338-351. PubMed PMID: 33693819
• Miller CG, Kundert JA, Prigge JR, Amato JA, Perez AE, Coppo L, Rizzo GN, Kavanaugh MP, Orlicky DJ, Shearn CT, Schmidt EE. Supplemental Ascorbate Diminishes DNA Damage Yet Depletes Glutathione and Increases Acute Liver Failure in a Mouse Model of Hepatic Antioxidant System Disruption. Antioxidants (Basel). 2021 Feb 27;10(3). PubMed PMID: 33673577
• Alnaas AA, Watson-Siriboe A, Tran S, Negussie M, Henderson JA, Osterberg JR, Lee Chon N, Harrott BM, Oviedo J, Lyakhova T, Michel C, Reisdorph N, Reisdorph R, Shearn CT, Lin H, Knight JD. Multivalent lipid targeting by the calcium-independent C2A domain of synaptotagmin-like protein 4/ granuphilin. J Biol Chem. 2020 Dec 4. [Epub ahead of print] PubMed PMID: 33277360
• Gao RY, Shearn CT, Orlicky DJ, Battista KD, Alexeev EE, Cartwright IM, Lanis JM, Kostelecky RE, Ju C, Colgan SP, Fennimore BP. Bile acids modulate colonic MAdCAM-1 expression in a murine model of combined cholestasis and colitis. Mucosal Immunol. 2020 Oct 1. [Epub ahead of print] PubMed PMID: 33004979
• Pan G, Deshpande M, Pang H, Stemmer PM, Carruthers NJ, Shearn CT, Backos DS, Palaniyandi SS. 4-Hydroxy-2-nonenal attenuates 8-oxoguanine DNA glycosylase 1 activity. J Cell Biochem. 2020 Jul 6. [Epub ahead of print] PubMed PMID: 32628320
• Shearn, C.T., Anderson, A.L., Miller, C.G., Noyd, R.C., Devereaux, M.W., Balasubramaniyan, N., Orlicky, D.J., Schmidt, E.E. and Sokol, R.J. Thioredoxin Reductase 1 is a critical mediator of hepatic inflammation during cholestatic liver injury. In press Hepatology Communications 2022.