Brian Stauffer, MD
Professor, Medicine-Cardiology

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Medical School:
  • MD, Pennsylvania State University College of Medicine (1996)
Undergraduate School:
  • BS, Eastern Mennonite University (VA) (1991)
Internship:
  • Case Western Reserve University-Cleveland Clinic Foundation-MetroHealth Medical Center Program (1997)
Residency:
  • Case Western Reserve University-Cleveland Clinic Foundation-MetroHealth Medical Center Program, Internal Medicine (1999)
Fellowships:
  • University of Colorado (University Hospital) Program, Cardiovascular Disease (2005)
Languages: English
Department: Medicine-Cardiology

Professional Titles

  • Medical Director, Integrative Vascular Biology Laboratory, CU Boulder
  • Medical Director, CU Boulder Clinical Translational Research Center, Colorado Clinical Translational Sciences Institute, UCDSOM
  • Co-Founder, Pediatric Cardiovascular Research Laboratory (PCRL)
  • Member, Scientific Advisory Research Committee, Colorado Clinical Translational Sciences Institute, UCDSOM
  • Chief, Division of Cardiology, Denver Health Medical Center

Recognition & Awards

  • 2015 Academic Excellence Award, Denver Health Medical Staff, Denver Health and Hospital Authority (2015)
  • Fellow, American College of Physicians (2014)
  • Fellow, American College of Cardiology (2007)

Teaching

  • Director, Cardiovascular Disease Core Curriculum (2007)
    School of Medicine, Medicine
  • Graduate Faculty (2003)
    Graduate School, University of Colorado - Boulder
  • Graduate Faculty (2015)
    Graduate School, Physiology & Biophysics

Publications

  • Babcock MC, DuBose LE, Witten TL, Stauffer BL, Hildreth KL, Schwartz RS, Kohrt WM, Moreau KL. Oxidative Stress and Inflammation Are Associated With Age-Related Endothelial Dysfunction in Men With Low Testosterone. J Clin Endocrinol Metab. 2022 Jan 18;107(2):e500-e514. PubMed PMID: 34597384
  • Stockelman KA, Bain AR, Goulding A, DeSouza NM, Rahaman C, Maly L, Greiner JJ, Stauffer BL, DeSouza CA. Negative Influence of Insufficient Sleep on Endothelial Vasodilator and Fibrinolytic Function in Hypertensive Adults. Hypertension. 2021 Dec;78(6):1829-1840. PubMed PMID: 34488434
  • Jeffrey DA, Pires Da Silva J, Garcia AM, Jiang X, Karimpour-Fard A, Toni LS, Lanzicher T, Peña B, Miyano CA, Nunley K, Korst A, Sbaizero O, Taylor MR, Miyamoto SD, Stauffer BL, Sucharov CC. Serum circulating proteins from pediatric patients with dilated cardiomyopathy cause pathologic remodeling and cardiomyocyte stiffness. JCI Insight. 2021 Oct 8;6(19). PubMed PMID: 34383712
  • Kelley GA, Kelley KS, Stauffer BL. Isometric exercise and inter-individual response differences on resting systolic and diastolic blood pressure in adults: a meta-analysis of randomized controlled trials. Blood Press. 2021 Oct;30(5):310-321. PubMed PMID: 34176377
  • Woulfe KC, Jeffrey DA, Pires Da Silva J, Wilson CE, Mahaffey JH, Lau E, Slavov D, Hailu F, Karimpour-Fard A, Dockstader K, Bristow MR, Stauffer BL, Miyamoto SD, Sucharov CC. Serum response factor deletion 5 regulates phospholamban phosphorylation and calcium uptake. J Mol Cell Cardiol. 2021 Oct;159:28-37. PubMed PMID: 34139234
  • Sanchez JM, Farasat M, Levy AE, Douglas IS, Stauffer BL, Tzou WS, West JJ. A novel approach to electrocardiography in the prone patient. Heart Rhythm O2. 2021 Feb;2(1):107-109. PubMed PMID: 34113910
  • Hailu FT, Karimpour-Fard A, Toni LS, Bristow MR, Miyamoto SD, Stauffer BL, Sucharov CC. Integrated analysis of miRNA-mRNA interaction in pediatric dilated cardiomyopathy. Pediatr Res. 2021 May 19. [Epub ahead of print] PubMed PMID: 34012027
  • Farasat M, Sanchez JM, West JJ, Burke JM, Prouse AF, Gore MO, Salame GA, Keach JW, Trent SA, Haigney MCP, Hogan SE, Peterson PN, Stauffer BL, Holland MR, Krantz MJ. A Point-of-Care Algorithm to Guide Proper Device Selection for Ambulatory Electrocardiography. Crit Pathw Cardiol. 2021 Sep 1;20(3):140-142. PubMed PMID: 33731601
  • Gist KM, Korst A, Nakano SJ, Stauffer BL, Karimpour-Fard A, Zhou W, Campbell K, Wempe MF, Sucharov CC, Miyamoto SD. Circulating cyclic adenosine monophosphate concentrations in milrinone treated paediatric patients after congenital heart surgery. Cardiol Young. 2021 Sep;31(9):1393-1400. PubMed PMID: 33533327
  • Stockelman KA, Bain AR, Dow CA, Diehl KJ, Greiner JJ, Stauffer BL, DeSouza CA. Regular aerobic exercise counteracts endothelial vasomotor dysfunction associated with insufficient sleep. Am J Physiol Heart Circ Physiol. 2021 Mar 1;320(3):H1080-H1088. PubMed PMID: 33416458
  • Babcock MC, DuBose LE, Witten TL, Brubaker A, Stauffer BL, Hildreth KL, Moreau KL. Assessment of macrovascular and microvascular function in aging males. J Appl Physiol (1985). 2021 Jan 1;130(1):96-103. PubMed PMID: 33151774
  • Babcock MC, DuBose LE, Witten TL, Brubaker A, Stauffer BL, Hildreth KL, Moreau KL. Assessment of macro and microvascular function in aging males. J Appl Physiol (1985). 2020 Nov 5. [Epub ahead of print] PubMed PMID: 33151774
  • Holland M, Burke J, Hulac S, Morris M, Bryskiewicz G, Goold A, McVaney K, Rappaport L, Stauffer BL. Excess Cardiac Arrest in the Community During the COVID-19 Pandemic. JACC Cardiovasc Interv. 2020 Aug 24;13(16):1968-1969. PubMed PMID: 32819492
  • Stockelman KA, Hijmans JG, Bammert TD, Greiner JJ, Stauffer BL, DeSouza CA. Circulating endothelial cell derived microvesicles are elevated with hypertension and associated with endothelial dysfunction. Can J Physiol Pharmacol. 2020 Aug;98(8):557-561. PubMed PMID: 32268071
  • Garcia AM, McPhaul JC, Sparagna GC, Jeffrey DA, Jonscher R, Patel SS, Sucharov CC, Stauffer BL, Miyamoto SD, Chatfield KC. Alteration of cardiolipin biosynthesis and remodeling in single right ventricle congenital heart disease. Am J Physiol Heart Circ Physiol. 2020 Apr 1;318(4):H787-H800. PubMed PMID: 32056460
  • Kelley GA, Kelley KS, Stauffer BL. Obesity and cardiovascular outcomes: another look at a meta-analysis of Mendelian randomization studies. J Investig Med. 2020 Feb;68(2):357-363. PubMed PMID: 31331941
  • Nakano SJ, Walker JS, Walker LA, Li X, Du Y, Miyamoto SD, Sucharov CC, Garcia AM, Mitchell MB, Ambardekar AV, Stauffer BL. Increased myocyte calcium sensitivity in end-stage pediatric dilated cardiomyopathy. Am J Physiol Heart Circ Physiol. 2019 Dec 1;317(6):H1221-H1230. PubMed PMID: 31625780
  • Catenacci VA, Ostendorf DM, Pan Z, Bing K, Wayland LT, Seyoum E, Stauffer BL, Phelan S, Creasy SA, Caldwell AE, Wyatt HR, Bessesen DH, Melanson EL. The Impact of Timing of Exercise Initiation on Weight Loss: An 18-Month Randomized Clinical Trial. Obesity (Silver Spring). 2019 Nov;27(11):1828-1838. PubMed PMID: 31565869
  • Kelley GA, Kelley KS, Stauffer BL. Obesity and cardiovascular outcomes: another look at a meta-analysis of Mendelian randomization studies. J Investig Med. 2019 Jul 21. [Epub ahead of print] PubMed PMID: 31331941
  • Chatfield KC, Sparagna GC, Chau S, Phillips EK, Ambardekar AV, Aftab M, Mitchell MB, Sucharov CC, Miyamoto SD, Stauffer BL. Elamipretide Improves Mitochondrial Function in the Failing Human Heart. JACC Basic Transl Sci. 2019 Apr;4(2):147-157. PubMed PMID: 31061916
  • Hijmans JG, Levy M, Garcia V, Lincenberg GM, Diehl KJ, Greiner JJ, Stauffer BL, DeSouza CA. Insufficient sleep is associated with a pro-atherogenic circulating microRNA signature. Exp Physiol. 2019 Jun;104(6):975-982. PubMed PMID: 31016755
  • Hijmans JG, Stockelman KA, Garcia V, Levy MV, Brewster LM, Bammert TD, Greiner JJ, Stauffer BL, Connick E, DeSouza CA. Circulating Microparticles Are Elevated in Treated HIV -1 Infection and Are Deleterious to Endothelial Cell Function. J Am Heart Assoc. 2019 Feb 19;8(4):e011134. PubMed PMID: 30779672
  • Garcia AM, Nakano SJ, Karimpour-Fard A, Nunley K, Blain-Nelson P, Stafford NM, Stauffer BL, Sucharov CC, Miyamoto SD. Phosphodiesterase-5 Is Elevated in Failing Single Ventricle Myocardium and Affects Cardiomyocyte Remodeling In Vitro. Circ Heart Fail. 2018 Sep;11(9):e004571. PubMed PMID: 30354365
  • Woulfe KC, Wilson CE, Nau S, Chau S, Phillips EK, Zang S, Tompkins C, Sucharov CC, Miyamoto SD, Stauffer BL. Acute isoproterenol leads to age-dependent arrhythmogenesis in guinea pigs. Am J Physiol Heart Circ Physiol. 2018 Oct 1;315(4):H1051-H1062. PubMed PMID: 30028197
  • Toni LS, Garcia AM, Jeffrey DA, Jiang X, Stauffer BL, Miyamoto SD, Sucharov CC. Optimization of phenol-chloroform RNA extraction. MethodsX. 2018;5:599-608. PubMed PMID: 29984193
  • Mariner PD, Korst A, Karimpour-Fard A, Stauffer BL, Miyamoto SD, Sucharov CC. Improved Detection of Circulating miRNAs in Serum and Plasma Following Rapid Heat/Freeze Cycling. Microrna. 2018;7(2):138-147. PubMed PMID: 29658445
  • Hijmans JG, Diehl KJ, Bammert TD, Kavlich PJ, Lincenberg GM, Greiner JJ, Stauffer BL, DeSouza CA. Association between hypertension and circulating vascular-related microRNAs. J Hum Hypertens. 2018 Jun;32(6):440-447. PubMed PMID: 29615793
  • Hijmans JG, Diehl KJ, Bammert TD, Kavlich PJ, Lincenberg GM, Greiner JJ, Stauffer BL, DeSouza CA. Influence of Overweight and Obesity on Circulating Inflammation-Related microRNA. Microrna. 2018;7(2):148-154. PubMed PMID: 29607782
  • Nakano SJ, Sucharov J, van Dusen R, Cecil M, Nunley K, Wickers S, Karimpur-Fard A, Stauffer BL, Miyamoto SD, Sucharov CC. Cardiac Adenylyl Cyclase and Phosphodiesterase Expression Profiles Vary by Age, Disease, and Chronic Phosphodiesterase Inhibitor Treatment. J Card Fail. 2017 Jan;23(1):72-80. PubMed PMID: 27427220
  • Stauffer BL, Dow CA, Diehl KJ, Bammert TD, Greiner JJ, DeSouza CA. Nebivolol, But Not Metoprolol, Treatment Improves Endothelial Fibrinolytic Capacity in Adults With Elevated Blood Pressure. J Am Heart Assoc. 2017 Nov 9;6(11). PubMed PMID: 29122812
  • Nakano SJ, Siomos AK, Garcia AM, Nguyen H, SooHoo M, Galambos C, Nunley K, Stauffer BL, Sucharov CC, Miyamoto SD. Fibrosis-Related Gene Expression in Single Ventricle Heart Disease. J Pediatr. 2017 Dec;191:82-90.e2. PubMed PMID: 29050751
  • Bain AR, Weil BR, Diehl KJ, Greiner JJ, Stauffer BL, DeSouza CA. Insufficient sleep is associated with impaired nitric oxide-mediated endothelium-dependent vasodilation. Atherosclerosis. 2017 Oct;265:41-46. PubMed PMID: 28846879
  • Tatman PD, Woulfe KC, Karimpour-Fard A, Jeffrey DA, Jaggers J, Cleveland JC, Nunley K, Taylor MR, Miyamoto SD, Stauffer BL, Sucharov CC. Pediatric dilated cardiomyopathy hearts display a unique gene expression profile. JCI Insight. 2017 Jul 20;2(14). [Epub ahead of print] PubMed PMID: 28724804
  • Dow CA, Stauffer BL, Brunjes DL, Greiner JJ, DeSouza CA. Regular aerobic exercise reduces endothelin-1-mediated vasoconstrictor tone in overweight and obese adults. Exp Physiol. 2017 Sep 1;102(9):1133-1142. PubMed PMID: 28635124
  • Bammert TD, Hijmans JG, Kavlich PJ, Lincenberg GM, Reiakvam WR, Fay RT, Greiner JJ, Stauffer BL, DeSouza CA. Influence of sex on the number of circulating endothelial microparticles and microRNA expression in middle-aged adults. Exp Physiol. 2017 Aug 1;102(8):894-900. PubMed PMID: 28568648
  • Held N, Little N, Krantz MJ, Stauffer BL. Refractory Cardiogenic Shock from Right Ventricular Infarction Successfully Managed with Inhaled Epoprostenol. Am J Case Rep. 2017 Mar 16;18:271-275. PubMed PMID: 28298620
  • Jiang X, Sucharov J, Stauffer BL, Miyamoto SD, Sucharov CC. Exosomes from pediatric dilated cardiomyopathy patients modulate a pathological response in cardiomyocytes. Am J Physiol Heart Circ Physiol. 2017 Apr 1;312(4):H818-H826. PubMed PMID: 28130338
  • Brown DA, Perry JB, Allen ME, Sabbah HN, Stauffer BL, Shaikh SR, Cleland JG, Colucci WS, Butler J, Voors AA, Anker SD, Pitt B, Pieske B, Filippatos G, Greene SJ, Gheorghiade M. Expert consensus document: Mitochondrial function as a therapeutic target in heart failure. Nat Rev Cardiol. 2017 Apr;14(4):238-250. PubMed PMID: 28004807
  • Medina E, Sucharov CC, Nelson P, Miyamoto SD, Stauffer BL. Molecular Changes in Children with Heart Failure Undergoing Left Ventricular Assist Device Therapy. J Pediatr. 2017 Mar;182:184-189.e1. PubMed PMID: 27908653
  • Woulfe KC, Siomos AK, Nguyen H, SooHoo M, Galambos C, Stauffer BL, Sucharov C, Miyamoto S. Fibrosis and Fibrotic Gene Expression in Pediatric and Adult Patients With Idiopathic Dilated Cardiomyopathy. J Card Fail. 2017 Apr;23(4):314-324. PubMed PMID: 27890770
  • Nakano SJ, Sucharov J, van Dusen R, Cecil M, Nunley K, Wickers S, Karimpur-Fard A, Stauffer BL, Miyamoto SD, Sucharov CC. Cardiac Adenylyl Cyclase and Phosphodiesterase Expression Profiles Vary by Age, Disease, and Chronic Phosphodiesterase Inhibitor Treatment. J Card Fail. 2017 Jan;23(1):72-80. PubMed PMID: 27427220
  • Brown DA, Perry JB, Allen ME, Sabbah HN, Stauffer BL, Shaikh SR, Cleland JG, Colucci WS, Butler J, Voors AA, Anker SD, Pitt B, Pieske B, Filippatos G, Greene SJ, Gheorghiade M. Expert consensus document: Mitochondrial function as a therapeutic target in heart failure. Nat Rev Cardiol. 2016 Dec 22. [Epub ahead of print] PubMed PMID: 28004807
  • Medina E, Sucharov CC, Nelson P, Miyamoto SD, Stauffer BL. Molecular Changes in Children with Heart Failure Undergoing Left Ventricular Assist Device Therapy. J Pediatr. 2016 Nov 29. [Epub ahead of print] PubMed PMID: 27908653
  • Woulfe KC, Siomos AK, Nguyen H, SooHoo M, Galambo C, Stauffer BL, Sucharov C, Miyamoto S. Fibrosis and Fibrotic Gene Expression in Pediatric and Adult Patients With Idiopathic Dilated Cardiomyopathy. J Card Fail. 2016 Nov 24. [Epub ahead of print] PubMed PMID: 27890770
  • Dow CA, Lincenberg GM, Greiner JJ, Stauffer BL, DeSouza CA. Endothelial vasodilator function in normal-weight adults with metabolic syndrome. Appl Physiol Nutr Metab. 2016 Oct;41(10):1013-1017. PubMed PMID: 27643673
  • Diehl KJ, Stauffer BL, Dow CA, Bammert TD, Brunjes DL, Greiner JJ, DeSouza CA. Chronic Nebivolol Treatment Suppresses Endothelin-1-Mediated Vasoconstrictor Tone in Adults With Elevated Blood Pressure. Hypertension. 2016 Jun;67(6):1196-204. PubMed PMID: 27113048
  • Dow CA, Templeton DL, Lincenberg GM, Greiner JJ, Stauffer BL, DeSouza CA. Elevations in C-reactive protein and endothelin-1 system activity in humans. Life Sci. 2016 Aug 15;159:66-70. PubMed PMID: 26685760
  • Dow CA, Templeton DL, Lincenberg GM, Greiner JJ, Stauffer BL, DeSouza CA. Elevations in C-reactive protein and endothelin-1 system activity in humans. Life Sci. 2015 Dec 11. [Epub ahead of print] PubMed PMID: 26685760
  • Dow CA, Stauffer BL, Greiner JJ, DeSouza CA. Influence of habitual high dietary fat intake on endothelium-dependent vasodilation. Appl Physiol Nutr Metab. 2015 Jul;40(7):711-5. PubMed PMID: 26058441
  • Stauffer BL, Dockstader K, Russell G, Hijmans J, Walker L, Cecil M, Demos-Davies K, Medway A, McKinsey TA, Sucharov CC. Transgenic over-expression of YY1 induces pathologic cardiac hypertrophy in a sex-specific manner. Biochem Biophys Res Commun. 2015 Jun 26;462(2):131-7. PubMed PMID: 25935483
  • Miyamoto SD, Karimpour-Fard A, Peterson V, Auerbach SR, Stenmark KR, Stauffer BL, Sucharov CC. Circulating microRNA as a biomarker for recovery in pediatric dilated cardiomyopathy. J Heart Lung Transplant. 2015 May;34(5):724-33. PubMed PMID: 25840506
  • Diehl KJ, Weil BR, Greiner JJ, Wright KP, Stauffer BL, DeSouza CA. Impaired endogenous fibrinolytic capacity in prehypertensive men. J Hum Hypertens. 2015 Aug;29(8):468-72. PubMed PMID: 25566873
  • Konhilas JP, Chen H, Luczak E, McKee LA, Regan J, Watson PA, Stauffer BL, Khalpey ZI, Mckinsey TA, Horn T, LaFleur B, Leinwand LA. Diet and sex modify exercise and cardiac adaptation in the mouse. Am J Physiol Heart Circ Physiol. 2015 Jan 15;308(2):H135-45. PubMed PMID: 25398983
  • Sucharov CC, Sucharov J, Karimpour-Fard A, Nunley K, Stauffer BL, Miyamoto SD. Micro-RNA expression in hypoplastic left heart syndrome. J Card Fail. 2015 Jan;21(1):83-8. PubMed PMID: 25291457
  • Nakano SJ, Miyamoto SD, Movsesian M, Nelson P, Stauffer BL, Sucharov CC. Age-related differences in phosphodiesterase activity and effects of chronic phosphodiesterase inhibition in idiopathic dilated cardiomyopathy. Circ Heart Fail. 2015 Jan;8(1):57-63. PubMed PMID: 25278000
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Professional Memberships

  • American College of Cardiology, Fellow
  • American College of Physicians, Fellow
  • American Physiological Society, Member
  • American Heart Association, Member

Practice Locations

UCHealth University of Colorado Hospital (UCH)
12605 E. 16th Ave
Aurora, CO 80045
720-848-0000

Denver Health
777 Bannock St
Denver, CO 80204
303-436-6000

Hospital Affiliation
  • University of Colorado Hospital
  • Denver Health Medical Center
Center Affiliations

Specialty Information

Specialties
  • Cardiovascular Disease, Board Certification (2005, 2015)
  • Internal Medicine, Board Certification (1999)
  • Cardiology, Board Certification (2005, 2015)

General Information

Medical Schools:
  • MD, Pennsylvania State University College of Medicine (1996)
Undergraduate Schools:
  • BS, Eastern Mennonite University (VA) (1991)
Internships:
  • Case Western Reserve University-Cleveland Clinic Foundation-MetroHealth Medical Center Program (1997)
Residency Programs:
  • Case Western Reserve University-Cleveland Clinic Foundation-MetroHealth Medical Center Program, Internal Medicine (1999)
Fellowships:
  • University of Colorado (University Hospital) Program, Cardiovascular Disease (2005)
Download CV
Languages: English
Department: Medicine-Cardiology
Contact Us
CU Anschutz
Fitzsimons Building

13001 East 17th Place
Campus Box C290
Aurora, CO 80045

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