Edward Lau, PhD
Assistant Professor, Medicine-Cardiology

Photo
Graduate School :
  • PhD, University of California, Los Angeles
Undergraduate School:
  • BA, University of California–Berkeley (CA)
Department: Medicine-Cardiology

Research Interests

I am interested in understanding intercellular communications and crosstalk in the heart using human induced pluripotent stem cell models and bioinformatics methods. Please see our website for details https://www.laulab.net.

Publications

  • Han Y, Wright JM, Lau E, Lam MPY. Determining Alternative Protein Isoform Expression Using RNA Sequencing and Mass Spectrometry. STAR Protoc. 2020 Dec 18;1(3):100138. PubMed PMID: 33377032
  • Chandy M, Rhee JW, Ozen MO, Williams DR, Pepic L, Liu C, Zhang H, Malisa J, Lau E, Demirci U, Wu JC. Atlas of Exosomal microRNAs Secreted From Human iPSC-Derived Cardiac Cell Types. Circulation. 2020 Nov 3;142(18):1794-1796. PubMed PMID: 33136510
  • Dostal V, Wood SD, Thomas CT, Han Y, Lau E, Lam MPY. Proteomic signatures of acute oxidative stress response to paraquat in the mouse heart. Sci Rep. 2020 Oct 28;10(1):18440. PubMed PMID: 33116222
  • Rhee JW, Yi H, Thomas D, Lam CK, Belbachir N, Tian L, Qin X, Malisa J, Lau E, Paik DT, Kim Y, Choi BS, Sayed N, Sallam K, Liao R, Wu JC. Modeling Secondary Iron Overload Cardiomyopathy with Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes. Cell Rep. 2020 Jul 14;32(2):107886. PubMed PMID: 32668256
  • Zhang JX, Lau E, Paik DT, Zhuge Y, Wu JC. High-throughput Preparation of DNA, RNA, and Protein from Cryopreserved Human iPSCs for Multi-omics Analysis. Curr Protoc Stem Cell Biol. 2020 Sep;54(1):e114. PubMed PMID: 32584494
  • Lau E, Paik DT, Wu JC. Systems-Wide Approaches in Induced Pluripotent Stem Cell Models. Annu Rev Pathol. 2019 Jan 24;14:395-419. PubMed PMID: 30379619
  • Seeger T, Shrestha R, Lam CK, Chen C, McKeithan WL, Lau E, Wnorowski A, McMullen G, Greenhaw M, Lee J, Oikonomopoulos A, Lee S, Yang H, Mercola M, Wheeler M, Ashley EA, Yang F, Karakikes I, Wu JC. A Premature Termination Codon Mutation in MYBPC3 Causes Hypertrophic Cardiomyopathy via Chronic Activation of Nonsense-Mediated Decay. Circulation. 2019 Feb 5;139(6):799-811. PubMed PMID: 30586709
  • Lau E, Han Y, Williams DR, Thomas CT, Shrestha R, Wu JC, Lam MPY. Splice-Junction-Based Mapping of Alternative Isoforms in the Human Proteome. Cell Rep. 2019 Dec 10;29(11):3751-3765.e5. PubMed PMID: 31825849
  • Lee J, Termglinchan V, Diecke S, Itzhaki I, Lam CK, Garg P, Lau E, Greenhaw M, Seeger T, Wu H, Zhang JZ, Chen X, Gil IP, Ameen M, Sallam K, Rhee JW, Churko JM, Chaudhary R, Chour T, Wang PJ, Snyder MP, Chang HY, Karakikes I, Wu JC. Activation of PDGF pathway links LMNA mutation to dilated cardiomyopathy. Nature. 2019 Aug;572(7769):335-340. PubMed PMID: 31316208
  • Olmeta-Schult F, Segal LM, Tyner S, Moon TA, Chow RD, Chakrabarty P, Pacesa M, Podgornaia AI, Chen J, Singh B, Cao B, Sidhu RRS, Tan BWQ, Sood P, Parker S, Scult MA, Van Haute D, Konstantinides N, Schwendimann BA, Srivastava S, Fiorenza R, Dutton-Regester K, Hale R, Polat EO, Lau E, Mayer AL, White ER. NextGen VOICES: Research resolutions. Science. 2018 Jan 5;359(6371):26-28. PubMed PMID: 29301998
  • Lee AS, Inayathullah M, Lijkwan MA, Zhao X, Sun W, Park S, Hong WX, Parekh MB, Malkovskiy AV, Lau E, Qin X, Pothineni VR, Sanchez-Freire V, Zhang WY, Kooreman NG, Ebert AD, Chan CKF, Nguyen PK, Rajadas J, Wu JC. Prolonged survival of transplanted stem cells after ischaemic injury via the slow release of pro-survival peptides from a collagen matrix. Nat Biomed Eng. 2018 Feb;2(2):104-113. PubMed PMID: 29721363
  • Lau E, Venkatraman V, Thomas CT, Wu JC, Van Eyk JE, Lam MPY. Identifying High-Priority Proteins Across the Human Diseasome Using Semantic Similarity. J Proteome Res. 2018 Dec 7;17(12):4267-4278. PubMed PMID: 30256117
  • Lau E, Wu JC. Omics, Big Data, and Precision Medicine in Cardiovascular Sciences. Circ Res. 2018 Apr 27;122(9):1165-1168. PubMed PMID: 29700063
  • Lam MP, Venkatraman V, Xing Y, Lau E, Cao Q, Ng DC, Su AI, Ge J, Van Eyk JE, Ping P. Data-Driven Approach To Determine Popular Proteins for Targeted Proteomics Translation of Six Organ Systems. J Proteome Res. 2016 Nov 4;15(11):4126-4134. PubMed PMID: 27356587
  • Gramolini A, Lau E, Liu PP. Identifying Low-Abundance Biomarkers: Aptamer-Based Proteomics Potentially Enables More Sensitive Detection in Cardiovascular Diseases. Circulation. 2016 Jul 26;134(4):286-9. PubMed PMID: 27444931
  • Lam MP, Lau E, Ng DC, Wang D, Ping P. Cardiovascular proteomics in the era of big data: experimental and computational advances. Clin Proteomics. 2016;13:23. PubMed PMID: 27980500
  • Lau E, Watson KE, Ping P. Connecting the Dots: From Big Data to Healthy Heart. Circulation. 2016 Aug 2;134(5):362-4. PubMed PMID: 27481999
  • Kudelko M, Chan CW, Sharma R, Yao Q, Lau E, Chu IK, Cheah KS, Tanner JA, Chan D. Label-Free Quantitative Proteomics Reveals Survival Mechanisms Developed by Hypertrophic Chondrocytes under ER Stress. J Proteome Res. 2016 Jan 4;15(1):86-99. PubMed PMID: 26587667
  • Lam MP, Venkatraman V, Cao Q, Wang D, Dincer TU, Lau E, Su AI, Xing Y, Ge J, Ping P, Van Eyk JE. Prioritizing Proteomics Assay Development for Clinical Translation. J Am Coll Cardiol. 2015 Jul 14;66(2):202-4. PubMed PMID: 26160638
  • Chan XC, Black CM, Lin AJ, Ping P, Lau E. Mitochondrial protein turnover: methods to measure turnover rates on a large scale. J Mol Cell Cardiol. 2015 Jan;78:54-61. PubMed PMID: 25451168
  • Lau E, Huang D, Cao Q, Dincer TU, Black CM, Lin AJ, Lee JM, Wang D, Liem DA, Lam MP, Ping P. Spatial and temporal dynamics of the cardiac mitochondrial proteome. Expert Rev Proteomics. 2015 Apr;12(2):133-46. PubMed PMID: 25752359
View All (21 Total) View Less

Practice Locations

University of Colorado Hospital (UCH)
12605 E. 16th Ave
Aurora, CO 80045
720-848-0000

Specialty Information

Specialties
  • Psychology

General Information

Graduate Schools:
  • PhD, University of California, Los Angeles (0001)
Undergraduate Schools:
  • BA, University of California–Berkeley (CA) (0001)
Department: Medicine-Cardiology
Contact Us
CU Anschutz
Fitzsimons Building

13001 East 17th Place
Campus Box C290
Aurora, CO 80045

Update My Profile
;