Marilyn Manco-Johnson, MD
Professor, Pediatrics-Heme/Onc and Bone Marrow Transplantation

Photo
Medical School:
  • MD, Jefferson Medical College of Thomas Jefferson University (1974)
Undergraduate School:
  • BS, Pennsylvania State University (PA) (1972)
Internship:
  • University of Colorado (1975)
Residency:
  • University of Colorado, Pediatrics (1977)
Fellowships:
  • University of Colorado, Pediatric Hematology / Oncology (1981)
Languages: English
Department: Pediatrics-Heme/Onc and Bone Marrow Transplantation

Recognition & Awards

  • Researcher of the Year, National Hemophilia Foundation, (2007)

Research Interests

I direct a wide variety of research studies designed to define optimal treatments for children with hemophilia and other bleeding disorders. My work on prophylactic use of clotting factor concentrates has revolutionized the treatment of children with severe hemophilia.

Teaching

  • Professor (1995)
    School of Medicine, Pediatrics

Publications

  • Lehmann M, Ashworth K, Manco-Johnson M, Di Paola J, Neeves KB, Ng CJ. Evaluation of a microfluidic flow assay to screen for von Willebrand disease and low von Willebrand factor levels. J Thromb Haemost. 2017 Oct 24. [Epub ahead of print] PubMed PMID: 29064615
  • Manco-Johnson MJ, Lundin B, Funk S, Peterfy C, Raunig D, Werk M, Kempton CL, Reding MT, Goranov S, Gercheva L, Rusen L, Uscatescu V, Pierdominici M, Engelen S, Pocoski J, Walker D, Hong W. Effect of late prophylaxis in hemophilia on joint status: a randomized trial. J Thromb Haemost. 2017 Nov;15(11):2115-2124. PubMed PMID: 28836341
  • Andersson NG, Auerswald G, Barnes C, Carcao M, Dunn AL, Fijnvandraat K, Hoffmann M, Kavakli K, Kenet G, Kobelt R, Kurnik K, Liesner R, Mäkipernaa A, Manco-Johnson MJ, Mancuso ME, Molinari AC, Nolan B, Perez Garrido R, Petrini P, Platokouki HE, Shapiro AD, Wu R, Ljung R. Intracranial haemorrhage in children and adolescents with severe haemophilia A or B - the impact of prophylactic treatment. Br J Haematol. 2017 Oct;179(2):298-307. PubMed PMID: 28699675
  • Manco-Johnson MJ, Soucie JM, Gill JC. Prophylaxis usage, bleeding rates, and joint outcomes of hemophilia, 1999 to 2010: a surveillance project. Blood. 2017 Apr 27;129(17):2368-2374. PubMed PMID: 28183693
  • Kulkarni R, Presley RJ, Lusher JM, Shapiro AD, Gill JC, Manco-Johnson M, Koerper MA, Abshire TC, DiMichele D, Hoots WK, Mathew P, Nugent DJ, Geraghty S, Evatt BL, Soucie JM. Complications of haemophilia in babies (first two years of life): a report from the Centers for Disease Control and Prevention Universal Data Collection System. Haemophilia. 2016 Nov 4. [Epub ahead of print] PubMed PMID: 27813214
  • Fischer K, Poonnoose P, Dunn AL, Babyn P, Manco-Johnson MJ, David JA, van der Net J, Feldman B, Berger K, Carcao M, de Kleijn P, Silva M, Hilliard P, Doria A, Srivastava A, Blanchette V. Choosing outcome assessment tools in haemophilia care and research: a multidisciplinary perspective. Haemophilia. 2016 Sep 15. [Epub ahead of print] PubMed PMID: 27633342
  • Kulkarni R, Presley RJ, Lusher JM, Shapiro AD, Gill JC, Manco-Johnson M, Koerper MA, Abshire TC, DiMichele D, Hoots WK, Mathew P, Nugent DJ, Geraghty S, Evatt BL, Soucie JM. Complications of haemophilia in babies (first two years of life): a report from the Centers for Disease Control and Prevention Universal Data Collection System. Haemophilia. 2016 Nov 4. [Epub ahead of print] PubMed PMID: 27813214
  • Boylan B, Rice AS, Neff AT, Manco-Johnson MJ, Kempton CL, Miller CH. Survey of the anti-factor IX immunoglobulin profiles in patients with hemophilia B using a fluorescence-based immunoassay. J Thromb Haemost. 2016 Oct;14(10):1931-1940. PubMed PMID: 27501440
  • Fischer K, Poonnoose P, Dunn AL, Babyn P, Manco-Johnson MJ, David JA, van der Net J, Feldman B, Berger K, Carcao M, de Kleijn P, Silva M, Hilliard P, Doria A, Srivastava A, Blanchette V. Choosing outcome assessment tools in haemophilia care and research: a multidisciplinary perspective. Haemophilia. 2016 Sep 15. [Epub ahead of print] PubMed PMID: 27633342
  • Bernard TJ, Beslow LA, Manco-Johnson MJ, Armstrong-Wells J, Boada R, Weitzenkamp D, Hollatz A, Poisson S, Amlie-Lefond C, Lo W, deVeber G, Goldenberg NA, Dowling MM, Roach ES, Fullerton HJ, Benseler SM, Jordan LC, Kirton A, Ichord RN. Inter-Rater Reliability of the CASCADE Criteria: Challenges in Classifying Arteriopathies. Stroke. 2016 Oct;47(10):2443-9. PubMed PMID: 27633024
  • Peyvandi F, Mannucci PM, Garagiola I, El-Beshlawy A, Elalfy M, Ramanan V, Eshghi P, Hanagavadi S, Varadarajan R, Karimi M, Manglani MV, Ross C, Young G, Seth T, Apte S, Nayak DM, Santagostino E, Mancuso ME, Sandoval Gonzalez AC, Mahlangu JN, Bonanad Boix S, Cerqueira M, Ewing NP, Male C, Owaidah T, Soto Arellano V, Kobrinsky NL, Majumdar S, Perez Garrido R, Sachdeva A, Simpson M, Thomas M, Zanon E, Antmen B, Kavakli K, Manco-Johnson MJ, Martinez M, Marzouka E, Mazzucconi MG, Neme D, Palomo Bravo A, Paredes Aguilera R, Prezotti A, Schmitt K, Wicklund BM, Zulfikar B, Rosendaal FR. A Randomized Trial of Factor VIII and Neutralizing Antibodies in Hemophilia A. N Engl J Med. 2016 May 26;374(21):2054-64. PubMed PMID: 27223147
  • Flood VH, Christopherson PA, Gill JC, Friedman KD, Haberichter SL, Bellissimo DB, Udani RA, Dasgupta M, Hoffmann RG, Ragni MV, Shapiro AD, Lusher JM, Lentz SR, Abshire TC, Leissinger C, Hoots WK, Manco-Johnson MJ, Gruppo RA, Boggio LN, Montgomery KT, Goodeve AC, James PD, Lillicrap D, Peake IR, Montgomery RR. Clinical and laboratory variability in a cohort of patients diagnosed with type 1 VWD in the United States. Blood. 2016 May 19;127(20):2481-8. PubMed PMID: 26862110
  • Manco-Johnson MJ, Bomgaars L, Palascak J, Shapiro A, Geil J, Fritsch S, Pavlova BG, Gelmont D. Efficacy and safety of protein C concentrate to treat purpura fulminans and thromboembolic events in severe congenital protein C deficiency. Thromb Haemost. 2016 Jul 4;116(1):58-68. PubMed PMID: 27052576
  • Ljung R, Fischer K, Carcao M, Santagostino E, Manco-Johnson MJ, Mathew P. Practical considerations in choosing a factor VIII prophylaxis regimen: Role of clinical phenotype and trough levels. Thromb Haemost. 2016 May 2;115(5):913-20. PubMed PMID: 26791493
  • Tiede A, Oldenburg J, Lissitchkov T, Knaub S, Bichler J, Manco-Johnson MJ. Prophylaxis vs. on-demand treatment with Nuwiq(®) (Human-cl rhFVIII) in adults with severe haemophilia A. Haemophilia. 2015 Nov 19. [Epub ahead of print] PubMed PMID: 26582282
  • Boylan B, Rice AS, Neff AT, Manco-Johnson MJ, Kempton CL, Miller CH. Survey of the anti-factor IX immunoglobulin profiles in patients with hemophilia B using a fluorescence-based immunoassay. J Thromb Haemost. 2016 Oct;14(10):1931-1940. PubMed PMID: 27501440
  • Tiede A, Oldenburg J, Lissitchkov T, Knaub S, Bichler J, Manco-Johnson MJ. Prophylaxis vs. on-demand treatment with Nuwiq(®) (Human-cl rhFVIII) in adults with severe haemophilia A. Haemophilia. 2015 Nov 19. [Epub ahead of print] PubMed PMID: 26582282
  • Ljung R, Fischer K, Carcao M, Santagostino E, Manco-Johnson MJ, Mathew P. Practical considerations in choosing a factor VIII prophylaxis regimen: Role of clinical phenotype and trough levels. Thromb Haemost. 2016 May 2;115(5):913-20. PubMed PMID: 26791493
  • Flood VH, Christopherson PA, Gill JC, Friedman KD, Haberichter SL, Bellissimo DB, Udani RA, Dasgupta M, Hoffmann RG, Ragni MV, Shapiro AD, Lusher JM, Lentz SR, Abshire TC, Leissinger C, Hoots WK, Manco-Johnson MJ, Gruppo RA, Boggio LN, Montgomery KT, Goodeve AC, James PD, Lillicrap D, Peake IR, Montgomery RR. Clinical and laboratory variability in a cohort of patients diagnosed with type 1 VWD in the United States. Blood. 2016 May 19;127(20):2481-8. PubMed PMID: 26862110
  • Manco-Johnson MJ, Bomgaars L, Palascak J, Shapiro A, Geil J, Fritsch S, Pavlova BG, Gelmont D. Efficacy and safety of protein C concentrate to treat purpura fulminans and thromboembolic events in severe congenital protein C deficiency. Thromb Haemost. 2016 Jul 4;116(1):58-68. PubMed PMID: 27052576
  • Bernard TJ, Beslow LA, Manco-Johnson MJ, Armstrong-Wells J, Boada R, Weitzenkamp D, Hollatz A, Poisson S, Amlie-Lefond C, Lo W, deVeber G, Goldenberg NA, Dowling MM, Roach ES, Fullerton HJ, Benseler SM, Jordan LC, Kirton A, Ichord RN. Inter-Rater Reliability of the CASCADE Criteria: Challenges in Classifying Arteriopathies. Stroke. 2016 Oct;47(10):2443-9. PubMed PMID: 27633024
  • Peyvandi F, Mannucci PM, Garagiola I, El-Beshlawy A, Elalfy M, Ramanan V, Eshghi P, Hanagavadi S, Varadarajan R, Karimi M, Manglani MV, Ross C, Young G, Seth T, Apte S, Nayak DM, Santagostino E, Mancuso ME, Sandoval Gonzalez AC, Mahlangu JN, Bonanad Boix S, Cerqueira M, Ewing NP, Male C, Owaidah T, Soto Arellano V, Kobrinsky NL, Majumdar S, Perez Garrido R, Sachdeva A, Simpson M, Thomas M, Zanon E, Antmen B, Kavakli K, Manco-Johnson MJ, Martinez M, Marzouka E, Mazzucconi MG, Neme D, Palomo Bravo A, Paredes Aguilera R, Prezotti A, Schmitt K, Wicklund BM, Zulfikar B, Rosendaal FR. A Randomized Trial of Factor VIII and Neutralizing Antibodies in Hemophilia A. N Engl J Med. 2016 May 26;374(21):2054-64. PubMed PMID: 27223147
  • Tiede A, Oldenburg J, Lissitchkov T, Knaub S, Bichler J, Manco-Johnson MJ. Prophylaxis vs. on-demand treatment with Nuwiq(®) (Human-cl rhFVIII) in adults with severe haemophilia A. Haemophilia. 2015 Nov 19. [Epub ahead of print] PubMed PMID: 26582282
  • Antun A, Monahan PE, Manco-Johnson MJ, Callaghan MU, Kanin M, Knoll C, Carpenter SL, Davis JA, Guerrera MF, Kruse-Jarres R, Ragni MV, Witmer C, McCracken CE, Kempton CL. Inhibitor recurrence after immune tolerance induction: a multicenter retrospective cohort study. J Thromb Haemost. 2015 Nov;13(11):1980-8. PubMed PMID: 26382916
  • Faiz AS, Khan I, Beckman MG, Bockenstedt P, Heit JA, Kulkarni R, Manco-Johnson M, Moll S, Ortel TL, Philipp CS. Characteristics and Risk Factors of Cancer Associated Venous Thromboembolism. Thromb Res. 2015 Sep;136(3):535-41. PubMed PMID: 26168693
  • Goldenberg NA, Abshire T, Blatchford PJ, Fenton LZ, Halperin JL, Hiatt WR, Kessler CM, Kittelson JM, Manco-Johnson MJ, Spyropoulos AC, Steg PG, Stence NV, Turpie AG, Schulman S. Multicenter randomized controlled trial on Duration of Therapy for Thrombosis in Children and Young Adults (the Kids-DOTT trial): pilot/feasibility phase findings. J Thromb Haemost. 2015 Sep;13(9):1597-605. PubMed PMID: 26118944
  • Lewis DA, Suchindran S, Beckman MG, Hooper WC, Grant AM, Heit JA, Manco-Johnson M, Moll S, Philipp CS, Kenney K, De Staercke C, Pyle ME, Chi JT, Ortel TL. Whole blood gene expression profiles distinguish clinical phenotypes of venous thromboembolism. Thromb Res. 2015 Apr;135(4):659-65. PubMed PMID: 25684211
  • Nakar C, Manco-Johnson MJ, Lail A, Donfield S, Maahs J, Chong Y, Blades T, Shapiro A. Prompt immune tolerance induction at inhibitor diagnosis regardless of titre may increase overall success in haemophilia A complicated by inhibitors: experience of two US centres. Haemophilia. 2015 Jan 11. [Epub ahead of print] PubMed PMID: 25581638
  • Armstrong-Wells J, Donnelly M, Post MD, Manco-Johnson MJ, Winn VD, Sébire G. Inflammatory predictors of neurologic disability after preterm premature rupture of membranes. Am J Obstet Gynecol. 2014 Sep 16. [Epub ahead of print] PubMed PMID: 25223243
  • Goldenberg NA, Jenkins S, Jack J, Armstrong-Wells J, Fenton LZ, Stence NV, Oleszek J, Boada R, Wilkening GN, Wilkinson C, Soep JB, Miyamoto SD, Bajaj L, Mourani PM, Manco-Johnson MJ, Bernard TJ. Arteriopathy, D-Dimer, and Risk of Poor Neurologic Outcome in Childhood-Onset Arterial Ischemic Stroke. J Pediatr. 2012 Dec 19. [Epub ahead of print] PubMed PMID: 23260102
  • Kelly D, C Zhang Q, M Soucie J, Manco-Johnson M, Dimichele D, the Joint Outcome Subcommittee of the Coordinating Committee for the Universal Data Collection Database and the Hemophilia Treatment Center Network Investigators. Prevalence of clinical hip abnormalities in haemophilia A and B: an analysis of the UDC database. Haemophilia. 2012 Dec 17. [Epub ahead of print] PubMed PMID: 23252621
  • Ortel TL, Kitchens CS, Erkan D, Brandão LR, Hahn S, James AH, Kulkarni R, Manco-Johnson MJ, Pericak-Vance M, Vance J. Clinical causes and treatment of the thrombotic storm. Expert Rev Hematol. 2012 Dec;5(6):653-9. PubMed PMID: 23216595
  • Hancock HS, Wang M, Gist KM, Gibson E, Miyamoto SD, Mourani PM, Manco-Johnson MJ, Goldenberg NA. Cardiac findings and long-term thromboembolic outcomes following pulmonary embolism in children: a combined retrospective-prospective inception cohort study. Cardiol Young. 2012 Oct 22;:1-9. [Epub ahead of print] PubMed PMID: 23088931
  • Manco-Johnson MJ. Collision sports and risk of bleeding in children with hemophilia. JAMA. 2012 Oct 10;308(14):1480-1. PubMed PMID: 23047364
  • Soucie JM, De Staercke C, Monahan PE, Recht M, Chitlur MB, Gruppo R, Hooper WC, Kessler C, Kulkarni R, Manco-Johnson MJ, Powell J, Pyle M, Riske B, Sabio H, Trimble S, the US Hemophilia Treatment Center Network. Evidence for the transmission of parvovirus B19 in patients with bleeding disorders treated with plasma-derived factor concentrates in the era of nucleic acid test screening. Transfusion. 2012 Sep 24. [Epub ahead of print] PubMed PMID: 22998193
  • Lundin B, Manco-Johnson ML, Ignas DM, Moineddin R, Blanchette VS, Dunn AL, Gibikote SV, Keshava SN, Ljung R, Manco-Johnson MJ, Miller SF, Rivard GE, Doria AS, International Prophylaxis Study Group. An MRI scale for assessment of haemophilic arthropathy from the International Prophylaxis Study Group. Haemophilia. 2012 Nov;18(6):962-70. PubMed PMID: 22765835
  • Moruf A, Spyropoulos AC, Schardt TQ, Gibson E, Manco-Johnson MJ, Wang M, Goldenberg NA. Peri-procedural bridging with low molecular weight heparin in patients receiving warfarin for venous thromboembolism: a pediatric experience. Thromb Res. 2012 Oct;130(4):612-5. PubMed PMID: 22749329
  • Pearson V, Ruzas C, Krebs NF, Goldenberg NA, Manco-Johnson MJ, Bernard TJ. Overweight and Obesity Are Increased in Childhood-Onset Cerebrovascular Disease. J Child Neurol. 2012 May 30. [Epub ahead of print] PubMed PMID: 22647484
  • Manco-Johnson MJ, Wang M, Goldenberg NA, Soep J, Gibson E, Knoll CM, Mourani PM. Treatment, survival, and thromboembolic outcomes of thrombotic storm in children. J Pediatr. 2012 Oct;161(4):682-8.e1. PubMed PMID: 22578585
  • Bombardier C, Villalobos-Menuey E, Ruegg K, Hathaway WE, Manco-Johnson MJ, Goldenberg NA. Monitoring hypercoagulability and hypofibrinolysis following acute venous Thromboembolism in children: application of the CloFAL assay in a prospective inception cohort study. Thromb Res. 2012 Sep;130(3):343-9. PubMed PMID: 22551977
  • Kedia S, Stence N, Manco-Johnson M, Armstrong-Wells J, Bernard TJ. Late cytotoxic edema in 2 children with hemiplegia: hemiplegic migraine or stroke?. Headache. 2012 Apr;52(4):674-8. PubMed PMID: 22404149
  • Bernard TJ, Manco-Johnson MJ, Lo W, MacKay MT, Ganesan V, DeVeber G, Goldenberg NA, Armstrong-Wells J, Dowling MM, Roach ES, Tripputi M, Fullerton HJ, Furie KL, Benseler SM, Jordan LC, Kirton A, Ichord R. Towards a consensus-based classification of childhood arterial ischemic stroke. Stroke. 2012 Feb;43(2):371-7. PubMed PMID: 22156694
  • Branchford BR, Mourani P, Bajaj L, Manco-Johnson M, Wang M, Goldenberg NA. Risk factors for in-hospital venous thromboembolism in children: a case-control study employing diagnostic validation. Haematologica. 2012 Apr;97(4):509-15. PubMed PMID: 22133768
  • Branchford BR, Gibson E, Manco-Johnson MJ, Goldenberg NA. Sensitivity of discharge diagnosis ICD-9 codes for pediatric venous thromboembolism is greater than specificity, but still suboptimal for surveillance and clinical research. Thromb Res. 2012 May;129(5):662-3. PubMed PMID: 22104422
  • Li C, Narkbunnam N, Samulski RJ, Asokan A, Hu G, Jacobson LJ, Manco-Johnson MJ, Monahan PE, Joint Outcome Study Investigators. Neutralizing antibodies against adeno-associated virus examined prospectively in pediatric patients with hemophilia. Gene Ther. 2012 Mar;19(3):288-94. PubMed PMID: 21697954
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Professional Memberships

  • Western Society for Pediatric Research (WSPR), Member
  • International Society for Thrombosis and Haemostasis, Member
  • American Society of Hematology, Member
  • American Society of Pediatric Hematology/Oncology, Member

Practice Locations

Children's Hospital Colorado
13123 East 16th Ave
Aurora, CO 80045
720-777-1234

Hemophilia & Thrombosis Center
13199 E. Montview Blvd
Suite 100
Aurora, CO 80045
303-724-0724

Hospital Affiliation
  • Children's Hospital Colorado
Center Affiliations

Specialty Information

Specialties
  • Pediatric Hematology / Oncology, Board Certification
Conditions & Treatments
  • Blood / Lymphatic System - Blood Disorders
  • Blood / Lymphatic System - Clotting Disorders
  • Blood / Lymphatic System - Bleeding Disorders
  • Cancers - Pediatric Cancer
  • Blood / Lymphatic System
  • Cancers
Clinical Interests
My clinical interests are Coagulation, Hemophilia and Thrombosis, and Neonatal Hematology

General Information

Medical Schools:
  • MD, Jefferson Medical College of Thomas Jefferson University (1974)
Undergraduate Schools:
  • BS, Pennsylvania State University (PA) (1972)
Internships:
  • University of Colorado (1975)
Residency Programs:
  • University of Colorado, Pediatrics (1977)
Fellowships:
  • University of Colorado, Pediatric Hematology / Oncology (1981)
Languages: English
Department: Pediatrics-Heme/Onc and Bone Marrow Transplantation
;