Jason Christie, PhD
Professor, Physiology & Biophysics

Publications

• Bonnan, A. Gaffield, M.A., Zhang, K., and Christie, J.M. (2023). Cerebellar motor memory expression requires learned alterations to the activity of inhibitory molecular layer interneurons.
• Bonnan, A., Gaffield, M.A., Zhang, K., and Christie, J.M. (2023). Cerebellar motor-memory expression requires learned alterations to the activity of inhibitory molecular layer interneurons. J. Neurosci. 43:601-612
• Chao, O.Y., Pathak, S.S., Zhang, H., Augustine, G., Christie, J.M., Kikuchi, C., Taniguchi, H., and Yang, Y-M. (2023). Social memory deficit gated by dysregulation of the cerebellar vermis. Nature Comm. 14:6007
• Zhang, K., Yang, Z., Gaffield, M.A., Gross, G.G., Arnold, D.B., and Christie, J.M. (2023). Molecular layer disinhibition unlocks climbing-fiber-instructed motor learning in the cerebellum. (bioRxiv: https://doi.org/10.1101/2023.08.04.552059)
• Gaffield, M.A., Sauerbrei, B.A., and Christie, J.M. (2022). The cerebellum encodes and influences the initiation and termination of discontinuous movements. eLife. 11e71464. PMCID: PMC907590
• Bonnan, A., Rowan, M.J.R., Baker, C.A., Bolton, M.M., and Christie, J.M. (2021). Autonomous Purkinje cell activation instructs bidirectional motor learning through evoked dendritic calcium signaling. Nature Comm. 12:2153.
• Jerez, D., Stuart, E., Schmitt, K., Guerrero-Given, D., Christie, J.M., Kamasawa, N., Smirnov, M.S. (2021). A deep learning approach to identifying immunogold particles in electron microscopy images. Scientific Reports. 11:7771.
• Gaffield, M.A., Bonnan, A., and Christie, J.M. (2019). Conversion of graded presynaptic climbing fiber activity into graded postsynaptic Ca2+ signals by Purkinje cell dendrites. Neuron. 102:762-769.
• Rowan, M.J.M.*, Bonnan, A.*, Zhang, K.*, Amat, A.B., Kikuchi, C., Taniguchi, H., Augustine, G., and Christie, J.M. (2018). Graded control of climbing fiber-mediated plasticity and learning by inhibition in the cerebellum. Neuron. 99: 999-1015.
• Gaffield, M.A., Rowan, M.J.M., Amat, A.B., Hirai, H., and Christie, J.M. (2018). Inhibition gates supralinear Ca2+ signaling in Purkinje cell dendrites during practiced movements. eLife. 7:e36246.
• Michaelson, S.D., Ozkan, E.D., Aceti, M., Maity, S., Llamosas, N., Weldon, M., Mizrachi, E., Vaissiere, T., Gaffield, M.A., Christie, J.M., Holder, J.L., Miller, C.A., Rumbaugh, G. (2018). The intellectual disability and autism gene SYNGAP1 regulates touch-related circuit function and behavior. Nature Neurosci. 21: 1704-1716.
• Rowan, M.J.M. and Christie, J.M. (2017). State-dependent alteration in Kv3 channel availability drives flexible synaptic signaling dependent on somatic subthreshold depolarization. Cell Reports. 18:2018-2029.
• Gaffield, M.A. and Christie, J.M. (2017). Movement rate is encoded and influenced by widespread, coherent activity of molecular layer interneurons in the cerebellum. J. Neurosci. 37:4751-4765.
• Amat, A.B.*, Rowan, M.J.M.*, Gaffield, M.A., Bonnan, A., Kikuchi, C., Taniguchi, H., and Christie, J.M. (2017). Using c-kit to genetically target cerebellar molecular layer interneurons in adult mice. PLoS One. 12:e0179347.
• Gaffield, M.A., Amat, S.B., Bito, H., and Christie, J.M. (2016). Chronic imaging of movement-related Purkinje cell activity in awake behaving mice. J. Neurophysiol. 115: 413-422.
• Rowan, M.J.M., DelCanto, G., Kamasawa, N., and Christie, J.M. (2016). Synapse-level determination of action potential duration by K+ channel clustering in axons. Neuron. 91:370-383.
• Rowan, M.J.M., Tranquil, E., and Christie, J.M. (2014). Distinct Kv channel subtypes uncouple spike signaling in the axonal initial segment and presynaptic boutons of cerebellar interneurons. J. Neurosci. 34: 6611-6623.
• Gaffield, M.A. and Christie, J.M. (2021). The cerebellum encodes and influences the initiation and termination of discontinuous movements. In revision, eLife (BioRxiv: 449622).
• Wu, W-C., Bradley, S.P., Christie, J.M., and Pugh, J.R. (2021). Mechanisms and consequences of cerebellar Purkinje cell disinhibition in a mouse model of Duchenne muscular dystrophy. In revision, J. Neurosci.
• Bonnan, A., Bradley, S.P., Zhang, K., and Christie, J.M. (2021) Cerebellar motor-memory expression requires learned alterations to the activity of inhibitory molecular layer interneurons. In review, eLife.