Joseph Cleveland, MD
Professor, Surgery-Cardiothoracic

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Medical School:
  • MD, University of Washington School of Medicine (1991)
Undergraduate School:
  • BS, University of Southern California (CA) (1987)
Internship:
  • University of Colorado (1992)
Residency:
  • University of Colorado, Chief Resident, Surgery (1998)
Fellowships:
  • University of Colorado, Thoracic and Cardiac (2001)
Languages: English
Department: Surgery-Cardiothoracic

Recognition & Awards

  • University of Colorado Hospital Outstanding Full Time Physician, University of Colorado Hospital (2015)
    Award given to outstanding full time physician by the UCH Medical Staff
  • President's Award for World Class Care, Recipient (2011)
  • Denver's Top Doctors, 5280 Magazine (2011)
  • Denver's Top Doctors, 5280 Magazine (2010)
  • 5th Annual Dwight McGoon National Teaching Award, AATS (2009)
    C0-recipient
  • Professionalism Award, Faculty Senate UCD (2007)

Research Interests

I'm interested in the effects of aging on heart surgery. My research also includes the evaluation of left ventricular assist devices as a bridge to heart transplantation and also for the treatment of advanced heart failure.

Teaching

  • Associate Professor (2005)
    School of Medicine, Surgery
  • Assistant Professor (2001)
    School of Medicine, Surgery

Publications

  • Beck DR, Foley L, Rowe JR, Moss AFD, Weitzel NS, Reece TB, Fullerton DA, Cleveland JC Jr, Bartels K. Right Ventricular Longitudinal Strain In Left Ventricular Assist Device Surgery-A Retrospective Cohort Study. J Cardiothorac Vasc Anesth. 2017 Dec;31(6):2096-2102. PubMed PMID: 29103855
  • Foley LS, Fullerton DA, Mares J, Sungelo M, Weyant MJ, Cleveland JC Jr, Reece TB. Erythropoietin's Beta Common Receptor Mediates Neuroprotection in Spinal Cord Neurons. Ann Thorac Surg. 2017 Dec;104(6):1909-1914. PubMed PMID: 29100648
  • Cleveland JC Jr. Functional survival: Alive and better. J Thorac Cardiovasc Surg. 2017 Dec;154(6):1988-1989. PubMed PMID: 28992968
  • Shroyer AL, Hattler B, Wagner TH, Collins JF, Baltz JH, Quin JA, Almassi GH, Kozora E, Bakaeen F, Cleveland JC Jr, Bishawi M, Grover FL. Five-Year Outcomes after On-Pump and Off-Pump Coronary-Artery Bypass. N Engl J Med. 2017 Aug 17;377(7):623-632. PubMed PMID: 28813218
  • Jessup M, Drazner MH, Book W, Cleveland JC Jr, Dauber I, Farkas S, Ginwalla M, Katz JN, Kirkwood P, Kittleson MM, Marine JE, Mather P, Morris AA, Polk DM, Sakr A, Schlendorf KH, Vorovich EE. 2017 ACC/AHA/HFSA/ISHLT/ACP Advanced Training Statement on Advanced Heart Failure and Transplant Cardiology (Revision of the ACCF/AHA/ACP/HFSA/ISHLT 2010 Clinical Competence Statement on Management of Patients With Advanced Heart Failure and Cardiac Transplant): A Report of the ACC Competency Management Committee. Circ Heart Fail. 2017 Jun;10(6). PubMed PMID: 28607153
  • Li F, Song R, Ao L, Reece TB, Cleveland JC Jr, Dong N, Fullerton DA, Meng X. ADAMTS5 Deficiency in Calcified Aortic Valves Is Associated With Elevated Pro-Osteogenic Activity in Valvular Interstitial Cells. Arterioscler Thromb Vasc Biol. 2017 Jul;37(7):1339-1351. PubMed PMID: 28546218
  • Song R, Fullerton DA, Ao L, Zhao KS, Reece TB, Cleveland JC Jr, Meng X. Altered MicroRNA Expression Is Responsible for the Pro-Osteogenic Phenotype of Interstitial Cells in Calcified Human Aortic Valves. J Am Heart Assoc. 2017 Apr 24;6(4). PubMed PMID: 28438736
  • Yao Q, Song R, Ao L, Cleveland JC Jr, Fullerton DA, Meng X. Neurotrophin 3 upregulates proliferation and collagen production in human aortic valve interstitial cells: a potential role in aortic valve sclerosis. Am J Physiol Cell Physiol. 2017 Jun 1;312(6):C697-C706. PubMed PMID: 28356268
  • Li F, Yao Q, Ao L, Cleveland JC Jr, Dong N, Fullerton DA, Meng X. Klotho suppresses high phosphate-induced osteogenic responses in human aortic valve interstitial cells through inhibition of Sox9. J Mol Med (Berl). 2017 Jul;95(7):739-751. PubMed PMID: 28332126
  • Patel AC, Dodson RB, Cornwell WK 3rd, Hunter KS, Cleveland JC Jr, Brieke A, Lindenfeld J, Ambardekar AV. Dynamic Changes in Aortic Vascular Stiffness in Patients Bridged to Transplant With Continuous-Flow Left Ventricular Assist Devices. JACC Heart Fail. 2017 Mar 4. [Epub ahead of print] PubMed PMID: 28285118
  • Hui H, Zhai Y, Ao L, Cleveland JC Jr, Liu H, Fullerton DA, Meng X. Klotho suppresses the inflammatory responses and ameliorates cardiac dysfunction in aging endotoxemic mice. Oncotarget. 2017 Feb 28;8(9):15663-15676. PubMed PMID: 28152512
  • Zeng Q, Song R, Fullerton DA, Ao L, Zhai Y, Li S, Ballak DB, Cleveland JC Jr, Reece TB, McKinsey TA, Xu D, Dinarello CA, Meng X. Interleukin-37 suppresses the osteogenic responses of human aortic valve interstitial cells in vitro and alleviates valve lesions in mice. Proc Natl Acad Sci U S A. 2017 Feb 14;114(7):1631-1636. PubMed PMID: 28137840
  • Aftab M, Cleveland JC Jr, Reece TB. Noteworthy Literature Published in 2016 for Cardiac Surgery. Semin Cardiothorac Vasc Anesth. 2017 Mar;21(1):30-35. PubMed PMID: 28134010
  • Mehra MR, Naka Y, Uriel N, Goldstein DJ, Cleveland JC Jr, Colombo PC, Walsh MN, Milano CA, Patel CB, Jorde UP, Pagani FD, Aaronson KD, Dean DA, McCants K, Itoh A, Ewald GA, Horstmanshof D, Long JW, Salerno C. A Fully Magnetically Levitated Circulatory Pump for Advanced Heart Failure. N Engl J Med. 2017 Feb 2;376(5):440-450. PubMed PMID: 27959709
  • Jacobs JP, Shahian DM, He X, O'Brien SM, Badhwar V, Cleveland JC Jr, Furnary AP, Magee MJ, Kurlansky PA, Rankin JS, Welke KF, Filardo G, Dokholyan RS, Peterson ED, Brennan JM, Han JM, McDonald D, Schmitz D, Edwards FH, Prager RL, Grover FL. Penetration, Completeness, and Representativeness of The Society of Thoracic Surgeons Adult Cardiac Surgery Database. Ann Thorac Surg. 2016 Jan;101(1):33-41. PubMed PMID: 26542437
  • Blum FE, Weiss GM, Cleveland JC Jr, Weitzel NS. Postoperative Management for Patients With Durable Mechanical Circulatory Support Devices. Semin Cardiothorac Vasc Anesth. 2015 Dec;19(4):318-30. PubMed PMID: 26660056
  • Wilkey BJ, Hanson R, Reece TB, Forman L, Burton JR Jr, Messenger JC, Kim MS, Cleveland JC Jr, Fiegel MJ, Nydam TL, Mandell MS. Transfemoral Transcatheter Aortic Valve Replacement for Mixed Aortic Valve Disease in Child's Class C Liver Disease Prior to Orthotopic Liver Transplantation: A Case Report. Semin Cardiothorac Vasc Anesth. 2015 Nov 29. [Epub ahead of print] PubMed PMID: 26620139
  • Jacobs JP, Shahian DM, Prager RL, Edwards FH, McDonald D, Han JM, D'Agostino RS, Jacobs ML, Kozower BD, Badhwar V, Thourani VH, Gaissert HA, Fernandez FG, Wright C, Fann JI, Paone G, Sanchez JA, Cleveland JC Jr, Brennan JM, Dokholyan RS, O'Brien SM, Peterson ED, Grover FL, Patterson GA. Introduction to the STS National Database Series: Outcomes Analysis, Quality Improvement, and Patient Safety. Ann Thorac Surg. 2015 Dec;100(6):1992-2000. PubMed PMID: 26525868
  • Shahian DM, He X, Jacobs JP, Kurlansky PA, Badhwar V, Cleveland JC Jr, Fazzalari FL, Filardo G, Normand SL, Furnary AP, Magee MJ, Rankin JS, Welke KF, Han J, O'Brien SM. The Society of Thoracic Surgeons Composite Measure of Individual Surgeon Performance for Adult Cardiac Surgery: A Report of The Society of Thoracic Surgeons Quality Measurement Task Force. Ann Thorac Surg. 2015 Oct;100(4):1315-24; discussion 1324-5. PubMed PMID: 26330012
  • Shahian DM, Grover FL, Prager RL, Edwards FH, Filardo G, O'Brien SM, He X, Furnary AP, Rankin JS, Badhwar V, Cleveland JC Jr, Fazzalari FL, Magee MJ, Han J, Jacobs JP. The Society of Thoracic Surgeons voluntary public reporting initiative: the first 4 years. Ann Surg. 2015 Sep;262(3):526-35; discussion 533-5. PubMed PMID: 26258322
  • Bennett DT, Zamora M, Reece TB, Mitchell JD, Cleveland JC Jr, Grover FL, Babu AN, Meguid RA, Fullerton DA, Weyant MJ. Continued Utility of Single-Lung Transplantation in Select Populations: Chronic Obstructive Pulmonary Disease. Ann Thorac Surg. 2015 Aug;100(2):437-42. PubMed PMID: 26141775
  • Yao Q, Song R, Ao L, Zhan Q, Cleveland JC Jr, Yu X, Fullerton DA, Meng X. Over-expression of neurotrophin 3 in human aortic valves affected by calcific disease induces the osteogenic responses via the Trk-Akt pathway. Biochim Biophys Acta. 2015 Sep;1852(9):1940-9. PubMed PMID: 26122822
  • Bell MT, Puskas F, Bennett DT, Cleveland JC Jr, Herson PS, Mares JM, Meng X, Weyant MJ, Fullerton DA, Brett Reece T. Clinical indicators of paraplegia underplay universal spinal cord neuronal injury from transient aortic occlusion. Brain Res. 2015 Aug 27;1618:55-60. PubMed PMID: 26005132
  • Foley LS, Fullerton DA, Bennett DT, Freeman KA, Mares J, Bell MT, Cleveland JC Jr, Weyant MJ, Meng X, Puskas F, Reece TB. Spinal Cord Ischemia-Reperfusion Injury Induces Erythropoietin Receptor Expression. Ann Thorac Surg. 2015 Jul;100(1):41-6; discussion 46. PubMed PMID: 25865765
  • Cleveland JC Jr. Invited commentary. Ann Thorac Surg. 2015 Apr;99(4):1334. PubMed PMID: 25841816
  • Freeman KA, Puskas F, Bell MT, Mares JM, Foley LS, Weyant MJ, Cleveland JC Jr, Fullerton DA, Meng X, Herson PS, Reece TB. Alpha-2 agonist attenuates ischemic injury in spinal cord neurons. J Surg Res. 2014 Dec 23. [Epub ahead of print] PubMed PMID: 25655994
  • Cleveland JC Jr, Reece TB. Noteworthy literature in cardiac surgery for 2014. Semin Cardiothorac Vasc Anesth. 2015 Mar;19(1):21-3. PubMed PMID: 25634929
  • Meyer DM, Rogers JG, Edwards LB, Callahan ER, Webber SA, Johnson MR, Vega JD, Zucker MJ, Cleveland JC Jr. The future direction of the adult heart allocation system in the United States. Am J Transplant. 2015 Jan;15(1):44-54. PubMed PMID: 25534445
  • Mares JM, Foley LS, Bell MT, Bennett DT, Freeman KA, Meng X, Weyant MJ, Cleveland JC Jr, Fullerton DA, Puskas F, Reece TB. Erythropoietin activates the phosporylated cAMP [adenosine 3'5' cyclic monophosphate] response element-binding protein pathway and attenuates delayed paraplegia after ischemia-reperfusion injury. J Thorac Cardiovasc Surg. 2014 Nov 13. [Epub ahead of print] PubMed PMID: 25500291
  • Freeman KA, Fullerton DA, Foley LS, Bell MT, Cleveland JC Jr, Weyant MJ, Mares J, Meng X, Puskas F, Reece TB. Spinal cord protection via alpha-2 agonist-mediated increase in glial cell-line-derived neurotrophic factor. J Thorac Cardiovasc Surg. 2014 Oct 15. [Epub ahead of print] PubMed PMID: 25454921
  • Reece TB, Cleveland JC Jr. Noteworthy Cardiac Surgical Literature in 2013. Semin Cardiothorac Vasc Anesth. 2014 Feb 3. [Epub ahead of print] PubMed PMID: 24492647
  • Cleveland JC Jr. Invited commentary. Ann Thorac Surg. 2014 Feb;97(2):616. PubMed PMID: 24484800
  • Nallamothu BK, Tommaso CL, Anderson HV, Malenka DJ, Anderson JL, Maniu CV, Cleveland JC Jr, McCabe KW, Dudley RA, Mortimer JD, Duffy PL, Patel MR, Faxon DP, Persell SD, Gurm HS, Rumsfeld JS, Hamilton LA, Shunk KA, Jensen NC, Smith SC Jr, Josephson RA, Stanko SJ, Watts B. ACC/AHA/SCAI/AMA-Convened PCPI/NCQA 2013 Performance Measures for Adults Undergoing Percutaneous Coronary Intervention: A Report of the American College of Cardiology /American Heart Association Task Force on Performance Measures, the Society for Cardiovascular Angiography and Interventions, the American Medical Association-Convened Physician Consortium for Performance Improvement, and the National Committee for Quality Assurance. J Am Coll Cardiol. 2013 Dec 17. [Epub ahead of print] PubMed PMID: 24361978
  • Nallamothu BK, Tommaso CL, Anderson HV, Anderson JL, Cleveland JC Jr, Dudley RA, Duffy PL, Faxon DP, Gurm HS, Hamilton LA, Jensen NC, Josephson RA, Malenka DJ, Maniu CV, McCabe KW, Mortimer JD, Patel MR, Persell SD, Rumsfeld JS, Shunk KA, Smith SC Jr, Stanko SJ, Watts B. ACC/AHA/SCAI/AMA-Convened PCPI/NCQA 2013 Performance Measures for Adults Undergoing Percutaneous Coronary Intervention: A Report of the American College of Cardiology/American Heart Association Task Force on Performance Measures, the Society for Cardiovascular Angiography and Interventions, the American Medical Association-Convened Physician Consortium for Performance Improvement, and the National Committee for Quality Assurance. Circulation. 2013 Dec 19. [Epub ahead of print] PubMed PMID: 24357402
  • Jones TS, Dunn CL, Wu DS, Cleveland JC Jr, Kile D, Robinson TN. Relationship between asking an older adult about falls and surgical outcomes. JAMA Surg. 2013 Dec;148(12):1132-8. PubMed PMID: 24108317
  • Bell MT, Puskas F, Agoston VA, Cleveland JC Jr, Freeman KA, Gamboni F, Herson PS, Meng X, Smith PD, Weyant MJ, Fullerton DA, Reece TB. Toll-like receptor 4-dependent microglial activation mediates spinal cord ischemia-reperfusion injury. Circulation. 2013 Sep 10;128(11 Suppl 1):S152-6. PubMed PMID: 24030400
  • Cleveland JC Jr. A perfect storm: type A aortic dissection and previous cardiac surgery. Circulation. 2013 Oct 8;128(15):1593-4. PubMed PMID: 24025593
  • Robinson TN, Wu DS, Sauaia A, Dunn CL, Stevens-Lapsley JE, Moss M, Stiegmann GV, Gajdos C, Cleveland JC Jr, Inouye SK. Slower walking speed forecasts increased postoperative morbidity and 1-year mortality across surgical specialties. Ann Surg. 2013 Oct;258(4):582-8; discussion 588-90. PubMed PMID: 23979272
  • Robinson TN, Wu DS, Pointer L, Dunn CL, Cleveland JC Jr, Moss M. Simple frailty score predicts postoperative complications across surgical specialties. Am J Surg. 2013 Oct;206(4):544-50. PubMed PMID: 23880071
  • Nadlonek N, Lee JH, Reece TB, Weyant MJ, Cleveland JC Jr, Meng X, Fullerton DA. Interleukin-1 Beta induces an inflammatory phenotype in human aortic valve interstitial cells through nuclear factor kappa Beta. Ann Thorac Surg. 2013 Jul;96(1):155-62. PubMed PMID: 23735716
  • Smith PD, Bell MT, Puskas F, Meng X, Cleveland JC Jr, Weyant MJ, Fullerton DA, Reece TB. Preservation of motor function after spinal cord ischemia and reperfusion injury through microglial inhibition. Ann Thorac Surg. 2013 May;95(5):1647-53. PubMed PMID: 23541432
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Professional Memberships

  • Society of Thoracic Surgeons, Workforce on Aging, Workforce on Surgical Treatment of End-Stage Cardiopulmonary Disease, Taskforce on Quality Initiatives, Workforce on Nomenclature and Coding, Workforce on National Databases
  • American Association for Thoracic Surgery, Member
  • Society of University Surgeons, Member
  • American College of Cardiology, Fellow
  • Western Thoracic Surgical Asociation, Program Committee
  • American College of Surgeons (ACS), Member
  • American College of Chest Physicians, Member
  • International Society of Heart and Lung Transplantation, Member
  • American Society of Transplant Surgeons, Member
  • American Geriatric Society, Member
  • Association for Academic Surgery, Member
  • American Physiological Society, Member
  • American Association for the Advancement of Science, Member
  • Denver Academy of Surgery, Member
  • Society of Critical Care Medicine, Member
  • Heart Failure Society of America, Member
  • Risk Management UCDHSC Sentinel Event Task Force, Invited Member
  • American Geriatric Society, Committee on Aging and Surgical Specialities
  • UNOS Region 8 Heart Review Board, Thoracic Committee Member
  • Donor Alliance, Medical Advisory Board
  • Essential Pharmaceuticals, Medical Advisory Board
  • American Heart Association (AHA), Member
  • American College of Cardiology, ACCF Council on Cardiovascular Care for Older Adults
  • INTERMAC, Committee Reviewer
  • American Medical Association, Member
  • AMA Physician Consortium for Performance Improvement, STS Representative
  • University of Colorado Hospital, Elected Member of the Medical Board

Practice Locations

UCH - Anschutz Outpatient Pavilion
1635 Aurora Ct
Aurora, CO 80045
720-848-0000

UCH - Anschutz Inpatient Pavilion
12605 E. 16th Ave
Aurora, CO 80045
720-848-0000

Hospital Affiliation
  • Denver Health Medical Center
  • University of Colorado Hospital
  • Veterans Affairs Medical Center
Center Affiliations

Specialty Information

Specialties
  • Thoracic and Cardiac, Board Certification (2002)
  • Surgery, Board Certification (1999)
  • Ventricular Assist Devices , Specialized Training (2001)
Conditions & Treatments
  • Heart and Circulation - Aneurysms
  • Heart and Circulation - Coronary Disease
  • Heart and Circulation - Heart Failure
  • Heart and Circulation - Heart Valve Diseases
  • Surgery - Heart Transplant Surgery
  • Heart and Circulation - Heart Diseases
  • Surgery - Cardiothoracic Surgery
  • Surgery - Open Heart Surgery
  • Surgery - Adult Cardiac Surgery
  • Heart and Circulation - Transcatheter Aortic Valve Replacement (TAVR)
  • Heart and Circulation
  • Surgery
  • Heart and Circulation - Structural Heart Disease
Clinical Interests
Heart valve surgery with expertise in mitral valve repair and aortic valve pathology, Ventricular Assist Devices (VAD), coronary artery bypass grafting surgery, and heart and lung transplantation. I am the surgical director of our VAD program and the surgical director of our heart transplant program.

Care Philosophy
I believe in providing the highest quality of care to my patients. I also ascribe to the mission statement of the University of Colorado Hospital.

Personal Interests
Golf, my family (wife and two teenage sons keep me busy), and travel.

Volunteer Activities
I serve on numerous national committees through the Society of Thoracic Surgeons. The committees seek to improve the quality of care to cardiac surgery patients. I provide “shadowing” opportunities for high school and college pre-med students.

General Information

Medical Schools:
  • MD, University of Washington School of Medicine (1991)
Undergraduate Schools:
  • BS, University of Southern California (CA) (1987)
Internships:
  • University of Colorado (1992)
Residency Programs:
  • University of Colorado, Chief Resident, Surgery (1998)
Fellowships:
  • University of Colorado, Thoracic and Cardiac (2001)
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Languages: English
Department: Surgery-Cardiothoracic
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