Isaac Harley, MD
Assistant Professor, Medicine-Rheumatology

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Medical School:
  • MD, University of Cincinnati College of Medicine (2014)
Graduate Schools :
  • MS, University of Oklahoma (2004)
  • PhD, University of Cincinnati (2014)
Undergraduate School:
  • BS, University of Oklahoma (OK) (2004)
Internship:
  • University of Colorado (2015)
Residency:
  • University of Colorado, Internal Medicine (2017)
Fellowships:
  • University of Colorado, Rheumatology (2020)
Languages: English
Department: Medicine-Rheumatology

Research Interests

– The etiology of Systemic Lupus Erythematosus – The application of genomics to improve care for rheumatic diseases – The genetics of systemic autoimmune and rheumatic diseases

Publications

  • Harris VM, Koelsch KA, Kurien BT, Harley ITW, Wren JD, Harley JB, Scofield RH. Characterization of cxorf21 Provides Molecular Insight Into Female-Bias Immune Response in SLE Pathogenesis. Front Immunol. 2019;10:2160. PubMed PMID: 31695690
  • Harley IT, Stankiewicz TE, Giles DA, Softic S, Flick LM, Cappelletti M, Sheridan R, Xanthakos SA, Steinbrecher KA, Sartor RB, Kohli R, Karp CL, Divanovic S. IL-17 signaling accelerates the progression of nonalcoholic fatty liver disease in mice. Hepatology. 2014 May;59(5):1830-9. PubMed PMID: 24115079
  • Vaughn SE, Foley C, Lu X, Patel ZH, Zoller EE, Magnusen AF, Williams AH, Ziegler JT, Comeau ME, Marion MC, Glenn SB, Adler A, Shen N, Nath S, Stevens AM, Freedman BI, Tsao BP, Jacob CO, Kamen DL, Brown EE, Gilkeson GS, Alarcón GS, Reveille JD, Anaya JM, James JA, Moser KL, Criswell LA, Vilá LM, Alarcón-Riquelme ME, Petri M, Scofield RH, Kimberly RP, Ramsey-Goldman R, Binjoo Y, Choi J, Bae SC, Boackle SA, Vyse TJ, Guthridge JM, Namjou B, Gaffney PM, Langefeld CD, Kaufman KM, Kelly JA, Harley IT, Harley JB, Kottyan LC. Lupus risk variants in the PXK locus alter B-cell receptor internalization. Front Genet. 2014;5:450. PubMed PMID: 25620976
  • Harley IT, Niewold TB, Stormont RM, Kaufman KM, Glenn SB, Franek BS, Kelly JA, Kilpatrick JR, Hutchings D, Divers J, Bruner GR, Edberg JC, McGwin G Jr, Petri MA, Ramsey-Goldman R, Reveille JD, Vilá-Pérez LM, Merrill JT, Gilkeson GS, Vyse TJ, Alarcón-Riquelme ME, Cho SK, Jacob CO, Alarcón GS, Moser KL, Gaffney PM, Kimberly RP, Bae SC, Langefeld CD, Harley JB, Guthridge JM, James JA. The role of genetic variation near interferon-kappa in systemic lupus erythematosus. J Biomed Biotechnol. 2010;2010. PubMed PMID: 20706608
  • Harley IT, Kaufman KM, Langefeld CD, Harley JB, Kelly JA. Genetic susceptibility to SLE: new insights from fine mapping and genome-wide association studies. Nat Rev Genet. 2009 May;10(5):285-90. PubMed PMID: 19337289

Professional Memberships

  • American College of Rheumatology, Member

Practice Locations

Rheumatology Clinic - Anschutz
1635 Aurora Ct
4th Floor
Aurora, CO 80045
720-848-7700

Hospital Affiliation
  • University of Colorado Hospital

Specialty Information

Specialties
  • Internal Medicine, Board Certification
  • Rheumatology, Board Certification
Conditions & Treatments
  • Immune System
  • Immune System - Autoimmune Disorders
Clinical Interests
- Systemic Lupus Erythematosus - Genetic Determinants of Autoimmune and Rheumatic Diseases

Care Philosophy
My goal is to provide excellent patient care. Doing so requires: 1) understanding each patient as a whole person – their goals, dreams and the challenges they face – and 2) forming a collaborative relationship so that we can work together to navigate diagnosis and treatment as it impacts their life.

General Information

Medical Schools:
  • MD, University of Cincinnati College of Medicine (2014)
Graduate Schools:
  • MS, University of Oklahoma (2004)
  • PhD, University of Cincinnati (2014)
Undergraduate Schools:
  • BS, University of Oklahoma (OK) (2004)
Internships:
  • University of Colorado (2015)
Residency Programs:
  • University of Colorado, Internal Medicine (2017)
Fellowships:
  • University of Colorado, Rheumatology (2020)
Languages: English
Department: Medicine-Rheumatology
Contact Us
CU Anschutz
Fitzsimons Building

13001 East 17th Place
Campus Box C290
Aurora, CO 80045

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