Eric Schmidt, MD
Professor, Medicine-Pulmonary Sciences & Critical Care

Professional Titles

• Professor

Recognition & Awards

• Fellow of the American Thoracic Society, American Thoracic Society (2019)
• Associate Editor, AJP-Lung, American Physiological Society (2019)
• American Thoracic Society Pulmonary Circulation Assembly Early Career Research Achievement Award, American Thoracic Society (2015)
• Giles F. Filley Memorial Award for Excellence in Respiratory Physiology and Medicine, American Physiological Society (2013)
• Outstanding Early Career Scholar Award, University of Colorado Department of Medicine (2013)
• Peak Performer Intensive Care Specialist, Rocky Mountain Hospital Medicine Symposium (2013)

Research Interests

Publications

• Beitler JR, Thompson BT, Baron RM, Bastarache JA, Denlinger LC, Esserman L, Gong MN, LaVange LM, Lewis RJ, Marshall JC, Martin TR, McAuley DF, Meyer NJ, Moss M, Reineck LA, Rubin E, Schmidt EP, Standiford TJ, Ware LB, Wong HR, Aggarwal NR, Calfee CS. Advancing precision medicine for acute respiratory distress syndrome. Lancet Respir Med. 2022 Jan;10(1):107-120. PubMed PMID: 34310901
• Shimoda LA, Bai C, Bartlett NW, Bastarache JA, Feghali-Bostwick C, Gunst SJ, Kuebler WM, Schmidt EP, Morty RE. Promoting our early career members at AJP-Lung : the Editorial Board Fellowship Program and the Next Generation Physiologist Highlights section at our Journal . Am J Physiol Lung Cell Mol Physiol. 2021 Nov 1;321(5):L844-L846. PubMed PMID: 34585617
• Douglas IS, Rosenthal CA, Swanson DD, Hiller T, Oakes J, Bach J, Whelchel C, Pickering J, George T, Kearns M, Hanley M, Mould K, Roark S, Mansoori J, Mehta A, Schmidt EP, Neumeier A. Safety and Outcomes of Prolonged Usual Care Prone Position Mechanical Ventilation to Treat Acute Coronavirus Disease 2019 Hypoxemic Respiratory Failure. Crit Care Med. 2021 Mar 1;49(3):490-502. PubMed PMID: 33405409
• Shimoda LA, Bai C, Bartlett NW, Bastarache JA, Feghali-Bostwick C, Kuebler WM, Prakash YS, Schmidt EP, Morty RE. Announcing the Editorial Board Fellowship Program of the American Journal of Physiology-Lung Cellular and Molecular Physiology . Am J Physiol Lung Cell Mol Physiol. 2021 Jul 1;321(1):L116-L118. PubMed PMID: 34105373
• Rizzo AN, Schmidt EP. ABO blood type: a window into the genetics of acute respiratory distress syndrome susceptibility. J Clin Invest. 2021 Jan 4;131(1). PubMed PMID: 33141764
• Oshima K, King SI, McMurtry SA, Schmidt EP. Endothelial Heparan Sulfate Proteoglycans in Sepsis: The Role of the Glycocalyx. Semin Thromb Hemost. 2021 Apr;47(3):274-282. PubMed PMID: 33794552
• Sullivan RC, Rockstrom MD, Schmidt EP, Hippensteel JA. Endothelial glycocalyx degradation during sepsis: Causes and consequences. Matrix Biol Plus. 2021 Dec;12:100094. PubMed PMID: 34917925
• Rizzo AN, Haeger SM, Oshima K, Yang Y, Wallbank AM, Jin Y, Lettau M, McCaig LA, Wickersham NE, McNeil JB, Zakharevich I, McMurtry SA, Langouët-Astrié CJ, Kopf KW, Voelker DR, Hansen KC, Shaver CM, Kerchberger VE, Peterson RA, Kuebler WM, Ochs M, Veldhuizen RA, Smith BJ, Ware LB, Bastarache JA, Schmidt EP. Alveolar epithelial glycocalyx degradation mediates surfactant dysfunction and contributes to acute respiratory distress syndrome. JCI Insight. 2021 Dec 7. [Epub ahead of print] PubMed PMID: 34874923
• Shimoda LA, Bai C, Bartlett NW, Bastarache JA, Feghali-Bostwick C, Gunst SJ, Kuebler WM, Schmidt EP, Morty RE. Promoting our early career members at AJP-Lung : the Editorial Board Fellowship Program and the Next Generation Physiologist Highlights section at our Journal . Am J Physiol Lung Cell Mol Physiol. 2021 Nov 1;321(5):L844-L846. PubMed PMID: 34585617
• Shimoda LA, Bai C, Bartlett NW, Bastarache JA, Feghali-Bostwick C, Kuebler WM, Prakash YS, Schmidt EP, Morty RE. Announcing the Editorial Board Fellowship Program of the American Journal of Physiology-Lung Cellular and Molecular Physiology . Am J Physiol Lung Cell Mol Physiol. 2021 Jul 1;321(1):L116-L118. PubMed PMID: 34105373
• Oshima K, King SI, McMurtry SA, Schmidt EP. Endothelial Heparan Sulfate Proteoglycans in Sepsis: The Role of the Glycocalyx. Semin Thromb Hemost. 2021 Apr;47(3):274-282. PubMed PMID: 33794552
• Douglas IS, Rosenthal CA, Swanson DD, Hiller T, Oakes J, Bach J, Whelchel C, Pickering J, George T, Kearns M, Hanley M, Mould K, Roark S, Mansoori J, Mehta A, Schmidt EP, Neumeier A. Safety and Outcomes of Prolonged Usual Care Prone Position Mechanical Ventilation to Treat Acute Coronavirus Disease 2019 Hypoxemic Respiratory Failure. Crit Care Med. 2021 Mar 1;49(3):490-502. PubMed PMID: 33405409
• LaRiviere WB, Han X, Oshima K, McMurtry SA, Linhardt RJ, Schmidt EP. Detection of Glycosaminoglycans by Polyacrylamide Gel Electrophoresis and Silver Staining. J Vis Exp. 2021 Feb 25;(168). PubMed PMID: 33720131
• Baron RM, Christman JW, Liu KD, Matthay MA, Self WH, McVerry BJ, Hite RD, Paine R 3rd, Wurfel MM, Shapiro NI, Adams PW, Schmidt EP, Ringwood N. Monitoring Research Blood Sampling in Critically Ill Patients: Avoiding Iatrogenic Anemia. Am J Respir Crit Care Med. 2020 Sep 15;202(6):885-887. PubMed PMID: 32357306
• LaRivière WB, Schmidt EP. Using the Extremes of Human Inflammation to Understand the Transcriptional Control of IL-18. Am J Respir Crit Care Med. 2020 Mar 1;201(5):503-504. PubMed PMID: 31898912
• LaRivière WB, Liao S, McMurtry SA, Oshima K, Han X, Zhang F, Yan S, Haeger SM, Ransom M, Bastarache JA, Linhardt RJ, Schmidt EP, Yang Y. Alveolar heparan sulfate shedding impedes recovery from bleomycin-induced lung injury. Am J Physiol Lung Cell Mol Physiol. 2020 Jun 1;318(6):L1198-L1210. PubMed PMID: 32320623
• Hippensteel JA, LaRiviere WB, Colbert JF, Langouët-Astrié CJ, Schmidt EP. Heparin as a therapy for COVID-19: current evidence and future possibilities. Am J Physiol Lung Cell Mol Physiol. 2020 Aug 1;319(2):L211-L217. PubMed PMID: 32519894
• Hippensteel JA, LaRiviere WB, Colbert JF, Langouët-Astrié CJ, Schmidt EP. Heparin as a therapy for COVID-19: current evidence and future possibilities. Am J Physiol Lung Cell Mol Physiol. 2020 Aug 1;319(2):L211-L217. PubMed PMID: 32519894
• Baron RM, Christman JW, Liu KD, Matthay MA, Self WH, McVerry BJ, Hite RD, Paine R 3rd, Wurfel MM, Shapiro NI, Adams PW, Schmidt EP, Ringwood N. Monitoring Research Blood Sampling in Critically Ill Patients: Avoiding Iatrogenic Anemia. Am J Respir Crit Care Med. 2020 Sep 15;202(6):885-887. PubMed PMID: 32357306
• LaRivière WB, Liao S, McMurtry SA, Oshima K, Han X, Zhang F, Yan S, Haeger SM, Ransom M, Bastarache JA, Linhardt RJ, Schmidt EP, Yang Y. Alveolar heparan sulfate shedding impedes recovery from bleomycin-induced lung injury. Am J Physiol Lung Cell Mol Physiol. 2020 Jun 1;318(6):L1198-L1210. PubMed PMID: 32320623
• Gómez BI, Dubick MA, Schmidt EP, Shupp JW, Burmeister DM. Plasma and Urinary Glycosaminoglycans as Evidence for Endotheliopathy in a Swine Burn Model. J Surg Res. 2020 Apr;248:28-37. PubMed PMID: 31841734
• Files DC, Hume PS, Krall J, Montemayor K, Schmidt EP, King LS. Grant Writing for Clinicians in Training: An Important Career Development Exercise. Chest. 2020 Apr;157(4):932-935. PubMed PMID: 31730834
• Gómez BI, Dubick MA, Schmidt EP, Shupp JW, Burmeister DM. Plasma and Urinary Glycosaminoglycans as Evidence for Endotheliopathy in a Swine Burn Model. J Surg Res. 2019 Dec 13;248:28-37. [Epub ahead of print] PubMed PMID: 31841734
• Files DC, Hume PS, Krall J, Montemayor K, Schmidt EP, King LS. Grant Writing for Clinicians in Training: An Important Career Development Exercise. Chest. 2019 Nov 12. [Epub ahead of print] PubMed PMID: 31730834
• Oshima K, Han X, Ouyang Y, El Masri R, Yang Y, Haeger SM, McMurtry SA, Lane TC, Davizon-Castillo P, Zhang F, Yue X, Vivès RR, Linhardt RJ, Schmidt EP. Loss of endothelial sulfatase-1 after experimental sepsis attenuates subsequent pulmonary inflammatory responses. Am J Physiol Lung Cell Mol Physiol. 2019 Nov 1;317(5):L667-L677. PubMed PMID: 31461325
• Hippensteel JA, Uchimido R, Tyler PD, Burke RC, Han X, Zhang F, McMurtry SA, Colbert JF, Lindsell CJ, Angus DC, Kellum JA, Yealy DM, Linhardt RJ, Shapiro NI, Schmidt EP. Intravenous fluid resuscitation is associated with septic endothelial glycocalyx degradation. Crit Care. 2019 Jul 23;23(1):259. PubMed PMID: 31337421
• Kwiecinski JM, Crosby HA, Valotteau C, Hippensteel JA, Nayak MK, Chauhan AK, Schmidt EP, Dufrêne YF, Horswill AR. Staphylococcus aureus adhesion in endovascular infections is controlled by the ArlRS-MgrA signaling cascade. PLoS Pathog. 2019 May;15(5):e1007800. PubMed PMID: 31116795
• Liao S, Eickelberg O, Schmidt EP, Yang Y. Direct Intrabronchial Administration to Improve the Selective Agent Deposition Within the Mouse Lung. J Vis Exp. 2019 May 20;(147). PubMed PMID: 31157786
• Zhang X, Han X, Xia K, Xu Y, Yang Y, Oshima K, Haeger SM, Perez MJ, McMurtry SA, Hippensteel JA, Ford JA, Herson PS, Liu J, Schmidt EP, Linhardt RJ. Circulating heparin oligosaccharides rapidly target the hippocampus in sepsis, potentially impacting cognitive functions. Proc Natl Acad Sci U S A. 2019 May 7;116(19):9208-9213. PubMed PMID: 31010931
• Hippensteel JA, Anderson BJ, Orfila JE, McMurtry SA, Dietz RM, Su G, Ford JA, Oshima K, Yang Y, Zhang F, Han X, Yu Y, Liu J, Linhardt RJ, Meyer NJ, Herson PS, Schmidt EP. Circulating heparan sulfate fragments mediate septic cognitive dysfunction. J Clin Invest. 2019 Apr 1;129(4):1779-1784. PubMed PMID: 30720464
• Uchimido R, Schmidt EP, Shapiro NI. The glycocalyx: a novel diagnostic and therapeutic target in sepsis. Crit Care. 2019 Jan 17;23(1):16. PubMed PMID: 30654825
• LaRivière WB, Schmidt EP. The Pulmonary Endothelial Glycocalyx in ARDS: A Critical Role for Heparan Sulfate. Curr Top Membr. 2018;82:33-52. PubMed PMID: 30360782
• Yang Y, Hippensteel JA, Schmidt EP. Intravital Microscopy in the Mouse Lung. Methods Mol Biol. 2018;1809:331-339. PubMed PMID: 29987798
• Hippensteel JA, Shapiro NI, Schmidt EP. Challenging Dogma: The Value of Bolus Fluids in the Early Resuscitation of Hyperdynamic Sepsis. Am J Respir Crit Care Med. 2018 Oct 15;198(8):981-983. PubMed PMID: 29940124
• Haeger SM, Liu X, Han X, McNeil JB, Oshima K, McMurtry SA, Yang Y, Ouyang Y, Zhang F, Nozik-Grayck E, Zemans RL, Tuder RM, Bastarache JA, Linhardt RJ, Schmidt EP. Epithelial Heparan Sulfate Contributes to Alveolar Barrier Function and Is Shed during Lung Injury. Am J Respir Cell Mol Biol. 2018 Sep;59(3):363-374. PubMed PMID: 29584451
• Oshima K, Haeger SM, Hippensteel JA, Herson PS, Schmidt EP. More than a biomarker: the systemic consequences of heparan sulfate fragments released during endothelial surface layer degradation (2017 Grover Conference Series). Pulm Circ. 2018 Jan-Mar;8(1):2045893217745786. PubMed PMID: 29199903
• Hippensteel JA, Schmidt EP. Sequestering Damage-associated Molecular Patterns in Critical Illness. A Novel Homeostatic Role for the Erythrocyte. Am J Respir Crit Care Med. 2018 Feb 15;197(4):416-418. PubMed PMID: 29120664
• Hippensteel JA, Schmidt EP. Sequestering DAMPs in Critical Illness: A Novel Homeostatic Role for the Erythrocyte. Am J Respir Crit Care Med. 2017 Nov 9. [Epub ahead of print] PubMed PMID: 29120664
• Neudecker V, Brodsky KS, Clambey ET, Schmidt EP, Packard TA, Davenport B, Standiford TJ, Weng T, Fletcher AA, Barthel L, Masterson JC, Furuta GT, Cai C, Blackburn MR, Ginde AA, Graner MW, Janssen WJ, Zemans RL, Evans CM, Burnham EL, Homann D, Moss M, Kreth S, Zacharowski K, Henson PM, Eltzschig HK. Neutrophil transfer of miR-223 to lung epithelial cells dampens acute lung injury in mice. Sci Transl Med. 2017 Sep 20;9(408). PubMed PMID: 28931657
• Zhang Y, Haeger SM, Yang Y, Dailey KL, Ford JA, Schmidt EP. Circulating Heparan Sulfate Fragments Attenuate Histone-Induced Lung Injury Independently of Histone Binding. Shock. 2017 Dec;48(6):666-673. PubMed PMID: 28538085
• Colbert JF, Ford JA, Haeger SM, Yang Y, Dailey KL, Allison KC, Neudecker V, Evans CM, Richardson VL, Brodsky KS, Faubel S, Eltzschig HK, Schmidt EP, Ginde AA. A model-specific role of microRNA-223 as a mediator of kidney injury during experimental sepsis. Am J Physiol Renal Physiol. 2017 Aug 1;313(2):F553-F559. PubMed PMID: 28515178
• Rau AS, Reinikovaite V, Schmidt EP, Taraseviciene-Stewart L, Deleyiannis FW. Electronic Cigarettes Are as Toxic to Skin Flap Survival as Tobacco Cigarettes. Ann Plast Surg. 2017 Jul;79(1):86-91. PubMed PMID: 28252546
• Yang Y, Haeger SM, Suflita MA, Zhang F, Dailey KL, Colbert JF, Ford JA, Picon MA, Stearman RS, Lin L, Liu X, Han X, Linhardt RJ, Schmidt EP. Fibroblast Growth Factor Signaling Mediates Pulmonary Endothelial Glycocalyx Reconstitution. Am J Respir Cell Mol Biol. 2017 Jun;56(6):727-737. PubMed PMID: 28187268
• Zhang X, Xu Y, Hsieh PH, Liu J, Lin L, Schmidt EP, Linhardt RJ. Chemoenzymatic synthesis of unmodified heparin oligosaccharides: cleavage of p-nitrophenyl glucuronide by alkaline and Smith degradation. Org Biomol Chem. 2017 Feb 1;15(5):1222-1227. PubMed PMID: 28091666
• Colbert JF, Schmidt EP, Faubel S, Ginde AA. Severe Sepsis Outcomes Among Hospitalizations With Inflammatory Bowel Disease. Shock. 2017 Feb;47(2):128-131. PubMed PMID: 27617672
• Schmidt EP, Overdier KH, Sun X, Lin L, Liu X, Yang Y, Ammons LA, Hiller TD, Suflita MA, Yu Y, Chen Y, Zhang F, Cothren Burlew C, Edelstein CL, Douglas IS, Linhardt RJ. Urinary Glycosaminoglycans Predict Outcomes in Septic Shock and Acute Respiratory Distress Syndrome. Am J Respir Crit Care Med. 2016 Aug 15;194(4):439-49. PubMed PMID: 26926297
• Haeger SM, Yang Y, Schmidt EP. Heparan Sulfate in the Developing, Healthy, and Injured Lung. Am J Respir Cell Mol Biol. 2016 Jul;55(1):5-11. PubMed PMID: 26982577
• Colbert JF, Schmidt EP. Endothelial and Microcirculatory Function and Dysfunction in Sepsis. Clin Chest Med. 2016 Jun;37(2):263-75. PubMed PMID: 27229643
• Schmidt EP, Kuebler WM, Lee WL, Downey GP. Adhesion Molecules: Master Controllers of the Circulatory System. Compr Physiol. 2016 Mar 15;6(2):945-73. PubMed PMID: 27065171
• Morris A, Wang B, Waern I, Venkatasamy R, Page C, Schmidt EP, Wernersson S, Li JP, Spina D. The role of heparanase in pulmonary cell recruitment in response to an allergic but not non-allergic stimulus. PLoS One. 2015;10(6):e0127032. PubMed PMID: 26039697
• Sun X, Li L, Overdier KH, Ammons LA, Douglas IS, Burlew CC, Zhang F, Schmidt EP, Chi L, Linhardt RJ. Analysis of Total Human Urinary Glycosaminoglycan Disaccharides by Liquid Chromatography-Tandem Mass Spectrometry. Anal Chem. 2015 Jun 16;87(12):6220-7. PubMed PMID: 26005898
• Riches DW, Burnham EL, Moss M, Downey GP, Schmidt EP. Introduction to the 57th annual Thomas L. Petty Aspen Lung Conference: Rebuilding the injured lung. Ann Am Thorac Soc. 2015 Mar;12 Suppl 1:S1-2. PubMed PMID: 25830827
• Kumar R, Mickael C, Chabon J, Gebreab L, Rutebemberwa A, Garcia AR, Koyanagi DE, Sanders L, Gandjeva A, Kearns MT, Barthel L, Janssen WJ, Mauad T, Bandeira A, Schmidt E, Tuder RM, Graham BB. The Causal Role of IL-4 and IL-13 in Schistosoma mansoni Pulmonary Hypertension. Am J Respir Crit Care Med. 2015 Oct 15;192(8):998-1008. PubMed PMID: 26192556
• Nadon AM, Perez MJ, Hernandez-Saavedra D, Smith LP, Yang Y, Sanders LA, Gandjeva A, Chabon J, Koyanagi DE, Graham BB, Tuder RM, Schmidt EP. Rtp801 suppression of epithelial mTORC1 augments endotoxin-induced lung inflammation. Am J Pathol. 2014 Sep;184(9):2382-9. PubMed PMID: 25016184
• Schmidt EP, Li G, Li L, Fu L, Yang Y, Overdier KH, Douglas IS, Linhardt RJ. The circulating glycosaminoglycan signature of respiratory failure in critically ill adults. J Biol Chem. 2014 Mar 21;289(12):8194-202. PubMed PMID: 24509853
• Lygizos MI, Yang Y, Altmann CJ, Okamura K, Hernando AA, Perez MJ, Smith LP, Koyanagi DE, Gandjeva A, Bhargava R, Tuder RM, Faubel S, Schmidt EP. Heparanase mediates renal dysfunction during early sepsis in mice. Physiol Rep. 2013 Nov;1(6):e00153. PubMed PMID: 24400155
• Damarla M, Parniani AR, Johnston L, Maredia H, Serebreni L, Hamdan O, Sidhaye VK, Shimoda LA, Myers AC, Crow MT, Schmidt EP, Machamer CE, Gaestel M, Rane MJ, Kolb TM, Kim BS, Damico RL, Hassoun PM. MK2 Mediates Apoptosis During Lung Vascular Permeability by Regulating Movement of Cleaved Caspase 3. Am J Respir Cell Mol Biol. 2013 Dec 4. [Epub ahead of print] PubMed PMID: 24304496
• Bhargava R, Altmann CJ, Andres-Hernando A, Webb RG, Okamura K, Yang Y, Falk S, Schmidt EP, Faubel S. Acute lung injury and acute kidney injury are established by four hours in experimental sepsis and are improved with pre, but not post, sepsis administration of TNF-a antibodies. PLoS One. 2013;8(11):e79037. PubMed PMID: 24265742
• Yang Y, Schmidt EP. The endothelial glycocalyx: an important regulator of the pulmonary vascular barrier. Tissue Barriers. 2013 Jan 1;1(1). PubMed PMID: 24073386
• Dengler V, Downey GP, Tuder RM, Eltzschig HK, Schmidt EP. Neutrophil intercellular communication in acute lung injury. Emerging roles of microparticles and gap junctions. Am J Respir Cell Mol Biol. 2013 Jul;49(1):1-5. PubMed PMID: 23815257
• Chow K, Fessel JP, Kaoriihida-Stansbury, Schmidt EP, Gaskill C, Alvarez D, Graham B, Harrison DG, Wagner DH Jr, Nozik-Grayck E, West JD, Klemm DJ, Majka SM. Dysfunctional resident lung mesenchymal stem cells contribute to pulmonary microvascular remodeling. Pulm Circ. 2013 Jan;3(1):31-49. PubMed PMID: 23662173
• Dengler V, Downey GP, Tuder RM, Eltzschig HK, Schmidt EP. Neutrophil Intercellular Communication in Acute Lung Injury: Emerging Roles of Microparticles and Gap Junctions. Am J Respir Cell Mol Biol. 2013 Mar 14. [Epub ahead of print] PubMed PMID: 23492190
• Yang Y, Yang G, Schmidt EP. In vivo measurement of the mouse pulmonary endothelial surface layer. J Vis Exp. 2013 Feb 22;(72):e50322. PubMed PMID: 23462690

Professional Memberships

• American Thoracic Society, Member, Fellow of the ATS
• Surgery, Anesthesiology, and Trauma (SAT) Study Section, Permanent Member
• American Physiological Society, Member, Respiratory Section Programming Co-chair
• Microcirculatory Society, Member