I am an integrated physiologist with a research emphasis on advancing our comprehension of the gut-brain-axis's role in metabolic regulation. My investigations center around two overarching themes. Firstly, we focus on understanding the role of a gut peptide, glucagon-like peptide-1 (GLP-1), on glucose homeostasis and how dysregulation of GLP-1 is involved with the onset of type 2 diabetes mellitus. Secondly, my focus extends to the adaptations within the gut-brain axis following bariatric surgery, exploring their correlation with significant weight loss and improvements in glucose and lipid homeostasis observed post-surgery. Employing in vivo physiology experimental tools in genetic mouse models, my research strives to uncover the underlying mechanisms driving these physiological phenomena.
Publications
Qiu W, Hutch CR, Wang Y, Wloszek J, Rucker RA, Myers MG Jr, Sandoval D. Multiple NTS neuron populations cumulatively suppress food intake. Elife. 2023 Dec 7;12. [Epub ahead of print] PubMed PMID: 38059498
Patel AR, Frikke-Schmidt H, Sabatini PV, Rupp AC, Sandoval DA, Myers MG Jr, Seeley RJ. Neither GLP-1 receptors nor GFRAL neurons are required for aversive or anorectic response to DON (vomitoxin). Am J Physiol Regul Integr Comp Physiol. 2023 Mar 13;324(5):R635-44. [Epub ahead of print] PubMed PMID: 36912475
Arble DM, Hutch CR, Hafner H, Stelmak D, Leix K, Sorrell J, Pressler JW, Gregg B, Sandoval DA. The role of preproglucagon peptides in regulating ß-cell morphology and responses to streptozotocin-induced diabetes. Am J Physiol Endocrinol Metab. 2023 Mar 1;324(3):E217-E225. PubMed PMID: 36652401
Sandoval DA, Patti ME. Glucose metabolism after bariatric surgery: implications for T2DM remission and hypoglycaemia. Nat Rev Endocrinol. 2023 Mar;19(3):164-176. PubMed PMID: 36289368
Vollbrecht PJ, Nesbitt KM, Addis VM, Boulnemour KM, Micheli DA, Smith KB, Sandoval DA, Kennedy RT, Ferrario CR. Differential regulation of nucleus accumbens glutamate and GABA in obesity-prone and obesity-resistant rats. J Neurochem. 2023 Feb;164(4):499-511. PubMed PMID: 36336816
Vollbrecht PJ, Nesbitt KM, Addis VM, Boulnemour KM, Micheli DA, Smith KB, Sandoval DA, Kennedy RT, Ferrario CR. Differential regulation of nucleus accumbens glutamate and GABA in obesity-prone and obesity-resistant rats. J Neurochem. 2022 Nov 6. [Epub ahead of print] PubMed PMID: 36336816
Sandoval DA, Patti ME. Glucose metabolism after bariatric surgery: implications for T2DM remission and hypoglycaemia. Nat Rev Endocrinol. 2022 Oct 26. [Epub ahead of print] PubMed PMID: 36289368
Shin JH, Bozadjieva-Kramer N, Shao Y, Lyons-Abbott S, Rupp AC, Sandoval DA, Seeley RJ. The gut peptide Reg3g links the small intestine microbiome to the regulation of energy balance, glucose levels, and gut function. Cell Metab. 2022 Nov 1;34(11):1765-1778.e6. PubMed PMID: 36240758
Kim KS, Peck BC, Hung YH, Koch-Laskowski K, Wood L, Dedhia PH, Spence JR, Seeley RJ, Sethupathy P, Sandoval DA. Vertical sleeve gastrectomy induces enteroendocrine cell differentiation of intestinal stem cells through bile acid signaling. JCI Insight. 2022 Jun 8;7(11). PubMed PMID: 35503251
Evers SS, Shao Y, Ramakrishnan SK, Shin JH, Bozadjieva-Kramer N, Irmler M, Stemmer K, Sandoval DA, Shah YM, Seeley RJ. Gut HIF2a signaling is increased after VSG, and gut activation of HIF2a decreases weight, improves glucose, and increases GLP-1 secretion. Cell Rep. 2022 Jan 18;38(3):110270. PubMed PMID: 35045308
Shao Y, Evers SS, Shin JH, Ramakrishnan SK, Bozadjieva-Kramer N, Yao Q, Shah YM, Sandoval DA, Seeley RJ. Vertical sleeve gastrectomy increases duodenal Lactobacillus spp. richness associated with the activation of intestinal HIF2a signaling and metabolic benefits. Mol Metab. 2022 Mar;57:101432. PubMed PMID: 34998940
Bethea M, Sandoval DA. Gut Factors Mediating the Physiological Impact of Bariatric Surgery. Curr Diab Rep. 2022 Aug;22(8):371-383. PubMed PMID: 35723770
Bozadjieva-Kramer N, Shin JH, Shao Y, Gutierrez-Aguilar R, Li Z, Heppner KM, Chiang S, Vargo SG, Granger K, Sandoval DA, MacDougald OA, Seeley RJ. Intestinal-derived FGF15 protects against deleterious effects of vertical sleeve gastrectomy in mice. Nat Commun. 2021 Aug 6;12(1):4768. PubMed PMID: 34362888
Bethea M, Bozadjieva-Kramer N, Sandoval DA. Preproglucagon Products and Their Respective Roles Regulating Insulin Secretion. Endocrinology. 2021 Oct 1;162(10). PubMed PMID: 34318874
Sandoval DA, Alonso LC, Gannon M, Sander M, Sussel L, Reusch JEB. Career Advancement for Women in Diabetes-Related Research: Developing and Retaining Female Talent. Diabetes Care. 2021 Aug;44(8):1744-1747. PubMed PMID: 34131046
de Lima JBM, Debarba LK, Rupp AC, Qi N, Ubah C, Khan M, Didyuk O, Ayyar I, Koch M, Sandoval DA, Sadagurski M. ARC(GHR) Neurons Regulate Muscle Glucose Uptake. Cells. 2021 May 3;10(5). PubMed PMID: 34063647
Hutch CR, Stelmak D, Kanke M, Koch-Laskowski K, Cummings B, Griffin C, Leix K, Sethupathy P, Singer K, Sandoval DA. Diet-dependent sex differences in the response to vertical sleeve gastrectomy. Am J Physiol Endocrinol Metab. 2021 Jul 1;321(1):E11-E23. PubMed PMID: 33998293
Sandoval D. Updating the Role of a-Cell Preproglucagon Products on GLP-1 Receptor-Mediated Insulin Secretion. Diabetes. 2020 Nov;69(11):2238-2245. PubMed PMID: 33082272
Singha A, Palavicini JP, Pan M, Farmer S, Sandoval D, Han X, Fujikawa T. Leptin Receptors in RIP-Cre(25Mgn) Neurons Mediate Anti-dyslipidemia Effects of Leptin in Insulin-Deficient Mice. Front Endocrinol (Lausanne). 2020;11:588447. PubMed PMID: 33071988
Bozadjieva Kramer N, Evers SS, Shin JH, Silverwood S, Wang Y, Burant CF, Sandoval DA, Seeley RJ. The Role of Elevated Branched-Chain Amino Acids in the Effects of Vertical Sleeve Gastrectomy to Reduce Weight and Improve Glucose Regulation. Cell Rep. 2020 Oct 13;33(2):108239. PubMed PMID: 33053352
Myronovych A, Bhattacharjee J, Salazar-Gonzalez RM, Tan B, Mowery S, Ferguson D, Ryan KK, Zhang W, Zhao X, Oehrle M, Setchell KD, Seeley RJ, Sandoval DA, Kohli R. Assessment of the role of FGF15 in mediating the metabolic outcomes of murine Vertical Sleeve Gastrectomy (VSG). Am J Physiol Gastrointest Liver Physiol. 2020 Sep 23. [Epub ahead of print] PubMed PMID: 32967428
Panaro BL, Yusta B, Matthews D, Koehler JA, Song Y, Sandoval DA, Drucker DJ. Intestine-selective reduction of Gcg expression reveals the importance of the distal gut for GLP-1 secretion. Mol Metab. 2020 Jul;37:100990. PubMed PMID: 32278655
Cheng W, Ndoka E, Hutch C, Roelofs K, MacKinnon A, Khoury B, Magrisso J, Kim KS, Rhodes CJ, Olson DP, Seeley RJ, Sandoval D, Myers MG Jr. Leptin receptor-expressing nucleus tractus solitarius neurons suppress food intake independently of GLP1 in mice. JCI Insight. 2020 Apr 9;5(7). PubMed PMID: 32182221
Davis EM, Sandoval DA. Glucagon-Like Peptide-1: Actions and Influence on Pancreatic Hormone Function. Compr Physiol. 2020 Mar 12;10(2):577-595. PubMed PMID: 32163198
Flak JN, Goforth PB, Dell'Orco J, Sabatini PV, Li C, Bozadjieva N, Sorensen M, Valenta A, Rupp A, Affinati AH, Cras-Méneur C, Ansari A, Sacksner J, Kodur N, Sandoval DA, Kennedy RT, Olson DP, Myers MG Jr. Ventromedial hypothalamic nucleus neuronal subset regulates blood glucose independently of insulin. J Clin Invest. 2020 Jun 1;130(6):2943-2952. PubMed PMID: 32134398
Evers SS, Kim KS, Bozadjieva N, Lewis AG, Farris D, Sorensen MJ, Kim Y, Whitesall SE, Kennedy RT, Michele DE, Seeley RJ, Sandoval DA. Continuous glucose monitoring reveals glycemic variability and hypoglycemia after vertical sleeve gastrectomy in rats. Mol Metab. 2020 Feb;32:148-159. PubMed PMID: 32029224
Cheng W, Gonzalez I, Pan W, Tsang AH, Adams J, Ndoka E, Gordian D, Khoury B, Roelofs K, Evers SS, MacKinnon A, Wu S, Frikke-Schmidt H, Flak JN, Trevaskis JL, Rhodes CJ, Fukada SI, Seeley RJ, Sandoval DA, Olson DP, Blouet C, Myers MG Jr. Calcitonin Receptor Neurons in the Mouse Nucleus Tractus Solitarius Control Energy Balance via the Non-aversive Suppression of Feeding. Cell Metab. 2020 Feb 4;31(2):301-312.e5. PubMed PMID: 31955990
Alvarez R, Sandoval DA, Seeley RJ. A rodent model of partial intestinal diversion: a novel metabolic operation. Surg Obes Relat Dis. 2020 Feb;16(2):270-281. PubMed PMID: 31874737
Framnes-DeBoer SN, Bakke E, Yalamanchili S, Peterson H, Sandoval DA, Seeley RJ, Arble DM. Bromocriptine improves glucose tolerance independent of circadian timing, prolactin, or the melanocortin-4 receptor. Am J Physiol Endocrinol Metab. 2020 Jan 1;318(1):E62-E71. PubMed PMID: 31794265
Hutch CR, Trakimas DR, Roelofs K, Pressler J, Sorrell J, Cota D, Obici S, Sandoval DA. Oea Signaling Pathways and the Metabolic Benefits of Vertical Sleeve Gastrectomy. Ann Surg. 2020 Mar;271(3):509-518. PubMed PMID: 30702457
Song Y, Koehler JA, Baggio LL, Powers AC, Sandoval DA, Drucker DJ. Gut-Proglucagon-Derived Peptides Are Essential for Regulating Glucose Homeostasis in Mice. Cell Metab. 2019 Nov 5;30(5):976-986.e3. PubMed PMID: 31495689
Hutch CR, Roelofs K, Haller A, Sorrell J, Leix K, D'Alessio DD, Augustin R, Seeley RJ, Klein T, Sandoval DA. The role of GIP and pancreatic GLP-1 in the glucoregulatory effect of DPP-4 inhibition in mice. Diabetologia. 2019 Oct;62(10):1928-1937. PubMed PMID: 31414143
Sandoval DA. Mechanisms for the metabolic success of bariatric surgery. J Neuroendocrinol. 2019 May;31(5):e12708. PubMed PMID: 30882956
Kim T, Holleman CL, Nason S, Arble DM, Ottaway N, Chabenne J, Loyd C, Kim JA, Sandoval D, Drucker DJ, DiMarchi R, Perez-Tilve D, Habegger KM. Hepatic Glucagon Receptor Signaling Enhances Insulin-Stimulated Glucose Disposal in Rodents. Diabetes. 2018 Nov;67(11):2157-2166. PubMed PMID: 30150304
Wood L, Roelofs K, Koch LG, Britton SL, Sandoval DA. Vertical sleeve gastrectomy corrects metabolic perturbations in a low-exercise capacity rat model. Mol Metab. 2018 May;11:189-196. PubMed PMID: 29519582
Adams JM, Pei H, Sandoval DA, Seeley RJ, Chang RB, Liberles SD, Olson DP. Liraglutide Modulates Appetite and Body Weight Through Glucagon-Like Peptide 1 Receptor-Expressing Glutamatergic Neurons. Diabetes. 2018 Aug;67(8):1538-1548. PubMed PMID: 29776968
Kim KS, Seeley RJ, Sandoval DA. Signalling from the periphery to the brain that regulates energy homeostasis. Nat Rev Neurosci. 2018 Apr;19(4):185-196. PubMed PMID: 29467468
Quarta C, Clemmensen C, Zhu Z, Yang B, Joseph SS, Lutter D, Yi CX, Graf E, García-Cáceres C, Legutko B, Fischer K, Brommage R, Zizzari P, Franklin BS, Krueger M, Koch M, Vettorazzi S, Li P, Hofmann SM, Bakhti M, Bastidas-Ponce A, Lickert H, Strom TM, Gailus-Durner V, Bechmann I, Perez-Tilve D, Tuckermann J, Hrabe de Angelis M, Sandoval D, Cota D, Latz E, Seeley RJ, Müller TD, DiMarchi RD, Finan B, Tschöp MH. Molecular Integration of Incretin and Glucocorticoid Action Reverses Immunometabolic Dysfunction and Obesity. Cell Metab. 2017 Oct 3;26(4):620-632.e6. PubMed PMID: 28943448
Hutch CR, Sandoval DA. Physiological and molecular responses to bariatric surgery: markers or mechanisms underlying T2DM resolution?. Ann N Y Acad Sci. 2017 Mar;1391(1):5-19. PubMed PMID: 27671525
Jessen L, Smith EP, Ulrich-Lai Y, Herman JP, Seeley RJ, Sandoval D, D'Alessio D. Central Nervous System GLP-1 Receptors Regulate Islet Hormone Secretion and Glucose Homeostasis in Male Rats. Endocrinology. 2017 Jul 1;158(7):2124-2133. PubMed PMID: 28430981
Sandoval DA, Seeley RJ. Physiology: Gut feeling for food choice. Nature. 2017 Feb 16;542(7641):302-303. PubMed PMID: 28178229
Evers SS, Sandoval DA, Seeley RJ. The Physiology and Molecular Underpinnings of the Effects of Bariatric Surgery on Obesity and Diabetes. Annu Rev Physiol. 2017 Feb 10;79:313-334. PubMed PMID: 27912678
Burmeister MA, Ayala JE, Smouse H, Landivar-Rocha A, Brown JD, Drucker DJ, Stoffers DA, Sandoval DA, Seeley RJ, Ayala JE. The Hypothalamic Glucagon-Like Peptide 1 Receptor Is Sufficient but Not Necessary for the Regulation of Energy Balance and Glucose Homeostasis in Mice. Diabetes. 2017 Feb;66(2):372-384. PubMed PMID: 27908915
Hutch CR, Sandoval D. The Role of GLP-1 in the Metabolic Success of Bariatric Surgery. Endocrinology. 2017 Dec 1;158(12):4139-4151. PubMed PMID: 29040429
Burmeister MA, Brown JD, Ayala JE, Stoffers DA, Sandoval DA, Seeley RJ, Ayala JE. The glucagon-like peptide-1 receptor in the ventromedial hypothalamus reduces short-term food intake in male mice by regulating nutrient sensor activity. Am J Physiol Endocrinol Metab. 2017 Dec 1;313(6):E651-E662. PubMed PMID: 28811293
Chambers AP, Sorrell JE, Haller A, Roelofs K, Hutch CR, Kim KS, Gutierrez-Aguilar R, Li B, Drucker DJ, D'Alessio DA, Seeley RJ, Sandoval DA. The Role of Pancreatic Preproglucagon in Glucose Homeostasis in Mice. Cell Metab. 2017 Apr 4;25(4):927-934.e3. PubMed PMID: 28325479
Loyd C, Magrisso IJ, Haas M, Balusu S, Krishna R, Itoh N, Sandoval DA, Perez-Tilve D, Obici S, Habegger KM. Fibroblast growth factor 21 is required for beneficial effects of exercise during chronic high-fat feeding. J Appl Physiol (1985). 2016 Sep 1;121(3):687-98. PubMed PMID: 27445299
Frikke-Schmidt H, O'Rourke RW, Lumeng CN, Sandoval DA, Seeley RJ. Does bariatric surgery improve adipose tissue function?. Obes Rev. 2016 Sep;17(9):795-809. PubMed PMID: 27272117
Sisley SR, Arble DM, Chambers AP, Gutierrez-Aguilar R, He Y, Xu Y, Gardner D, Moore DD, Seeley RJ, Sandoval DA. Hypothalamic Vitamin D Improves Glucose Homeostasis and Reduces Weight. Diabetes. 2016 Sep;65(9):2732-41. PubMed PMID: 27217488
Kulkarni BV, LaSance K, Sorrell JE, Lemen L, Woods SC, Seeley RJ, Sandoval D. The role of proximal versus distal stomach resection in the weight loss seen after vertical sleeve gastrectomy. Am J Physiol Regul Integr Comp Physiol. 2016 Nov 1;311(5):R979-R987. PubMed PMID: 27581811
Seeley RJ, Sandoval DA. Targeting the brain as a cure for type 2 diabetes. Nat Med. 2016 Jul 7;22(7):709-11. PubMed PMID: 27387884
Sandoval D. Roux-en-Y Gastric Bypass and Vertical Sleeve Gastrectomy: Divergent Pathways to Improved Glucose Homeostasis. Gastroenterology. 2016 Feb;150(2):309-12. PubMed PMID: 26710990
Arble DM, Pressler JW, Sorrell J, Wevrick R, Sandoval DA. Sleeve gastrectomy leads to weight loss in the Magel2 knockout mouse. Surg Obes Relat Dis. 2016 Dec;12(10):1795-1802. PubMed PMID: 27396546
Arble DM, Holland J, Ottaway N, Sorrell J, Pressler JW, Morano R, Woods SC, Seeley RJ, Herman JP, Sandoval DA, Perez-Tilve D. The melanocortin-4 receptor integrates circadian light cues and metabolism. Endocrinology. 2015 May;156(5):1685-91. PubMed PMID: 25730108
Seeley RJ, Chambers AP, Sandoval DA. The role of gut adaptation in the potent effects of multiple bariatric surgeries on obesity and diabetes. Cell Metab. 2015 Mar 3;21(3):369-78. PubMed PMID: 25662404
Finan B, Yang B, Ottaway N, Smiley DL, Ma T, Clemmensen C, Chabenne J, Zhang L, Habegger KM, Fischer K, Campbell JE, Sandoval D, Seeley RJ, Bleicher K, Uhles S, Riboulet W, Funk J, Hertel C, Belli S, Sebokova E, Conde-Knape K, Konkar A, Drucker DJ, Gelfanov V, Pfluger PT, Müller TD, Perez-Tilve D, DiMarchi RD, Tschöp MH. A rationally designed monomeric peptide triagonist corrects obesity and diabetes in rodents. Nat Med. 2015 Jan;21(1):27-36. PubMed PMID: 25485909
Arble DM, Sandoval DA, Seeley RJ. Mechanisms underlying weight loss and metabolic improvements in rodent models of bariatric surgery. Diabetologia. 2015 Feb;58(2):211-20. PubMed PMID: 25374275
Pressler JW, Haller A, Sorrell J, Wang F, Seeley RJ, Tso P, Sandoval DA. Vertical sleeve gastrectomy restores glucose homeostasis in apolipoprotein A-IV KO mice. Diabetes. 2015 Feb;64(2):498-507. PubMed PMID: 25157093
Sandoval D, Sisley SR. Brain GLP-1 and insulin sensitivity. Mol Cell Endocrinol. 2015 Dec 15;418 Pt 1:27-32. PubMed PMID: 25724479
Arble DM, Sandoval DA, Turek FW, Woods SC, Seeley RJ. Metabolic effects of bariatric surgery in mouse models of circadian disruption. Int J Obes (Lond). 2015 Aug;39(8):1310-8. PubMed PMID: 25869599
Sandoval DA, D'Alessio DA. Physiology of proglucagon peptides: role of glucagon and GLP-1 in health and disease. Physiol Rev. 2015 Apr;95(2):513-48. PubMed PMID: 25834231
Kohli R, Myronovych A, Tan BK, Salazar-Gonzalez RM, Miles L, Zhang W, Oehrle M, Sandoval DA, Ryan KK, Seeley RJ, Setchell KD. Bile Acid Signaling: Mechanism for Bariatric Surgery, Cure for NASH?. Dig Dis. 2015;33(3):440-6. PubMed PMID: 26045281
Ryan KK, Tremaroli V, Clemmensen C, Kovatcheva-Datchary P, Myronovych A, Karns R, Wilson-Pérez HE, Sandoval DA, Kohli R, Bäckhed F, Seeley RJ. FXR is a molecular target for the effects of vertical sleeve gastrectomy. Nature. 2014 May 8;509(7499):183-8. PubMed PMID: 24670636
Sandoval D. Old dog, new trick: a direct role for leptin in regulating microbiota composition. Endocrinology. 2014 Mar;155(3):653-5. PubMed PMID: 24564414
Smith EP, An Z, Wagner C, Lewis AG, Cohen EB, Li B, Mahbod P, Sandoval D, Perez-Tilve D, Tamarina N, Philipson LH, Stoffers DA, Seeley RJ, D'Alessio DA. The role of ß cell glucagon-like peptide-1 signaling in glucose regulation and response to diabetes drugs. Cell Metab. 2014 Jun 3;19(6):1050-7. PubMed PMID: 24836562
Sisley S, Gutierrez-Aguilar R, Scott M, D'Alessio DA, Sandoval DA, Seeley RJ. Neuronal GLP1R mediates liraglutide's anorectic but not glucose-lowering effect. J Clin Invest. 2014 Jun;124(6):2456-63. PubMed PMID: 24762441
Heppner KM, Piechowski CL, Müller A, Ottaway N, Sisley S, Smiley DL, Habegger KM, Pfluger PT, Dimarchi R, Biebermann H, Tschöp MH, Sandoval DA, Perez-Tilve D. Both acyl and des-acyl ghrelin regulate adiposity and glucose metabolism via central nervous system ghrelin receptors. Diabetes. 2014 Jan;63(1):122-31. PubMed PMID: 24062249
Chambers AP, Smith EP, Begg DP, Grayson BE, Sisley S, Greer T, Sorrell J, Lemmen L, LaSance K, Woods SC, Seeley RJ, D'Alessio DA, Sandoval DA. Regulation of gastric emptying rate and its role in nutrient-induced GLP-1 secretion in rats after vertical sleeve gastrectomy. Am J Physiol Endocrinol Metab. 2014 Feb 15;306(4):E424-32. PubMed PMID: 24368666
Li B, Matter EK, Hoppert HT, Grayson BE, Seeley RJ, Sandoval DA. Identification of optimal reference genes for RT-qPCR in the rat hypothalamus and intestine for the study of obesity. Int J Obes (Lond). 2014 Feb;38(2):192-7. PubMed PMID: 23736358
Mul JD, Begg DP, Haller AM, Pressler JW, Sorrell J, Woods SC, Farese RV Jr, Seeley RJ, Sandoval DA. MGAT2 deficiency and vertical sleeve gastrectomy have independent metabolic effects in the mouse. Am J Physiol Endocrinol Metab. 2014 Dec 1;307(11):E1065-72. PubMed PMID: 25315695
Sisley S, Smith K, Sandoval DA, Seeley RJ. Differences in acute anorectic effects of long-acting GLP-1 receptor agonists in rats. Peptides. 2014 Aug;58:1-6. PubMed PMID: 24879927
Bielohuby M, Sisley S, Sandoval D, Herbach N, Zengin A, Fischereder M, Menhofer D, Stoehr BJ, Stemmer K, Wanke R, Tschöp MH, Seeley RJ, Bidlingmaier M. Impaired glucose tolerance in rats fed low-carbohydrate, high-fat diets. Am J Physiol Endocrinol Metab. 2013 Nov 1;305(9):E1059-70. PubMed PMID: 23982154
Chambers AP, Sandoval DA, Seeley RJ. Integration of satiety signals by the central nervous system. Curr Biol. 2013 May 6;23(9):R379-88. PubMed PMID: 23660361
Mul JD, Begg DP, Barrera JG, Li B, Matter EK, D'Alessio DA, Woods SC, Seeley RJ, Sandoval DA. High-fat diet changes the temporal profile of GLP-1 receptor-mediated hypophagia in rats. Am J Physiol Regul Integr Comp Physiol. 2013 Jul 1;305(1):R68-77. PubMed PMID: 23616105
Wilson-Pérez HE, Chambers AP, Ryan KK, Li B, Sandoval DA, Stoffers D, Drucker DJ, Pérez-Tilve D, Seeley RJ. Vertical sleeve gastrectomy is effective in two genetic mouse models of glucagon-like Peptide 1 receptor deficiency. Diabetes. 2013 Jul;62(7):2380-5. PubMed PMID: 23434938
Grayson BE, Seeley RJ, Sandoval DA. Wired on sugar: the role of the CNS in the regulation of glucose homeostasis. Nat Rev Neurosci. 2013 Jan;14(1):24-37. PubMed PMID: 23232606
Chambers AP, Kirchner H, Wilson-Perez HE, Willency JA, Hale JE, Gaylinn BD, Thorner MO, Pfluger PT, Gutierrez JA, Tschöp MH, Sandoval DA, Seeley RJ. The effects of vertical sleeve gastrectomy in rodents are ghrelin independent. Gastroenterology. 2013 Jan;144(1):50-52.e5. PubMed PMID: 22995675
Kim DH, Sartor MA, Bain JR, Sandoval D, Stevens RD, Medvedovic M, Newgard CB, Woods SC, Seeley RJ. Rapid and weight-independent improvement of glucose tolerance induced by a peptide designed to elicit apoptosis in adipose tissue endothelium. Diabetes. 2012 Sep;61(9):2299-310. PubMed PMID: 22733798
Chambers AP, Wilson-Perez HE, McGrath S, Grayson BE, Ryan KK, D'Alessio DA, Woods SC, Sandoval DA, Seeley RJ. Effect of vertical sleeve gastrectomy on food selection and satiation in rats. Am J Physiol Endocrinol Metab. 2012 Oct 15;303(8):E1076-84. PubMed PMID: 22932782
Sandoval D, Barrera JG, Stefater MA, Sisley S, Woods SC, D'Alessio DD, Seeley RJ. The anorectic effect of GLP-1 in rats is nutrient dependent. PLoS One. 2012;7(12):e51870. PubMed PMID: 23284795