Kika Sucharov, PhD
Professor, Medicine-Cardiology

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Graduate Schools :
  • PhD, University of Pennsylvania (1997)
  • MS, Federal University of Rio de Janeiro, Brazil (1995)
Undergraduate School:
  • BS, Federal University of Rio de Janeiro, Brazil (1990)
Fellowships:
  • University of Colorado, Postdoctoral Research Fellow (2002)
  • University of Colorado, Postdoctoral Research Fellow (2004)
Languages: English
Department: Medicine-Cardiology

Research Interests

Our main goal is to identify potential new therapeutic agents for the treatment of heart failure.

Publications

  • Sucharov CC. Paracrine Factors in Uremic Cardiomyopathy. JACC Basic Transl Sci. 2020 Feb;5(2):167-168. PubMed PMID: 32142069
  • Garcia AM, McPhaul JC, Sparagna GC, Jeffrey DA, Jonscher RL, Patel S, Sucharov CC, Stauffer BL, Miyamoto SD, Chatfield KC. Alteration of Cardiolipin Biosynthesis and Remodeling in Single Right Ventricle Congenital Heart Disease. Am J Physiol Heart Circ Physiol. 2020 Feb 14. [Epub ahead of print] PubMed PMID: 32056460
  • Nakano SJ, Walker JS, Walker LA, Li X, Du Y, Miyamoto SD, Sucharov CC, Garcia AM, Mitchell MB, Ambardekar AV, Stauffer BL. Increased myocyte calcium sensitivity in end-stage pediatric dilated cardiomyopathy. Am J Physiol Heart Circ Physiol. 2019 Dec 1;317(6):H1221-H1230. PubMed PMID: 31625780
  • Allawzi A, McDermott I, Delaney C, Nguyen K, Banimostafa L, Trumpie A, Hernandez-Lagunas L, Riemondy K, Gillen A, Hesselberth J, El Kasmi K, Sucharov CC, Janssen WJ, Stenmark K, Bowler R, Nozik-Grayck E. Redistribution of EC-SOD resolves bleomycin-induced inflammation via increased apoptosis of recruited alveolar macrophages. FASEB J. 2019 Dec;33(12):13465-13475. PubMed PMID: 31560857
  • Aguado BA, Schuetze KB, Grim JC, Walker CJ, Cox AC, Ceccato TL, Tan AC, Sucharov CC, Leinwand LA, Taylor MRG, McKinsey TA, Anseth KS. Transcatheter aortic valve replacements alter circulating serum factors to mediate myofibroblast deactivation. Sci Transl Med. 2019 Sep 11;11(509). PubMed PMID: 31511425
  • Chatfield KC, Sparagna GC, Chau S, Phillips EK, Ambardekar AV, Aftab M, Mitchell MB, Sucharov CC, Miyamoto SD, Stauffer BL. Elamipretide Improves Mitochondrial Function in the Failing Human Heart. JACC Basic Transl Sci. 2019 Apr;4(2):147-157. PubMed PMID: 31061916
  • Sucharov CC, Nakano SJ, Slavov D, Schwisow JA, Rodriguez E, Nunley K, Medway A, Stafford N, Nelson P, McKinsey TA, Movsesian M, Minobe W, Carroll IA, Taylor MRG, Bristow MR. A PDE3A Promoter Polymorphism Regulates cAMP-Induced Transcriptional Activity in Failing Human Myocardium. J Am Coll Cardiol. 2019 Mar 19;73(10):1173-1184. PubMed PMID: 30871701
  • Patil MA, Upadhyay AK, Hernandez-Lagunas L, Good R, Carpenter TC, Sucharov CC, Nozik-Grayck E, Kompella UB. Targeted delivery of YSA-functionalized and non-functionalized polymeric nanoparticles to injured pulmonary vasculature. Artif Cells Nanomed Biotechnol. 2018 Nov 19;:1-8. [Epub ahead of print] PubMed PMID: 30450979
  • Garcia AM, Nakano SJ, Karimpour-Fard A, Nunley K, Blain-Nelson P, Stafford NM, Stauffer BL, Sucharov CC, Miyamoto SD. Phosphodiesterase-5 Is Elevated in Failing Single Ventricle Myocardium and Affects Cardiomyocyte Remodeling In Vitro. Circ Heart Fail. 2018 Sep;11(9):e004571. PubMed PMID: 30354365
  • Jeffrey DA, Sucharov CC. CELF1 regulates gap junction integrity contributing to dilated cardiomyopathy. Noncoding RNA Investig. 2018 Mar;2. PubMed PMID: 30198017
  • Coverstone ED, Bach RG, Chen L, Bierut LJ, Li AY, Lenzini PA, O'Neill HC, Spertus JA, Sucharov CC, Stitzel JA, Schilling JD, Cresci S. A novel genetic marker of decreased inflammation and improved survival after acute myocardial infarction. Basic Res Cardiol. 2018 Aug 10;113(5):38. PubMed PMID: 30097758
  • Woulfe KC, Wilson CE, Nau S, Chau S, Phillips EK, Zang S, Tompkins C, Sucharov CC, Miyamoto SD, Stauffer BL. Acute isoproterenol leads to age-dependent arrhythmogenesis in guinea pigs. Am J Physiol Heart Circ Physiol. 2018 Oct 1;315(4):H1051-H1062. PubMed PMID: 30028197
  • Good RJ, Hernandez-Lagunas L, Allawzi A, Maltzahn JK, Vohwinkel CU, Upadhyay AK, Kompella UB, Birukov KG, Carpenter TC, Sucharov CC, Nozik-Grayck E. MicroRNA dysregulation in lung injury: the role of the miR-26a/EphA2 axis in regulation of endothelial permeability. Am J Physiol Lung Cell Mol Physiol. 2018 Oct 1;315(4):L584-L594. PubMed PMID: 30024304
  • Garcia AM, Allawzi A, Tatman P, Hernandez-Lagunas L, Swain K, Mouradian G, Bowler R, Karimpour-Fard A, Sucharov CC, Nozik-Grayck E. R213G polymorphism in SOD3 protects against bleomycin-induced inflammation and attenuates induction of proinflammatory pathways. Physiol Genomics. 2018 Sep 1;50(9):807-816. PubMed PMID: 30004839
  • Toni LS, Garcia AM, Jeffrey DA, Jiang X, Stauffer BL, Miyamoto SD, Sucharov CC. Optimization of phenol-chloroform RNA extraction. MethodsX. 2018;5:599-608. PubMed PMID: 29984193
  • Miyamoto SD, Sucharov CC, Woulfe KC. Differential Response to Heart Failure Medications in Children. Prog Pediatr Cardiol. 2018 Jun;49:27-30. PubMed PMID: 29962825
  • Mariner PD, Korst A, Karimpour-Fard A, Stauffer BL, Miyamoto SD, Sucharov CC. Improved Detection of Circulating miRNAs in Serum and Plasma Following Rapid Heat/Freeze Cycling. Microrna. 2018;7(2):138-147. PubMed PMID: 29658445
  • Nakano SJ, Sucharov J, van Dusen R, Cecil M, Nunley K, Wickers S, Karimpur-Fard A, Stauffer BL, Miyamoto SD, Sucharov CC. Cardiac Adenylyl Cyclase and Phosphodiesterase Expression Profiles Vary by Age, Disease, and Chronic Phosphodiesterase Inhibitor Treatment. J Card Fail. 2017 Jan;23(1):72-80. PubMed PMID: 27427220
  • Nakano SJ, Siomos AK, Garcia AM, Nguyen H, SooHoo M, Galambos C, Nunley K, Stauffer BL, Sucharov CC, Miyamoto SD. Fibrosis-Related Gene Expression in Single Ventricle Heart Disease. J Pediatr. 2017 Dec;191:82-90.e2. PubMed PMID: 29050751
  • Woulfe KC, Sucharov CC. Midkine's Role in Cardiac Pathology. J Cardiovasc Dev Dis. 2017 Sep;4(3). PubMed PMID: 28920060
  • Kheyfets VO, Sucharov CC, Truong U, Dunning J, Hunter K, Ivy D, Miyamoto S, Shandas R. Circulating miRNAs in Pediatric Pulmonary Hypertension Show Promise as Biomarkers of Vascular Function. Oxid Med Cell Longev. 2017;2017:4957147. PubMed PMID: 28819545
  • Tatman PD, Woulfe KC, Karimpour-Fard A, Jeffrey DA, Jaggers J, Cleveland JC, Nunley K, Taylor MR, Miyamoto SD, Stauffer BL, Sucharov CC. Pediatric dilated cardiomyopathy hearts display a unique gene expression profile. JCI Insight. 2017 Jul 20;2(14). [Epub ahead of print] PubMed PMID: 28724804
  • Jiang X, Sucharov J, Stauffer BL, Miyamoto SD, Sucharov CC. Exosomes from pediatric dilated cardiomyopathy patients modulate a pathological response in cardiomyocytes. Am J Physiol Heart Circ Physiol. 2017 Apr 1;312(4):H818-H826. PubMed PMID: 28130338
  • Medina E, Sucharov CC, Nelson P, Miyamoto SD, Stauffer BL. Molecular Changes in Children with Heart Failure Undergoing Left Ventricular Assist Device Therapy. J Pediatr. 2017 Mar;182:184-189.e1. PubMed PMID: 27908653
  • Woulfe KC, Siomos AK, Nguyen H, SooHoo M, Galambos C, Stauffer BL, Sucharov C, Miyamoto S. Fibrosis and Fibrotic Gene Expression in Pediatric and Adult Patients With Idiopathic Dilated Cardiomyopathy. J Card Fail. 2017 Apr;23(4):314-324. PubMed PMID: 27890770
  • Nakano SJ, Sucharov J, van Dusen R, Cecil M, Nunley K, Wickers S, Karimpur-Fard A, Stauffer BL, Miyamoto SD, Sucharov CC. Cardiac Adenylyl Cyclase and Phosphodiesterase Expression Profiles Vary by Age, Disease, and Chronic Phosphodiesterase Inhibitor Treatment. J Card Fail. 2017 Jan;23(1):72-80. PubMed PMID: 27427220
  • Medina E, Sucharov CC, Nelson P, Miyamoto SD, Stauffer BL. Molecular Changes in Children with Heart Failure Undergoing Left Ventricular Assist Device Therapy. J Pediatr. 2016 Nov 29. [Epub ahead of print] PubMed PMID: 27908653
  • Woulfe KC, Siomos AK, Nguyen H, SooHoo M, Galambo C, Stauffer BL, Sucharov C, Miyamoto S. Fibrosis and Fibrotic Gene Expression in Pediatric and Adult Patients With Idiopathic Dilated Cardiomyopathy. J Card Fail. 2016 Nov 24. [Epub ahead of print] PubMed PMID: 27890770
  • Stratton MS, Lin CY, Anand P, Tatman PD, Ferguson BS, Wickers ST, Ambardekar AV, Sucharov CC, Bradner JE, Haldar SM, McKinsey TA. Signal-Dependent Recruitment of BRD4 to Cardiomyocyte Super-Enhancers Is Suppressed by a MicroRNA. Cell Rep. 2016 Aug 2;16(5):1366-78. PubMed PMID: 27425608
  • Nakano SJ, Nelson P, Sucharov CC, Miyamoto SD. Myocardial Response to Milrinone in Single Right Ventricle Heart Disease. J Pediatr. 2016 Jul;174:199-203.e5. PubMed PMID: 27181939
  • Wang D, Zhang H, Li M, Frid MG, Flockton AR, McKeon BA, Yeager ME, Fini MA, Morrell NW, Pullamsetti SS, Velegala S, Seeger W, McKinsey TA, Sucharov CC, Stenmark KR. MicroRNA-124 controls the proliferative, migratory, and inflammatory phenotype of pulmonary vascular fibroblasts. Circ Res. 2014 Jan 3;114(1):67-78. PubMed PMID: 24122720
  • Sucharov CC, Hijmans JG, Sobus RD, Melhado WF, Miyamoto SD, Stauffer BL. ß-Adrenergic receptor antagonism in mice: a model for pediatric heart disease. J Appl Physiol (1985). 2013 Oct 1;115(7):979-87. PubMed PMID: 23887897
  • Stauffer BL, Russell G, Nunley K, Miyamoto SD, Sucharov CC. miRNA expression in pediatric failing human heart. J Mol Cell Cardiol. 2013 Apr;57:43-6. PubMed PMID: 23333438
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Practice Locations

University of Colorado Hospital (UCH)
12605 E. 16th Ave
Aurora, CO 80045
720-848-0000

Hospital Affiliation
  • University of Colorado Hospital

General Information

Graduate Schools:
  • PhD, University of Pennsylvania (1997)
  • MS, Federal University of Rio de Janeiro, Brazil (1995)
Undergraduate Schools:
  • BS, Federal University of Rio de Janeiro, Brazil (1990)
Fellowships:
  • University of Colorado, Postdoctoral Research Fellow (2002)
  • University of Colorado, Postdoctoral Research Fellow (2004)
Languages: English
Department: Medicine-Cardiology
Contact Us
CU Anschutz
Fitzsimons Building

13001 East 17th Place
Campus Box C290
Aurora, CO 80045

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