Mark Dell'acqua, PhD
Professor, Pharmacology

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Department: Pharmacology

Publications

  • Rajgor D, Purkey AM, Sanderson JL, Welle TM, Garcia JD, Dell'Acqua ML, Smith KR. Local miRNA-Dependent Translational Control of GABA(A)R Synthesis during Inhibitory Long-Term Potentiation. Cell Rep. 2020 Jun 23;31(12):107785. PubMed PMID: 32579917
  • Purkey AM, Dell'Acqua ML. Phosphorylation-Dependent Regulation of Ca(2 )-Permeable AMPA Receptors During Hippocampal Synaptic Plasticity. Front Synaptic Neurosci. 2020;12:8. PubMed PMID: 32292336
  • Cochrane, VA, Yang, Z, Dell’Acqua, ML, Shyng S-L (2020) AKAP79/150 coordinates leptin-induced PKA activation to regulate KATP channel trafficking in pancreatic beta-cells. J Biol Chem – under revision. bioRxiv https://www.biorxiv.org/content/10.1101/2020.11.25.397059v1.abstract
  • Dittmer PJ, Dell'Acqua ML, Sather WA. Synaptic crosstalk conferred by a zone of differentially regulated Ca(2 ) signaling in the dendritic shaft adjoining a potentiated spine. Proc Natl Acad Sci U S A. 2019 Jul 2;116(27):13611-13620. PubMed PMID: 31209051
  • Murphy JG, Crosby KC, Dittmer PJ, Sather WA, Dell'Acqua ML. AKAP79/150 recruits the transcription factor NFAT to regulate signaling to the nucleus by neuronal L-type Ca(2 ) channels. Mol Biol Cell. 2019 Jul 1;30(14):1743-1756. PubMed PMID: 31091162
  • Wild AR, Sinnen BL, Dittmer PJ, Kennedy MJ, Sather WA, Dell'Acqua ML. Synapse-to-Nucleus Communication through NFAT Is Mediated by L-type Ca(2 ) Channel Ca(2 ) Spike Propagation to the Soma. Cell Rep. 2019 Mar 26;26(13):3537-3550.e4. PubMed PMID: 30917310
  • Crosby KC, Gookin SE, Garcia JD, Hahm KM, Dell'Acqua ML, Smith KR. Nanoscale Subsynaptic Domains Underlie the Organization of the Inhibitory Synapse. Cell Rep. 2019 Mar 19;26(12):3284-3297.e3. PubMed PMID: 30893601
  • Gibson ES, Woolfrey KM, Li H, Hogan PG, Nemenoff RA, Heasley LE, Dell'Acqua ML. Subcellular Localization and Activity of the Mitogen-Activated Protein Kinase Kinase 7 (MKK7) ? Isoform are Regulated through Binding to the Phosphatase Calcineurin. Mol Pharmacol. 2019 Jan;95(1):20-32. PubMed PMID: 30404891
  • Purkey AM, Woolfrey KM, Crosby KC, Stich DG, Chick WS, Aoto J, Dell'Acqua ML. AKAP150 Palmitoylation Regulates Synaptic Incorporation of Ca(2 )-Permeable AMPA Receptors to Control LTP. Cell Rep. 2018 Oct 23;25(4):974-987.e4. PubMed PMID: 30355502
  • Dell'Acqua ML, Woolfrey KM. FRETting over postsynaptic PKC signaling. Nat Neurosci. 2018 Aug;21(8):1021-1022. PubMed PMID: 30013172
  • Sanderson JL, Scott JD, Dell'Acqua ML. Control of Homeostatic Synaptic Plasticity by AKAP-Anchored Kinase and Phosphatase Regulation of Ca(2 )-Permeable AMPA Receptors. J Neurosci. 2018 Mar 14;38(11):2863-2876. PubMed PMID: 29440558
  • Guercio LA, Hofmann ME, Swinford-Jackson SE, Sigman JS, Wimmer ME, Dell'Acqua ML, Schmidt HD, Pierce RC. A-Kinase Anchoring Protein 150 (AKAP150) Promotes Cocaine Reinstatement by Increasing AMPA Receptor Transmission in the Accumbens Shell. Neuropsychopharmacology. 2018 May;43(6):1395-1404. PubMed PMID: 29317777
  • Wild AR, Dell'Acqua ML. Potential for therapeutic targeting of AKAP signaling complexes in nervous system disorders. Pharmacol Ther. 2018 May;185:99-121. PubMed PMID: 29262295
  • Woolfrey KM, O'Leary H, Goodell DJ, Robertson HR, Horne EA, Coultrap SJ, Dell'Acqua ML, Bayer KU. CaMKII regulates the depalmitoylation and synaptic removal of the scaffold protein AKAP79/150 to mediate structural long-term depression. J Biol Chem. 2018 Feb 2;293(5):1551-1567. PubMed PMID: 29196604
  • Guercio LA, Hofmann ME, Swinford-Jackson SE, Sigman JS, Wimmer ME, Dell'Acqua ML, Schmidt HD, Pierce RC. A-Kinase Anchoring Protein 150 (AKAP150) Promotes Cocaine Reinstatement by Increasing AMPA Receptor Transmission in the Accumbens Shell. Neuropsychopharmacology. 2017 Dec 12. [Epub ahead of print] PubMed PMID: 29317777
  • Wild AR, Dell'Acqua ML. Potential for therapeutic targeting of AKAP signaling complexes in nervous system disorders. Pharmacol Ther. 2017 Dec 17. [Epub ahead of print] PubMed PMID: 29262295
  • Woolfrey KM, O'Leary H, Goodell DJ, Robertson HR, Horne EA, Coultrap SJ, Dell'Acqua ML, Bayer KU. CaMKII regulates the de-palmitoylation and synaptic removal of AKAP79/150 to mediate structural LTD. J Biol Chem. 2017 Dec 1. [Epub ahead of print] PubMed PMID: 29196604
  • Dittmer PJ, Wild AR, Dell'Acqua ML, Sather WA. STIM1 Ca(2 ) Sensor Control of L-type Ca(2 )-Channel-Dependent Dendritic Spine Structural Plasticity and Nuclear Signaling. Cell Rep. 2017 Apr 11;19(2):321-334. PubMed PMID: 28402855
  • Sinnen BL, Bowen AB, Forte JS, Hiester BG, Crosby KC, Gibson ES, Dell'Acqua ML, Kennedy MJ. Optogenetic Control of Synaptic Composition and Function. Neuron. 2017 Feb 8;93(3):646-660.e5. PubMed PMID: 28132827
  • Freund RK, Graw S, Choo KS, Stevens KE, Leonard S, Dell'Acqua ML. Genetic knockout of the a7 nicotinic acetylcholine receptor gene alters hippocampal long-term potentiation in a background strain-dependent manner. Neurosci Lett. 2016 Aug 3;627:1-6. PubMed PMID: 27233215
  • Freund RK, Gibson ES, Potter H, Dell'Acqua ML. Inhibition of the Motor Protein Eg5/Kinesin-5 in Amyloid ß-Mediated Impairment of Hippocampal Long-Term Potentiation and Dendritic Spine Loss. Mol Pharmacol. 2016 May;89(5):552-9. PubMed PMID: 26957206
  • Sanderson JL, Gorski JA, Dell'Acqua ML. NMDA Receptor-Dependent LTD Requires Transient Synaptic Incorporation of Ca²?-Permeable AMPARs Mediated by AKAP150-Anchored PKA and Calcineurin. Neuron. 2016 Mar 2;89(5):1000-15. PubMed PMID: 26938443
  • Nieves-Cintrón M, Nystoriak MA, Prada MP, Johnson K, Fayer W, Dell'Acqua ML, Scott JD, Navedo MF. Selective down-regulation of KV2.1 function contributes to enhanced arterial tone during diabetes. J Biol Chem. 2016 Mar 4;291(10):4912. PubMed PMID: 26945093
  • Nieves-Cintrón M, Hirenallur-Shanthappa D, Nygren PJ, Hinke SA, Dell'Acqua ML, Langeberg LK, Navedo M, Santana LF, Scott JD. AKAP150 participates in calcineurin/NFAT activation during the down-regulation of voltage-gated K( ) currents in ventricular myocytes following myocardial infarction. Cell Signal. 2016 Jul;28(7):733-40. PubMed PMID: 26724383
  • Nieves-Cintrón M, Hirenallur-Shanthappa D, Nygren PJ, Hinke SA, Dell'Acqua ML, Langeberg LK, Navedo M, Santana LF, Scott JD. AKAP150 participates in calcineurin/NFAT activation during the down-regulation of voltage-gated K( ) currents in ventricular myocytes following myocardial infarction. Cell Signal. 2015 Dec 24. [Epub ahead of print] PubMed PMID: 26724383
  • Woolfrey KM, Dell'Acqua ML. Coordination of Protein Phosphorylation and Dephosphorylation in Synaptic Plasticity. J Biol Chem. 2015 Nov 27;290(48):28604-12. PubMed PMID: 26453308
  • Yu T, Taussig MD, DiPatrizio NV, Astarita G, Piomelli D, Bergman BC, Dell'Acqua ML, Eckel RH, Wang H. Deficiency of Lipoprotein Lipase in Neurons Decreases AMPA Receptor Phosphorylation and Leads to Neurobehavioral Abnormalities in Mice. PLoS One. 2015;10(8):e0135113. PubMed PMID: 26263173
  • Samelson BK, Gore BB, Whiting JL, Nygren PJ, Purkey AM, Colledge M, Langeberg LK, Dell'Acqua ML, Zweifel LS, Scott JD. A-kinase Anchoring Protein 79/150 Recruits Protein Kinase C to Phosphorylate Roundabout Receptors. J Biol Chem. 2015 May 29;290(22):14107-19. PubMed PMID: 25882844
  • Nieves-Cintrón M, Nystoriak MA, Prada MP, Johnson K, Fayer W, Dell'Acqua ML, Scott JD, Navedo MF. Selective down-regulation of KV2.1 function contributes to enhanced arterial tone during diabetes. J Biol Chem. 2015 Mar 20;290(12):7918-29. PubMed PMID: 25670860
  • Woolfrey KM, Sanderson JL, Dell'Acqua ML. The palmitoyl acyltransferase DHHC2 regulates recycling endosome exocytosis and synaptic potentiation through palmitoylation of AKAP79/150. J Neurosci. 2015 Jan 14;35(2):442-56. PubMed PMID: 25589740
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General Information

Department: Pharmacology
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