Aurélie Ledreux, PhD, MS
Assistant Professor, Neurosurgery

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Languages: English, French
Department: Neurosurgery

Professional Titles

  • Assistant Professor

Research Interests

My current research interests encompass neurodegenerative diseases and healthy brain aging. My lab uses clinical samples as well as animal models to investigate neurodegeneration and neuroinflammation as underlying mechanisms in Alzheimer’s disease, Down syndrome as well as traumatic brain injury.


  • Iulita MF, Granholm AC, Carmona-Iragui M, Hamlett ED, Fortea J, Ledreux A. Fluid biomarkers for Alzheimer’s disease in Down syndrome: current status and novel trends. In: The neurobiology of aging and Alzheimer disease in Down syndrome. Head E, Lott I (Eds), Elsevier, pp. 97-128.
  • Nicastri CM, McFeeley B, Simon SS, Ledreux A, Håkansson K, Granholm A-C, Mohammed A, Daffner K. BDNF mediates improvement in cognitive performance after computerized cognitive training in healthy older adults. Submitted to Alzheimer’s and Dementia, Nov. 2021
  • Ahmed J, Fitch TC, Donnelly CM, Joseph JA, Bassil MA, Son A, Zhang C, Ledreux A, Horowitz S, Qin Y, Paredes DA, Kumar S. Foldamers reveal and validate novel therapeutic targets associated with toxic a-synuclein self-assembly. Submitted to Nature Communications, Nov 2021.
  • Ledreux A, Thomas S, Hamlett ED, Gilmore A, Trautman CW, Margittai M, Fortea J, Granholm A-C (2021). Small neuron-derived extracellular vesicles from individuals with Down syndrome propagate Tau pathology in the wildtype mouse brain. Journal of Clinical Medicine 10 (17), 3931
  • Grossberg AN, Bettcher B, Gorgens K, Ledreux A (2021). A 6-week learning intervention increases serum BDNF levels in healthy older adults. Frontiers in Aging 35.
  • Grossberg AN, Koza LA, Ledreux A, Prusmack C, Krishnamurthy HK, Jayaraman V, Granholm A-C, Linseman DA (2021). A multiplex chemiluminescent immunoassay for serological profiling of COVID-19-positive symptomatic and asymptomatic patients. Nature Communications 12, 740
  • Granholm A-C, Ledreux A (2021). Biomarkers show value of studying dementia in Down syndrome. Nature Reviews Neurology
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Professional Memberships

  • International Society for Extracellular Vesicles, Member
  • Trisomy 21 Research Society, Member

General Information

Download CV
Languages: English, French
Department: Neurosurgery
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Campus Box C290
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