Sharon R. Pine, PhD
Visiting Professor, Medicine-Medical Oncology

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Graduate School :
  • PhD, New York Medical College
Undergraduate School:
  • BA, Arcadia University (PA)
Fellowships:
  • National Cancer Institute, Lung Cancer Research
Department: Medicine-Medical Oncology

Professional Titles

  • Director of the Thoracic Oncology Research Initiative (TORI)
  • Pia and Fred R. Hirsch Endowed Chair in Lung Cancer Research

Publications

  • Bhatt V, Lan T, Wang W, Kong J, Lopes EC, Wang J, Khayati K, Raju A, Rangel M, Lopez E, Hu ZS, Luo X, Su X, Malhotra J, Hu W, Pine SR, White E, Guo JY. Inhibition of autophagy and MEK promotes ferroptosis in Lkb1-deficient Kras-driven lung tumors. Cell Death Dis. 2023 Jan 26;14(1):61. PubMed PMID: 36702816
  • Malhotra J, Paddock LE, Lin Y, Pine SR, Habib MH, Stroup A, Manne S. Racial disparities in follow-up care of early-stage lung cancer survivors. J Cancer Surviv. 2023 Oct;17(5):1259-1265. PubMed PMID: 35318568
  • Zhong H, Lu W, Tang Y, Wiel C, Wei Y, Cao J, Riedlinger G, Papagiannakopoulos T, Guo JY, Bergo MO, Kang Y, Ganesan S, Sabaawy HE, Pine SR. SOX9 drives KRAS-induced lung adenocarcinoma progression and suppresses anti-tumor immunity. Oncogene. 2023 Jun;42(27):2183-2194. PubMed PMID: 37258742
  • Bhatt V, Lan T, Wang W, Kong J, Lopes EC, Wang J, Khayati K, Raju A, Rangel M, Lopez E, Hu ZS, Luo X, Su X, Malhotra J, Hu W, Pine SR, White E, Guo JY. Inhibition of autophagy and MEK promotes ferroptosis in Lkb1-deficient Kras-driven lung tumors. Cell Death Dis. 2023 Jan 26;14(1):61. PubMed PMID: 36702816
  • Hoang DT, Dinstag G, Hermida LC, Ben-Zvi DS, Elis E, Caley K, Sammut SJ, Sinha S, Sinha N, Dampier CH, Stossel C, Patil T, Rajan A, Lassoued W, Strauss J, Bailey S, Allen C, Redman J, Beker T, Jiang P, Golan T, Wilkinson S, Sowalsky AG, Pine SR, Caldas C, Gulley JL, Aldape K, Aharonov R, Stone EA, Ruppin E. Prediction of cancer treatment response from histopathology images through imputed transcriptomics. Res Sq. 2023 Sep 15. PubMed PMID: 37790315
  • Castellano GM, Zeeshan S, Garbuzenko OB, Sabaawy HE, Malhotra J, Minko T, Pine SR. Inhibition of Mtorc1/2 and DNA-PK via CC-115 Synergizes with Carboplatin and Paclitaxel in Lung Squamous Cell Carcinoma. Mol Cancer Ther. 2022 Sep 6;21(9):1381-1392. PubMed PMID: 35732569
  • Malhotra J, Ryan B, Patel M, Chan N, Guo Y, Aisner J, Jabbour SK, Pine S. Clinical outcomes and immune phenotypes associated with STK11 co-occurring mutations in non-small cell lung cancer. J Thorac Dis. 2022 Jun;14(6):1772-1783. PubMed PMID: 35813711
  • Chambers AM, Lupo KB, Wang J, Cao J, Utturkar S, Lanman N, Bernal-Crespo V, Jalal S, Pine SR, Torregrosa-Allen S, Elzey BD, Matosevic S. Engineered natural killer cells impede the immunometabolic CD73-adenosine axis in solid tumors. Elife. 2022 Jul 11;11. PubMed PMID: 35815945
  • Malhotra J, Paddock LE, Lin Y, Pine SR, Habib MH, Stroup A, Manne S. Racial disparities in follow-up care of early-stage lung cancer survivors. J Cancer Surviv. 2022 Mar 22. [Epub ahead of print] PubMed PMID: 35318568
  • Kwon M, Rubio G, Nolan N, Auteri P, Volmar JA, Adem A, Javidian P, Zhou Z, Verzi MP, Pine SR, Libutti SK. FILIP1L Loss Is a Driver of Aggressive Mucinous Colorectal Adenocarcinoma and Mediates Cytokinesis Defects through PFDN1. Cancer Res. 2021 Nov 1;81(21):5523-5539. PubMed PMID: 34417201
  • Sabaawy HE, Ryan BM, Khiabanian H, Pine SR. JAK/STAT of all trades: linking inflammation with cancer development, tumor progression and therapy resistance. Carcinogenesis. 2021 Dec 31;42(12):1411-1419. PubMed PMID: 34415330
  • Arauz RF, Byun JS, Tandon M, Sinha S, Kuhn S, Taylor S, Zingone A, Mitchell KA, Pine SR, Gardner K, Perez-Stable EJ, Napoles AM, Ryan BM. Whole-Exome Profiling of NSCLC Among African Americans. J Thorac Oncol. 2020 Dec;15(12):1880-1892. PubMed PMID: 32931935
  • Castellano GM, Pine SR. Liquid biopsies in non-small cell lung cancer management: what can we learn from methylation status and mutant allele frequencies?. Transl Lung Cancer Res. 2020 Aug;9(4):951-955. PubMed PMID: 32953473
  • Mitchell KA, Shah E, Bowman ED, Zingone A, Nichols N, Pine SR, Kittles RA, Ryan BM. Relationship between West African ancestry with lung cancer risk and survival in African Americans. Cancer Causes Control. 2019 Nov;30(11):1259-1268. PubMed PMID: 31468279
  • Castellano GM, Aisner J, Burley SK, Vallat B, Yu HA, Pine SR, Ganesan S. A Novel Acquired Exon 20 EGFR M766Q Mutation in Lung Adenocarcinoma Mediates Osimertinib Resistance but is Sensitive to Neratinib and Poziotinib. J Thorac Oncol. 2019 Nov;14(11):1982-1988. PubMed PMID: 31254668
  • Meaney CL, Mitchell KA, Zingone A, Brown D, Bowman E, Yu Y, Wenzlaff AS, Neslund-Dudas C, Pine SR, Cao L, Schwartz AG, Ryan BM. Circulating Inflammation Proteins Associated With Lung Cancer in African Americans. J Thorac Oncol. 2019 Jul;14(7):1192-1203. PubMed PMID: 30953795
  • Malhotra J, Jabbour SK, Pine S. Impact of surveillance frequency on survival in non-small cell lung cancer (NSCLC) survivors. Transl Lung Cancer Res. 2019 Dec;8(Suppl 4):S347-S350. PubMed PMID: 32038912
  • Pine SR, Ryan BM. Identifying therapeutic vulnerabilities in lung cancer: application of a chemistry-first approach. Transl Lung Cancer Res. 2018 Sep;7(Suppl 3):S265-S269. PubMed PMID: 30393619
  • Pine SR. Rethinking Gamma-secretase Inhibitors for Treatment of Non-small-Cell Lung Cancer: Is Notch the Target?. Clin Cancer Res. 2018 Dec 15;24(24):6136-6141. PubMed PMID: 30104200
  • Kulkarni A, Al-Hraishawi H, Simhadri S, Hirshfield KM, Chen S, Pine S, Jeyamohan C, Sokol L, Ali S, Teo ML, White E, Rodriguez-Rodriguez L, Mehnert JM, Ganesan S. BRAF Fusion as a Novel Mechanism of Acquired Resistance to Vemurafenib in BRAF(V600E) Mutant Melanoma. Clin Cancer Res. 2017 Sep 15;23(18):5631-5638. PubMed PMID: 28539463
  • Morgan KM, Fischer BS, Lee FY, Shah JJ, Bertino JR, Rosenfeld J, Singh A, Khiabanian H, Pine SR. Gamma Secretase Inhibition by BMS-906024 Enhances Efficacy of Paclitaxel in Lung Adenocarcinoma. Mol Cancer Ther. 2017 Dec;16(12):2759-2769. PubMed PMID: 28978720
  • Hong X, Liu W, Song R, Shah JJ, Feng X, Tsang CK, Morgan KM, Bunting SF, Inuzuka H, Zheng XF, Shen Z, Sabaawy HE, Liu L, Pine SR. SOX9 is targeted for proteasomal degradation by the E3 ligase FBW7 in response to DNA damage. Nucleic Acids Res. 2016 Oct 14;44(18):8855-8869. PubMed PMID: 27566146
  • Pine SR, Mechanic LE, Enewold L, Bowman ED, Ryan BM, Cote ML, Wenzlaff AS, Loffredo CA, Olivo-Marston S, Chaturvedi A, Caporaso NE, Schwartz AG, Harris CC. Differential Serum Cytokine Levels and Risk of Lung Cancer Between African and European Americans. Cancer Epidemiol Biomarkers Prev. 2016 Mar;25(3):488-97. PubMed PMID: 26711330
  • Ryan BM, Robles AI, McClary AC, Haznadar M, Bowman ED, Pine SR, Brown D, Khan M, Shiraishi K, Kohno T, Okayama H, Modali R, Yokota J, Harris CC. Identification of a functional SNP in the 3'UTR of CXCR2 that is associated with reduced risk of lung cancer. Cancer Res. 2015 Feb 1;75(3):566-75. PubMed PMID: 25480945
  • Ryan BM, Pine SR, Chaturvedi AK, Caporaso N, Harris CC. A combined prognostic serum interleukin-8 and interleukin-6 classifier for stage 1 lung cancer in the prostate, lung, colorectal, and ovarian cancer screening trial. J Thorac Oncol. 2014 Oct;9(10):1494-503. PubMed PMID: 25170636
  • Capaccione KM, Hong X, Morgan KM, Liu W, Bishop JM, Liu L, Markert E, Deen M, Minerowicz C, Bertino JR, Allen T, Pine SR. Sox9 mediates Notch1-induced mesenchymal features in lung adenocarcinoma. Oncotarget. 2014 Jun 15;5(11):3636-50. PubMed PMID: 25004243
  • Capaccione KM, Pine SR. The Notch signaling pathway as a mediator of tumor survival. Carcinogenesis. 2013 Jul;34(7):1420-30. PubMed PMID: 23585460
  • Mondal AM, Horikawa I, Pine SR, Fujita K, Morgan KM, Vera E, Mazur SJ, Appella E, Vojtesek B, Blasco MA, Lane DP, Harris CC. p53 isoforms regulate aging- and tumor-associated replicative senescence in T lymphocytes. J Clin Invest. 2013 Dec;123(12):5247-57. PubMed PMID: 24231352
  • Ryan BM, Calhoun KM, Pine SR, Bowman ED, Robles AI, Ambs S, Harris CC. MDM2 SNP285 does not antagonize the effect of SNP309 in lung cancer. Int J Cancer. 2012 Dec 1;131(11):2710-6. PubMed PMID: 22487911
  • Patel SA, Ramkissoon SH, Bryan M, Pliner LF, Dontu G, Patel PS, Amiri S, Pine SR, Rameshwar P. Delineation of breast cancer cell hierarchy identifies the subset responsible for dormancy. Sci Rep. 2012;2:906. PubMed PMID: 23205268
  • Schwartz AG, Wenzlaff AS, Bock CH, Ruterbusch JJ, Chen W, Cote ML, Artis AS, Van Dyke AL, Land SJ, Harris CC, Pine SR, Spitz MR, Amos CI, Levin AM, McKeigue PM. Admixture mapping of lung cancer in 1812 African-Americans. Carcinogenesis. 2011 Mar;32(3):312-7. PubMed PMID: 21115650
  • Pine SR, Mechanic LE, Enewold L, Chaturvedi AK, Katki HA, Zheng YL, Bowman ED, Engels EA, Caporaso NE, Harris CC. Increased levels of circulating interleukin 6, interleukin 8, C-reactive protein, and risk of lung cancer. J Natl Cancer Inst. 2011 Jul 20;103(14):1112-22. PubMed PMID: 21685357
  • Chaturvedi AK, Caporaso NE, Katki HA, Wong HL, Chatterjee N, Pine SR, Chanock SJ, Goedert JJ, Engels EA. C-reactive protein and risk of lung cancer. J Clin Oncol. 2010 Jun 1;28(16):2719-26. PubMed PMID: 20421535
  • Pine SR, Ryan BM, Varticovski L, Robles AI, Harris CC. Microenvironmental modulation of asymmetric cell division in human lung cancer cells. Proc Natl Acad Sci U S A. 2010 Feb 2;107(5):2195-200. PubMed PMID: 20080668
  • Fujita K, Mondal AM, Horikawa I, Nguyen GH, Kumamoto K, Sohn JJ, Bowman ED, Mathe EA, Schetter AJ, Pine SR, Ji H, Vojtesek B, Bourdon JC, Lane DP, Harris CC. p53 isoforms Delta133p53 and p53beta are endogenous regulators of replicative cellular senescence. Nat Cell Biol. 2009 Sep;11(9):1135-42. PubMed PMID: 19701195
  • Olivo-Marston SE, Yang P, Mechanic LE, Bowman ED, Pine SR, Loffredo CA, Alberg AJ, Caporaso N, Shields PG, Chanock S, Wu Y, Jiang R, Cunningham J, Jen J, Harris CC. Childhood exposure to secondhand smoke and functional mannose binding lectin polymorphisms are associated with increased lung cancer risk. Cancer Epidemiol Biomarkers Prev. 2009 Dec;18(12):3375-83. PubMed PMID: 19959685
  • Martin RC, Barker DF, Doll MA, Pine SR, Mechanic L, Bowman ED, Harris CC, Hein DW. Manganese superoxide dismutase gene coding region polymorphisms lack clinical incidence in general population. DNA Cell Biol. 2008 Jun;27(6):321-3. PubMed PMID: 18466086
  • Pine SR, Marshall B, Varticovski L. Lung cancer stem cells. Dis Markers. 2008;24(4-5):257-66. PubMed PMID: 18525120
  • Pine SR, Mechanic LE, Ambs S, Bowman ED, Chanock SJ, Loffredo C, Shields PG, Harris CC. Lung cancer survival and functional polymorphisms in MBL2, an innate-immunity gene. J Natl Cancer Inst. 2007 Sep 19;99(18):1401-9. PubMed PMID: 17848669
  • Pine SR, Guo Q, Yin C, Jayabose S, Druschel CM, Sandoval C. Incidence and clinical implications of GATA1 mutations in newborns with Down syndrome. Blood. 2007 Sep 15;110(6):2128-31. PubMed PMID: 17576817
  • Sandoval C, Pine SR. Down syndrome and GATA1-related transient leukemia. J Pediatr. 2007 Mar;150(3):e34. PubMed PMID: 17307526
  • Sabaawy HE, Sandoval C, Guo Q, Yin C, Kulangara A, Lee J, Wormser G, Jayabose S, Pine SR. Lymphoproliferative clonal origin of AIDS-related non-Hodgkin's lymphoma. Leuk Lymphoma. 2007 Apr;48(4):812-5. PubMed PMID: 17454643
  • Pine SR, Mechanic LE, Bowman ED, Welsh JA, Chanock SC, Shields PG, Harris CC. MDM2 SNP309 and SNP354 are not associated with lung cancer risk. Cancer Epidemiol Biomarkers Prev. 2006 Aug;15(8):1559-61. PubMed PMID: 16896050
  • Pine SR, Guo Q, Yin C, Jayabose S, Levendoglu-Tugal O, Ozkaynak MF, Sandoval C. GATA1 as a new target to detect minimal residual disease in both transient leukemia and megakaryoblastic leukemia of Down syndrome. Leuk Res. 2005 Nov;29(11):1353-6. PubMed PMID: 15916804
  • Sandoval C, Pine SR, Guo Q, Sastry S, Stewart J, Kronn D, Jayabose S. Tetrasomy 21 transient leukemia with a GATA1 mutation in a phenotypically normal trisomy 21 mosaic infant: case report and review of the literature. Pediatr Blood Cancer. 2005 Jan;44(1):85-91. PubMed PMID: 15390279
  • Pine SR, Yin C, Matloub YH, Sabaawy HE, Sandoval C, Levendoglu-Tugal O, Ozkaynak MF, Jayabose S. Detection of central nervous system leukemia in children with acute lymphoblastic leukemia by real-time polymerase chain reaction. J Mol Diagn. 2005 Feb;7(1):127-32. PubMed PMID: 15681484
  • Pine SR, Moy FH, Wiemels JL, Gill RK, Levendoglu-Tugal O, Ozkaynak MF, Sandoval C, Jayabose S. Real-time quantitative PCR: standardized detection of minimal residual disease in pediatric acute lymphoblastic leukemia. Polymerase chain reaction. J Pediatr Hematol Oncol. 2003 Feb;25(2):103-8. PubMed PMID: 12571459
  • Pine SR, Wiemels JL, Jayabose S, Sandoval C. TEL-AML1 fusion precedes differentiation to pre-B cells in childhood acute lymphoblastic leukemia. Leuk Res. 2003 Feb;27(2):155-64. PubMed PMID: 12526921
  • Wiemels JL, Leonard BC, Wang Y, Segal MR, Hunger SP, Smith MT, Crouse V, Ma X, Buffler PA, Pine SR. Site-specific translocation and evidence of postnatal origin of the t(1;19) E2A-PBX1 fusion in childhood acute lymphoblastic leukemia. Proc Natl Acad Sci U S A. 2002 Nov 12;99(23):15101-6. PubMed PMID: 12415113
  • Mayer SP, Jayabose S, Tugal O, Ozkaynak MF, Rosenblum-Vos L, Sandoval C. Origin of a central nervous system lymphoid neoplasm in an immunocompromised host with acute lymphoblastic leukemia. Leuk Lymphoma. 2002 Sep;43(9):1881-4. PubMed PMID: 12685849
  • Senzaki H, Smith CJ, Juang GJ, Isoda T, Mayer SP, Ohler A, Paolocci N, Tomaselli GF, Hare JM, Kass DA. Cardiac phosphodiesterase 5 (cGMP-specific) modulates beta-adrenergic signaling in vivo and is down-regulated in heart failure. FASEB J. 2001 Aug;15(10):1718-26. PubMed PMID: 11481219
  • Deptala A, Mayer SP. Detection of minimal residual disease. Methods Cell Biol. 2001;64:385-420. PubMed PMID: 11070849
  • Wiemels JL, Alexander FE, Cazzaniga G, Biondi A, Mayer SP, Greaves M. Microclustering of TEL-AML1 translocation breakpoints in childhood acute lymphoblastic leukemia. Genes Chromosomes Cancer. 2000 Nov;29(3):219-28. PubMed PMID: 10992297
  • Sandoval C, Mayer SP, Ozkaynak MF, Tugal O, Jayabose S. Trisomy 5 as a sole cytogenetic abnormality in pediatric acute lymphoblastic leukemia. Cancer Genet Cytogenet. 2000 Apr 1;118(1):69-71. PubMed PMID: 10731595
  • Sandoval C, Mayer SP, Giamelli J, Farley T, Ozkaynak MF, Tugal O, Jayabose S. Cytogenetic abnormalities during clinical, immunophenotypic, and molecular remission in pediatric acute lymphoblastic leukemia. Cancer Genet Cytogenet. 2000 Apr 1;118(1):9-13. PubMed PMID: 10731583
  • Mayer SP, Giamelli J, Sandoval C, Roach AS, Fevzi Ozkaynak M, Tugal O, Rovera G, Jayabose S. Quantitation of leukemia clone-specific antigen gene rearrangements by a single-step PCR and fluorescence-based detection method. Leukemia. 1999 Nov;13(11):1843-52. PubMed PMID: 10557060
  • Dibenedetto SP, Lo Nigro L, Mayer SP, Rovera G, Schilirò G. Detectable molecular residual disease at the beginning of maintenance therapy indicates poor outcome in children with T-cell acute lymphoblastic leukemia. Blood. 1997 Aug 1;90(3):1226-32. PubMed PMID: 9242556
  • Jacobsohn MK, Bauder S, Pine SR, Jacobsohn GM. Cholesterol limits estrogen uptake by liposomes and erythrocyte membranes. Biochim Biophys Acta. 1994 Oct 12;1195(1):131-40. PubMed PMID: 7918555
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Practice Locations

University of Colorado Cancer Center - Anschutz Medical Campus
1665 Aurora Ct
Aurora, CO 80045
720-848-0300

General Information

Graduate Schools:
  • PhD, New York Medical College (0001)
Undergraduate Schools:
  • BA, Arcadia University (PA) (0001)
Fellowships:
  • National Cancer Institute, Lung Cancer Research (0001)
Department: Medicine-Medical Oncology
SOM Resources
CU Resources
Contact Us
CU Anschutz
Fitzsimons Building
13001 East 17th Place
Campus Box C290
Aurora, CO 80045

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