Eileen Chang, PhD, MCR
Instructor, Pediatrics-Neonatology

Graduate Schools :
  • PhD, University of Florida College of Medicine
  • MCR, Oregon Health And Science University
Undergraduate School:
  • BS, Georgia Institute of Technology
Languages: English, Mandarin, Taiwanese
Department: Pediatrics-Neonatology


  • Stremming J, Chang EI, Knaub LA, Armstrong ML, Baker PR 2nd, Wesolowski SR, Reisdorph N, Reusch JEB, Brown LD. Lower citrate synthase activity, mitochondrial complex expression, and fewer oxidative myofibers characterize skeletal muscle from growth-restricted fetal sheep. Am J Physiol Regul Integr Comp Physiol. 2022 Mar 1;322(3):R228-R240. PubMed PMID: 34907787
  • Brown LD, Palmer C, Teynor L, Boehmer BH, Stremming J, Chang EI, White A, Jones AK, Cilvik SN, Wesolowski SR, Rozance PJ. Fetal Sex Does Not Impact Placental Blood Flow or Placental Amino Acid Transfer in Late Gestation Pregnant Sheep With or Without Placental Insufficiency. Reprod Sci. 2022 Jun;29(6):1776-1789. PubMed PMID: 34611848
  • Stremming J, Heard S, White A, Chang EI, Shaw SC, Wesolowski SR, Jonker SS, Rozance PJ, Brown LD. IGF-1 infusion to fetal sheep increases organ growth but not by stimulating nutrient transfer to the fetus. Am J Physiol Endocrinol Metab. 2021 Mar 1;320(3):E527-E538. PubMed PMID: 33427051
  • White A, Stremming J, Boehmer BH, Chang EI, Jonker SS, Wesolowski SR, Brown LD, Rozance PJ. Reduced glucose-stimulated insulin secretion following a 1-wk IGF-1 infusion in late gestation fetal sheep is due to an intrinsic islet defect. Am J Physiol Endocrinol Metab. 2021 Jun 1;320(6):E1138-E1147. PubMed PMID: 33938236
  • Chang EI, Hetrick B, Wesolowski SR, McCurdy CE, Rozance PJ, Brown LD. A Two-Week Insulin Infusion in Intrauterine Growth Restricted Fetal Sheep at 75% Gestation Increases Skeletal Myoblast Replication but Did Not Restore Muscle Mass or Increase Fiber Number. Front Endocrinol (Lausanne). 2021;12:785242. PubMed PMID: 34917036
  • Jonker SS, Giraud GD, Chang EI, Elman MR, Louey S. Coronary vascular growth matches IGF-1-stimulated cardiac growth in fetal sheep. FASEB J. 2020 Aug;34(8):10041-10055. PubMed PMID: 32573852
  • Chang EI, Wesolowski SR, Gilje EA, Baker PR 2nd, Reisz JA, D'Alessandro A, Hay WW Jr, Rozance PJ, Brown LD. Skeletal muscle amino acid uptake is lower and alanine production is greater in late gestation intrauterine growth-restricted fetal sheep hindlimb. Am J Physiol Regul Integr Comp Physiol. 2019 Nov 1;317(5):R615-R629. PubMed PMID: 31483682
  • Chang EI, Rozance PJ, Wesolowski SR, Nguyen LM, Shaw SC, Sclafani RA, Bjorkman KK, Peter AK, Hay W Jr, Brown LD. Rates of myogenesis and myofiber numbers are reduced in late gestation IUGR fetal sheep. J Endocrinol. 2019 Dec 19;244(2):339-352. PubMed PMID: 31751294
  • Chang EI, Zarate MA, Arndt TJ, Richards EM, Rabaglino MB, Keller-Wood M, Wood CE. Ketamine Reduces Inflammation Pathways in the Hypothalamus and Hippocampus Following Transient Hypoxia in the Late-Gestation Fetal Sheep. Front Physiol. 2018;9:1858. PubMed PMID: 30666211
  • White A, Louey S, Chang EI, Boehmer BH, Goldstrohm D, Jonker SS, Rozance PJ. A 1 week IGF-1 infusion decreases arterial insulin concentrations but increases pancreatic insulin content and islet vascularity in fetal sheep. Physiol Rep. 2018 Sep;6(17):e13840. PubMed PMID: 30175552
  • Zarate MA, Chang EI, Wood CE. Effects of ketamine on the fetal transcriptomic response to umbilical cord occlusion: comparison with hypoxic hypoxia in the cerebral cortex. J Physiol. 2018 Dec;596(23):6063-6077. PubMed PMID: 29882596
  • Zarate MA, Rodriguez MD, Chang EI, Russell JT, Arndt TJ, Richards EM, Ocasio BA, Aranda E, Gordon EM, Yu K, Neu J, Keller-Wood M, Triplett EW, Wood CE. Post-hypoxia Invasion of the fetal brain by multidrug resistant Staphylococcus. Sci Rep. 2017 Jul 25;7(1):6458. PubMed PMID: 28743956
  • Zarate MA, Chang EI, Antolic A, Wood CE. Ketamine modulates fetal hemodynamic and endocrine responses to umbilical cord occlusion. Physiol Rep. 2016 Sep;4(17). PubMed PMID: 27597770
  • Chang EI, Zárate MA, Rabaglino MB, Richards EM, Keller-Wood M, Wood CE. Ketamine suppresses hypoxia-induced inflammatory responses in the late-gestation ovine fetal kidney cortex. J Physiol. 2016 Mar 1;594(5):1295-310. PubMed PMID: 26497972
  • Chang EI, Zárate MA, Rabaglino MB, Richards EM, Arndt TJ, Keller-Wood M, Wood CE. Ketamine decreases inflammatory and immune pathways after transient hypoxia in late gestation fetal cerebral cortex. Physiol Rep. 2016 Mar;4(6). PubMed PMID: 27033443
  • Rabaglino MB, Chang EI, Richards EM, James MO, Keller-Wood M, Wood CE. Genomic Effect of Triclosan on the Fetal Hypothalamus: Evidence for Altered Neuropeptide Regulation. Endocrinology. 2016 Jul;157(7):2686-97. PubMed PMID: 27145008
  • Wood CE, Chang EI, Richards EM, Rabaglino MB, Keller-Wood M. Transcriptomics Modeling of the Late-Gestation Fetal Pituitary Response to Transient Hypoxia. PLoS One. 2016;11(2):e0148465. PubMed PMID: 26859870
  • Chang EI, Wood CE. Ketamine Attenuates the ACTH Response to Hypoxia in Late-Gestation Ovine Fetus. Neonatology. 2015;107(4):249-55. PubMed PMID: 25721799
  • Wood CE, Rabaglino MB, Richards E, Denslow N, Zarate MA, Chang EI, Keller-Wood M. Transcriptomics of the fetal hypothalamic response to brachiocephalic occlusion and estradiol treatment. Physiol Genomics. 2014 Jul 15;46(14):523-32. PubMed PMID: 24824211
  • Ashraf H, Pradhan L, Chang EI, Terada R, Ryan NJ, Briggs LE, Chowdhury R, Zárate MA, Sugi Y, Nam HJ, Benson DW, Anderson RH, Kasahara H. A mouse model of human congenital heart disease: high incidence of diverse cardiac anomalies and ventricular noncompaction produced by heterozygous Nkx2-5 homeodomain missense mutation. Circ Cardiovasc Genet. 2014 Aug;7(4):423-433. PubMed PMID: 25028484
  • Wood CE, Rabaglino MB, Chang EI, Denslow N, Keller-Wood M, Richards E. Genomics of the fetal hypothalamic cellular response to transient hypoxia: endocrine, immune, and metabolic responses. Physiol Genomics. 2013 Jul 2;45(13):521-7. PubMed PMID: 23653468
  • Shaffer HA, Rood MK, Kashlan B, Chang EI, Doyle DF, Azizi B. BAPJ69-4A: a yeast two-hybrid strain for both positive and negative genetic selection. J Microbiol Methods. 2012 Oct;91(1):22-9. PubMed PMID: 22796058
  • Warren SA, Briggs LE, Zeng H, Chuang J, Chang EI, Terada R, Li M, Swanson MS, Lecker SH, Willis MS, Spinale FG, Maupin-Furlowe J, McMullen JR, Moss RL, Kasahara H. Myosin light chain phosphorylation is critical for adaptation to cardiac stress. Circulation. 2012 Nov 27;126(22):2575-88. PubMed PMID: 23095280
  • Jones JA, Zavadzkas JA, Chang EI, Sheats N, Koval C, Stroud RE, Spinale FG, Ikonomidis JS. Cellular phenotype transformation occurs during thoracic aortic aneurysm development. J Thorac Cardiovasc Surg. 2010 Sep;140(3):653-9. PubMed PMID: 20219212
  • Mukherjee R, Rivers WT, Ruddy JM, Matthews RG, Koval CN, Plyler RA, Chang EI, Patel RK, Kern CB, Stroud RE, Spinale FG. Long-term localized high-frequency electric stimulation within the myocardial infarct: effects on matrix metalloproteinases and regional remodeling. Circulation. 2010 Jul 6;122(1):20-32. PubMed PMID: 20566951
  • Mukherjee R, Zavadzkas JA, Rivers WT, McLean JE, Chang EI, Bouges S, Matthews RG, Koval CN, Stroud RE, Spinale FG. Short-term disruption in regional left ventricular electrical conduction patterns increases interstitial matrix metalloproteinase activity. Am J Physiol Heart Circ Physiol. 2010 Jul;299(1):H217-24. PubMed PMID: 20472759
  • Shah SA, Spinale FG, Ikonomidis JS, Stroud RE, Chang EI, Reed CE. Differential matrix metalloproteinase levels in adenocarcinoma and squamous cell carcinoma of the lung. J Thorac Cardiovasc Surg. 2010 Apr;139(4):984-90; discussion 990. PubMed PMID: 20304142
  • Zavadzkas JA, Plyler RA, Bouges S, Koval CN, Rivers WT, Beck CU, Chang EI, Stroud RE, Mukherjee R, Spinale FG. Cardiac-restricted overexpression of extracellular matrix metalloproteinase inducer causes myocardial remodeling and dysfunction in aging mice. Am J Physiol Heart Circ Physiol. 2008 Oct;295(4):H1394-402. PubMed PMID: 18689500
  • Azizi B, Chang EI, Doyle DF. Chemical complementation: small-molecule-based genetic selection in yeast. Biochem Biophys Res Commun. 2003 Jul 4;306(3):774-80. PubMed PMID: 12810086
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Professional Memberships

  • Society for Reproductive Investigation, Member
  • Perinatal Research Society, Member
  • International Society for Developmental Origins of Health and Disease (DOHaD), Member
  • The American Physiological Society, Member

Practice Locations

Center Affiliations

General Information

Graduate Schools:
  • PhD, University of Florida College of Medicine (0001)
  • MCR, Oregon Health And Science University (0001)
Undergraduate Schools:
  • BS, Georgia Institute of Technology (0001)
Languages: English, Mandarin, Taiwanese
Department: Pediatrics-Neonatology
Contact Us
CU Anschutz
Fitzsimons Building

13001 East 17th Place
Campus Box C290
Aurora, CO 80045

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