Dennis Roop, PhD
Professor, Dermatology

Publications

• Goldstein NB, Steel A, Tomb L, Berk Z, Hu J, Balaya V, Hoaglin L, Ganuthula K, Patel M, Mbika E, Robinson WA, Roop DR, Norris DA, Birlea SA. Vitiligo non-responding lesions to narrow band UVB have intriguing cellular and molecular abnormalities that may prevent epidermal repigmentation. Pigment Cell Melanoma Res. 2024 Feb 11. [Epub ahead of print] PubMed PMID: 38343115
• Modlin RL, Anandasabapathy N, Kaplan D, O'Shea J, Roop D, Leachman S. Microbes, Autoimmunity, and Cancer: 69th Annual Montagna Symposium on the Biology of Skin. J Invest Dermatol. 2024 Jan 31. [Epub ahead of print] PubMed PMID: 38300199
• Pavlova M, Balaiya V, Flores JC, Ferreyros M, Bush K, Hopkin A, Kogut I, Roop DR, Bilousova G. The Development of an Advanced Model for Multilayer Human Skin Reconstruction In Vivo. Bio Protoc. 2024 Jan 20;14(2):e4919. PubMed PMID: 38268973
• Neumayer G, Torkelson JL, Li S, McCarthy K, Zhen HH, Vangipuram M, Jackow J, Rami A, Hansen C, Guo Z, Gaddam S, Pappalardo A, Li L, Cramer A, Roy KR, Nguyen TM, Tanabe K, McGrath PS, Bruckner A, Bilousova G, Roop D, Bailey I, Tang JY, Christiano A, Steinmetz LM, Wernig M, Oro AE. A scalable, GMP-compatible, autologous organotypic cell therapy for Dystrophic Epidermolysis Bullosa. bioRxiv. 2023 Mar 1. PubMed PMID: 36909618
• Ishitsuka Y, Roop DR. Loricrin at the Boundary between Inside and Outside. Biomolecules. 2022 May 6;12(5). PubMed PMID: 35625601
• Ishitsuka Y, Ogawa T, Nakamura Y, Kubota N, Fujisawa Y, Watanabe R, Okiyama N, Fujimoto M, Roop DR, Ishida-Yamamoto A. Loricrin and NRF2 Coordinate Cornification. JID Innov. 2022 Jan;2(1):100065. PubMed PMID: 35024686
• Ogawa T, Ishitsuka Y, Nakamura Y, Watanabe R, Okiyama N, Fujisawa Y, Fujimoto M, Roop DR, Nomura T. Loricrin Protects against Chemical Carcinogenesis. J Invest Dermatol. 2022 Jul;142(7):2023-2026.e1. PubMed PMID: 34968502
• Ishitsuka Y, Roop DR, Ogawa T. "Structural imprinting" of the cutaneous immune effector function. Tissue Barriers. 2021 Jan 2;9(1):1851561. PubMed PMID: 33270506
• Morton JJ, Alzofon N, Keysar SB, Chimed TS, Reisinger J, Perrenoud L, Le PN, Nieto C, Gomez K, Miller B, Yeager R, Gao D, Tan AC, Somerset H, Medina T, Wang XJ, Wang JH, Robinson W, Roop DR, Gonzalez R, Jimeno A. Studying Immunotherapy Resistance in a Melanoma Autologous Humanized Mouse Xenograft. Mol Cancer Res. 2021 Feb;19(2):346-357. PubMed PMID: 33087417
• Ishitsuka Y, Roop DR. The Epidermis: Redox Governor of Health and Diseases. Antioxidants (Basel). 2021 Dec 26;11(1). PubMed PMID: 35052551
• Ogawa T, Ishitsuka Y, Nakamura Y, Watanabe R, Okiyama N, Fujisawa Y, Fujimoto M, Roop DR, Nomura T. Loricrin Protects against Chemical Carcinogenesis. J Invest Dermatol. 2021 Dec 27. [Epub ahead of print] PubMed PMID: 34968502
• Warshauer EM, Brown A, Fuentes I, Shortt J, Gignoux C, Montinaro F, Metspalu M, Youssefian L, Vahidnezhad H, Jacków J, Christiano AM, Uitto J, Fajardo-Ramírez ÓR, Salas-Alanis JC, McGrath JA, Consuegra L, Rivera C, Maier PA, Runfeldt G, Behar DM, Skorecki K, Sprecher E, Palisson F, Norris DA, Bruckner AL, Kogut I, Bilousova G, Roop DR. Ancestral patterns of recessive dystrophic epidermolysis bullosa mutations in Hispanic populations suggest sephardic ancestry. Am J Med Genet A. 2021 Nov;185(11):3390-3400. PubMed PMID: 34435747
• Ishitsuka Y, Roop DR, Ogawa T. "Structural imprinting" of the cutaneous immune effector function. Tissue Barriers. 2021 Jan 2;9(1):1851561. PubMed PMID: 33270506
• Morton JJ, Alzofon N, Keysar SB, Chimed TS, Reisinger J, Perrenoud L, Le PN, Nieto C, Gomez K, Miller B, Yeager R, Gao D, Tan AC, Somerset H, Medina T, Wang XJ, Wang JH, Robinson W, Roop DR, Gonzalez R, Jimeno A. Studying Immunotherapy Resistance in a Melanoma Autologous Humanized Mouse Xenograft. Mol Cancer Res. 2021 Feb;19(2):346-357. PubMed PMID: 33087417
• Goldstein NB, Steel A, Barbulescu CC, Koster MI, Wright MJ, Jones KL, Gao B, Ward B, Woessner B, Trottier Z, Pakieser J, Hu J, Lambert KA, Shellman YG, Fujita M, Robinson WA, Roop DR, Norris DA, Birlea SA. Melanocyte Precursors in the Hair Follicle Bulge of Repigmented Vitiligo Skin Are Controlled by RHO-GTPase, KCTD10, and CTNNB1 Signaling. J Invest Dermatol. 2021 Mar;141(3):638-647.e13. PubMed PMID: 32800877
• Barbulescu CC, Goldstein NB, Roop DR, Norris DA, Birlea SA. Harnessing the Power of Regenerative Therapy for Vitiligo and Alopecia Areata. J Invest Dermatol. 2020 Jan;140(1):29-37. PubMed PMID: 31196751
• Barbulescu CC, Goldstein NB, Roop DR, Norris DA, Birlea SA. Harnessing the Power of Regenerative Therapy for Vitiligo and Alopecia Areata. J Invest Dermatol. 2020 Jan;140(1):29-37. PubMed PMID: 31196751
• Ishitsuka Y, Ogawa T, Roop D. The KEAP1/NRF2 Signaling Pathway in Keratinization. Antioxidants (Basel). 2020 Aug 14;9(8). PubMed PMID: 32823937
• Goldstein NB, Steel A, Barbulescu CC, Koster MI, Wright MJ, Jones KL, Gao B, Ward B, Woessner B, Trottier Z, Pakieser J, Hu J, Lambert KA, Shellman YG, Fujita M, Robinson WA, Roop DR, Norris DA, Birlea SA. Melanocyte Precursors in the Hair Follicle Bulge of Repigmented Vitiligo Skin Are Controlled by RHO-GTPase, KCTD10, and CTNNB1 Signaling. J Invest Dermatol. 2020 Aug 13. [Epub ahead of print] PubMed PMID: 32800877
• Ogawa T, Ishitsuka Y, Nakamura Y, Kubota N, Saito A, Fujisawa Y, Watanabe R, Okiyama N, Suga Y, Roop DR, Fujimoto M. NRF2 Augments Epidermal Antioxidant Defenses and Promotes Atopy. J Immunol. 2020 Aug 15;205(4):907-914. PubMed PMID: 32690656
• Ishitsuka Y, Roop DR. Loricrin: Past, Present, and Future. Int J Mol Sci. 2020 Mar 25;21(7). PubMed PMID: 32218335
• Kubick BJ, Fan X, Crouch A, McCarthy R, Roop DR. Tracing the Equilibrium Phase of Cancer Immunoediting in Epidermal Neoplasms via Longitudinal Intravital Imaging. J Invest Dermatol. 2020 Apr;140(4):891-900.e10. PubMed PMID: 31542435
• Kubick BJ, Fan X, Crouch A, McCarthy R, Roop DR. Tracing the Equilibrium Phase of Cancer Immunoediting in Epidermal Neoplasms via Longitudinal Intravital Imaging. J Invest Dermatol. 2019 Sep 19. [Epub ahead of print] PubMed PMID: 31542435
• Crumrine D, Khnykin D, Krieg P, Man MQ, Celli A, Mauro TM, Wakefield JS, Menon G, Mauldin E, Miner JH, Lin MH, Brash AR, Sprecher E, Radner FPW, Choate K, Roop D, Uchida Y, Gruber R, Schmuth M, Elias PM. Mutations in Recessive Congenital Ichthyoses Illuminate the Origin and Functions of the Corneocyte Lipid Envelope. J Invest Dermatol. 2019 Apr;139(4):760-768. PubMed PMID: 30471252
• Crumrine D, Khnykin D, Krieg P, Man MQ, Celli A, Mauro TM, Wakefield JS, Menon G, Mauldin E, Miner JH, Lin MH, Brash AR, Sprecher E, Radner FPW, Choate K, Roop D, Uchida Y, Gruber R, Schmuth M, Elias PM. Mutations in Recessive Congenital Ichthyoses Illuminate the Origin and Functions of the Corneocyte Lipid Envelope. J Invest Dermatol. 2018 Nov 22. [Epub ahead of print] PubMed PMID: 30471252
• Ishitsuka Y, Roop DR. Loricrin Confers Photoprotective Function against UVB in Corneocytes. J Invest Dermatol. 2018 Dec;138(12):2684-2687. PubMed PMID: 29932941
• Kogut I, McCarthy SM, Pavlova M, Astling DP, Chen X, Jakimenko A, Jones KL, Getahun A, Cambier JC, Pasmooij AMG, Jonkman MF, Roop DR, Bilousova G. High-efficiency RNA-based reprogramming of human primary fibroblasts. Nat Commun. 2018 Feb 21;9(1):745. PubMed PMID: 29467427
• Goldstein NB, Koster MI, Jones KL, Gao B, Hoaglin LG, Robinson SE, Wright MJ, Birlea SI, Luman A, Lambert KA, Shellman YG, Fujita M, Robinson WA, Roop DR, Norris DA, Birlea SA. Repigmentation of Human Vitiligo Skin by NBUVB Is Controlled by Transcription of GLI1 and Activation of the ß-Catenin Pathway in the Hair Follicle Bulge Stem Cells. J Invest Dermatol. 2018 Mar;138(3):657-668. PubMed PMID: 29054607
• Keysar SB, Le PN, Miller B, Jackson BC, Eagles JR, Nieto C, Kim J, Tang B, Glogowska MJ, Morton JJ, Padilla-Just N, Gomez K, Warnock E, Reisinger J, Arcaroli JJ, Messersmith WA, Wakefield LM, Gao D, Tan AC, Serracino H, Vasiliou V, Roop DR, Wang XJ, Jimeno A. Regulation of Head and Neck Squamous Cancer Stem Cells by PI3K and SOX2. J Natl Cancer Inst. 2017 Jan;109(1). PubMed PMID: 27634934
• Keysar SB, Le PN, Miller B, Jackson BC, Eagles JR, Nieto C, Kim J, Tang B, Glogowska MJ, Morton JJ, Padilla-Just N, Gomez K, Warnock E, Reisinger J, Arcaroli JJ, Messersmith WA, Wakefield LM, Gao D, Tan AC, Serracino H, Vasiliou V, Roop DR, Wang XJ, Jimeno A. Regulation of Head and Neck Squamous Cancer Stem Cells by PI3K and SOX2. J Natl Cancer Inst. 2017 Jan;109(1). PubMed PMID: 27634934
• Birlea SA, Costin GE, Roop DR, Norris DA. Trends in Regenerative Medicine: Repigmentation in Vitiligo Through Melanocyte Stem Cell Mobilization. Med Res Rev. 2017 Jul;37(4):907-935. PubMed PMID: 28029168
• Yang N, Leung EL, Liu C, Li L, Eguether T, Jun Yao XJ, Jones EC, Norris DA, Liu A, Clark RA, Roop DR, Pazour GJ, Shroyer KR, Chen J. INTU is essential for oncogenic Hh signaling through regulating primary cilia formation in basal cell carcinoma. Oncogene. 2017 Aug 31;36(35):4997-5005. PubMed PMID: 28459465
• Liu Y, Snedecor ER, Zhang X, Xu Y, Huang L, Jones EC, Zhang L, Clark RA, Roop DR, Qin C, Chen J. Correction of Hair Shaft Defects through Allele-Specific Silencing of Mutant Krt75. J Invest Dermatol. 2016 Jan;136(1):45-51. PubMed PMID: 26763422
• Bowles DW, Keysar SB, Eagles JR, Wang G, Glogowska MJ, McDermott JD, Le PN, Gao D, Ray CE, Rochon PJ, Roop DR, Tan AC, Serracino HS, Jimeno A. A pilot study of cetuximab and the hedgehog inhibitor IPI-926 in recurrent/metastatic head and neck squamous cell carcinoma. Oral Oncol. 2016 Feb;53:74-9. PubMed PMID: 26705064
• Morton JJ, Bird G, Keysar SB, Astling DP, Lyons TR, Anderson RT, Glogowska MJ, Estes P, Eagles JR, Le PN, Gan G, McGettigan B, Fernandez P, Padilla-Just N, Varella-Garcia M, Song JI, Bowles DW, Schedin P, Tan AC, Roop DR, Wang XJ, Refaeli Y, Jimeno A. XactMice: humanizing mouse bone marrow enables microenvironment reconstitution in a patient-derived xenograft model of head and neck cancer. Oncogene. 2016 Jan 21;35(3):290-300. PubMed PMID: 25893296
• Bowles DW, Keysar SB, Eagles JR, Wang G, Glogowska MJ, McDermott JD, Le PN, Gao D, Ray CE, Rochon PJ, Roop DR, Tan AC, Serracino HS, Jimeno A. A pilot study of cetuximab and the hedgehog inhibitor IPI-926 in recurrent/metastatic head and neck squamous cell carcinoma. Oral Oncol. 2016 Feb;53:74-9. PubMed PMID: 26705064
• Liu Y, Snedecor ER, Zhang X, Xu Y, Huang L, Jones EC, Zhang L, Clark RA, Roop DR, Qin C, Chen J. Correction of Hair Shaft Defects through Allele-Specific Silencing of Mutant Krt75. J Invest Dermatol. 2016 Jan;136(1):45-51. PubMed PMID: 26763422
• Ishitsuka Y, Huebner AJ, Rice RH, Koch PJ, Speransky VV, Steven AC, Roop DR. Lce1 Family Members Are Nrf2-Target Genes that Are Induced to Compensate for the Loss of Loricrin. J Invest Dermatol. 2016 Aug;136(8):1656-63. PubMed PMID: 27167730
• Goldstein NB, Koster MI, Hoaglin LG, Wright MJ, Robinson SE, Robinson WA, Roop DR, Norris DA, Birlea SA. Isolating RNA from precursor and mature melanocytes from human vitiligo and normal skin using laser capture microdissection. Exp Dermatol. 2016 Oct;25(10):805-11. PubMed PMID: 27193292
• Rice RH, Durbin-Johnson BP, Ishitsuka Y, Salemi M, Phinney BS, Rocke DM, Roop DR. Proteomic Analysis of Loricrin Knockout Mouse Epidermis. J Proteome Res. 2016 Aug 5;15(8):2560-6. PubMed PMID: 27418529
• Zhang L, Ferreyros M, Feng W, Hupe M, Crumrine DA, Chen J, Elias PM, Holleran WM, Niswander L, Hohl D, Williams T, Torchia EC, Roop DR. Defects in Stratum Corneum Desquamation Are the Predominant Effect of Impaired ABCA12 Function in a Novel Mouse Model of Harlequin Ichthyosis. PLoS One. 2016 Aug 23;11(8):e0161465. PubMed PMID: 27551807
• Rorke EA, Adhikary G, Young CA, Roop DR, Eckert RL. Suppressing AP1 factor signaling in the suprabasal epidermis produces a keratoderma phenotype. J Invest Dermatol. 2015 Jan;135(1):170-80. PubMed PMID: 25050598
• Kumar V, Bouameur JE, Bär J, Rice RH, Hornig-Do HT, Roop DR, Schwarz N, Brodesser S, Thiering S, Leube RE, Wiesner RJ, Brazel CB, Heller S, Binder H, Löffler-Wirth H, Seibel P, Magin TM. A keratin scaffold regulates epidermal barrier formation, mitochondrial lipid composition, and activity. J Cell Biol. 2015 Dec 7;211(5):1057-75. PubMed PMID: 26644517
• Riemondy K, Wang XJ, Torchia EC, Roop DR, Yi R. MicroRNA-203 represses selection and expansion of oncogenic Hras transformed tumor initiating cells. Elife. 2015 Jul 23;4. PubMed PMID: 26203562
• Goldstein NB, Koster MI, Hoaglin LG, Spoelstra NS, Kechris KJ, Robinson SE, Robinson WA, Roop DR, Norris DA, Birlea SA. Narrow Band Ultraviolet B Treatment for Human Vitiligo Is Associated with Proliferation, Migration, and Differentiation of Melanocyte Precursors. J Invest Dermatol. 2015 Aug;135(8):2068-76. PubMed PMID: 25822579
• Rorke EA, Adhikary G, Young CA, Roop DR, Eckert RL. Suppressing AP1 factor signaling in the suprabasal epidermis produces a keratoderma phenotype. J Invest Dermatol. 2015 Jan;135(1):170-80. PubMed PMID: 25050598
• Bilousova G, Roop DR. Induced pluripotent stem cells in dermatology: potentials, advances, and limitations. Cold Spring Harb Perspect Med. 2014 Nov 3;4(11):a015164. PubMed PMID: 25368014
• van Steensel MA, Coulombe PA, Kaspar RL, Milstone LM, McLean IW, Roop DR, Smith FJ, Sprecher E, Schwartz ME. Report of the 10th Annual International Pachyonychia Congenita Consortium Meeting. J Invest Dermatol. 2014 Mar;134(3):588-91. PubMed PMID: 24518109
• Kogut I, Roop DR, Bilousova G. Differentiation of human induced pluripotent stem cells into a keratinocyte lineage. Methods Mol Biol. 2014;1195:1-12. PubMed PMID: 24510784
• Schäfer M, Willrodt AH, Kurinna S, Link AS, Farwanah H, Geusau A, Gruber F, Sorg O, Huebner AJ, Roop DR, Sandhoff K, Saurat JH, Tschachler E, Schneider MR, Langbein L, Bloch W, Beer HD, Werner S. Activation of Nrf2 in keratinocytes causes chloracne (MADISH)-like skin disease in mice. EMBO Mol Med. 2014 Apr;6(4):442-57. PubMed PMID: 24503019
• Dallaglio K, Petrachi T, Marconi A, Truzzi F, Lotti R, Saltari A, Morandi P, Puviani M, Maiorana A, Roop DR, Pincelli C. Isolation and characterization of squamous cell carcinoma-derived stem-like cells: role in tumor formation. Int J Mol Sci. 2013 Sep 26;14(10):19540-55. PubMed PMID: 24077125
• White RA, Neiman JM, Reddi A, Han G, Birlea S, Mitra D, Dionne L, Fernandez P, Murao K, Bian L, Keysar SB, Goldstein NB, Song N, Bornstein S, Han Z, Lu X, Wisell J, Li F, Song J, Lu SL, Jimeno A, Roop DR, Wang XJ. Epithelial stem cell mutations that promote squamous cell carcinoma metastasis. J Clin Invest. 2013 Oct 1;123(10):4390-404. PubMed PMID: 23999427
• Chari NS, Romano RA, Koster MI, Jaks V, Roop D, Flores ER, Teglund S, Sinha S, Gruber W, Aberger F, Medeiros LJ, Toftgard R, McDonnell TJ. Interaction between the TP63 and SHH pathways is an important determinant of epidermal homeostasis. Cell Death Differ. 2013 Aug;20(8):1080-8. PubMed PMID: 23686138
• Yasuda M, Claypool DJ, Guevara E, Roop DR, Chen J. Genetic manipulation of keratinocyte stem cells with lentiviral vectors. Methods Mol Biol. 2013;989:143-51. PubMed PMID: 23483393
• Bilousova G, Roop DR. Generation of functional multipotent keratinocytes from mouse induced pluripotent stem cells. Methods Mol Biol. 2013;961:337-50. PubMed PMID: 23325655
• Torchia EC, Zhang L, Huebner AJ, Sen S, Roop DR. Aurora kinase-A deficiency during skin development impairs cell division and stratification. J Invest Dermatol. 2013 Jan;133(1):78-86. PubMed PMID: 22832491