David Fleischer, MD
Associate Professor, Pediatrics-Allergy

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Medical School:
  • MD, Emory University School of Medicine (1997)
Undergraduate School:
  • BA, University of Pennsylvania (Philadelphia, PA) (1992)
Internship:
  • Johns Hopkins University School of Medicine Program (1998)
Residency:
  • Johns Hopkins University School of Medicine Program, Pediatrics (2000)
Languages: English
Department: Pediatrics-Allergy

Professional Titles

  • Associate Professor, Pediatrics-Allergy
  • Associate Section Head
  • Director, Allergy and Immunology Center
Research interests for Patients:
My research focuses on food allergy, in particular peanut and tree nut allergies. I am interested in why certain patients with food allergies outgrow them more readily and sooner than others. I am an investigator in treatments for food allergy, including oral, sublingual, and epicutaneous immunotherapies.

Teaching

  • Associate Professor of Pediatrics (2014)
    School of Medicine, Pediatrics
    Food Allergy

Publications

  • Vandenplas Y, Latiff AHA, Fleischer DM, Gutiérrez-Castrellón P, Miqdady MS, Smith PK, von Berg A, Greenhawt MJ. Partially hydrolyzed formula in non-exclusively breastfed infants: A systematic review and expert consensus. Nutrition. 2019 Jan;57:268-274. PubMed PMID: 30223233
  • Chan ES, Greenhawt MJ, Fleischer DM, Caubet JC. Managing Cross-Reactivity in Those with Peanut Allergy. J Allergy Clin Immunol Pract. 2018 Nov 22. [Epub ahead of print] PubMed PMID: 30472327
  • Vickery BP, Vereda A, Casale TB, Beyer K, du Toit G, Hourihane JO, Jones SM, Shreffler WG, Marcantonio A, Zawadzki R, Sher L, Carr WW, Fineman S, Greos L, Rachid R, Ibáñez MD, Tilles S, Assa’ad AH, Nilsson C, Rupp N, Welch MJ, Sussman G, Chinthrajah S, Blumchen K, Sher E, Spergel JM, Leickly FE, Zielen S, Wang J, Sanders GM, Wood RA, Cheema A, Bindslev-Jensen C, Leonard S, Kachru R, Johnston DT, Hampel FC Jr, Kim EH, Anagnostou A, Pongracic JA, Ben-Shoshan M, Sharma HP, Stillerman A, Windom HH, Yang WH, Muraro A, Zubeldia JM, Sharma V, Dorsey MJ, Chong HJ, Ohayon J, Bird JA, Carr TF, Siri D, Fernández-Rivas M, Jeong DK, Fleischer DM, Lieberman JA, Dubois AEJ, Tsoumani M, Ciaccio CE, Portnoy JM, Mansfield LE, Fritz SB, Lanser BJ, Matz J, Oude Elberink HNG, Varshney P, Dilly SG, Adelman DC, Burks AW. AR101 Oral Immunotherapy for Peanut Allergy. N Engl J Med. 2018 Nov 22;379(21):1991-2001. PubMed PMID: 30449234
  • Chehade M, Jones SM, Pesek RD, Burks AW, Vickery BP, Wood RA, Leung DYM, Furuta GT, Fleischer DM, Henning AK, Dawson P, Lindblad RW, Sicherer SH, Abonia JP, Sherrill JD, Sampson HA, Rothenberg ME. Phenotypic Characterization of Eosinophilic Esophagitis in a Large Multicenter Patient Population from the Consortium for Food Allergy Research. J Allergy Clin Immunol Pract. 2018 Sep - Oct;6(5):1534-1544.e5. PubMed PMID: 30075341
  • Bird JA, Fleischer DM, Groetch M, Nowak-Wegrzyn A, Sicherer S, Young MC. Additional oral food challenge considerations. J Allergy Clin Immunol. 2018 Jun;141(6):2322. PubMed PMID: 29692338
  • Shaker M, Stukus D, Chan ES, Fleischer DM, Spergel JM, Greenhawt M. "To screen or not to screen": Comparing the health and economic benefits of early peanut introduction strategies in five countries. Allergy. 2018 Aug;73(8):1707-1714. PubMed PMID: 29601091
  • Greenhawt M, Chan ES, Fleischer DM, Hicks A, Wilson R, Shaker M, Venter C, Stukus D. Caregiver and expecting caregiver support for early peanut introduction guidelines. Ann Allergy Asthma Immunol. 2018 Jun;120(6):620-625. PubMed PMID: 29524559
  • Shreffler WG, Baumert JL, Remington BC, Koppelman SJ, Dinakar C, Fleischer DM, Kim E, Tilles SA, Spergel JM. The importance of reducing risk in peanut allergy: Current and future therapies. Ann Allergy Asthma Immunol. 2018 Feb;120(2):124-127. PubMed PMID: 29289463
  • Fleischer DM, Udkoff J, Borok J, Friedman A, Nicol N, Bienstock J, Lio P, Tollefson MM, Eichenfield LF. Atopic dermatitis: skin care and topical therapies. Semin Cutan Med Surg. 2017 Sep;36(3):104-110. PubMed PMID: 28895956
  • Eichenfield LF, Ahluwalia J, Davis DM, Fleischer DM, Waldman A, Spergel J. Curriculum United for Better Eczema Care: why, how, and what?. Semin Cutan Med Surg. 2017 Sep;36(3):93-94. PubMed PMID: 28895953
  • Dunn SE, Vicini JL, Glenn KC, Fleischer DM, Greenhawt MJ. The allergenicity of genetically modified foods from genetically engineered crops: A narrative and systematic review. Ann Allergy Asthma Immunol. 2017 Sep;119(3):214-222.e3. PubMed PMID: 28890018
  • Venter C, Brown T, Meyer R, Walsh J, Shah N, Nowak-Wegrzyn A, Chen TX, Fleischer DM, Heine RG, Levin M, Vieira MC, Fox AT. Better recognition, diagnosis and management of non-IgE-mediated cow's milk allergy in infancy: iMAP-an international interpretation of the MAP (Milk Allergy in Primary Care) guideline. Clin Transl Allergy. 2017;7:26. PubMed PMID: 28852472
  • Greenhawt MJ, Fleischer DM. Primary Prevention of Food Allergy. Curr Allergy Asthma Rep. 2017 Apr;17(4):26. PubMed PMID: 28421513
  • Abrams EM, Greenhawt M, Fleischer DM, Chan ES. Early Solid Food Introduction: Role in Food Allergy Prevention and Implications for Breastfeeding. J Pediatr. 2017 May;184:13-18. PubMed PMID: 28410085
  • Wang J, Fleischer DM. Should Peanut Be Banned in Schools?. J Allergy Clin Immunol Pract. 2017 Mar - Apr;5(2):290-294. PubMed PMID: 28283154
  • Fleischer DM. Life after LEAP: How to implement advice on introducing peanuts in early infancy. J Paediatr Child Health. 2017 Mar;53(S1):3-9. PubMed PMID: 28276109
  • Togias A, Cooper SF, Acebal ML, Assa'ad A, Baker JR Jr, Beck LA, Block J, Byrd-Bredbenner C, Chan ES, Eichenfield LF, Fleischer DM, Fuchs GJ 3rd, Furuta GT, Greenhawt MJ, Gupta RS, Habich M, Jones SM, Keaton K, Muraro A, Plaut M, Rosenwasser LJ, Rotrosen D, Sampson HA, Schneider LC, Sicherer SH, Sidbury R, Spergel J, Stukus DR, Venter C, Boyce JA. Addendum guidelines for the prevention of peanut allergy in the United States: Report of the National Institute of Allergy and Infectious Diseases-sponsored expert panel. J Allergy Clin Immunol. 2017 Jan;139(1):29-44. PubMed PMID: 28065278
  • Bird JA, Groetch M, Allen KJ, Bock SA, Leonard S, Nowak-Wegrzyn AH, Sicherer S, Clark A, Fleischer DM, Venter C, Vickery B, Young MC. Conducting an Oral Food Challenge to Peanut in an Infant. J Allergy Clin Immunol Pract. 2017 Mar - Apr;5(2):301-311.e1. PubMed PMID: 27838326
  • Greenhawt M, Fleischer DM, Chan ES, Venter C, Stukus D, Gupta R, Spergel JM. LEAPing through the looking glass: secondary analysis of the effect of skin test size and age of introduction on peanut tolerance after early peanut introduction. Allergy. 2017 Aug;72(8):1254-1260. PubMed PMID: 27896827
  • Venter C, Fleischer DM. Diets for diagnosis and management of food allergy: The role of the dietitian in eosinophilic esophagitis in adults and children. Ann Allergy Asthma Immunol. 2016 Nov;117(5):468-471. PubMed PMID: 27592143
  • Fleischer DM, Venter C, Vandenplas Y. Hydrolyzed Formula for Every Infant?. Nestle Nutr Inst Workshop Ser. 2016;86:51-65. PubMed PMID: 27336594
  • Greenhawt M, Fleischer DM, Spergel JM. Is It Time for a Randomized Trial on Early Introduction of Milk?. J Allergy Clin Immunol Pract. 2016 May-Jun;4(3):489-90. PubMed PMID: 27157938
  • Greenhawt MJ, Fleischer DM, Atkins D, Chan ES. The Complexities of Early Peanut Introduction for the Practicing Allergist. J Allergy Clin Immunol Pract. 2016 Mar-Apr;4(2):221-5. PubMed PMID: 26968960
  • Jones SM, Burks AW, Keet C, Vickery BP, Scurlock AM, Wood RA, Liu AH, Sicherer SH, Henning AK, Lindblad RW, Dawson P, Berin C, Fleischer DM, Leung DY, Plaut M, Sampson HA. Long-term treatment with egg oral immunotherapy enhances sustained unresponsiveness that persists after cessation of therapy. J Allergy Clin Immunol. 2016 Apr;137(4):1117-27.e1-10. PubMed PMID: 26924470
  • Jones SM, Agbotounou WK, Fleischer DM, Burks AW, Pesek RD, Harris MW, Martin L, Thebault C, Ruban C, Benhamou PH. Safety of epicutaneous immunotherapy for the treatment of peanut allergy: A phase 1 study using the Viaskin patch. J Allergy Clin Immunol. 2016 Apr;137(4):1258-61.e1-10. PubMed PMID: 26920463
  • Sindher S, Fleischer DM, Spergel JM. Advances in the Treatment of Food Allergy: Sublingual and Epicutaneous Immunotherapy. Immunol Allergy Clin North Am. 2016 Feb;36(1):39-54. PubMed PMID: 26617226
  • Fleischer DM, Sampson HA. Reply. J Allergy Clin Immunol. 2015 Nov 14. [Epub ahead of print] PubMed PMID: 26589587
  • Fleischer DM, Sampson HA. Reply. J Allergy Clin Immunol. 2015 Nov 13. [Epub ahead of print] PubMed PMID: 26586039
  • Friedlander JA, DeBoer EM, Soden JS, Furuta GT, Menard-Katcher CD, Atkins D, Fleischer DM, Kramer RE, Deterding RR, Capocelli KE, Prager JD. Unsedated transnasal esophagoscopy for monitoring therapy in pediatric eosinophilic esophagitis. Gastrointest Endosc. 2015 Jul 2. [Epub ahead of print] PubMed PMID: 26142551
  • Fleischer DM, Sampson HA. Reply. J Allergy Clin Immunol. 2015 Nov 14. [Epub ahead of print] PubMed PMID: 26589587
  • Fleischer DM, Sampson HA. Reply. J Allergy Clin Immunol. 2015 Nov 13. [Epub ahead of print] PubMed PMID: 26586039
  • Lanser BJ, Wright BL, Orgel KA, Vickery BP, Fleischer DM. Current Options for the Treatment of Food Allergy. Pediatr Clin North Am. 2015 Dec;62(6):1531-49. PubMed PMID: 26456449
  • Friedlander JA, DeBoer EM, Soden JS, Furuta GT, Menard-Katcher CD, Atkins D, Fleischer DM, Kramer RE, Deterding RR, Capocelli KE, Prager JD. Unsedated transnasal esophagoscopy for monitoring therapy in pediatric eosinophilic esophagitis. Gastrointest Endosc. 2015 Jul 2. [Epub ahead of print] PubMed PMID: 26142551
  • Fleischer DM, Sicherer S, Greenhawt M, Campbell D, Chan E, Muraro A, Halken S, Katz Y, Ebisawa M, Eichenfield L, Sampson H, Lack G, Du Toit G, Roberts G, Bahnson H, Feeney M, Hourihane J, Spergel J, Young M, As'aad A, Allen K, Prescott S, Kapur S, Saito H, Agache I, Akdis CA, Arshad H, Beyer K, Dubois A, Eigenmann P, Fernandez-Rivas M, Grimshaw K, Hoffman-Sommergruber K, Host A, Lau S, O'Mahony L, Mills C, Papadopoulos N, Venter C, Agmon-Levin N, Kessel A, Antaya R, Drolet B, Rosenwasser L. Consensus communication on early peanut introduction and the prevention of peanut allergy in high-risk infants. J Allergy Clin Immunol. 2015 Aug;136(2):258-61. PubMed PMID: 26100082
  • Greenhawt M, Chan ES, Fleischer DM. Peanut consumption in infants at risk for peanut allergy. N Engl J Med. 2015 May 28;372(22):2164-5. PubMed PMID: 26017832
  • Klinnert MD, McQuaid EL, Fedele DA, Faino A, Strand M, Robinson J, Atkins D, Fleischer DM, Hourihane JO, Cohen S, Fransen H. Children's Food Allergies: Development of the Food Allergy Management and Adaptation Scale. J Pediatr Psychol. 2015 Jul;40(6):572-80. PubMed PMID: 25797945
  • Burks AW, Wood RA, Jones SM, Sicherer SH, Fleischer DM, Scurlock AM, Vickery BP, Liu AH, Henning AK, Lindblad R, Dawson P, Plaut M, Sampson HA. Sublingual immunotherapy for peanut allergy: Long-term follow-up of a randomized multicenter trial. J Allergy Clin Immunol. 2015 May;135(5):1240-8.e1-3. PubMed PMID: 25656999
  • Chehade M, Aceves SS, Furuta GT, Fleischer DM. Food allergy and eosinophilic esophagitis: what do we do?. J Allergy Clin Immunol Pract. 2015 Jan-Feb;3(1):25-32. PubMed PMID: 25577614
  • Fleischer DM, Burks AW. Pitfalls in food allergy diagnosis: serum IgE testing. J Pediatr. 2015 Jan;166(1):8-10. PubMed PMID: 25449218
  • Fleischer DM, Sicherer S, Greenhawt M, Campbell D, Chan E, Muraro A, Halken S, Katz Y, Ebisawa M, Eichenfield L, Sampson H, Lack G, Du Toit G, Roberts G, Bahnson H, Feeney M, Hourihane J, Spergel J, Young M, As'aad A, Allen K, Prescott S, Kapur S, Saito H, Agache I, Akdis CA, Arshad H, Beyer K, Dubois A, Eigenmann P, Fernandez-Rivas M, Grimshaw K, Hoffman-Sommergruber K, Host A, Lau S, O'Mahony L, Mills C, Papadopoulos N, Venter C, Agmon-Levin N, Kessel A, Antaya R, Drolet B, Rosenwasser L. Consensus communication on early peanut introduction and the prevention of peanut allergy in high-risk infants. Ann Allergy Asthma Immunol. 2015 Aug;115(2):87-90. PubMed PMID: 26122934
  • Fleischer DM, Sicherer S, Greenhawt M, Campbell D, Chan E, Muraro A, Halken S, Katz Y, Ebisawa M, Eichenfield L, Sampson H, Lack G, Du Toit G, Roberts G, Bahnson H, Feeney M, Hourihane J, Spergel J, Young M, As'aad A, Allen K, Prescott S, Kapur S, Saito H, Agache I, Akdis CA, Arshad H, Beyer K, Dubois A, Eigenmann P, Fernandez-Rivas M, Grimshaw K, Hoffman-Sommergruber K, Host A, Lau S, O'Mahony L, Mills C, Papadopoulos N, Venter C, Agmon-Levin N, Kessel A, Antaya R, Drolet B, Rosenwasser L. Consensus communication on early peanut introduction and the prevention of peanut allergy in high-risk infants. Allergy. 2015 Oct;70(10):1193-5. PubMed PMID: 26148305
  • Fleischer DM, Sicherer S, Greenhawt M, Campbell D, Chan E, Muraro A, Halken S, Katz Y, Ebisawa M, Eichenfield L, Sampson H, Lack G, Du Toit G, Roberts G, Bahnson H, Feeney M, Hourihane J, Spergel J, Young M, As'aad A, Allen K, Prescott S, Kapur S, Saito H, Agache I, Akdis CA, Arshad H, Beyer K, Dubois A, Eigenmann P, Fernandez-Rivas M, Grimshaw K, Hoffman-Sommergruber K, Host A, Lau S, O'Mahony L, Mills C, Papadopoulos N, Venter C, Agmon-Levin N, Kessel A, Antaya R, Drolet B, Rosenwasser L. Consensus Communication on Early Peanut Introduction and the Prevention of Peanut Allergy in High-risk Infants. Pediatrics. 2015 Aug 31. [Epub ahead of print] PubMed PMID: 26324871
  • Fleischer DM, Sicherer S, Greenhawt M, Campbell D, Chan ES, Muraro A, Halken S, Katz Y, Ebisawa M, Eichenfield L, Sampson H. Consensus communication on early peanut introduction and the prevention of peanut allergy in high-risk infants. Allergy Asthma Clin Immunol. 2015;11(1):23. PubMed PMID: 26300927
  • Fleischer DM, Sicherer S, Greenhawt M, Campbell D, Chan ES, Muraro A, Halken S, Katz Y, Ebisawa M, Eichenfield L, Sampson H. Consensus communication on early peanut introduction and the prevention of peanut allergy in high-risk infants. World Allergy Organ J. 2015;8(1):27. PubMed PMID: 26312127
  • Fleischer DM, Sicherer S, Greenhawt M, Campbell D, Chan E, Muraro A, Halken S, Katz Y, Ebisawa M, Eichenfield L, Sampson H, Lack G, Du Toit G, Roberts G, Bahnson H, Feeney M, Hourihane J, Spergel J, Young M, As'aad A, Allen K, Prescott S, Kapur S, Saito H, Agache I, Akdis CA, Arshad H, Beyer K, Dubois A, Eigenmann P, Fernandez-Rivas M, Grimshaw K, Hoffman-Sommergruber K, Host A, Lau S, O'Mahony L, Mills C, Papadopoulos N, Venter C, Agmon-Levin N, Kessel A, Antaya R, Drolet B, Rosenwasser L. Consensus Communication on Early Peanut Introduction and the Prevention of Peanut Allergy in High-risk Infants. Pediatrics. 2015 Aug 31. [Epub ahead of print] PubMed PMID: 26324871
  • Fleischer DM, Sicherer S, Greenhawt M, Campbell D, Chan E, Muraro A, Halken S, Katz Y, Ebisawa M, Eichenfield L, Sampson H, Lack G, Du Toit G, Roberts G, Bahnson H, Feeney M, Hourihane J, Spergel J, Young M, As'aad A, Allen K, Prescott S, Kapur S, Saito H, Agache I, Akdis CA, Arshad H, Beyer K, Dubois A, Eigenmann P, Fernandez-Rivas M, Grimshaw K, Hoffman-Sommergruber K, Host A, Lau S, O'Mahony L, Mills C, Papadopoulos N, Venter C, Agmon-Levin N, Kessel A, Antaya R, Drolet B, Rosenwasser L. Consensus Communication on Early Peanut Introduction and Prevention of Peanut Allergy in High-Risk Infants. Pediatr Dermatol. 2015 Sep 10. [Epub ahead of print] PubMed PMID: 26354148
  • Kottyan LC, Davis BP, Sherrill JD, Liu K, Rochman M, Kaufman K, Weirauch MT, Vaughn S, Lazaro S, Rupert AM, Kohram M, Stucke EM, Kemme KA, Magnusen A, He H, Dexheimer P, Chehade M, Wood RA, Pesek RD, Vickery BP, Fleischer DM, Lindbad R, Sampson HA, Mukkada VA, Putnam PE, Abonia JP, Martin LJ, Harley JB, Rothenberg ME. Genome-wide association analysis of eosinophilic esophagitis provides insight into the tissue specificity of this allergic disease. Nat Genet. 2014 Aug;46(8):895-900. PubMed PMID: 25017104
  • Klinnert MD, Silveira L, Harris R, Moore W, Atkins D, Fleischer DM, Menard-Katcher C, Aceves S, Spergel JM, Franciosi JP, Furuta GT. Health-related quality of life over time in children with eosinophilic esophagitis and their families. J Pediatr Gastroenterol Nutr. 2014 Sep;59(3):308-16. PubMed PMID: 24897164
  • Sicherer SH, Wood RA, Vickery BP, Jones SM, Liu AH, Fleischer DM, Dawson P, Mayer L, Burks AW, Grishin A, Stablein D, Sampson HA. The natural history of egg allergy in an observational cohort. J Allergy Clin Immunol. 2014 Feb;133(2):492-9. PubMed PMID: 24636473
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Professional Memberships

  • AAAAI, Fellow
  • ACAAI, Fellow
  • EAACI, Member

Practice Locations

Children's Hospital Colorado
13123 East 16th Ave
Aurora, CO 80045
720-777-1234

Hospital Affiliation
  • Children's Hospital Colorado
  • University of Colorado Hospital

Specialty Information

Specialties
  • Pediatrics, Board Certification (2000, 2008)
  • Allergy and Immunology, Board Certification (2005, 2015)
Conditions & Treatments
  • Lungs and Breathing - Asthma
  • Immune System - Allergies
  • Immune System
  • Immune System - Eczema
  • Lungs and Breathing
Clinical Interest for Patients
My primary clinical interest is food allergy - from the time point of accurate diagnosis, usually at a young age, and the multidisciplinary care of the patient to include psychosocial and dietitian support, through the natural history and hopefully resolution of the allergy. I also believe in helping the patient and the family navigate the management of food allergy from the young age, through important transitions to self-care of school-age children, and then independent living with food allergy as adolescents and adults.

Care Philosophy
When caring for any patient with any medical problem, patient care should involve not just treating the condition, but how that condition affects the patient AND the family as a whole. Treating food-allergic patients requires us to do this, as food allergy affects all aspects of life and the entire family. We are fortunate that Children's Hospital Colorado provides us with the tools to take a multidisciplinary treatment approach to our patients and families, with a team of staff that includes psychosocial support, dietary management, and the most recent food allergy research. And now Children's Hospital Colorado has paired this multidisciplinary care with a state of the art Allergy and Immunology Center, featuring one of the largest food challenge and research units in the world.

Public Speaking
Yes
Food Allergy

General Information

Medical Schools:
  • MD, Emory University School of Medicine (1997)
Undergraduate Schools:
  • BA, University of Pennsylvania (Philadelphia, PA) (1992)
Internships:
  • Johns Hopkins University School of Medicine Program (1998)
Residency Programs:
  • Johns Hopkins University School of Medicine Program, Pediatrics (2000)
Download CV
Languages: English
Department: Pediatrics-Allergy
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