Shi-Long Lu, MD, PhD
Associate Professor, Otolaryngology

Medical School:
  • MD, China Medical University - Shenyang (1987)
Graduate School :
  • PhD, Tokyo Medical and Dental University (1999)
Languages: English
Department: Otolaryngology

Recognition & Awards

  • Research Career Development Award, Dermatology Foundation (2007)
  • Albert Kligman Fellowship, Society of Investigative Dermatology (2005)
  • Certificate of Appreciation for Mentoring Next Generation of Scientists, OHSU (2005)
  • Best Presentation Award, 6th International Conference of Head and Neck Cancer (2004)
  • Scholarship for PhD Degree, Japanese Government (Monbusho) (1995)
  • Young Investigator Award, Chinese Association for Science and Technology (1993)

Research Interests

My research focuses on fundamental and translational aspects on head and neck cancers, including head and neck squamous cell carcinoma (HNSCC) and salivary gland tumors (SGTs). Specifically, my lab works on delineating the roles of PI3K and TGF??signaling pathway, cancer stem cell, and oral microbiome in HNSCC pathogenesis, identifying saliva biomarkers for early detection, recurrence, and surveillance of HNSCC, and developing novel therapeutic approaches for HNSCC. Several key discoveries from my lab are: (1) We were among the firsts to develop multiple genetically engineered mouse models (GEMMs) of HNSCC in both PI3K and TGFß pathways. In combination with tobacco carcinogenesis protocol, these models develop HNSCC, which mimic human HNSCC etiologically, pathologically and molecularly. (2) We recently developed GEMMs for human SGTs, and are using these models to study the role of PTEN and Smad4 in SGT pathogenesis. (3) We have identified a panel of methylated genomic loci encoding microRNAs, which can be detected in patient saliva, to serve as biomarkers for early diagnosis, recurrence, and surveillance of HNSCC patients. (4). In collaboration with our colleague, we are among the firsts to study the functional role of oral microbiome in HNSCC pathogenesis and its impact on immunotherapy and PI3K targeted therapy. (5). In collaboration with our colleague, we are developing a novel therapeutic approach using an immunotoxin-based therapy on HNSCC models we have developed.


  • Chen X, Cao Y, Sedhom W, Lu L, Liu Y, Wang H, Oka M, Bornstein S, Said S, Song J, Lu SL. Distinct roles of PIK3CA in the enrichment and maintenance of cancer stem cells in head and neck squamous cell carcinoma. Mol Oncol. 2020 Jan;14(1):139-158. PubMed PMID: 31600013
  • Yang CX, Sedhom W, Song J, Lu SL: The role of microRNAs in recurrence and metastasis of head and neck squamous cell carcinoma. Cancers, 11: 395 (2019)
  • Cao Y, Feng Y, Gao L, Li X, Jin Q, Wang Y, Xu Y, Jin F, Lu SL*, Wei M: Artemisinin enhances the anti-tumor immune response in 4T1 breast cancer cells in vitro and in vivo. International Immunopharmacology, 70: 110-116 (2019)
  • Lu SL, Hsu FM, Tsai CL, Lee JM, Huang PM, Hsu CH, Lin CC, Chang YL, Hsieh MS, Cheng JC. Improved prognosis with induction chemotherapy in pathological complete responders after trimodality treatment for esophageal squamous cell carcinoma: Hypothesis generating for adjuvant treatment. Eur J Surg Oncol. 2019 Aug;45(8):1498-1504. PubMed PMID: 30910457
  • Cao Y, Green K, Quattlebaum S, Milam B, Lu L, Gao D, HE H, Li N, Gao L, Hall F, Whinery M, Handley E, Ma Y, Jin F, Xiao J, Wei M, Smith D, Bornstein S, Gross N, Pyeon D, Song J, Lu SL: Methylated genomic loci encoding microRNAs in saliva as a biomarker panel in tissue and saliva for head and neck squamous cell carcinoma. Clinical Epigenetics, 10:43 (2018). PMCID: PMC5883341
  • Cao Y, Liu H, Gao L, Lu L, Du L, Bai H, Li J, Said S, Wang X, Song J, Serkova N, Wei M, Xiao J, Lu SL: Cooperation between Pten and Smad4 in mouse salivary gland tumor formation and progression. Neoplasia, 20: 764-774 (2018). PMCID: PMC6031150
  • Du L, Chen X, Cao Y, Lu L, Zhang F, Bornstein S, Li Y, Owens P, Malkoski S, Said S, Jin F, Kulesz-Martin M, Gross N, Wang XJ, Lu SL. Overexpression of PIK3CA in murine head and neck epithelium drives tumor invasion and metastasis through PDK1 and enhanced TGFß signaling. Oncogene. 2016 Sep 1;35(35):4641-52. PubMed PMID: 26876212
  • Du L, Chen X, Shen J, Zhang F, Lu SL: PIK3CA overexpression induces epithelial-mesenchymal transition and progression of head and neck squamous cell carcinoma. Annual Meeting of American Association of Cancer Research. Washington DC, 2013
  • Malkoski SP, Cleaver TG, Thompson JJ, Sutton WP, Haeger SM, Rodriguez KJ, Lu SL, Merrick D, Wang XJ. Role of PTEN in Basal Cell Derived Lung Carcinogenesis. Mol Carcinog. 2013 Apr 26. [Epub ahead of print] PubMed PMID: 23625632
  • Du L, Shen J, Weems A, and Lu SL*: Role of phosphatidylinositol-3-kinase pathway in head and neck squamous cell carcinoma. J Oncol in press (2012)
  • Minor J, Wang X, Zhang F, Song J, Jimeno A, Wang XJ, Lu X, Gross N, Kulesz-Martin M, Wang D, Lu SL*: Methylation of microRNA-9 is a specific and sensitive biomarker for oral and oropharyngeal squamous cell carcinomas. Oral Oncol 48: 73-8 (2012)
  • Lu SL:Role of DNA repair in head and neck cancer in [DNA repair] ed by Francesca Storici. Intech
  • Weber S, Bornstein S, Li, Y, Malkoski S, Wang D, Rustgi A, Kulesz-Martin M, Wang XJ, Lu SL*: Tobacco-specific carcinogen nitrosamine 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone induces AKT activation in head and neck epithelia. Int. J Oncol 39:1193-1198 (2011)
  • Lu SL: DNA repair defects in head and neck cancer. In [DNA Repair and Human Health] ed. Sonya Vengrova. Intech, pp. 373-384 (2011).
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Professional Memberships

  • American Association of Cancer Research (AACR), Member
  • Society of Investigative Dermatology, Member
  • Colorado BioScience Association, Member
  • American Society of Clinical Oncology (ASCO), Member
  • American Association of Dental Research (AADR)-Diagnostic Sciences Group, Member
  • International Association of Dental Research (IADR)-Salivary Research Group, Member

Specialty Information

  • Otolaryngology

General Information

Medical Schools:
  • MD, China Medical University - Shenyang (1987)
Graduate Schools:
  • PhD, Tokyo Medical and Dental University (1999)
Languages: English
Department: Otolaryngology