Xianzhong Meng, MD, PhD
Professor, Surgery-Cardiothoracic

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Languages: English
Department: Surgery-Cardiothoracic

Professional Titles

  • Profesor

Publications

  • Zhao P, Yao Q, Zhang P, The E, Zhai Y, Ao L, Jarret MJ, Dinarello DA, Fullerton DA, Meng X. Single-cell RNA-seq reveals novel proinflammatory EndMT in human coronary artery-on-a-chip under atheroprone flow. Science Advances 7(34):eabg1694, 2021
  • Jarrett MJ, Houk AK, McCuistion PE, Weyant MJ, Reece TB, Meng X, Fullerton DA. Wnt signaling mediates pro-fibrogenic activity in human aortic valve interstitial cells. Ann Thorac Surg 112:519-525, 2021
  • Jarrett MJ, Yao Q, Venardos N, Weyant MJ, Reece TB, Meng X, Fullerton DA. Simvastatin downregulates osteogenic response in cultured human aortic valve interstitial cells. J Thorac Cardiovasc Surg 161:e261-e271, 2021
  • Deng X, Meng X, Fullerton DA, Stone M, Jaggers J. Complement up-regulates Runx-2 to induce pro-fibrogenic change in human aortic valve interstitial cells. Ann Thorac Surg 112:1962-1972, 2021
  • Halpern AL, Kohtz PD, White AM, Houk AK, Rehring JF, Hanson L, McCarter MD, Joshi M, Meng X, Fullerton DA, Weyant MJ. Secretory phospholipase A2 IIa mediates expression of growth factor receptors in esophageal adenocarcinoma. Dig Dis Sci 66:784-795, 2021
  • Gergen AK, Jarrett MJ, Li A, White AM, Meng X, Fullerton DA, Weyant MJ. Secretory phospholipase A2 inhibition attenuates adhesive properties of esophageal Barrett’s cells. J Surg Res 259:562-568, 2021
  • Gergen AK, Kohtz PD, Halpern AL, White AM, Meng X, Fullerton DA, Weyant MJ. Statins inhibit Toll-like receptor 4-mediated growth of human esophageal adenocarcinoma cells. J Surg Res 260:436-447, 2021
  • The E, Yao Q, Zhang P, Zhai Y, Ao L, Fullerton DA, Meng X. Mechanistic roles of matrilin-2 and Klotho in modulating the inflammatory activity of human aortic valve cells. Cells 9:385, 2020.
  • Yao Q, The E, Ao L, Zhai Y, Osterholt MK, Fullerton DA, Meng X. TLR4 stimulation promotes human AVIC fibrogenic activity through upregulation of neurotrophin 3 production. Int J Mol Sci 21:1276, 2020.
  • Zhang P, The E, Nedumaran B, Ao L, Jarrett MJ, Xu D, Fullerton DA, Meng X. Monocytes enhance the inflammatory response to TLR2 stimulation in aortic valve interstitial cells through paracrine up-regulation of TLR2 level. Int J Biol Sci 16:3062-3074, 2020.
  • Zhou P, Li Q, Su S, Dong W, Zong S, Ma Q, Yang X, Zuo D, Zheng S, Meng X, Xu D, Zeng Q. Interleukin 37 suppresses M1 macrophage polarization through inhibition of the Notch1 and nuclear factor kappa B pathways. Front Cell Dev Biol 8:56, 2020.
  • Gergen AK, Kohtz PD, Halpern AL, LI A, Meng X, Reece TB, Fullerton DA, Weyant MJ. Activation of Toll-like receptor 2 promotes proliferation of human lung adenocarcinoma cells. Anticancer Res 40:5361-5369, 2020.
  • Halpern AL, Kohtz PD, White AM, Houk AK, Rehring JF, Hanson L, McCarter MD, Joshi M, Meng X, Fullerton DA, Weyant MJ. Secretory phospholipase A2 IIa mediates expression of growth factor receptors in esophageal adenocarcinoma. Dig Dis Sci, in press.
  • Jarrett MJ,Houk AK, McCuistion PE, Weyant MJ, Reece TB, Meng X, Fullerton DA. Wnt signaling mediates pro-fibrogenic activity in human aortic valve interstitial cells. Ann Thorac Surg, in press.
  • Jarrett MJ, Yao Q, Venardos N, Weyant MJ, Reece TB, Meng X, Fullerton DA. Simvastatin downregulates osteogenic response in cultured human aortic valve interstitial cells. J Thorac Cardiovasc Surg, in press.
  • Ikeno Y, Ghincea CV, Roda GF, Cheng L, Aftab M, Meng X, Weyant MJ, Cleveland JC, Fullerton DA, Reece TB. Optimizing nicorandil for spinal cord protection in a murine model of complex aortic intervention. Semin Thorac Cardiovasc Surg, in press.
  • Gergen AK, Kohtz PD, Halpern AL, White AM, Meng X, Fullerton DA, Weyant MJ. Statins inhibit Toll-like receptor 4-mediated growth of human esophageal adenocarcinoma cells. J Surg Res, in press.
  • Venardos N, Gergen AK, Jarrett MJ, Weyant MJ, Reece TB, Meng X, Fullerton DA. Warfarin induces calcification of the aortic valve via ERK1/2 and ß-catenin signaling. Ann Thorac Surg, in press
View All (18 Total) View Less

Professional Memberships

  • American Heart Association, Scientific Concil member
  • Shock Society, Award Committee member
  • American Physiology Society, member
  • International Society of Heart Research, member
  • Society of Critical Care Medicine, member
Public Speaking
Yes

General Information

Download CV
Languages: English
Department: Surgery-Cardiothoracic
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13001 East 17th Place
Campus Box C290
Aurora, CO 80045

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