Xianzhong Meng, MD, PhD
Professor, Surgery-Cardiothoracic
Professional Titles
- Profesor
Publications
- Pratap A, Qualman A, Garrett H, The E, Chauhan A, Idrovo J, Chen L, Wani S, Meguid R, Meng X. Targeting glypican 1 reverses resistance to 5-fluorouracil in esophageal adenocarcinoma cells. Anticancer Res 43:3411-3418, 2023
- The E, Zhai Y, Yao Q, Ao l, Li S, Fullerton DA, Dinarello CA, Meng X. Recombinant IL-37 exerts an anti-inflammatory effect on human aortic valve interstitial cells through extracellular and intracellular actions. Int J Biol Sci 19:3908–3919, 2023
- Zhai Y, Yao Q, The E, Ao L, Fullerton DA, Meng X. Aging exacerbates cardiac dysfunction and mortality in sepsis through enhancing TLR2 activity. Front Cardiovasc Med 10:1293866, 2023
- Deng X, Meng X, Fullerton DA, Stone M, Iguidbashian J, Jaggers J. Complement cross talks with H-K-ATPase to up-regulate Runx-2 in human aortic valve interstitial cells. J Surg Res 286:118-126, 2023
- Li X, Zhai Y, Yao Q, The E, Ao L, Fullerton DA, Yu K, Meng X. Up-regulation of myocardial klotho expression to promote cardiac functional recovery in old mice following endotoxemia. Research Square
- Pratap A, Qualman A, Garrett H, Westbrook L, The E, Mitra S, Cordero M, Monge KM, Idrovo JP, Chauhan A, Cheng L, Cohen MJ, Mungo B, Wani S, Meguid RA, McCarter MD, Meng X. Silencing Glypican-1 enhances the antitumor effects of Pictilisib via downregulating PI3K/Akt/ERK signaling in chemo-resistant esophageal adenocarcinoma. Mol Cell Oncol 10:2238873, 2023.
- The E, deGraaf DM, Zhai Y, Yao Q, Ao L, Fullerton DA, Dinarello CA, Meng X. Interleukin 38 alleviates aortic valve calcification by inhibition of NLRP3. Proc Nat Acad Sci USA 119(36):e2202577119, 2022
- Pratap A, Li A, Westbrook L, Gergen AK, Mitra S, Chauhan A, Chen L, Weyant ML, McCarter M, Wani S, Meguid R, Mitchell JD, Cohen M, Fullerton DA, Meng X. Glypican 1 is a prognostic marker and promotes neoplastic properties I esophagogastric adenocarcinoma. J Gastrointest Oncol 13:2082-2104, 2022
- Luo Z, The E, Zhang P, Zhai Y, Yao Q, Ao L, Zeng Q, Fullerton DA, Meng X. Monocytes Augment Inflammatory Responses in Human Aortic Valve Interstitial Cells via ß2-Integrin/ICAM-1-Mediated Signaling. Inflamm Res 71:681-694, 2022
- Gergen AK, Madsen HJ, Li A, Cheng L, Meng X, Fullerton DA, Pratap A, Weyant MJ. Simvastatin inhibits histologic changes associated with gastroduodenal reflux in a murine model. Digest Dis Sci 67:4732-4741, 2022
- Zhai Y, Ao L, Yao Q, The E, Fullerton DA, Meng X. Elevated expression of TLR2 in aging hearts exacerbates cardiac inflammatory response and adverse remodeling following ischemia and reperfusion injury. Front Immunol 13:891570, 2022
- Li J, Zeng Q, Xiong Z, Xian G, Liu Z, Zhan Q, Lai W, Ao L, Meng X, Ren H, Xu D. Trimethylamine-N-oxide induces osteogenic responses in human aortic valve interstitial cells in vitro and aggravates aortic valve lesions in mice. Cardiovac Res 118:2018-2030, 2022
- Zhang P, The E, Luo Z, Zhai Y, Yao Q, Ao L, Fullerton DA, Xu D, Meng X. Pro-inflammatory mediators released by activated monocytes promote aortic valve fibrocalcific activity. Mol Med 28(1):5, 2022
- Gergen AK, Jarrett MJ, Li A, Cheng L, Tilva KR, Madsen HJ, Meng X, Fullerton DA, Weyant MJ. Expression of adhesion molecules in a gastroduodenal reflux murine model. Ann Thorac Surg 113:926-933, 2022
- Venardos N, Gergen AK, Jarrett MJ, Weyant MJ, Reece TB, Meng X, Fullerton DA. Warfarin induces calcification of the aortic valve via ERK1/2 and ß-catenin signaling. Ann Thorac Surg 113:824-835, 2022
- Ikeno Y, Ghincea CV, Roda GF, Cheng L, Aftab M, Meng X, Weyant MJ, Cleveland JC, Fullerton DA, Reece TB. Optimizing nicorandil for spinal cord protection in a murine model of complex aortic intervention. Semin Thorac Cardiovasc Surg 34:28-38, 2022
- Zhao P, Yao Q, Zhang P, The E, Zhai Y, Ao L, Jarret MJ, Dinarello DA, Fullerton DA, Meng X. Single-cell RNA-seq reveals novel proinflammatory EndMT in human coronary artery-on-a-chip under atheroprone flow. Science Advances 7(34):eabg1694, 2021
- Jarrett MJ, Houk AK, McCuistion PE, Weyant MJ, Reece TB, Meng X, Fullerton DA. Wnt signaling mediates pro-fibrogenic activity in human aortic valve interstitial cells. Ann Thorac Surg 112:519-525, 2021
- Jarrett MJ, Yao Q, Venardos N, Weyant MJ, Reece TB, Meng X, Fullerton DA. Simvastatin downregulates osteogenic response in cultured human aortic valve interstitial cells. J Thorac Cardiovasc Surg 161:e261-e271, 2021
- Deng X, Meng X, Fullerton DA, Stone M, Jaggers J. Complement up-regulates Runx-2 to induce pro-fibrogenic change in human aortic valve interstitial cells. Ann Thorac Surg 112:1962-1972, 2021
- Halpern AL, Kohtz PD, White AM, Houk AK, Rehring JF, Hanson L, McCarter MD, Joshi M, Meng X, Fullerton DA, Weyant MJ. Secretory phospholipase A2 IIa mediates expression of growth factor receptors in esophageal adenocarcinoma. Dig Dis Sci 66:784-795, 2021
- Gergen AK, Jarrett MJ, Li A, White AM, Meng X, Fullerton DA, Weyant MJ. Secretory phospholipase A2 inhibition attenuates adhesive properties of esophageal Barrett’s cells. J Surg Res 259:562-568, 2021
- Gergen AK, Kohtz PD, Halpern AL, White AM, Meng X, Fullerton DA, Weyant MJ. Statins inhibit Toll-like receptor 4-mediated growth of human esophageal adenocarcinoma cells. J Surg Res 260:436-447, 2021
- The E, Yao Q, Zhang P, Zhai Y, Ao L, Fullerton DA, Meng X. Mechanistic roles of matrilin-2 and Klotho in modulating the inflammatory activity of human aortic valve cells. Cells 9:385, 2020.
- Yao Q, The E, Ao L, Zhai Y, Osterholt MK, Fullerton DA, Meng X. TLR4 stimulation promotes human AVIC fibrogenic activity through upregulation of neurotrophin 3 production. Int J Mol Sci 21:1276, 2020.
- Zhang P, The E, Nedumaran B, Ao L, Jarrett MJ, Xu D, Fullerton DA, Meng X. Monocytes enhance the inflammatory response to TLR2 stimulation in aortic valve interstitial cells through paracrine up-regulation of TLR2 level. Int J Biol Sci 16:3062-3074, 2020.
- Zhou P, Li Q, Su S, Dong W, Zong S, Ma Q, Yang X, Zuo D, Zheng S, Meng X, Xu D, Zeng Q. Interleukin 37 suppresses M1 macrophage polarization through inhibition of the Notch1 and nuclear factor kappa B pathways. Front Cell Dev Biol 8:56, 2020.
- Gergen AK, Kohtz PD, Halpern AL, LI A, Meng X, Reece TB, Fullerton DA, Weyant MJ. Activation of Toll-like receptor 2 promotes proliferation of human lung adenocarcinoma cells. Anticancer Res 40:5361-5369, 2020.
- Halpern AL, Kohtz PD, White AM, Houk AK, Rehring JF, Hanson L, McCarter MD, Joshi M, Meng X, Fullerton DA, Weyant MJ. Secretory phospholipase A2 IIa mediates expression of growth factor receptors in esophageal adenocarcinoma. Dig Dis Sci, in press.
- Jarrett MJ,Houk AK, McCuistion PE, Weyant MJ, Reece TB, Meng X, Fullerton DA. Wnt signaling mediates pro-fibrogenic activity in human aortic valve interstitial cells. Ann Thorac Surg, in press.
- Jarrett MJ, Yao Q, Venardos N, Weyant MJ, Reece TB, Meng X, Fullerton DA. Simvastatin downregulates osteogenic response in cultured human aortic valve interstitial cells. J Thorac Cardiovasc Surg, in press.
- Ikeno Y, Ghincea CV, Roda GF, Cheng L, Aftab M, Meng X, Weyant MJ, Cleveland JC, Fullerton DA, Reece TB. Optimizing nicorandil for spinal cord protection in a murine model of complex aortic intervention. Semin Thorac Cardiovasc Surg, in press.
- Gergen AK, Kohtz PD, Halpern AL, White AM, Meng X, Fullerton DA, Weyant MJ. Statins inhibit Toll-like receptor 4-mediated growth of human esophageal adenocarcinoma cells. J Surg Res, in press.
- Venardos N, Gergen AK, Jarrett MJ, Weyant MJ, Reece TB, Meng X, Fullerton DA. Warfarin induces calcification of the aortic valve via ERK1/2 and ß-catenin signaling. Ann Thorac Surg, in press
Public Speaking
Yes
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