Mary Weiser-Evans, PhD
Professor, Medicine-Renal Med Diseases/Hypertension

Professional Titles

• Charles Boettcher II Professor of Medicine

Teaching

Publications

• Austin J. Jolly, Sizhao Lu, Allison M. Dubner, Keith A. Strand, Marie F. Mutryn, Aaron Pilotti-Riley, Etienne P. Danis, Raphael A. Nemenoff Karen S. Moulton, Mark W. Majesky, and Mary C.M. Weiser-Evans (2023) The chromatin remodeler Brg1 directs smooth muscle-derived adventitial progenitor-to-myofibroblast differentiation and in situ vascular fibrosis. JCI Insight, March 28:e164862. PMC10243795
• Okamura DM, Nguyen ED, Collins SJ, Yoon K, Gere JB, Weiser-Evans MCM, Beier DR, Majesky MW. (2023) Mammalian organ regeneration in spiny mice. Special issue: Comparative & Extreme Physiology. J Muscle Res Cell Motility, Jun;44(2):39-52. PMID: 36131170 (PMCID currently pending)
• Kayo Okamura, Sizhao Lu, Zhibin He, Chris Altmann, John Montford, Amy Li, M. Scott Lucia, David Orlicky, Mary Weiser-Evans, Sarah Faubel (2023) "L-6 mediates the hepatic acute phase response after prerenal azotemia in a clinically-defined murine model. AJP-Renal Physiology, Sep 1;325(3):F328-F344.
• Majesky MW, Weiser-Evans MCM. (2022) The adventitia in hypertension. Special issue: Emerging mechanisms in the pathogenesis of hypertension. Biochem Pharmacol, 205:115259. PMID: 36150432
• Emily K. Kleczko, Trista K. Hinz, Teresa T. Nguyen, Natalia J. Gurule, Andre Navarro, Anh T. Le, Amber M. Johnson, Jeff Kwak, Diana I. Polhac, Eric T. Clambey, Mary Weiser-Evans, Daniel T. Merrick, Michael C. Yang, Tejas Patil, Erin L. Schenk, Lynn E. Heasley, Raphael A. Nemenoff (2023) Durable responses to alectinib in murine models of EML4-ALK lung cancer requires adaptive immunity. Nat Precision Oncology, 7(1):15. PMC9899278
• Emily K Kleczko, Anh T Le, Trista K Hinz, Teresa T Nguyen, Andre Navarro, Cheng-Jun Hu, Ana M. Selman, Eric T Clambey, Daniel T Merrick4, Sizhao Lu, Mary Weiser-Evans, Raphael A Nemenoff, Lynn E Heasley (2023) Novel EGFR-Mutant Mouse Models of Lung Adenocarcinoma Reveal Adaptive Immunity Requirement for Durable Osimertinib Response. Cancer Letters, Mar 1;556:216062.
• Emily K. Kleczko, Joanna M. Poczobutt, Andre C. Navarro, Jennifer Laskowski, Amber M. Johnson, Sean P. Korpela, Natalia J. Gurule, Lynn E. Heasley, Katharina Hopp, Mary C.M. Weiser-Evans, Elizabeth B. Gottlin, Ryan T. Bushey, Michael J. Campa, Edward F. Patz Jr., Joshua M. Thurman, and Raphael A. Nemenoff (2023) Upregulation of complement proteins in lung cancer cells mediates tumor progression. Frontiers in Oncology, in press. PMC9849673
• Calen A Steiner, Samuel D Koch, Tamara Evanoff, Nichole Welch, Rachael Kostelecky, Rosemary Callahan, Emily M Murphy, Caroline H T Hall, Sizhao Lu, Mary CM Weiser-Evans, Ian M Cartwright, Sean P Colgan (2023) The TNFdARE mouse as a model of intestinal fibrosis. Am J Pathol, May 9:S0002-9440(23)00166-9. (PMCID currently pending)
• Benjamin McNair, Sydney Polson, Samantha Shorthill, Aykhan Yusifov, Lori Walker, Mary Weiser-Evans, Elizabeth Kovacs, and Danielle Bruns (2023) Metformin protects against pulmonary hypertension-induced right ventricular dysfunction in an age- and sex-specific manner independent of cardiac AMPK. American Journal of Physiology-Heart and Circulatory Physiology, Aug 1;325(2):H278-H292. (PMCID currently pending)
• Allison M Dubner, Sizhao Lu, Austin J Jolly, Tysen Noble, Tyler Hinthorn, Raphael A Nemenoff, Karen S Moulton, Mark W Majesky, Mary CM Weiser-Evans (2023) Confounding effects of tamoxifen: Cautionary and practical considerations for the use of tamoxifen-inducible mouse models in atherosclerosis research. Arterioscler Thromb Vasc Biol, Nov;43(11):2223-2230. PMC10615862
• Allison M Dubner, Sizhao Lu, Austin J Jolly, Keith A Strand, Marie F Mutryn, Tyler Hinthorn, Tysen Noble, Raphael A Nemenoff, Karen S Moulton, Mark W Majesky, Mary CM Weiser-Evans (2023) Smooth muscle-derived adventitial progenitor cells promote key cell type transitions controlling plaque stability in atherosclerosis in a Klf4-dependent manner. JCI Insight, Nov 22;8(22):e174639.
• Valentina d’Escamard, Daniella Kadian-dodov, Lijiang Ma, Shouneng Peng, Annette King, Allison Thomas, Bhargravi Vonguru, Yang Xu, Katherine C. Michelis, Emir Bander, Rihab Bouchareb, Adrien Georges, Aya Nomura-Kitabayashi, Yu Zhou, Elena Chepurko, Vadim, Chepurko, Marika Fava, Temo Barwan, Anelechi Anyanwu, Farzan Filsoufi, Sander Florman, Nabila Bouatia-Naji, Manuel Mayr, Michael G. Katz, Ke Hao, Johan LM Björkegren, Sizhao Lu, Mary CM Weiser-Evans, Jeffrey Olin, Jason Kovacic (2023) Integrative Gene Regulatory Network Analysis Discloses Key Driver Genes of Fibromuscular Dysplasia in Females: the DEFINE-FMD study. Nature Cardiovasc Research, under review after revision.
• PMC9849673
• PMC8742724
• PMID: 35331421
• PMID: 35512358
• PMID: 35512358
• PMID: 36131170
• PMID: 36150432
• Amber M. Johnson, Jennifer M. Boland, Julia Wrobel, Mary C.M. Weiser-Evans, Emily K. Klezcko, Eric T. Clambey, Raphael A. Nemenoff, and Erin L. Schenk (2021) Cancer cell-specific major histocompatibility complex II expression as a determinant of the immune infiltrate organization and function in the NSCLC tumor microenvironment. Journal of Thoracic Oncology, in press.
• Austin J. Jolly, Sizhao Lu, Keith A. Strand, Allison M. Dubner, Marie F. Mutryn, Raphael A. Nemenoff, Mark W. Majesky, Karen S. Moulton, and Mary C.M. Weiser-Evans (2021) Heterogeneous Subpopulations of Adventitial Progenitor Cells Regulate Vascular Homeostasis and Pathological Vascular Remodeling. Cardiovascular Research, in press.
• Bradley S. Ferguson, Sara A. Wennersten, Kimberly M. Demos-Davies, Maria A. Cavasin, Matthew S. Stratton, Tianjing Hu, Marcello Rubino, Stephen M. Keyse, Robert A. McKnight, Robert H. Lane, Eva Nozik-Grayck, Mary C. M. Weiser-Evans, and Timothy A. McKinsey (2021) A DUSP5-Dependent Feedback Loop Controls Smooth Muscle Proliferation, Pulmonary Hypertension and Right Ventricular Hypertrophy. Am Journal Phys – Heart Circulatory Phys, in press.
• Amrut V. Ambardekar, MD; Matthew S. Stratton, PhD; Evgenia Dobrinskikh, PhD; Kendall S. Hunter, PhD; Philip D. Tatman; Madeleine E. Lemieux, PhD; Joseph C. Cleveland, MD; Rubin M. Tuder, MD; Mary C.M. Weiser-Evans, PhD; Karen S. Moulton, MD; Timothy A. McKinsey, PhD. (2021) Continuous-Flow LVADs Downregulate Matrix-Degrading Enzyme Expression and Promote Fibrosis in the Human Aorta. J Am Col Cardiology, in press.
• John Montford, Colin Bauer, Jeremy Rahkola, Julie Reisz, Katharina Hopp, Danielle Soranno, Jelena Klawitter, Mary Weiser-Evans, Raphael Nemenoff, Sarah Faubel, and Seth Furgeson. (2021) 15-Lipoxygenase Worsens Renal Fibrosis, Inflammation, and Metabolism in a Murine Model of Ureteral Obstruction. Am J Physiology – Renal Physiology, in press.
• Amrut V. Ambardekar, MD; Matthew S. Stratton, PhD; Mary C.M. Weiser-Evans, PhD; Karen S. Moulton, MD; Timothy A. McKinsey, PhD. (2022) Aortic Valve Remodeling in CF-LVAD: Beyond the Arterial Wall. J Am Col Cardiology, in press.
• Amrut V. Ambardekar, MD; Matthew S. Stratton, PhD; Mary C.M. Weiser-Evans, PhD; Karen S. Moulton, MD; Timothy A. McKinsey, PhD (2022) Reply: Aortic valve remodeling in CF-LVAD: Beyond the arterial wall. Journal Am Col Cardiology, in press.
• PMC9074982
• PMC8464501
• PMC8410116
• PMC8562886
• S Lu, MCM Weiser-Evans (2019) Nuclear focal adhesion kinase: Novel endogenous antagonist of focal adhesion kinase-mediated smooth muscle proliferation and neointima formation. Circulation Research, 125(2):167-169.
• Lu S, Strand KA, Mutryn MF, Tucker RM, Jolly AJ, Furgeson SB, Moulton KS, Nemenoff RA, Weiser-Evans MCM. PTEN (Phosphatase and Tensin Homolog) Protects Against Ang II (Angiotensin II)-induced Pathological Vascular Fibrosis and Remodeling-Brief Report. Arterioscler Thromb Vasc Biol. 2020 Feb;40(2):394-403.
• Strand KA, Lu S, Mutryn MF, Li L, Zhou Q, Enyart BT, Jolly AJ, Dubner AM, Moulton KS, Nemenoff RA, Koch KA, LaBarbera DV, Weiser-Evans MCM. High Throughput Screen Identifies the DNMT1 (DNA Methyltransferase-1) Inhibitor, 5-Azacytidine, as a Potent Inducer of PTEN (Phosphatase and Tensin Homolog): Central Role for PTEN in 5-Azacytidine Protection Against Pathological Vascular Remodeling. Arterioscler Thromb Vasc Biol. 2020 Aug;40(8):1854-1869.
• S Lu, A Jolly, K Strand, AM Dubner, MF Mutryn, K.S. Moulton, R.A. Nemenoff, M.W. Majesky, MCM Weiser-Evans (2020) Smooth muscle-derived progenitor cell myofibroblast differentiation through KLF4 downregulation promotes arterial remodeling and fibrosis. J Clinical Investigation Insight, 5(23):e139445
• Wu W, Wang C, Zang H, Qi L, Azhar M, Nagarkatti M, Nagarkatti P, Cai G, Weiser-Evans MCM, Cui T. Mature Vascular Smooth Muscle Cells, but Not Endothelial Cells, Serve as the Major Cellular Source of Intimal Hyperplasia in Vein Grafts. Arterioscler Thromb Vasc Biol. 2020 Aug;40(8):1870-1890.
• TR Sippel, AM Johnson, HY Li, D Hanson, TT Nguyen, BL Bullock, JM Poczobutt, JW Kwak, E Kleczko, MCM Weiser-Evans, RA Nemenoff (2019) Activation of PPAR? in Myeloid Cells Promotes Progression of Epithelial Lung Tumors through TGF- ß1. Molecular Cancer Research, 17(8):1748-1758.
• S Lu, MCM Weiser-Evans (2019) Nuclear focal adhesion kinase: Novel endogenous antagonist of focal adhesion kinase-mediated smooth muscle proliferation and neointima formation. Circulation Research, 125(2):167-169.
• S Lu, K Strand, M Mutryn, R Tucker, M Cavasin, S Furgeson, RA Nemenoff, and MCM Weiser-Evans (2019) PTEN protects against Angiotensin II-induced pathological cardiovascular fibrosis and remodeling. ATVB, 40(2):394-403.
• KS Moulton, M Li, K Strand, S Burgett, P Mcclatchey, R Tucker, S Furgeson, S Lu, B Kirkpatrick, JC Cleveland, RA Nemenoff, A Ambardekar, MCM Weiser-Evans (2018) PTEN deficiency promotes pathological vascular remodeling of human coronary arteries. J Clinical Investigation Insight, Feb. 22; 3(4).
• AV Ambardekar, MCM Weiser-Evans, M Li, SN Purohit, M Aftab, B Reece, KS Moulton (2018) Coronary artery remodeling and fibrosis with continuous-flow left ventricular assist device support. Circulation Heart Failure, 11(5):e004491.
• MW Majesky, H Horita, A Ostriker, JN Regan, XR Dong, J Poczobutt, RA Nemenoff, and MCM Weiser-Evans (2017) Differentiated smooth muscle cells generate a subpopulation of resident vascular progenitor cells in the adventitia regulated by Klf4. Circulation Research, 120:296-311. PMC5250562
• MCM Weiser-Evans (2017) Smooth muscle differentiation control comes full circle: the circular non-coding RNA, circActa2, functions as a miRNA sponge to "fine-tune" SMA expression. Circulation Research, 121(6):591-593. PMC5679083
• Poczobutt JM, Nguyen TT, Hanson D, Li H, Sippel TR, Weiser-Evans MC, Gijon M, Murphy RC, Nemenoff RA. Deletion of 5-Lipoxygenase in the Tumor Microenvironment Promotes Lung Cancer Progression and Metastasis through Regulating T Cell Recruitment. J Immunol. 2016 Jan 15;196(2):891-901. PubMed PMID: 26663781
• H Horita, CL Wysoczynski, LA Walker, KS Moulton, M Li, A Ostriker, R Tucker, TA McKinsey, MEA Churchill, RA Nemenoff, and MCM Weiser-Evans (2016) Nuclear PTEN functions as an essential regulator of SRF-dependent transcription to control smooth muscle differentiation. Nature Communications, 7:10830.
• MW Majesky, H Horita, A Ostriker, JN Regan, XR Dong, J Poczobutt, RA Nemenoff, and MCM Weiser-Evans (2017) Differentiated smooth muscle cells generate a subpopulation of resident vascular progenitor cells in the adventitia regulated by Klf4. Circulation Research, 120:296-311. *Circulation Research Editorial of this manuscript and Cover Figure
• Roe ND, Xu X, Kandadi MR, Hu N, Pang J, Weiser-Evans MC, Ren J. Targeted deletion of PTEN in cardiomyocytes renders cardiac contractile dysfunction through interruption of Pink1-AMPK signaling and autophagy. Biochim Biophys Acta. 2015 Feb;1852(2):290-8. PubMed PMID: 25229693
• X Xu, ND Roe, MCM Weiser-Evans, J Ren (2014) Inhibition of mTOR with rapamycin reverses hypertrophic cardiomyopathy in mice with cardiomyocytes-specific knockout of PTEN. Hypertension, 63(4):729-39. PMC Journal in process
• A Ostriker, HN Horita, J Poczobutt, MCM Weiser-Evans*, RA Nemenoff* (2014) Vascular Smooth Muscle Cell-derived TGF-b Promotes Maturation of Neointima-Associated Macrophages, ATVB, 34(4):877-86. PMC3966963
• H Horita, SB Furgeson, A Ostriker, KA Olszewski, T Sullivan, LR Villegas, M Levine, JE Parr, CD Cool, RA Nemenoff, and MCM Weiser-Evans (2013) Inactivation of PTEN Selectively in Smooth Muscle Cells Synergizes with Hypoxia to Induce Severe Pulmonary Arterial Hypertension. JAHA, 31;2(3):e000188.
• Nguyen Anh, Delphine Gomez, Robert D Bell, Julie H Campbell, Alexander W Clowes, Giulio Gabbiani, Cecilia M Giachelli, Michael S Parmacek, Elaine W Raines, Nancy J Rusch, Mei Y Speer, Michael Sturek, Johan Thyberg, Dwight A Towler, Mary CM Weiser-Evans, Chen Yan, Joseph M Miano, Gary K Owens (2013) Smooth Muscle Cell Plasticity: Fact or Fiction? Circ Res, 4;112(1):17-22.
• MA Cavasin, K Demos-Davies, TR Horn, LA Walker, DD Lemon, N Birdsey, MCM Weiser-Evans, J Harral, DC Irwin, A Anwar, ME Yeager, M Li, PA Watson, RA Nemenoff, PM Buttrick, KR Stenmark, and TA McKinsey (2012) Selective class I HDAC inhibition suppresses hypoxia-induced cardiopulmonary remodeling through an anti-proliferative mechanism. Circ Res, 110(5):739-48. PMC Journal in process
• Nguyen Anh, Delphine Gomez, Robert D Bell, Julie H Campbell, Alexander W Clowes, Giulio Gabbiani, Cecilia M Giachelli, Michael S Parmacek, Elaine W Raines, Nancy J Rusch, Mei Y Speer, Michael Sturek, Johan Thyberg, Dwight A Towler, Mary CM Weiser-Evans, Chen Yan, Joseph M Miano, Gary K Owens (2012) Smooth Muscle Cell Plasticity: Fact or Fiction? In press, Circ Res.
• RA Nemenoff, H Horita, AC Ostriker, SB Furgeson, PA Simpson, V Van Putten, JT Crossno, S Offermanns, and MCM Weiser-Evans (2011) SDF-1a Induction in Mature Smooth Muscle Cells by Inactivation of PTEN is a Critical Mediator of Exacerbated Injury-Induced Neointima Formation. ATVB Jun;31(6):1300-8. PMCID: PMC3111081
• H Horita, P Simpson, A Ostriker, S Furgeson, V vanPutten, MCM Weiser-Evans*, and RA Nemenoff* (2011) Serum response factor regulates expression of PTEN through a micro-RNA network in vascular smooth muscle cells. ATVB, 31:2909-19. *Equal Corresponding Authors PMCID: PMC3220738H Horita, P Simpson, A Ostriker, S Furgeson, V vanPutten, MCM Weiser-Evans*, and RA Nemenoff* (2011) Serum response factor regulates expression of PTEN through a micro-RNA network in vascular smooth muscle cells. ATVB, 31:2909-19. *Equal Corresponding Authors PMCID: PMC3220738
• SB Furgeson, PA Simpson, I Park, V VanPutten, RA Nemenoff, and MCM Weiser-Evans (2010) Heterozygous Disruption of PTEN in Smooth Muscle Promotes a Pro-inflammatory Phenotype and Enhances Neointima Formation. Cardiovascular Res, May 1;86(2):274-82.
• MCM Weiser-Evans, XQ Wang, R Choudhary, J Amin, V Van Putten and RA Nemenoff (2009) Cytosolic phospholipase A2 in the lung tumor microenvironment is critical for tumor progression and metastasis. Cancer Research, 69(5):1733-8. PMC2653105
• RA Nemenoff , P Simpson , S Furgeson , N Kaplan-Albuquerque , J Crossno , P Garl , J Cooper, and MCM Weiser-Evans (2008) Targeted deletion of PTEN in smooth muscle cells results in vascular remodeling and recruitment of progenitor cells through induction of SDF-1a. Circulation Research 102:1036-1045
• Kaplan-Albuquerque N, Bogaert YE, Van Putten V, Weiser-Evans MCM, and Raphael A. Nemenoff. (2005) Patterns of gene expression differentially regulated by PDGF and hypertrophic stimuli in vascular smooth muscle cells: markers for phenotypic modulation and response to injury. J Biol Chem. 280(20):19966-76.
• PMID: 36657561

Professional Memberships

• American Heart Association Arteriosclerosis, Thrombosis and Vascular Biology, Fellow
• North American Vascular Biology Organization, Member