Jonathan Gutman, MD
Associate Professor, Medicine-Hematology

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Medical School:
  • MD, New York University School of Medicine (2002)
Undergraduate School:
  • BA, Princeton University (NJ) (1996)
Internship:
  • University of Colorado (University Hospital) Program (2003)
Residency:
  • University of Colorado (University Hospital) Program, Internal Medicine (2005)
Fellowships:
  • University of Washington Program, Medical Oncology (2009)
  • Fred Hutchinson Cancer Research Center (2009)
Languages: English
Department: Medicine-Hematology

Research Interests

I am focused on clinical research in blood cancers and stem cell transplantation with an emphasis on cord blood transplantation. I am also the co-medical director of the University of Colorado Cord Blood Bank.

Publications

  • 51. Prashant Sharma, Neel Gakhar, Jennifer MacDonald, Maheen Abidi, Esther Benamu, Valida Bajrovic, Enkhtsetseg Purev, Bradley M. Haverkos, Jennifer Tobin, Jeff Kaiser, Stephanie Chase, Matthew Miller, Adriana Weinberg, and Jonathan A Gutman. Letermovir prophylaxis through day 100 post-transplant is safe and effective compared to alternative CMV prophylaxis strategies following adult cord blood and haploidentical cord blood transplantation. Bone Marrow Transplant. 2020 Apr;55(4):780-786.
  • 52. Gutman JA, Pollyea DA. Hypomethylating agents with venetoclax: have we discovered the holy grail? Curr Opin Hematol. 2020 Mar;27(2):76-80.
  • 53. Shanshan Pei, Daniel A. Pollyea, Annika Gustafson, Brett M. Stevens, Mohammad Minhajuddin, Rui Fu, Kent A. Riemondy, Austin E. Gillen, Ryan M. Sheridan, Jihye Kim, James Costello, Maria L. Amaya, Anagha Inguva, Amanda Winters, Haobin Ye, Anna Krug, Courtney L. Jones, Biniam Adane, Nabilah Khan, Jessica Ponder, Jeffrey Schowinsky, Diana Abbott, Andrew Hammes , Jason R. Myers, John M. Ashton, Travis Nemkov, Angelo D'Alessandro, Jonathan A. Gutman, Stephen W. Fesik, Haley E. Ramsey, Michael R. Savona , Clayton A. Smith, Craig T Jordan. Monocytic Subclones Confer Resistance to Venetoclax-Based Therapy in Acute Myeloid Leukemia Patients. Cancer Discovery. 2020 Apr;10(4):536-551.
  • 54. Prashant Sharma, Enkhtsetseg Purev, Bradley Haverkos, Daniel A. Pollyea, Evan Cherry, Manali Kamdar, Tomer Mark, Peter Forsberg, Daniel Sherbenou, Andrew Hammes, Rachel Rabinovitch, Clayton A. Smith, Jonathan A. Gutman. Adult cord blood transplant results in comparable overall survival and improved GRFS versus matched related transplant. Blood Advances. 2020 May 26;4(10):2227-2235.
  • 55. Jason P. Cooper, Barry E. Storer, Noa Granot, Boglarka Gyurkocza, Mohamed L. Sorror, Thomas R. Chauncey, Judith Shizuru, Georg-Nikolaus Franke, Michael B. Maris, Michael Boyer, Benedetto Bruno, Firoozeh Sahebi, Amelia A. Langston, Parameswaran Hari, Edward D. Agura, Søren Lykke Petersen, Richard T. Maziarz, Wolfgang Bethge, Julie Asch, Jonathan A. Gutman, Gitte Olesen, Andrew M. Yeager, Kai Hübel, William J. Hogan, David G. Maloney, Marco Mielcarek, Paul J. Martin, Mary E. D. Flowers, George E. Georges, Ann E. Woolfrey, H. Joachim Deeg, Bart L. Scott, George B. McDonald, Rainer Storb, and Brenda M. Sandmaier. Allogeneic hematopoietic cell transplantation with non-myeloablative conditioning for patients with hematologic malignancies: Improved outcomes over two decades. Haemalogica. 2020 Jun 4:haematol.2020.248187. Online ahead of print.
  • 56. Andrew Kent, Sumithira Vasu, Derek Schatz, Natalie Monson, Steven Devine, Clayton Smith, Jonathan A. Gutman*, Daniel A. Pollyea* (shared senior authorship). Glasdegib as Maintenance Therapy for AML and MDS Patients at High Risk for Post-Allogeneic Stem Cell Transplant Relapse. Blood Advances. 2020 Jul 14;4(13):3102-3108.
  • 57. Saad A, de Lima M, Anand S, Bhatt VR, Bookout R, Chen G, Couriel D, Di Stasi A, El-Jawahri A, Giralt S, Gutman J, Ho V, Horwitz M, Hsu J, Juckett M, Kharfan-Dabaja MA, Loren A, Meade J, Mielcarek M, Moreira J, Nakamura R, Nieto Y, Roddy J, Satyanarayana G, Schroeder M, Tan CR, Tzachanis D, Burn J, Pluchino L. Hematopoietic Cell Transplantation, Version 2.2020, NCCN Clinical Practice Guidelines in Oncology. J Natl Compr Canc Netw. 2020 May 1;18(5):599-634.
  • 57. Saad A, de Lima M, Anand S, Bhatt VR, Bookout R, Chen G, Couriel D, Di Stasi A, El-Jawahri A, Giralt S, Gutman J, Ho V, Horwitz M, Hsu J, Juckett M, Kharfan-Dabaja MA, Loren A, Meade J, Mielcarek M, Moreira J, Nakamura R, Nieto Y, Roddy J, Satyanarayana G, Schroeder M, Tan CR, Tzachanis D, Burn J, Pluchino L. Hematopoietic Cell Transplantation, Version 2.2020, NCCN Clinical Practice Guidelines in Oncology. J Natl Compr Canc Netw. 2020 May 1;18(5):599-634.
  • 58. Filippo Milano, Jonathan A Gutman, H. Joachim Deeg, Eneida R Nemecek, Joachim Baumgart, Laurel Thur, Ann Dahlberg, Rachel B Salit, Corinne Summers, Frederick R Appelbaum, Colleen Delaney. Treosulfan-based Conditioning is Feasibel and Effective for Cord Blood Recipients: A Phase II Multi-center Study. Blood Advances. 2020 Jul 28;4(14):3302-3310.
  • 59. Matthew A Miller, PharmD, Kyle C Molina, PharmD, Jonathan A Gutman, MD, Sias Scherger, MD, Jessica M Lum, MD, Sherif B Mossad, MD, Mary Burgess, MD, Matthew P Cheng, MD, Sally T Chuang, MD, Samantha E Jacobs, MD, Dante P Melendez, MD, Dimpy P Shah, MD, Andrea Zimmer, MD, M Rizwan Sohail, MD, Sadia Syed, MD, Randall C Walker, MD, Eric M Poeschla, MD, Maheen Z Abidi, MD. Mucormycosis in Hematopoietic cell Transplant Recipients and in patients with Hematological Malignancies in the Era of New Antifungal Agents. Open Forum Infectious Diseases. 2020 12/30.
  • 60. Abbott D, Cherry E, Amaya M, McMahon C, Schwartz M, Winters A, Schowinsky J, Jordan CT, Smith C, Gutman JA, Pollyea DA. The propriety of upgrading responses to venetoclax?+?azacitidine in newly diagnosed patients with acute myeloid leukemia. Leuk Lymphoma. 2020 Dec 30:1-9. doi: 10.1080/10428194.2020.1864358. Online ahead of print.
  • 57. Mangala Iyengar, Enkhtsetseg Purev, Brad Haverkos, Clayton Smith, Daniel Pollyea, Jonathan A Gutman. Incidence of Pulmonary GVHD is Increased and Incidence of Late Infection and Pulmonary Embolism is Comparable Comparing Adult MRD Versus Cord Transplant Patients. ASBMT 2020. Poster.
  • 58. Matthew A Miller, Kyle C Molina, Sias Scherger, Jessica Lum, Sherif B Mossad, Mary Burgess, Matthew P Chang, Sally Chuang, Samantha Jacobs, Dante Melendez, Dimpy P Shah, M Rizwan Sohail, Sadia Syed, Randall C Walker, Andrea Zimmer, Jonathan A Gutman, Maheen Z Abidi. Survival Among Patients with Hematologic Malignancies and Recipients of Hematopoietic Cell Transplant with Invasive Mucormycosis. ASBMT 2020. Poster.
  • 59. Hannah Choe, Nirav N. Shah, Patrice Chevallier, Marie Thérèse Rubio, Mark A. Schroeder, Nancy M. Hardy, Patrick J. Stiff, Carlos Solano, Ibrahim Yakoub-Agha, Jonathan A. Gutman, Scott D. Rowley, Maria Caterina Mico, Elisabetta Terruzzi, Rafael F. Duarte, Rodica Morariu-Zamfir, Michael Arbushites, Kai Ding, and Miguel-Angel Perales. A Single-Arm, Open-Label Phase 1 Study of Itacitinib (ITA) with Calcineurin Inhibitor (CNI)–Based Interventions for Prophylaxis of Graft-Versus-Host Disease (GVHD; GRAVITAS-119). ASH 2020. Oral.
  • 60. Jonathan A. Gutman, Amanda Winters, Maria L Amaya, Christine M. McMahon, Jeffrey Schowinsky, Diana Abbott, Andrew Hammes, Shanshan Pei, Brett M. Stevens, Craig T. Jordan, Clayton Smith and Daniel A. Pollyea. Venetoclax and Azacitidine for Newly Diagnosed Non-Elderly Adult Patients with Acute Myeloid Leukemia and Adverse Risk Features. ASH 2020. Poster.
  • 61. Daniel A. Pollyea, Amanda Winters, Craig T. Jordan, Clayton Smith, and Jonathan A. Gutman. Allogeneic Transplant Improves AML Outcomes Compared to Maintenance Venetoclax and Azacitidine Following Response to Initial Venetoclax and Azacitidine Therapy ASH 2020. Oral.
  • 62. Andrew Kent, Daniel A. Pollyea, Amanda Winters, Craig T. Jordan, Clayton Smith, and Jonathan A. Gutman. Venetoclax Is Safe and Tolerable As Post-Transplant Maintenance Therapy for AML Patients at High Risk for Relapse. ASH 2020. Poster.
  • Pei S, Minhajuddin M, D'Alessandro A, Nemkov T, Stevens BM, Adane B, Khan N, Hagen FK, Yadav VK, De S, Ashton JM, Hansen KC, Gutman JA, Pollyea DA, Crooks PA, Smith C, Jordan CT. Rational design of a parthenolide-based drug regimen that selectively eradicates acute myelogenous leukemia stem cells. J Biol Chem. 2016 Nov 25;291(48):25280. PubMed PMID: 27888238
  • Pei S, Minhajuddin M, D'Alessandro A, Nemkov T, Stevens BM, Adane B, Khan N, Hagen FK, Yadav VK, De S, Ashton JM, Hansen KC, Gutman JA, Pollyea DA, Crooks PA, Smith C, Jordan CT. Rational Design of a Parthenolide-based Drug Regimen That Selectively Eradicates Acute Myelogenous Leukemia Stem Cells. J Biol Chem. 2016 Oct 14;291(42):21984-22000. PubMed PMID: 27573247
  • Gavin KM, Gutman JA, Kohrt WM, Wei Q, Shea KL, Miller HL, Sullivan TM, Erickson PF, Helm KM, Acosta AS, Childs CR, Musselwhite E, Varella-Garcia M, Kelly K, Majka SM, Klemm DJ. De novo generation of adipocytes from circulating progenitor cells in mouse and human adipose tissue. FASEB J. 2016 Mar;30(3):1096-108. PubMed PMID: 26581599
  • Stevens B, Maxson J, Tyner J, Smith CA, Gutman JA, Robinson W, Jordan CT, Lee CK, Swisshelm K, Tobin J, Wei Q, Schowinsky J, Rinella S, Lee HG, Pollyea DA. Clonality of neutrophilia associated with plasma cell neoplasms: report of a SETBP1 mutation and analysis of a single institution series. Leuk Lymphoma. 2016;57(4):927-34. PubMed PMID: 26389776
  • Gyurkocza B, Gutman J, Nemecek ER, Bar M, Milano F, Ramakrishnan A, Scott B, Fang M, Wood B, Pagel JM, Baumgart J, Delaney C, Maziarz RT, Sandmaier BM, Estey EH, Appelbaum FR, Storer BE, Deeg HJ. Treosulfan, Fludarabine, and 2-Gy Total Body Irradiation Followed by Allogeneic Hematopoietic Cell Transplantation in Patients with Myelodysplastic Syndrome and Acute Myeloid Leukemia. Biol Blood Marrow Transplant. 2014 Jan 16. [Epub ahead of print] PubMed PMID: 24440648
  • Bird GA, Polsky A, Estes P, Hanlon T, Hamilton H, Morton JJ, Gutman J, Jimeno A, Turner BC, Refaeli Y. Expansion of human and murine hematopoietic stem and progenitor cells ex vivo without genetic modification using MYC and Bcl-2 fusion proteins. PLoS One. 2014;9(8):e105525. PubMed PMID: 25170611
  • Pollyea DA, Gutman JA, Gore L, Smith CA, Jordan CT. Targeting acute myeloid leukemia stem cells: a review and principles for the development of clinical trials. Haematologica. 2014 Aug;99(8):1277-84. PubMed PMID: 25082785
  • Gyurkocza B, Gutman J, Nemecek ER, Bar M, Milano F, Ramakrishnan A, Scott B, Fang M, Wood B, Pagel JM, Baumgart J, Delaney C, Maziarz RT, Sandmaier BM, Estey EH, Appelbaum FR, Storer BE, Deeg HJ. Treosulfan, fludarabine, and 2-Gy total body irradiation followed by allogeneic hematopoietic cell transplantation in patients with myelodysplastic syndrome and acute myeloid leukemia. Biol Blood Marrow Transplant. 2014 Apr;20(4):549-55. PubMed PMID: 24440648
  • Babilonia KM, Golightly LK, Gutman JA, Hassell KL, Kaiser JN, Kiser TH, Klem PM, Trujillo TC. Antithrombotic therapy in patients with thrombocytopenic cancer: outcomes associated with reduced-dose, low-molecular-weight heparin during hospitalization. Clin Appl Thromb Hemost. 2014 Nov;20(8):799-806. PubMed PMID: 25022565
  • Narayanan V, Gutman JA, Pollyea DA, Jimeno A. Omacetaxine mepesuccinate for the treatment of chronic myeloid leukemia. Drugs Today (Barc). 2013 Jul;49(7):447-56. PubMed PMID: 23914353
  • Narayanan V, Pollyea DA, Gutman JA, Jimeno A. Ponatinib for the treatment of chronic myeloid leukemia and Philadelphia chromosome-positive acute lymphoblastic leukemia. Drugs Today (Barc). 2013 Apr;49(4):261-9. PubMed PMID: 23616953
  • Coffey DG, Pollyea DA, Myint H, Smith C, Gutman JA. Adjusting DLCO for Hb and its effects on the Hematopoietic Cell Transplantation-specific Comorbidity Index. Bone Marrow Transplant. 2013 Sep;48(9):1253-6. PubMed PMID: 23503530
  • Ostronoff F, Milano F, Gooley T, Gutman JA, McSweeney P, Petersen FB, Sandmaier BM, Storb R, Delaney C. Double umbilical cord blood transplantation in patients with hematologic malignancies using a reduced-intensity preparative regimen without antithymocyte globulin. Bone Marrow Transplant. 2013 Jun;48(6):782-6. PubMed PMID: 23241738
  • Petz LD, Redei I, Bryson Y, Regan D, Kurtzberg J, Shpall E, Gutman J, Querol S, Clark P, Tonai R, Santos S, Bravo A, Spellman S, Gragert L, Rossi J, Li S, Li H, Senitzer D, Zaia J, Rosenthal J, Forman S, Chow R. Hematopoietic cell transplantation with cord blood for cure of HIV infections. Biol Blood Marrow Transplant. 2013 Mar;19(3):393-7. PubMed PMID: 23089564
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Practice Locations

UCHealth Blood Disorders and Cell Therapies Center - Anschutz Medical Campus
1665 Aurora Court
3rd floor, Anschutz Cancer Pavilion
Aurora, CO 80045
720-848-6400

UCH - Anschutz Inpatient Pavilion
12605 E. 16th Ave
Aurora, CO 80045
720-848-0000

Hospital Affiliation
  • University of Colorado Hospital
Center Affiliations

Specialty Information

Specialties
  • Internal Medicine, Board Certification (2005)
  • Medical Oncology, Board Certification (2009)
Conditions & Treatments
  • Cancers
  • Cancers - Blood and Marrow Transplant
  • Cancers - Leukemia (Adult Acute)
  • Cancers - Leukemia (Adult Chronic)
  • Cancers - Lymphoma
  • Cancers - Myeloma
Clinical Interests
My primary area of interest is cord blood transplantation, and my broader interests include acute leukemias and all aspects of allogeneic stem cell transplantation.

Personal Interests
Dr. Gutman received his BA in history from Princeton University. He completed medical school at New York University, residency at the University of Colorado, and fellowship at the Fred Hutchinson Cancer Research Center. He returned to the University of Colorado in 2009. He serves as the director of allogeneic stem cell transplantation, co-medical director of the University of Colorado Cord Blood Bank, laboratory medical director of the clinical stem cell laboratory, and chairman of the University of Colorado Cancer Center Protocol Review and Monitoring system. His research focuses on optimization of allogeneic transplantation and immunotherapy with a particular emphasis on cord blood transplantation. He is an ad hoc reviewer for numerous journals and is the principal investigator on numerous clinical trials. In addition he serves on several national committees related to improving stem cell transplantation.

General Information

Medical Schools:
  • MD, New York University School of Medicine (2002)
Undergraduate Schools:
  • BA, Princeton University (NJ) (1996)
Internships:
  • University of Colorado (University Hospital) Program (2003)
Residency Programs:
  • University of Colorado (University Hospital) Program, Internal Medicine (2005)
Fellowships:
  • University of Washington Program, Medical Oncology (2009)
  • Fred Hutchinson Cancer Research Center (2009)
Download CV
Languages: English
Department: Medicine-Hematology
Contact Us
CU Anschutz
Fitzsimons Building

13001 East 17th Place
Campus Box C290
Aurora, CO 80045

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