Michael Bristow, MD, PhD
Professor, Medicine-Cardiology

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Medical School:
  • MD, University of Illinois College of Medicine (1970)
Graduate School :
  • PhD, University of Illinois, Chicago (1971)
Internship:
  • Stanford University Program (1972)
Residency:
  • Stanford University Program, Internal Medicine (1977)
Fellowships:
  • Stanford Hospital and Clinics Program, Cardiovascular Disease (1978)
Languages: English
Department: Medicine-Cardiology

Professional Titles

  • Professor of Medicine, Cardiology
  • Director, Pharmacogenomics, CU-CVI

Recognition & Awards

  • Guest Editor in Chief, JACC: Basic to Translational Science, JACC (2020)

Publications

  • Haywood ME, Cocciolo A, Porter KF, Dobrinskikh E, Slavov D, Graw SL, Reece TB, Ambardekar AV, Bristow MR, Mestroni L, Taylor MRG. Transcriptome signature of ventricular arrhythmia in dilated cardiomyopathy reveals increased fibrosis and activated TP53. J Mol Cell Cardiol. 2020 Feb;139:124-134. PubMed PMID: 31958463
  • O'Connor CM, Bristow MR. Changing U.S. Heart Failure Research Culture: Part 2-Recognizing Frontline Investigators and Coordinators. JACC Heart Fail. 2020 Dec;8(12):1050-1051. PubMed PMID: 33272381
  • Bristow MR, Zisman LS, Altman NL, Gilbert EM, Lowes BD, Minobe WA, Slavov D, Schwisow JA, Rodriguez EM, Carroll IA, Keuer TA, Buttrick PM, Kao DP. Dynamic Regulation of SARS-Cov-2 Binding and Cell Entry Mechanisms in Remodeled Human Ventricular Myocardium. JACC Basic Transl Sci. 2020 Sep;5(9):871-883. PubMed PMID: 32838074
  • Haywood ME, Cocciolo A, Porter KF, Dobrinskikh E, Slavov D, Graw SL, Reece TB, Ambardekar AV, Bristow MR, Mestroni L, Taylor MRG. Transcriptome signature of ventricular arrhythmia in dilated cardiomyopathy reveals increased fibrosis and activated TP53. J Mol Cell Cardiol. 2020 Feb;139:124-134. PubMed PMID: 31958463
  • Piccini JP, MD, Healey JS, Abraham WT, ……Bristow MR, Connolly SJ. Pharmacogenomic guided beta-blocker therapy with bucindolol reduces atrial fibrillation burden compared to metoprolol succinate: The GENETIC-AF Trial. HRS 2020.
  • Healey JS, Piccini JP, Abraham WT, ……Bristow MR, Connolly SJ. Impact of pharmacogenetic-guided bucindolol versus metoprolol succinate on the overall burden of clinical events in patients with atrial fibrillation and heart failure: The GENETIC-AF Trial. HRS 2020.
  • Abraham WT, Bristow MR, Piccini JP,………..Dufton C, Connolly SJ. Bucindolol is associated with a lower Incidence of dose limiting bradycardia in heart failure patients with atrial fibrillation: The GENETIC-AF Trial. HRS 2020.
  • Sucharov CC, Nakano SJ, Slavov D, Schwisow JA, Rodriguez E, Nunley K, Medway A, Stafford N, Nelson P, McKinsey TA, Movsesian M, Minobe W, Carroll IA, Taylor MRG, Bristow MR. A PDE3A Promoter Polymorphism Regulates cAMP-Induced Transcriptional Activity in Failing Human Myocardium. J Am Coll Cardiol. 2019 Mar 19;73(10):1173-1184. PubMed PMID: 30871701
  • Piccini JP, Abraham WT, Dufton C, Carroll IA, Healey JS, van Veldhuisen DJ, Sauer WH, Anand IS, White M, Wilton SB, Aleong R, Rienstra M, Krueger SK, Ayala-Paredes F, Khaykin Y, Merkely B, Miloradovic V, Wranicz JK, Ilkhanoff L, Ziegler PD, Davis G, Emery LL, Marshall D, Kao DP, Bristow MR, Connolly SJ. Bucindolol for the Maintenance of Sinus Rhythm in a Genotype-Defined HF Population: The GENETIC-AF Trial. JACC Heart Fail. 2019 Jul;7(7):586-598. PubMed PMID: 31042551
  • Shamoun F, De Marco T, DeMets D, Mei C, Lindenfeld J, Saxon LA, Boehmer JP, Leigh J, Yong P, Feldman AM, Bristow MR. Impact of Degree of Left Ventricular Remodeling on Clinical Outcomes From Cardiac Resynchronization Therapy. JACC Heart Fail. 2019 Apr;7(4):281-290. PubMed PMID: 30738980
  • Toni LS, Carroll IA, Jones KL, Schwisow JA, Minobe WA, Rodriguez EM, Altman NL, Lowes BD, Gilbert EM, Buttrick PM, Kao DP, Bristow MR. Correction: Sequential analysis of myocardial gene expression with phenotypic change: Use of cross-platform concordance to strengthen biologic relevance. PLoS One. 2019;14(10):e0224389. PubMed PMID: 31639152
  • Toni LS, Carroll IA, Jones KL, Schwisow JA, Minobe WA, Rodriguez EM, Altman NL, Lowes BD, Gilbert EM, Buttrick PM, Kao DP, Bristow MR. Sequential analysis of myocardial gene expression with phenotypic change: Use of cross-platform concordance to strengthen biologic relevance. PLoS One. 2019;14(8):e0221519. PubMed PMID: 31469842
  • Sweet ME, Cocciolo A, Slavov D, Jones KL, Sweet JR, Graw SL, Reece TB, Ambardekar AV, Bristow MR, Mestroni L, Taylor MRG. Transcriptome analysis of human heart failure reveals dysregulated cell adhesion in dilated cardiomyopathy and activated immune pathways in ischemic heart failure. BMC Genomics. 2018 Nov 12;19(1):812. PubMed PMID: 30419824
  • Parikh KS, Fiuzat M, Davis G, Neely M, Blain-Nelson P, Whellan DJ, Abraham WT, Adams KF Jr, Felker GM, Liggett SB, O'Connor CM, Bristow MR. Dose Response of ß-Blockers in Adrenergic Receptor Polymorphism Genotypes. Circ Genom Precis Med. 2018 Aug;11(8):e002210. PubMed PMID: 30354340
  • Myers VD, Gerhard GS, McNamara DM, Tomar D, Madesh M, Kaniper S, Ramsey FV, Fisher SG, Ingersoll RG, Kasch-Semenza L, Wang J, Hanley-Yanez K, Lemster B, Schwisow JA, Ambardekar AV, Degann SH, Bristow MR, Sheppard R, Alexis JD, Tilley DG, Kontos CD, McClung JM, Taylor AL, Yancy CW, Khalili K, Seidman JG, Seidman CE, McTiernan CF, Cheung JY, Feldman AM. Association of Variants in BAG3 With Cardiomyopathy Outcomes in African American Individuals. JAMA Cardiol. 2018 Oct 1;3(10):929-938. PubMed PMID: 30140897
  • Begay RL, Graw SL, Sinagra G, Asimaki A, Rowland TJ, Slavov DB, Gowan K, Jones KL, Brun F, Merlo M, Miani D, Sweet M, Devaraj K, Wartchow EP, Gigli M, Puggia I, Salcedo EE, Garrity DM, Ambardekar AV, Buttrick P, Reece TB, Bristow MR, Saffitz JE, Mestroni L, Taylor MRG. Filamin C Truncation Mutations Are Associated With Arrhythmogenic Dilated Cardiomyopathy and Changes in the Cell-Cell Adhesion Structures. JACC Clin Electrophysiol. 2018 Apr;4(4):504-514. PubMed PMID: 30067491
  • Bristow MR, Leinwand LA, Olson EN. Entrepreneurialism in the Translational Biologic Sciences: Why, How, and However. JACC Basic Transl Sci. 2018 Feb;3(1):1-8. PubMed PMID: 30062188
  • Piccini JP, Connolly SJ, Abraham WT, Healey JS, Steinberg BA, Al-Khalidi HR, Dignacco P, van Veldhuisen DJ, Sauer WH, White M, Wilton SB, Anand IS, Dufton C, Marshall DA, Aleong RG, Davis GW, Clark RL, Emery LL, Bristow MR. A genotype-directed comparative effectiveness trial of Bucindolol and metoprolol succinate for prevention of symptomatic atrial fibrillation/atrial flutter in patients with heart failure: Rationale and design of the GENETIC-AF trial. Am Heart J. 2018 May;199:51-58. PubMed PMID: 29754666
  • O'Connor CM, Bristow MR. Changing the Research Culture in the United States. JACC Heart Fail. 2018 Apr;6(4):344-345. PubMed PMID: 29598937
  • O'Connor CM, Psotka MA, Fiuzat M, Lindenfeld J, Abraham WT, Bristow MR, Canos D, Harrington RA, Hillebrenner M, Jessup M, Malik FI, Solomon SD, Stockbridge N, Tcheng JE, Unger EF, Whellan DJ, Zuckerman B, Califf RM. Improving Heart Failure Therapeutics Development in the United States: The Heart Failure Collaboratory. J Am Coll Cardiol. 2018 Jan 30;71(4):443-453. PubMed PMID: 29389362
  • Bristow MR. Contractile reserve and the response to cardiac resynchronization therapy. Int J Cardiol. 2018 Feb 1;252:234-235. PubMed PMID: 29249434
  • Leary PJ, Kronmal RA, Bluemke DA, Buttrick PM, Jones KL, Kao DP, Kawut SM, Krieger EV, Lima JA, Minobe W, Ralph DD, Tedford RJ, Weiss NS, Bristow MR. Histamine H(2) Receptor Polymorphisms, Myocardial Transcripts, and Heart Failure (from the Multi-Ethnic Study of Atherosclerosis and Beta-Blocker Effect on Remodeling and Gene Expression Trial). Am J Cardiol. 2018 Jan 15;121(2):256-261. PubMed PMID: 29191567
  • Bristow MR, Quaife RA. The adrenergic system in pulmonary arterial hypertension: bench to bedside (2013 Grover Conference series). Pulm Circ. 2015 Sep;5(3):415-23. PubMed PMID: 26401244
  • Vehlow C, Kao DP, Bristow MR, Hunter LE, Weiskopf D, Görg C. Visual analysis of biological data-knowledge networks. BMC Bioinformatics. 2015 Apr 29;16:135. PubMed PMID: 25925016
  • Fordyce CB, Roe MT, Ahmad T, Libby P, Borer JS, Hiatt WR, Bristow MR, Packer M, Wasserman SM, Braunstein N, Pitt B, DeMets DL, Cooper-Arnold K, Armstrong PW, Berkowitz SD, Scott R, Prats J, Galis ZS, Stockbridge N, Peterson ED, Califf RM. Cardiovascular drug development: is it dead or just hibernating?. J Am Coll Cardiol. 2015 Apr 21;65(15):1567-82. PubMed PMID: 25881939
  • Kao DP, Lowes BD, Gilbert EM, Minobe W, Epperson LE, Meyer LK, Ferguson DA, Volkman AK, Zolty R, Borg CD, Quaife RA, Bristow MR. Therapeutic Molecular Phenotype of ß-Blocker-Associated Reverse-Remodeling in Nonischemic Dilated Cardiomyopathy. Circ Cardiovasc Genet. 2015 Apr;8(2):270-83. PubMed PMID: 25637602
  • Hinterberg MA, Kao DP, Bristow MR, Hunter LE, Port JD, Görg C. Peax: interactive visual analysis and exploration of complex clinical phenotype and gene expression association. Pac Symp Biocomput. 2015;:419-30. PubMed PMID: 25592601
  • Hinterberg MA, Kao DP, Bristow MR, Hunter LE, Port JD, Görg C. Peax: interactive visual analysis and exploration of complex clinical phenotype and gene expression association. Pac Symp Biocomput. 2015;:419-30. PubMed PMID: 25592601
  • Bristow MR, Aleong RG. Treatment of the heart failure patient with atrial fibrillation: a major unmet need. JACC Heart Fail. 2013 Feb;1(1):29-30. PubMed PMID: 24621796
  • Aleong RG, Sauer WH, Davis G, Murphy GA, Port JD, Anand IS, Fiuzat M, O'Connor CM, Abraham WT, Liggett SB, Bristow MR. Prevention of Atrial Fibrillation by Bucindolol Is Dependent on the Beta(1)389 Arg/Gly Adrenergic Receptor Polymorphism. JACC Heart Fail. 2013 Aug 1;1(4):338-344. PubMed PMID: 24159564
  • Fiuzat M, O'Connor CM, Gueyffier F, Mascette AM, Geller NL, Mebazaa A, Voors AA, Adams KF, Piña IL, Neyses L, Muntendam P, Felker GM, Pitt B, Zannad F, Bristow MR. Biomarker-guided therapies in heart failure: a forum for unified strategies. J Card Fail. 2013 Aug;19(8):592-9. PubMed PMID: 23910590
  • Feldman AM, Mann DL, She L, Bristow MR, Maisel AS, McNamara DM, Walsh R, Lee DL, Wos S, Lang I, Wells G, Drazner MH, Schmedtje JF Jr, Pauly DF, Sueta CA, Di Maio M, Kron IL, Velazquez EJ, Lee KL. Prognostic significance of biomarkers in predicting outcome in patients with coronary artery disease and left ventricular dysfunction: results of the biomarker substudy of the Surgical Treatment for Ischemic Heart Failure trials. Circ Heart Fail. 2013 May;6(3):461-72. PubMed PMID: 23584092
  • Aleong RG, Sauer WH, Robertson AD, Liggett SB, Bristow MR. Adrenergic receptor polymorphisms and prevention of ventricular arrhythmias with bucindolol in patients with chronic heart failure. Circ Arrhythm Electrophysiol. 2013 Feb;6(1):137-43. PubMed PMID: 23275278
  • Kao DP, Davis G, Aleong R, O'Connor CM, Fiuzat M, Carson PE, Anand IS, Plehn JF, Gottlieb SS, Silver MA, Lindenfeld J, Miller AB, White M, Murphy GA, Sauer W, Bristow MR. Effect of bucindolol on heart failure outcomes and heart rate response in patients with reduced ejection fraction heart failure and atrial fibrillation. Eur J Heart Fail. 2013 Mar;15(3):324-33. PubMed PMID: 23223178
  • Chung MK, Zidar D, Bristow MR, Cameron S, Chan T, Harding CV, Kwon DH, Singth T, Tilton J, Tsai EJ, Tucker NR, Barnard J, Loscalzo J. COVID-19 and Cardiovascular Disease: from Bedside to Bench to Bedside. Circulation, in press. 2021.
  • Knight WE, Cao Y, Ying-Hsi L, Sparagna GC, Bai B, Zhao Y, Chi C, Du Y, Londono P, Reisz JA, Brown BC, Taylor MRG, Abardekar AV, Cleveland JC, McKinsey TA, Jeong MY, Walker LA, Woulfe KC, D’ Alessandro A, Bristow MR, Buttrick PM, Song K. Maturation of human induced pluripotent stem cell-derived cardiomyocytes for modeling hypertrophic cardiomyopathy. doi: https://doi.org/10.1101/2020.01.16.909598 Stem Cell Reports, in press. 2021
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Professional Memberships

  • American Heart Association, Fellow
  • American College of Cardiology, Fellow
  • International Society for Heart Transplant, Member
  • American Federation for Clinical Research, Member
  • American Society of Transplant Physicians, Member
  • Association of American Physicians, Member
  • Heart Failure Society of America, Founding Member, Fellow
  • American Society for Clinical Investigation, Member, Emeritus
  • British Cardiac Society, Invited Member
  • Association of University Cardiologists, Member
  • Heart Rhythm Society, Member
  • European Society of Cardiology, Member

Practice Locations

University of Colorado Hospital (UCH)
12605 E. 16th Ave
Aurora, CO 80045
720-848-0000

UCHealth Heart Failure Program - Anschutz
12505 E. 16th Ave
Anschutz Inpatient Pavilion 2, 3rd floor
Aurora, CO 80045
720-848-5300

UCHealth Heart & Vascular Center - Anschutz
12505 E. 16th Ave
Anschutz Inpatient Pavilion 2, 3rd floor
Aurora, CO 80045
720-848-5300

Hospital Affiliation
  • University of Colorado Hospital

Specialty Information

Specialties
  • Internal Medicine, Board Certification (1977)
  • Cardiovascular Disease, Board Certification (1981)
  • Cardiology, Board Certification (1981)

General Information

Medical Schools:
  • MD, University of Illinois College of Medicine (1970)
Graduate Schools:
  • PhD, University of Illinois, Chicago (1971)
Internships:
  • Stanford University Program (1972)
Residency Programs:
  • Stanford University Program, Internal Medicine (1977)
Fellowships:
  • Stanford Hospital and Clinics Program, Cardiovascular Disease (1978)
Languages: English
Department: Medicine-Cardiology
;