Maria Nagel, MD
Research Professor, Neurology

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Medical School:
  • MD, University of Illinois College of Medicine (2002)
Undergraduate School:
  • BA, University of Chicago (IL) (1991)
Internship:
  • University of Colorado (University Hospital) Program (2003)
Residency:
  • University of Colorado (University Hospital) Program, Neurology (2006)
Languages: English
Department: Neurology

Professional Titles

  • Research Professor, Neurology
  • Professor, Department of Neurology
  • Professor, Department of Ophthalmology

Recognition & Awards

  • Fellow, American Neurological Association (2013)
  • Grateful Patient and Family Award, University of Colorado Hospital (2011)
  • MBA Oldstone Pioneer Lectureship Award for an Investigator in Training, International Society for NeuroVirology (2006)
  • Award for Most Outstanding Research by a Neurology Resident, Department of Neurology, University of Colorado School of Medicine (2006)

Research Interests

Stroke, giant cell arteritis, headache, dermatomal distribution pain and facial pain syndromes due to VZV and HSV infection.

Publications

  • Nagel MA, Bubak AN. Herpes Zoster, a Rash of Cerebrovascular Events. Mayo Clin Proc. 2019 May;94(5):742-744. PubMed PMID: 31054599
  • Jones D, Como CN, Jing L, Blackmon A, Neff CP, Krueger O, Bubak AN, Palmer BE, Koelle DM, Nagel MA. Varicella zoster virus productively infects human peripheral blood mononuclear cells to modulate expression of immunoinhibitory proteins and blocking PD-L1 enhances virus-specific CD8 T cell effector function. PLoS Pathog. 2019 Mar;15(3):e1007650. PubMed PMID: 30870532
  • Blackmon AM, Como CN, Bubak AN, Mescher T, Jones D, Nagel MA. Varicella Zoster Virus Alters Expression of Cell Adhesion Proteins in Human Perineurial Cells Via Interleukin 6. J Infect Dis. 2019 Mar 5. [Epub ahead of print] PubMed PMID: 30835269
  • Como CN, Bubak AN, Blackmon AM, Jones D, Mueller NH, Davidson R, Nagel MA. Varicella Zoster Virus Induces Differential Cell-Type Specific Responses in Human Corneal Epithelial Cells and Keratocytes. Invest Ophthalmol Vis Sci. 2019 Feb 1;60(2):704-711. PubMed PMID: 30786281
  • Traina-Dorge V, Palmer BE, Coleman C, Hunter M, Frieman A, Gilmore A, Altrock K, Doyle-Meyers L, Nagel MA, Mahalingam R. Reactivation of Simian Varicella Virus in Rhesus Macaques after CD4 T Cell Depletion. J Virol. 2019 Feb 1;93(3). PubMed PMID: 30404798
  • Mahalingam R, Kaufer BB, Ouwendijk WJD, Verjans GMGM, Coleman C, Hunter M, Das A, Palmer BE, Clambey E, Nagel MA, Traina-Dorge V. Attenuation of Simian Varicella Virus Infection by Enhanced Green Fluorescent Protein in Rhesus Macaques. J Virol. 2018 Jan 17. [Epub ahead of print] PubMed PMID: 29343566
  • Betker JL, Jones D, Childs CR, Helm KM, Terrell K, Nagel MA, Anchordoquy TJ. Nanoparticle uptake by circulating leukocytes: A major barrier to tumor delivery. J Control Release. 2018 Sep 28;286:85-93. PubMed PMID: 30030182
  • Bubak AN, Como CN, Blackmon AM, Frietze S, Mescher T, Jones D, Cohrs RJ, Paucek P, Baird NL, Nagel MA. Varicella Zoster Virus Induces Nuclear Translocation of the Neurokinin-1 Receptor, Promoting Lamellipodia Formation and Viral Spread in Spinal Astrocytes. J Infect Dis. 2018 Sep 8;218(8):1324-1335. PubMed PMID: 29788447
  • Mahalingam R, Kaufer BB, Ouwendijk WJD, Verjans GMGM, Coleman C, Hunter M, Das A, Palmer BE, Clambey E, Nagel MA, Traina-Dorge V. Attenuation of Simian Varicella Virus Infection by Enhanced Green Fluorescent Protein in Rhesus Macaques. J Virol. 2018 Apr 1;92(7). PubMed PMID: 29343566
  • Nagel MA, Bubak AN. Varicella Zoster Virus Vasculopathy. J Infect Dis. 2018 Sep 22;218(suppl_2):S107-S112. PubMed PMID: 30247600
  • Bubak AN, Como CN, Blackmon AM, Jones D, Nagel MA. Varicella zoster virus differentially alters morphology and suppresses proinflammatory cytokines in primary human spinal cord and hippocampal astrocytes. J Neuroinflammation. 2018 Nov 15;15(1):318. PubMed PMID: 30442152
  • Traina-Dorge V, Palmer BE, Coleman C, Hunter M, Frieman A, Gilmore A, Altrock K, Doyle-Meyers L, Nagel MA, Mahalingam R. Reactivation of Simian Varicella Virus (SVV) in Rhesus Macaques After CD4 T Cell Depletion. J Virol. 2018 Nov 7. [Epub ahead of print] PubMed PMID: 30404798
  • Nagel MA, Jones D, Wyborny A. Varicella zoster virus vasculopathy: The expanding clinical spectrum and pathogenesis. J Neuroimmunol. 2017 Jul 15;308:112-117. PubMed PMID: 28335992
  • Owens GP, Nagel MA, Mahalingam R, Cohrs RJ. Donald H. Gilden, M.D. J Neuroimmunol. 2017 Jul 15;308:2-5. PubMed PMID: 28087078
  • Jones D, Neff CP, Palmer BE, Stenmark K, Nagel MA. Varicella zoster virus-infected cerebrovascular cells produce a proinflammatory environment. Neurol Neuroimmunol Neuroinflamm. 2017 Sep;4(5):e382. PubMed PMID: 29159203
  • Yawn BP, Wollan PC, Nagel MA, Gilden D. Risk of Stroke and Myocardial Infarction After Herpes Zoster in Older Adults in a US Community Population. Mayo Clin Proc. 2016 Jan;91(1):33-44. PubMed PMID: 26704438
  • Jones D, Blackmon A, Neff CP, Palmer BE, Gilden D, Badani H, Nagel MA. Varicella-Zoster Virus Downregulates Programmed Death Ligand 1 and Major Histocompatibility Complex Class I in Human Brain Vascular Adventitial Fibroblasts, Perineurial Cells, and Lung Fibroblasts. J Virol. 2016 Dec 1;90(23):10527-10534. PubMed PMID: 27630241
  • Gilden D, Grose C, White T, Nagae L, Hendricks RL, Cohrs RJ, Nagel MA. Successful antiviral treatment after 6years of chronic progressive neurological disease attributed to VZV brain infection. J Neurol Sci. 2016 Sep 15;368:240-2. PubMed PMID: 27538641
  • Nagel MA, Gilden D. Burning mouth syndrome associated with varicella zoster virus. BMJ Case Rep. 2016 Jul 5;2016. PubMed PMID: 27382016
  • Jones D, Alvarez E, Selva S, Gilden D, Nagel MA. Proinflammatory cytokines and matrix metalloproteinases in CSF of patients with VZV vasculopathy. Neurol Neuroimmunol Neuroinflamm. 2016 Jun 13;3(4):e246. PubMed PMID: 27340684
  • Nagel MA, Burns TM, Gilden D. SUNCT headaches after ipsilateral ophthalmic-distribution zoster. J Neurol Sci. 2016 Jul 15;366:207-8. PubMed PMID: 27288808
  • Gilden D, Nagel MA. Varicella zoster virus triggers the immunopathology of giant cell arteritis. Curr Opin Rheumatol. 2016 Jul;28(4):376-82. PubMed PMID: 27224742
  • Gilden D, White T, Khmeleva N, Katz BJ, Nagel MA. Blinded search for varicella zoster virus in giant cell arteritis (GCA)-positive and GCA-negative temporal arteries. J Neurol Sci. 2016 May 15;364:141-3. PubMed PMID: 27084233
  • Gilden D, White T, Boyer PJ, Galetta KM, Hedley-Whyte ET, Frank M, Holmes D, Nagel MA. Varicella Zoster Virus Infection in Granulomatous Arteritis of the Aorta. J Infect Dis. 2016 Jun 15;213(12):1866-71. PubMed PMID: 27037084
  • Gilden D, White T, Khmeleva N, Boyer PJ, Nagel MA. VZV in biopsy-positive and -negative giant cell arteritis: Analysis of 100 temporal arteries. Neurol Neuroimmunol Neuroinflamm. 2016 Mar 9;3(2):e216. PubMed PMID: 27027098
  • Gilden D, Nagel MA. Varicella zoster virus and giant cell arteritis. Curr Opin Infect Dis. 2016 Jun;29(3):275-9. PubMed PMID: 26871403
  • Badani H, White T, Schulick N, Raeburn CD, Topkaya I, Gilden D, Nagel MA. Frequency of varicella zoster virus DNA in human adrenal glands. J Neurovirol. 2016 Jun;22(3):400-2. PubMed PMID: 26843382
  • Nagel MA, Gilden D. Developments in Varicella Zoster Virus Vasculopathy. Curr Neurol Neurosci Rep. 2016 Feb;16(2):12. PubMed PMID: 26750127
  • Yawn BP, Wollan PC, Nagel MA, Gilden D. Risk of Stroke and Myocardial Infarction After Herpes Zoster in Older Adults in a US Community Population. Mayo Clin Proc. 2016 Jan;91(1):33-44. PubMed PMID: 26704438
  • Nagel MA, White T, Gilden D. Varicella-Zoster Virus in Giant Cell Arteritis--Reply. JAMA Neurol. 2016 Feb;73(2):239. PubMed PMID: 26659618
  • Nagel MA, White T, Gilden D. Varicella-Zoster Virus in Giant Cell Arteritis-Reply. JAMA Neurol. 2015 Dec 14;:1. [Epub ahead of print] PubMed PMID: 26659618
  • Lavi E, Gilden D, Nagel M, White T, Grose C. Prevalence and distribution of VZV in temporal arteries of patients with giant cell arteritis. Neurology. 2015 Nov 24;85(21):1914-5. PubMed PMID: 26598436
  • Nagel MA, Choe A, Rempel A, Wyborny A, Stenmark K, Gilden D. Differential regulation of matrix metalloproteinases in varicella zoster virus-infected human brain vascular adventitial fibroblasts. J Neurol Sci. 2015 Nov 15;358(1-2):444-6. PubMed PMID: 26443282
  • Nagel MA, White T, Khmeleva N, Rempel A, Boyer PJ, Bennett JL, Haller A, Lear-Kaul K, Kandasmy B, Amato M, Wood E, Durairaj V, Fogt F, Tamhankar MA, Grossniklaus HE, Poppiti RJ, Bockelman B, Keyvani K, Pollak L, Mendlovic S, Fowkes M, Eberhart CG, Buttmann M, Toyka KV, Meyer-Ter-Vehn T, Petursdottir V, Gilden D. Analysis of Varicella-Zoster Virus in Temporal Arteries Biopsy Positive and Negative for Giant Cell Arteritis. JAMA Neurol. 2015 Nov 1;72(11):1281-7. PubMed PMID: 26349037
  • Gilden D, Nagel M. Varicella Zoster Virus in Temporal Arteries of Patients With Giant Cell Arteritis. J Infect Dis. 2015 Jul 15;212 Suppl 1:S37-9. PubMed PMID: 26116729
  • Gilden D, White T, Galetta SL, Fogt F, Nagel MA. Widespread arterial infection by varicella-zoster virus explains refractory giant cell arteritis. Neurol Neuroimmunol Neuroinflamm. 2015 Aug;2(4):e125. PubMed PMID: 26090509
  • Golas L, Bennett JL, White TM, Skarf B, Lesser R, Nagel MA, Gilden D. Varicella Zoster Virus in Ischemic Optic Neuropathy. Ophthalmology. 2015 Oct;122(10):2142-5. PubMed PMID: 26050536
  • Nagel MA, Lenggenhager D, White T, Khmeleva N, Heintzman A, Boyer PJ, Gilden D. Disseminated VZV infection and asymptomatic VZV vasculopathy after steroid abuse. J Clin Virol. 2015 May;66:72-5. PubMed PMID: 25866342
  • Nagel MA, Choe A, Traktinskiy I, Gilden D. Burning mouth syndrome due to herpes simplex virus type 1. BMJ Case Rep. 2015 Apr 1;2015. PubMed PMID: 25833911
  • Nagel MA, Gilden D. The relationship between herpes zoster and stroke. Curr Neurol Neurosci Rep. 2015 Apr;15(4):16. PubMed PMID: 25712420
  • Gilden D, White T, Khmeleva N, Heintzman A, Choe A, Boyer PJ, Grose C, Carpenter JE, Rempel A, Bos N, Kandasamy B, Lear-Kaul K, Holmes DB, Bennett JL, Cohrs RJ, Mahalingam R, Mandava N, Eberhart CG, Bockelman B, Poppiti RJ, Tamhankar MA, Fogt F, Amato M, Wood E, Durairaj V, Rasmussen S, Petursdottir V, Pollak L, Mendlovic S, Chatelain D, Keyvani K, Brueck W, Nagel MA. Prevalence and distribution of VZV in temporal arteries of patients with giant cell arteritis. Neurology. 2015 May 12;84(19):1948-55. PubMed PMID: 25695965
  • Gilden D, White TM, Nagae L, Gurdin WH, Boyer PJ, Nagel MA. Successful Antiviral Treatment of Giant Cell Arteritis and Takayasu Arteritis. JAMA Neurol. 2015 Aug;72(8):943-6. PubMed PMID: 26258736
  • Nandhagopal R, Khmeleva N, Jayakrishnan B, White T, Al Azri F, George J, Heintzman A, Al Zeedy K, Rorke-Adams L, Gujjar AR, Schmid DS, Al-Asmi A, Nagel MA, Jacob PC, Gilden D. Varicella zoster virus pneumonitis and brainstem encephalitis without skin rash in an immunocompetent adult. Open Forum Infect Dis. 2014 Sep;1(2):ofu064. PubMed PMID: 25734134
  • Nagel MA, James SF, Traktinskiy I, Wyborny A, Choe A, Rempel A, Baird NL, Gilden D. Inhibition of phosphorylated-STAT1 nuclear translocation and antiviral protein expression in human brain vascular adventitial fibroblasts infected with varicella-zoster virus. J Virol. 2014 Oct;88(19):11634-7. PubMed PMID: 25056900
  • Gilden D, Nagel MA, Cohrs RJ. Varicella-zoster. Handb Clin Neurol. 2014;123:265-83. PubMed PMID: 25015490
  • El Kasmi KC, Pugliese SC, Riddle SR, Poth JM, Anderson AL, Frid MG, Li M, Pullamsetti SS, Savai R, Nagel MA, Fini MA, Graham BB, Tuder RM, Friedman JE, Eltzschig HK, Sokol RJ, Stenmark KR. Adventitial fibroblasts induce a distinct proinflammatory/profibrotic macrophage phenotype in pulmonary hypertension. J Immunol. 2014 Jul 15;193(2):597-609. PubMed PMID: 24928992
  • Teodoro T, Nagel MA, Geraldes R, White T, Mahalingam R, Batista P, Wellish M, Pimentel J, Khmeleva N, Heintzman A, Albuquerque L, Boyer PJ, Choe A, Peralta R, Gilden D. Biopsy-negative, varicella zoster virus (VZV)-positive giant cell arteritis, zoster, VZV encephalitis and ischemic optic neuropathy, all in one. J Neurol Sci. 2014 Aug 15;343(1-2):195-7. PubMed PMID: 24923742
  • Liberman AL, Nagel MA, Hurley MC, Caprio FZ, Bernstein RA, Gilden D. Rapid development of 9 cerebral aneurysms in varicella-zoster virus vasculopathy. Neurology. 2014 Jun 10;82(23):2139-41. PubMed PMID: 24827494
  • Nagel MA, Gilden D. Update on varicella zoster virus vasculopathy. Curr Infect Dis Rep. 2014 Jun;16(6):407. PubMed PMID: 24819870
  • Nagel MA, Gilden D. Neurological complications of varicella zoster virus reactivation. Curr Opin Neurol. 2014 Jun;27(3):356-60. PubMed PMID: 24792344
  • Nagel MA, Rempel A, Huntington J, Kim F, Choe A, Gilden D. Frequency and abundance of alphaherpesvirus DNA in human thoracic sympathetic ganglia. J Virol. 2014 Jul;88(14):8189-92. PubMed PMID: 24789785
  • Nagel MA, Khmeleva N, Choe A, Gutierrez J, Gilden D. Varicella zoster virus (VZV) in cerebral arteries of subjects at high risk for VZV reactivation. J Neurol Sci. 2014 Apr 15;339(1-2):32-4. PubMed PMID: 24556269
  • Sabry A, Hauk PJ, Jing H, Su HC, Stence NV, Mirsky DM, Nagel MA, Abbott JK, Dragone LL, Armstrong-Wells J, Curtis DJ, Cohrs R, Schmid DS, Gilden D, Gelfand EW. Vaccine strain varicella-zoster virus-induced central nervous system vasculopathy as the presenting feature of DOCK8 deficiency. J Allergy Clin Immunol. 2014 Apr;133(4):1225-7. PubMed PMID: 24418481
  • Birlea M, Nagel MA, Khmeleva N, Choe A, Kleinschmidt-Demasters B, Hevner R, Boyer P, Lear-Kaul KC, Bos N, Wellish M, Cohrs RJ, Gilden D. Varicella-zoster virus trigeminal ganglioneuritis without rash. Neurology. 2014 Jan 7;82(1):90-2. PubMed PMID: 24285619
  • Nagel MA. Varicella zoster virus vasculopathy: clinical features and pathogenesis. J Neurovirol. 2014 Apr;20(2):157-63. PubMed PMID: 23918503
  • Nagel MA, Gilden D. The challenging patient with varicella-zoster virus disease. Neurol Clin Pract. 2013 Apr;3(2):109-117. PubMed PMID: 23914320
  • Gilden D, Nagel MA, Cohrs RJ, Mahalingam R. The variegate neurological manifestations of varicella zoster virus infection. Curr Neurol Neurosci Rep. 2013 Sep;13(9):374. PubMed PMID: 23884722
  • Nagel MA, Gilden D. Complications of varicella zoster virus reactivation. Curr Treat Options Neurol. 2013 Aug;15(4):439-53. PubMed PMID: 23794213
  • Nagel MA, Choe A, Gilden D, Traina-Dorge V, Cohrs RJ, Mahalingam R. GeXPS multiplex PCR analysis of the simian varicella virus transcriptome in productively infected cells in culture and acutely infected ganglia. J Virol Methods. 2013 Oct;193(1):151-8. PubMed PMID: 23769859
  • Tsai J, Nagel MA, Gilden D. Skin rash in meningitis and meningoencephalitis. Neurology. 2013 May 7;80(19):1808-11. PubMed PMID: 23650233
  • Nagel MA, Bennett JL, Khmeleva N, Choe A, Rempel A, Boyer PJ, Gilden D. Multifocal VZV vasculopathy with temporal artery infection mimics giant cell arteritis. Neurology. 2013 May 28;80(22):2017-21. PubMed PMID: 23635966
  • Nagel MA, Choe A, Khmeleva N, Overton L, Rempel A, Wyborny A, Traktinskiy I, Gilden D. Search for varicella zoster virus and herpes simplex virus-1 in normal human cerebral arteries. J Neurovirol. 2013 Apr;19(2):181-5. PubMed PMID: 23456953
  • Mathias M, Nagel MA, Khmeleva N, Boyer PJ, Choe A, Durairaj VD, Bennett JL, Mandava N, Gilden D. VZV multifocal vasculopathy with ischemic optic neuropathy, acute retinal necrosis and temporal artery infection in the absence of zoster rash. J Neurol Sci. 2013 Feb 15;325(1-2):180-2. PubMed PMID: 23312850
  • Nagel MA, Russman AN, Feit H, Traktinskiy I, Khmeleva N, Schmid DS, Skarf B, Gilden D. VZV ischemic optic neuropathy and subclinical temporal artery infection without rash. Neurology. 2013 Jan 8;80(2):220-2. PubMed PMID: 23255829
  • Nagel MA, Traktinskiy I, Stenmark KR, Frid MG, Choe A, Gilden D. Varicella-zoster virus vasculopathy: immune characteristics of virus-infected arteries. Neurology. 2013 Jan 1;80(1):62-8. PubMed PMID: 23243076
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Professional Memberships

  • International Society for NeuroVirology, Member
  • American Neurological Association, Fellow
  • American Heart Association, Member
  • Rocky Mountain Virology Club, Member
  • American Society of Microbiology, Member

Practice Locations

Neurosciences Center - Anschutz
1635 Aurora Ct
4th Floor
Aurora, CO 80045
720-848-2080

UCH - Anschutz Outpatient Pavilion
1635 Aurora Ct
Aurora, CO 80045
720-848-0000

Hospital Affiliation
  • University of Colorado Hospital

Specialty Information

Specialties
  • Neurology, Board Certification (2009)
  • Colorado Medical License, License (2002)
Conditions & Treatments
  • Brain and Nervous System
  • Infections - Viral Infections
  • Infections
Clinical Interests
I am interested in clinical neurology, acute and chronic virus infections of the nervous system and virus latency in the nervous system.

Care Philosophy
I work closely with my patients and their family doctors to develop a comprehensive plan of care.

Volunteer Activities
Promoting diversity in the health sciences

Public Speaking
Yes
Grand Rounds at University of Colorado, other academic institutions and medical/scientific conferences

General Information

Medical Schools:
  • MD, University of Illinois College of Medicine (2002)
Undergraduate Schools:
  • BA, University of Chicago (IL) (1991)
Internships:
  • University of Colorado (University Hospital) Program (2003)
Residency Programs:
  • University of Colorado (University Hospital) Program, Neurology (2006)
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Languages: English
Department: Neurology
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