Samuel Dominguez, MD, PhD
Associate Professor, Pediatrics-Infectious Diseases

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Medical School:
  • MD, University of Chicago Division of the Biological Sciences The Pritzker School of Medicine (2000)
Undergraduate School:
  • BA, Houghton College (NY) (1992)
Internship:
  • University of Chicago/Comer Children's Hospital Program (2001)
Residency:
  • University of Chicago/Comer Children's Hospital Program, Pediatrics (2003)
Fellowships:
  • University of Colorado (University Hospital) Program, Pediatric Infectious Diseases (2007)
Languages: English
Department: Pediatrics-Infectious Diseases

Professional Titles

  • Associate Professor, Pediatrics-Infectious Diseases
  • Associate Professor of Pediatrics
Research interests for Patients:
I am interested in enterovirus infections

Teaching

  • Course Director/Facilitator (2015)
    Colorado School of Public Health,
    Epidemiology of Infectious Diseases
  • Microbiology Rounds – leader (2016)
    School of Medicine, Pediatrics
    Children's Hospital Colorado
  • Global Health and Disaster Course – director of laboratory course (2017)
    Colorado School of Public Health, Pediatrics

Publications

  • Messacar K, Robinson CC, Dominguez SR. Letter to the editor: economic analysis lacks external validity to support universal syndromic testing for suspected meningitis/encephalitis. Future Microbiol. 2018 Nov;13:1553-1554. PubMed PMID: 30421966
  • Messacar K, Sillau S, Hopkins SE, Otten C, Wilson-Murphy M, Wong B, Santoro JD, Treister A, Bains HK, Torres A, Zabrocki L, Glanternik JR, Hurst AL, Martin JA, Schreiner T, Makhani N, DeBiasi RL, Kruer MC, Tremoulet AH, Van Haren K, Desai J, Benson LA, Gorman MP, Abzug MJ, Tyler KL, Dominguez SR. Safety, tolerability, and efficacy of fluoxetine as an antiviral for acute flaccid myelitis. Neurology. 2018 Nov 9. [Epub ahead of print] PubMed PMID: 30413631
  • Messacar K, Dominguez SR. Blood PCR testing for enteroviruses in young children. Lancet Infect Dis. 2018 Oct 30. [Epub ahead of print] PubMed PMID: 30389483
  • Searns J, Cataldi JR, McCormack K, Simões E, Messacar K, Dominguez SR. A 4-Year-Old Boy With an Unusual Bacterial Meningitis Infection. J Pediatric Infect Dis Soc. 2018 Oct 9. [Epub ahead of print] PubMed PMID: 30299497
  • Messacar K, Hamilton SL, Prinzi AM, Mitchell JC, Beil ED, Dowell EB, Dominguez SR. Rapid identification of nonblood sterile site broth cultures using the FilmArray blood culture identification panel. Diagn Microbiol Infect Dis. 2018 Jul 31. [Epub ahead of print] PubMed PMID: 30213466
  • Messacar K, Burakoff A, Nix WA, Rogers S, Oberste MS, Gerber SI, Spence-Davizon E, Herlihy R, Dominguez SR. Notes from the Field: Enterovirus A71 Neurologic Disease in Children - Colorado, 2018. MMWR Morb Mortal Wkly Rep. 2018 Sep 14;67(36):1017-1018. PubMed PMID: 30212441
  • Dominguez SR, Pretty K, Hengartner R, Robinson CC. Comparison of Herpes Simplex Virus PCR with Culture for Virus Detection in Multisource Surface Swab Specimens from Neonates. J Clin Microbiol. 2018 Oct;56(10). PubMed PMID: 29875197
  • Messacar K, Asturias EJ, Hixon AM, Van Leer-Buter C, Niesters HGM, Tyler KL, Abzug MJ, Dominguez SR. Enterovirus D68 and acute flaccid myelitis-evaluating the evidence for causality. Lancet Infect Dis. 2018 Aug;18(8):e239-e247. PubMed PMID: 29482893
  • Jone PN, Anderson MS, Mulvahill MJ, Heizer H, Glodé MP, Dominguez SR. Infliximab Plus Intravenous Immunoglobulin (IVIG) Versus IVIG Alone as Initial Therapy in Children With Kawasaki Disease Presenting With Coronary Artery Lesions: Is Dual Therapy More Effective?. Pediatr Infect Dis J. 2018 Oct;37(10):976-980. PubMed PMID: 29461447
  • Saporta-Keating SR, Simões EAF, Yu G, Federman S, Mirsky D, Dominguez SR, Chiu CY, Messacar K. A Child With Intermittent Headaches and Eosinophilic Meningitis. J Pediatric Infect Dis Soc. 2018 Feb 9. [Epub ahead of print] PubMed PMID: 29438532
  • Nycz BT, Dominguez SR, Friedman D, Hilden JM, Ir D, Robertson CE, Frank DN. Evaluation of bloodstream infections, Clostridium difficile infections, and gut microbiota in pediatric oncology patients. PLoS One. 2018;13(1):e0191232. PubMed PMID: 29329346
  • Messacar K, Fischer M, Dominguez SR, Tyler KL, Abzug MJ. Encephalitis in US Children. Infect Dis Clin North Am. 2017 Dec 7. [Epub ahead of print] PubMed PMID: 29224854
  • Searns JB, Robinson CC, Wei Q, Yuan J, Hamilton S, Pretty K, Donaldson N, Parker SK, Dominguez SR. Validation of a novel molecular diagnostic panel for pediatric musculoskeletal infections: Integration of the cepheid Xpert MRSA/SA SSTI and laboratory-developed real-time PCR assays for clindamycin resistance genes and Kingella kingae detection. J Microbiol Methods. 2018 Dec 7. [Epub ahead of print] PubMed PMID: 30527965
  • Nycz BT, Dominguez SR, Friedman D, Hilden JM, Ir D, Robertson CE, Frank DN. Correction: Evaluation of bloodstream infections, Clostridium difficile infections, and gut microbiota in pediatric oncology patients. PLoS One. 2018;13(5):e0197530. PubMed PMID: 29746574
  • Brumbaugh DE, De Zoeten EF, Pyo-Twist A, Fidanza S, Hughes S, Dolan SA, Child J, Dominguez SR. An Intragastric Fecal Microbiota Transplantation Program for Treatment of Recurrent Clostridium difficile in Children is Efficacious, Safe, and Inexpensive. J Pediatr. 2017 Nov 30. [Epub ahead of print] PubMed PMID: 29198534
  • Messacar K, Abzug MJ, Dominguez SR. The changing epidemiology of acute flaccid paralysis warrants a paradigm shift in surveillance. J Med Virol. 2018 Jan;90(1):1-2. PubMed PMID: 29023852
  • Muthuri SG, Venkatesan S, Myles PR, Leonardi-Bee J, Lim WS, Mamun AA, Anovadiya AP, Araújo WN, Azziz-Baumgartner E, Báez C, Bantar C, Barhoush MM, Bassetti M, Beovic B, Bingisser R, Bonmarin I, Borja-Aburto VH, Cao B, Carratala J, Cuezzo MR, Denholm JT, Dominguez SR, Duarte PA, Dubnov-Raz G, Echavarria M, Fanella S, Fraser J, Gao Z, Gérardin P, Giannella M, Gubbels S, Herberg J, Iglesias AL, Hoeger PH, Hoffmann M, Hu X, Islam QT, Jiménez MF, Kandeel A, Keijzers G, Khalili H, Khandaker G, Knight M, Kusznierz G, Kuzman I, Kwan AM, Amine IL, Langenegger E, Lankarani KB, Leo YS, Linko R, Liu P, Madanat F, Manabe T, Mayo-Montero E, McGeer A, Memish ZA, Metan G, Mikic D, Mohn KG, Moradi A, Nymadawa P, Ozbay B, Ozkan M, Parekh D, Paul M, Poeppl W, Polack FP, Rath BA, Rodríguez AH, Siqueira MM, Skret-Magierlo J, Talarek E, Tang JW, Torres A, Törün SH, Tran D, Uyeki TM, van Zwol A, Vaudry W, Velyvyte D, Vidmar T, Zarogoulidis P, Nguyen-Van-Tam JS. Impact of neuraminidase inhibitors on influenza A(H1N1)pdm09-related pneumonia: an IPD meta-analysis. Influenza Other Respir Viruses. 2015 Nov 25. [Epub ahead of print] PubMed PMID: 26602067
  • Dantes R, Epson EE, Dominguez SR, Dolan S, Wang F, Hurst A, Parker SK, Johnston H, West K, Anderson L, Rasheed JK, Moulton-Meissner H, Noble-Wang J, Limbago B, Dowell E, Hilden JM, Guh A, Pollack LA, Gould CV. Investigation of a cluster of Clostridium difficile infections in a pediatric oncology setting. Am J Infect Control. 2015 Oct 22. [Epub ahead of print] PubMed PMID: 26601705
  • Midgley CM, Watson JT, Nix WA, Curns AT, Rogers SL, Brown BA, Conover C, Dominguez SR, Feikin DR, Gray S, Hassan F, Hoferka S, Jackson MA, Johnson D, Leshem E, Miller L, Nichols JB, Nyquist AC, Obringer E, Patel A, Patel M, Rha B, Schneider E, Schuster JE, Selvarangan R, Seward JF, Turabelidze G, Oberste MS, Pallansch MA, Gerber SI. Severe respiratory illness associated with a nationwide outbreak of enterovirus D68 in the USA (2014): a descriptive epidemiological investigation. Lancet Respir Med. 2015 Nov;3(11):879-87. PubMed PMID: 26482320
  • Phadke D, Patel SS, Dominguez SR, Heizer H, Anderson MS, Glode MP, Jone PN. Tissue Doppler Imaging as a Predictor of Immunoglobulin Resistance in Kawasaki Disease. Pediatr Cardiol. 2015 May 21. [Epub ahead of print] PubMed PMID: 25991572
  • Greninger AL, Naccache SN, Messacar K, Clayton A, Yu G, Somasekar S, Federman S, Stryke D, Anderson C, Yagi S, Messenger S, Wadford D, Xia D, Watt JP, Van Haren K, Dominguez SR, Glaser C, Aldrovandi G, Chiu CY. A novel outbreak enterovirus D68 strain associated with acute flaccid myelitis cases in the USA (2012-14): a retrospective cohort study. Lancet Infect Dis. 2015 Jun;15(6):671-82. PubMed PMID: 25837569
  • Maloney JA, Mirsky DM, Messacar K, Dominguez SR, Schreiner T, Stence NV. MRI Findings in Children with Acute Flaccid Paralysis and Cranial Nerve Dysfunction Occurring during the 2014 Enterovirus D68 Outbreak. AJNR Am J Neuroradiol. 2014 Nov 20. [Epub ahead of print] PubMed PMID: 25414005
  • Messacar K, Robinson CC, Bagdure D, Curtis DJ, Glodé MP, Dominguez SR. Rhino/enteroviruses in hospitalized children: a comparison to influenza viruses. J Clin Virol. 2013 Jan;56(1):41-5. PubMed PMID: 23078869
  • Dominguez SR, Anderson MS. Advances in the treatment of Kawasaki disease. Curr Opin Pediatr. 2012 Dec 31. [Epub ahead of print] PubMed PMID: 23283289
  • Eladawy M, Dominguez SR, Anderson MS, Glodé MP. Kawasaki Disease Presenting To the Pediatric Gastroenterologist: A Diagnostic Challenge. J Pediatr Gastroenterol Nutr. 2012 Oct 18. [Epub ahead of print] PubMed PMID: 23085893
  • Dominguez SR, Sims GE, Wentworth DE, Halpin RA, Robinson CC, Town CD, Holmes KV. Genomic analysis of 16 Colorado human NL63 coronaviruses identifies a new genotype, high sequence diversity in the N-terminal domain of the spike gene and evidence of recombination. J Gen Virol. 2012 Nov;93(Pt 11):2387-98. PubMed PMID: 22837419
  • Dominguez SR, Anderson MS, El-Adawy M, Glodé MP. Preventing coronary artery abnormalities: a need for earlier diagnosis and treatment of kawasaki disease. Pediatr Infect Dis J. 2012 Dec;31(12):1217-20. PubMed PMID: 22760536
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Professional Memberships

  • Christian Medical and Dental Association, Member
  • American Academy of Pediatrics, Member
  • Christian Community Health, Fellow
  • Pediatric Infectious Disease Society, Member
  • Infectious Disease Society of America, Member
  • American Society of Microbiology, Member

Practice Locations

Children's Hospital Colorado
13123 East 16th Ave
Aurora, CO 80045
720-777-1234

Hospital Affiliation
  • Children's Hospital Colorado

Specialty Information

Specialties
  • Pediatric Infectious Diseases, Board Certification (2007)
  • Pediatrics, Board Certification (2003)
Conditions & Treatments
  • Child and Teen Health
  • Infections
Clinical Interest for Patients
I am interested in caring for children with any pediatric infectious disease. I have particular interests in Kawasaki Disease, emerging pathogens, respiratory viral infections, and Clostridium difficile infections.

Care Philosophy
I strive to provide compassionate, evidence based, family centered care for my patients. I believe in listening and partnering with families to find the best treatment option for their children. I strive to treat every child in the way I would want others to care for my own children.

General Information

Medical Schools:
  • MD, University of Chicago Division of the Biological Sciences The Pritzker School of Medicine (2000)
Undergraduate Schools:
  • BA, Houghton College (NY) (1992)
Internships:
  • University of Chicago/Comer Children's Hospital Program (2001)
Residency Programs:
  • University of Chicago/Comer Children's Hospital Program, Pediatrics (2003)
Fellowships:
  • University of Colorado (University Hospital) Program, Pediatric Infectious Diseases (2007)
Languages: English
Department: Pediatrics-Infectious Diseases
;