Ivor Douglas, MD
Professor, Medicine-Pulmonary Sciences & Critical Care

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Medical School:
  • MD, University Of the Witwatersrand, Johannesburg, South Africa (1990)
Internships:
  • University of Chicago Program (1995)
  • Johannesburg General Hospital (1992)
Residencies:
  • University of Chicago Program, Internal Medicine (1996)
  • Johannesburg General Hospital, Critical Care Medicine (1994)
Fellowships:
  • University of Chicago Program, Pulmonary Disease and Critical Care Medicine (1999)
Languages: English
Department: Medicine-Pulmonary Sciences & Critical Care

Professional Titles

  • Medicine Director, Medical Intensive Care Denver Health Medical Center
  • Chief, Pulmonary Sciences & Critical Care

Recognition & Awards

  • Best Doctors in America?, Best Doctors, Inc. (2020)
    2008-2020
  • Top Doctor in Denver, 5280 Magazine (2019)
    Voted a 5280 best doctor by my peers in response to the question, "Which physician would you trust to treat you and your family?" 2008-2019
  • Peak Performers Award , Rocky Mountain Society of Hospital Medicine (2014)
    2010-2014

Publications

  • Douglas IS, Rosenthal CA, Swanson DD, Hiller T, Oakes J, Bach J, Whelchel C, Pickering J, George T, Kearns M, Hanley M, Mould K, Roark S, Mansoori J, Mehta A, Schmidt EP, Neumeier A. Safety and Outcomes of Prolonged Usual Care Prone Position Mechanical Ventilation to Treat Acute Coronavirus Disease 2019 Hypoxemic Respiratory Failure. Crit Care Med. 2021 Jan 18. [Epub ahead of print] PubMed PMID: 33405409
  • Tong A, Baumgart A, Evangelidis N, Viecelli AK, Carter SA, Azevedo LC, Cooper T, Bersten A, Cervantes L, Chew DP, Crowe S, Douglas IS, Flemyng E, Elliott JH, Hannan E, Horby P, Howell M, Ju A, Lee J, Lorca E, Lynch D, Manera KE, Marshall JC, Gonzalez AM, McKenzie A, Mehta S, Mer M, Morris AC, Needham DM, Nseir S, Povoa P, Reid M, Sakr Y, Shen N, Smyth AR, Simpson AJ, Snelling T, Strippoli GFM, Teixeira-Pinto A, Torres A, Turner T, Webb S, Williamson PR, Woc-Colburn L, Zhang J, Craig JC. Core Outcome Measures for Trials in People With Coronavirus Disease 2019: Respiratory Failure, Multiorgan Failure, Shortness of Breath, and Recovery. Crit Care Med. 2021 Jan 5;Publish Ahead of Print. [Epub ahead of print] PubMed PMID: 33400475
  • Mehta AB, Walkey AJ, Curran-Everett D, Matlock D, Douglas IS. Stability of Do-Not-Resuscitate Orders in Hospitalized Adults: A Population-Based Cohort Study. Crit Care Med. 2021 Feb 1;49(2):240-249. PubMed PMID: 33264125
  • Self WH, Semler MW, Leither LM, Casey JD, Angus DC, Brower RG, Chang SY, Collins SP, Eppensteiner JC, Filbin MR, Files DC, Gibbs KW, Ginde AA, Gong MN, Harrell FE Jr, Hayden DL, Hough CL, Johnson NJ, Khan A, Lindsell CJ, Matthay MA, Moss M, Park PK, Rice TW, Robinson BRH, Schoenfeld DA, Shapiro NI, Steingrub JS, Ulysse CA, Weissman A, Yealy DM, Thompson BT, Brown SM, Steingrub J, Smithline H, Tiru B, Tidswell M, Kozikowski L, Thornton-Thompson S, De Souza L, Hou P, Baron R, Massaro A, Aisiku I, Fredenburgh L, Seethala R, Johnsky L, Riker R, Seder D, May T, Baumann M, Eldridge A, Lord C, Shapiro N, Talmor D, O’Mara T, Kirk C, Harrison K, Kurt L, Schermerhorn M, Banner-Goodspeed V, Boyle K, Dubosh N, Filbin M, Hibbert K, Parry B, Lavin-Parsons K, Pulido N, Lilley B, Lodenstein C, Margolin J, Brait K, Jones A, Galbraith J, Peacock R, Nandi U, Wachs T, Matthay M, Liu K, Kangelaris K, Wang R, Calfee C, Yee K, Hendey G, Chang S, Lim G, Qadir N, Tam A, Beutler R, Levitt J, Wilson J, Rogers A, Vojnik R, Roque J, Albertson T, Chenoweth J, Adams J, Pearson S, Juarez M, Almasri E, Fayed M, Hughes A, Hillard S, Huebinger R, Wang H, Vidales E, Patel B, Ginde A, Moss M, Baduashvili A, McKeehan J, Finck L, Higgins C, Howell M, Douglas I, Haukoos J, Hiller T, Lyle C, Cupelo A, Caruso E, Camacho C, Gravitz S, Finigan J, Griesmer C, Park P, Hyzy R, Nelson K, McDonough K, Olbrich N, Williams M, Kapoor R, Nash J, Willig M, Ford H, Gardner-Gray J, Ramesh M, Moses M, Ng Gong M, Aboodi M, Asghar A, Amosu O, Torres M, Kaur S, Chen JT, Hope A, Lopez B, Rosales K, Young You J, Mosier J, Hypes C, Natt B, Borg B, Salvagio Campbell E, Hite RD, Hudock K, Cresie A, Alhasan F, Gomez-Arroyo J, Duggal A, Mehkri O, Hastings A, Sahoo D, Abi Fadel F, Gole S, Shaner V, Wimer A, Meli Y, King A, Terndrup T, Exline M, Pannu S, Robart E, Karow S, Hough C, Robinson B, Johnson N, Henning D, Campo M, Gundel S, Seghal S, Katsandres S, Dean S, Khan A, Krol O, Jouzestani M, Huynh P, Weissman A, Yealy D, Scho... Effect of Hydroxychloroquine on Clinical Status at 14 Days in Hospitalized Patients With COVID-19: A Randomized Clinical Trial. JAMA. 2020 Dec 1;324(21):2165-2176. PubMed PMID: 33165621
  • Coleman JR, Leasia K, Douglas IS, Hosokawa P, Lawless RA, Moore EE, Pieracci F. Quantifying the expense of deferring surgical stabilization of rib fractures: Operative management of rib fractures is associated with significantly lower charges. J Trauma Acute Care Surg. 2020 Dec;89(6):1032-1038. PubMed PMID: 32890348
  • Tong A, Elliott JH, Azevedo LC, Baumgart A, Bersten A, Cervantes L, Chew DP, Cho Y, Cooper T, Crowe S, Douglas IS, Evangelidis N, Flemyng E, Hannan E, Horby P, Howell M, Lee J, Liu E, Lorca E, Lynch D, Marshall JC, Gonzalez AM, McKenzie A, Manera KE, McLeod C, Mehta S, Mer M, Morris AC, Nseir S, Povoa P, Reid M, Sakr Y, Shen N, Smyth AR, Snelling T, Strippoli GF, Teixeira-Pinto A, Torres A, Turner T, Viecelli AK, Webb S, Williamson PR, Woc-Colburn L, Zhang J, Craig JC. Core Outcomes Set for Trials in People With Coronavirus Disease 2019. Crit Care Med. 2020 Nov;48(11):1622-1635. PubMed PMID: 32804792
  • Evangelidis N, Tong A, Howell M, Teixeira-Pinto A, Elliott JH, Azevedo LC, Bersten A, Cervantes L, Chew DP, Crowe S, Douglas IS, Flemyng E, Horby P, Lee J, Lorca E, Lynch D, Marshall JC, McKenzie A, Mehta S, Mer M, Morris AC, Nseir S, Povoa P, Reid M, Sakr Y, Shen N, Smyth AR, Snelling T, Strippoli GFM, Torres A, Turner T, Webb S, Williamson PR, Woc-Colburn L, Zhang J, Baumgart A, Cabrera S, Cho Y, Cooper T, Guha C, Liu E, Gonzalez AM, McLeod C, Natale P, Saglimbene V, Viecelli AK, Craig JC. International Survey to Establish Prioritized Outcomes for Trials in People With Coronavirus Disease 2019. Crit Care Med. 2020 Nov;48(11):1612-1621. PubMed PMID: 32804789
  • Wunderink RG, Srinivasan A, Barie PS, Chastre J, Dela Cruz CS, Douglas IS, Ecklund M, Evans SE, Evans SR, Gerlach AT, Hicks LA, Howell M, Hutchinson ML, Hyzy RC, Kane-Gill SL, Lease ED, Metersky ML, Munro N, Niederman MS, Restrepo MI, Sessler CN, Simpson SQ, Swoboda SM, Guillamet CV, Waterer GW, Weiss CH. Antibiotic Stewardship in the Intensive Care Unit. An Official American Thoracic Society Workshop Report in Collaboration with the AACN, CHEST, CDC, and SCCM. Ann Am Thorac Soc. 2020 May;17(5):531-540. PubMed PMID: 32356696
  • Douglas IS, Alapat PM, Corl KA, Exline MC, Forni LG, Holder AL, Kaufman DA, Khan A, Levy MM, Martin GS, Sahatjian JA, Seeley E, Self WH, Weingarten JA, Williams M, Hansell DM. Fluid Response Evaluation in Sepsis Hypotension and Shock: A Randomized Clinical Trial. Chest. 2020 Oct;158(4):1431-1445. PubMed PMID: 32353418
  • Douglas IS. Comments About Diabetes Insipidus After Discontinuation of Vasopressin Infusion for Treatment of Shock. Crit Care Med. 2020 Mar;48(3):e256-e257. PubMed PMID: 32058399
  • Mansoori JN, Linde-Zwirble W, Hou PC, Havranek EP, Douglas IS. Variability in usual care fluid resuscitation and risk-adjusted outcomes for mechanically ventilated patients in shock. Crit Care. 2020 Jan 28;24(1):25. PubMed PMID: 31992351
  • Denson JL, Knoeckel J, Kjerengtroen S, Johnson R, McNair B, Thornton O, Douglas IS, Wechsler ME, Burke RE. Improving end-of-rotation transitions of care among ICU patients. BMJ Qual Saf. 2020 Mar;29(3):250-259. PubMed PMID: 31685581
  • Maddux AB, Hiller TD, Overdier KH, Pyle LL, Douglas IS. Innate Immune Function and Organ Failure Recovery in Adults With Sepsis. J Intensive Care Med. 2019 Jun;34(6):486-494. PubMed PMID: 28372498
  • Mehta AB, Walkey AJ, Curran-Everett D, Matlock D, Douglas IS. Hospital Mechanical Ventilation Volume and Patient Outcomes: Too Much of a Good Thing?. Crit Care Med. 2019 Mar;47(3):360-368. PubMed PMID: 30585831
  • Douglas IS, Bednash JS, Fein DG, Mallampalli RK, Mansoori JN, Gershengorn HB. Update in Critical Care and Acute Respiratory Distress Syndrome 2018. Am J Respir Crit Care Med. 2019 Jun 1;199(11):1335-1343. PubMed PMID: 30958975
  • Mehta AB, Walkey AJ, Curran-Everett D, Douglas IS. One-Year Outcomes Following Tracheostomy for Acute Respiratory Failure. Crit Care Med. 2019 Nov;47(11):1572-1581. PubMed PMID: 31397716
  • Moss M, Huang DT, Brower RG, Ferguson ND, Ginde AA, Gong MN, Grissom CK, Gundel S, Hayden D, Hite RD, Hou PC, Hough CL, Iwashyna TJ, Khan A, Liu KD, Talmor D, Thompson BT, Ulysse CA, Yealy DM, Angus DC. Early Neuromuscular Blockade in the Acute Respiratory Distress Syndrome. N Engl J Med. 2019 May 23;380(21):1997-2008. PubMed PMID: 31112383
  • Ginde AA, Brower RG, Caterino JM, Finck L, Banner-Goodspeed VM, Grissom CK, Hayden D, Hough CL, Hyzy RC, Khan A, Levitt JE, Park PK, Ringwood N, Rivers EP, Self WH, Shapiro NI, Thompson BT, Yealy DM, Talmor D. Early High-Dose Vitamin D(3) for Critically Ill, Vitamin D-Deficient Patients. N Engl J Med. 2019 Dec 26;381(26):2529-2540. PubMed PMID: 31826336
  • Lanspa MJ, Gong MN, Schoenfeld DA, Lee KT, Grissom CK, Hou PC, Serpa-Neto A, Brown SM, Iwashyna TJ, Yealy DM, Hough CL, Brower RG, Calfee CS, Hyzy RC, Matthay MA, Miller RR 3rd, Steingrub JS, Thompson BT, Miller CD, Clemmer TP, Hendey GW, Huang DT, Mathews KS, Qadir N, Tidswell M. Prospective Assessment of the Feasibility of a Trial of Low-Tidal Volume Ventilation for Patients with Acute Respiratory Failure. Ann Am Thorac Soc. 2019 Mar;16(3):356-362. PubMed PMID: 30407869
  • Mehta AB, Walkey AJ, Curran-Everett D, Matlock D, Douglas IS. Hospital Mechanical Ventilation Volume and Patient Outcomes: Too Much of a Good Thing?. Crit Care Med. 2018 Dec 21. [Epub ahead of print] PubMed PMID: 30585831
  • Borg B, Douglas IS, Hull M, Keniston A, Moss M, Clark BJ. Alcohol misuse and outpatient follow-up after hospital discharge: a retrospective cohort study. Addict Sci Clin Pract. 2018 Dec 4;13(1):24. PubMed PMID: 30514357
  • Girard TD, Exline MC, Carson SS, Hough CL, Rock P, Gong MN, Douglas IS, Malhotra A, Owens RL, Feinstein DJ, Khan B, Pisani MA, Hyzy RC, Schmidt GA, Schweickert WD, Hite RD, Bowton DL, Masica AL, Thompson JL, Chandrasekhar R, Pun BT, Strength C, Boehm LM, Jackson JC, Pandharipande PP, Brummel NE, Hughes CG, Patel MB, Stollings JL, Bernard GR, Dittus RS, Ely EW. Haloperidol and Ziprasidone for Treatment of Delirium in Critical Illness. N Engl J Med. 2018 Dec 27;379(26):2506-2516. PubMed PMID: 30346242
  • Lahm T, Douglas IS, Archer SL, Bogaard HJ, Chesler NC, Haddad F, Hemnes AR, Kawut SM, Kline JA, Kolb TM, Mathai SC, Mercier O, Michelakis ED, Naeije R, Tuder RM, Ventetuolo CE, Vieillard-Baron A, Voelkel NF, Vonk-Noordegraaf A, Hassoun PM. Assessment of Right Ventricular Function in the Research Setting: Knowledge Gaps and Pathways Forward. An Official American Thoracic Society Research Statement. Am J Respir Crit Care Med. 2018 Aug 15;198(4):e15-e43. PubMed PMID: 30109950
  • Self WH, Semler MW, Bellomo R, Brown SM, deBoisblanc BP, Exline MC, Ginde AA, Grissom CK, Janz DR, Jones AE, Liu KD, Macdonald SPJ, Miller CD, Park PK, Reineck LA, Rice TW, Steingrub JS, Talmor D, Yealy DM, Douglas IS, Shapiro NI. Liberal Versus Restrictive Intravenous Fluid Therapy for Early Septic Shock: Rationale for a Randomized Trial. Ann Emerg Med. 2018 Oct;72(4):457-466. PubMed PMID: 29753517
  • Park BH, Shin MH, Douglas IS, Chung KS, Song JH, Kim SY, Kim EY, Jung JY, Kang YA, Chang J, Kim YS, Park MS. Erythropoietin-Producing Hepatoma Receptor Tyrosine Kinase A2 Modulation Associates with Protective Effect of Prone Position in Ventilator-induced Lung Injury. Am J Respir Cell Mol Biol. 2018 Apr;58(4):519-529. PubMed PMID: 29216437
  • Durfee J, Johnson T, Batal H, Long J, Rinehart D, Everhart R, Oronce CI, Douglas I, Moore K, Atherly A. The impact of tailored intervention services on charges and mortality for adult super-utilizers. Healthc (Amst). 2018 Dec;6(4):253-258. PubMed PMID: 28847571
  • Mehta AB, Cooke CR, Douglas IS, Lindenauer PK, Wiener RS, Walkey AJ. Association of Early Do-Not-Resuscitate Orders with Unplanned Readmissions among Patients Hospitalized for Pneumonia. Ann Am Thorac Soc. 2017 Jan;14(1):103-109. PubMed PMID: 27753520
  • Mehta AB, Cooke CR, Douglas IS, Lindenauer PK, Wiener RS, Walkey AJ. Association of Early Do-Not-Resuscitate Orders with Unplanned Readmissions among Patients Hospitalized for Pneumonia. Ann Am Thorac Soc. 2017 Jan;14(1):103-109. PubMed PMID: 27753520
  • Holguin F, Moughrabieh MA, Ojeda V, Patel SR, Peyrani P, Pinedo M, Celedón JC, Douglas IS, Upson DJ, Roman J. Respiratory Health in Migrant Populations: A Crisis Overlooked. Ann Am Thorac Soc. 2017 Feb;14(2):153-159. PubMed PMID: 28146384
  • Maddux A., Hiller T., Overdier K., Pyle L., Douglas IS. 2017 Innate Immune Function and Organ Failure Recovery in Adults with Sepsis. Journal of Intensive Care Medicine (In Press)
  • Douglas IS, Pulmonary infections in Critical/Intensive Care - Rapid Diagnosis and Optimizing Antimicrobial Usage. Current Opinion in Pulmonary Medicine 2017 (In Press)
  • Fang WF, Douglas IS, Chen YM, Lin CY, Kao HC, Fang YT, Huang CH, Chang YT, Huang KT, Wang YH, Wang CC, Lin MC. Development and validation of immune dysfunction score to predict 28-day mortality of sepsis patients. PLoS One. 2017;12(10):e0187088. PubMed PMID: 29073262
  • Durfee J, Johnson T, Batal H, Long J, Rinehart D, Everhart R, Oronce CI, Douglas I, Moore K, Atherly A. The impact of tailored intervention services on charges and mortality for adult super-utilizers. Healthc (Amst). 2017 Aug 25. [Epub ahead of print] PubMed PMID: 28847571
  • Leem AY, Shin MH, Douglas IS, Song JH, Chung KS, Kim EY, Jung JY, Kang YA, Chang J, Kim YS, Park MS. All-trans retinoic acid attenuates bleomycin-induced pulmonary fibrosis via downregulating EphA2-EphrinA1 signaling. Biochem Biophys Res Commun. 2017 Sep 23;491(3):721-726. PubMed PMID: 28743499
  • Mehta AB, Douglas IS, Walkey AJ. Evidence-based Utilization of Noninvasive Ventilation and Patient Outcomes. Ann Am Thorac Soc. 2017 Nov;14(11):1667-1673. PubMed PMID: 28541747
  • Clark BJ, Jones J, Reed KD, Hodapp R, Douglas IS, Van Pelt D, Burnham EL, Moss M. The Experience of Patients with Alcohol Misuse after Surviving a Critical Illness. A Qualitative Study. Ann Am Thorac Soc. 2017 Jul;14(7):1154-1161. PubMed PMID: 28406727
  • Maddux AB, Hiller TD, Overdier KH, Pyle LL, Douglas IS. Innate Immune Function and Organ Failure Recovery in Adults With Sepsis. J Intensive Care Med. 2017 Jan 1;:885066617701903. [Epub ahead of print] PubMed PMID: 28372498
  • Stahel PF, Douglas IS, VanderHeiden TF, Weckbach S. The history of risk: a review. World J Emerg Surg. 2017;12:15. PubMed PMID: 28293279
  • Douglas IS. Pulmonary infections in critical/intensive care - rapid diagnosis and optimizing antimicrobial usage. Curr Opin Pulm Med. 2017 May;23(3):198-203. PubMed PMID: 28257317
  • Holguin F, Moughrabieh MA, Ojeda V, Patel SR, Peyrani P, Pinedo M, Celedón JC, Douglas IS, Upson DJ, Roman J. Respiratory Health in Migrant Populations: A Crisis Overlooked. Ann Am Thorac Soc. 2017 Feb;14(2):153-159. PubMed PMID: 28146384
  • Mehta AB, Cooke CR, Douglas IS, Lindenauer PK, Wiener RS, Walkey AJ. Association of Early Do-Not-Resuscitate Orders with Unplanned Readmissions among Patients Hospitalized for Pneumonia. Ann Am Thorac Soc. 2017 Jan;14(1):103-109. PubMed PMID: 27753520
  • Park BH, Shin MH, Douglas IS, Chung KS, Song JH, Kim SY, Kim EY, Jung JY, Kang YA, Chang J, Kim YS, Park MS. EphA2 Modulation Associates with Protective Effect of Prone Position in Ventilator-induced Lung Injury. Am J Respir Cell Mol Biol. 2017 Dec 7. [Epub ahead of print] PubMed PMID: 29216437
  • Lyon SM, Moore N, Douglas IS, Cooke CR. Update on the Affordable Care Act: King v. Burwell and Obergefell v. Hodge. Ann Am Thorac Soc. 2016 Jan 5. [Epub ahead of print] PubMed PMID: 26731515
  • Mehta AB, Douglas IS, Walkey AJ. Reply: Hospital Noninvasive Ventilation for Acute Exacerbations of Chronic Obstructive Pulmonary Disease: Another Look at the Same Coin. Ann Am Thorac Soc. 2016 Dec;13(12):2279-2280. PubMed PMID: 27925793
  • Hong JY, Shin MH, Douglas IS, Chung KS, Kim EY, Jung JY, Kang YA, Kim SK, Chang J, Kim YS, Park MS. Inhibition of EphA2/EphrinA1 signal attenuates lipopolysaccharide-induced lung injury. Clin Sci (Lond). 2016 Nov 1;130(21):1993-2003. PubMed PMID: 27549114
  • Mehta AB, Douglas IS, Walkey AJ. Hospital Noninvasive Ventilation Case Volume and Outcomes of Acute Exacerbations of Chronic Obstructive Pulmonary Disease. Ann Am Thorac Soc. 2016 Oct;13(10):1752-1759. PubMed PMID: 27404021
  • Wilson KC, Gould MK, Krishnan JA, Boyd CM, Brozek JL, Cooke CR, Douglas IS, Goodman RA, Joo MJ, Lareau S, Mularski RA, Patel MR, Rosenfeld RM, Shanawani H, Slatore C, Sockrider M, Sufian B, Thomson CC, Wiener RS. An Official American Thoracic Society Workshop Report. A Framework for Addressing Multimorbidity in Clinical Practice Guidelines for Pulmonary Disease, Critical Illness, and Sleep Disorders. Ann Am Thorac Soc. 2016 Mar;13(3):S12-21. PubMed PMID: 26963362
  • Schmidt EP, Overdier KH, Sun X, Lin L, Liu X, Yang Y, Ammons LA, Hiller TD, Suflita MA, Yu Y, Chen Y, Zhang F, Cothren Burlew C, Edelstein CL, Douglas IS, Linhardt RJ. Urinary Glycosaminoglycans Predict Outcomes in Septic Shock and Acute Respiratory Distress Syndrome. Am J Respir Crit Care Med. 2016 Aug 15;194(4):439-49. PubMed PMID: 26926297
  • Douglas IS. New diagnostic methods for pneumonia in the ICU. Curr Opin Infect Dis. 2016 Apr;29(2):197-204. PubMed PMID: 26859725
  • Lyon SM, Moore N, Douglas IS, Cooke CR. Update on the Affordable Care Act. King v. Burwell and Obergefell v. Hodge. Ann Am Thorac Soc. 2016 Mar;13(3):324-8. PubMed PMID: 26731515
  • Douglas IS, Price CS, Overdier KH, Wolken RF, Metzger SW, Hance KR, Howson DC. Rapid Automated Microscopy for Microbiologic Surveillance of Ventilator-associated Pneumonia. Am J Respir Crit Care Med. 2015 Jan 13. [Epub ahead of print] PubMed PMID: 25585163
  • Douglas IS, Albertson TE, Folan P, Hanania NA, Tashkin DP, Upson DJ, Leone FT. Implications of Marijuana Decriminalization on the Practice of Pulmonary, Critical Care, and Sleep Medicine. A Report of the American Thoracic Society Marijuana Workgroup. Ann Am Thorac Soc. 2015 Nov;12(11):1700-10. PubMed PMID: 26540421
  • Hough CL, Caldwell ES, Cox CE, Douglas IS, Kahn JM, White DB, Seeley EJ, Bangdiwala SI, Rubenfeld GD, Angus DC, Carson SS. Development and Validation of a Mortality Prediction Model for Patients Receiving 14 Days of Mechanical Ventilation. Crit Care Med. 2015 Nov;43(11):2339-45. PubMed PMID: 26247337
  • Lammi MR, Aiello B, Burg GT, Rehman T, Douglas IS, Wheeler AP, deBoisblanc BP. Response to fluid boluses in the fluid and catheter treatment trial. Chest. 2015 Oct;148(4):919-26. PubMed PMID: 26020673
  • Sun X, Li L, Overdier KH, Ammons LA, Douglas IS, Burlew CC, Zhang F, Schmidt EP, Chi L, Linhardt RJ. Analysis of Total Human Urinary Glycosaminoglycan Disaccharides by Liquid Chromatography-Tandem Mass Spectrometry. Anal Chem. 2015 Jun 16;87(12):6220-7. PubMed PMID: 26005898
  • Maddux AB, Douglas IS. Is the developmentally immature immune response in paediatric sepsis a recapitulation of immune tolerance?. Immunology. 2015 May;145(1):1-10. PubMed PMID: 25691226
  • Douglas IS, Price CS, Overdier KH, Wolken RF, Metzger SW, Hance KR, Howson DC. Rapid automated microscopy for microbiological surveillance of ventilator-associated pneumonia. Am J Respir Crit Care Med. 2015 Mar 1;191(5):566-73. PubMed PMID: 25585163
  • Festic E, Bansal V, Kor DJ, Gajic O. SpO2/FiO2 ratio on hospital admission is an indicator of early acute respiratory distress syndrome development among patients at risk. J Intensive Care Med. 2015 May;30(4):209-16. PubMed PMID: 24362445
  • Leone FT, Douglas IS. The Emergence of E-Cigarettes: A Triumph of Wishful Thinking over Science. Ann Am Thorac Soc. 2014 Feb;11(2):216-9. PubMed PMID: 24575986
  • Schmidt EP, Li G, Li L, Fu L, Yang Y, Overdier KH, Douglas IS, Linhardt RJ. The Circulating Glycosaminoglycan Signature of Respiratory Failure in Critically Ill Adults. J Biol Chem. 2014 Feb 7. [Epub ahead of print] PubMed PMID: 24509853
  • Otten D, Liao MM, Wolken R, Douglas IS, Mishra R, Kao A, Barrett W, Drasler E, Byyny RL, Haukoos JS. Comparison of bag-valve-mask hand-sealing techniques in a simulated model. Ann Emerg Med. 2014 Jan;63(1):6-12.e3. PubMed PMID: 23937957
  • Goodson CM, Clark BJ, Douglas IS. Predictors of severe alcohol withdrawal syndrome: a systematic review and meta-analysis. Alcohol Clin Exp Res. 2014 Oct;38(10):2664-77. PubMed PMID: 25346507
  • Liao MM, Lezotte D, Lowenstein SR, Howard K, Finley Z, Feng Z, Byyny RL, Sankoff JD, Douglas IS, Haukoos JS. Sensitivity of systemic inflammatory response syndrome for critical illness among ED patients. Am J Emerg Med. 2014 Nov;32(11):1319-25. PubMed PMID: 25205616
  • Fang WF, Douglas IS, Wang CC, Kao HC, Chang YT, Tseng CC, Huang KT, Chang HC, Lin MC. 5-Lipoxygenase activating protein (FLAP) dependent leukotriene biosynthesis inhibition (MK591) attenuates Lipid A endotoxin-induced inflammation. PLoS One. 2014;9(7):e102622. PubMed PMID: 25025775
  • National Heart, Lung, and Blood Institute ARDS Clinical Trials Network, Truwit JD, Bernard GR, Steingrub J, Matthay MA, Liu KD, Albertson TE, Brower RG, Shanholtz C, Rock P, Douglas IS, deBoisblanc BP, Hough CL, Hite RD, Thompson BT. Rosuvastatin for sepsis-associated acute respiratory distress syndrome. N Engl J Med. 2014 Jun 5;370(23):2191-200. PubMed PMID: 24835849
  • Kahn JM, Gould MK, Krishnan JA, Wilson KC, Au DH, Cooke CR, Douglas IS, Feemster LC, Mularski RA, Slatore CG, Wiener RS, ATS Ad Hoc Committee on the Development of Performance Measures from ATS Guidelines. An official American thoracic society workshop report: developing performance measures from clinical practice guidelines. Ann Am Thorac Soc. 2014 May;11(4):S186-95. PubMed PMID: 24828810
  • Fernandez-Bustamante A, Klawitter J, Repine JE, Agazio A, Janocha AJ, Shah C, Moss M, Douglas IS, Tran ZV, Erzurum SC, Christians U, Seres T. Early effect of tidal volume on lung injury biomarkers in surgical patients with healthy lungs. Anesthesiology. 2014 Sep;121(3):469-81. PubMed PMID: 24809976
  • Kim HJ, Ravichandran K, Ozkok A, Wang Q, He Z, Jani A, Ljubanovic D, Douglas IS, Edelstein CL. The water-soluble triptolide derivative PG490-88 protects against cisplatin-induced acute kidney injury. J Pharmacol Exp Ther. 2014 Jun;349(3):518-25. PubMed PMID: 24727856
  • Lyon SM, Douglas IS, Cooke CR. Medicaid expansion under the Affordable Care Act. Implications for insurance-related disparities in pulmonary, critical care, and sleep. Ann Am Thorac Soc. 2014 May;11(4):661-7. PubMed PMID: 24708065
  • Leone FT, Douglas IS. The emergence of e-cigarettes: a triumph of wishful thinking over science. Ann Am Thorac Soc. 2014 Feb;11(2):216-9. PubMed PMID: 24575986
  • Schmidt EP, Li G, Li L, Fu L, Yang Y, Overdier KH, Douglas IS, Linhardt RJ. The circulating glycosaminoglycan signature of respiratory failure in critically ill adults. J Biol Chem. 2014 Mar 21;289(12):8194-202. PubMed PMID: 24509853
  • Otten D, Liao MM, Wolken R, Douglas IS, Mishra R, Kao A, Barrett W, Drasler E, Byyny RL, Haukoos JS. Comparison of bag-valve-mask hand-sealing techniques in a simulated model. Ann Emerg Med. 2014 Jan;63(1):6-12.e3. PubMed PMID: 23937957
  • Surviving sepsis campaign: international guidelines for management of severe sepsis and septic shock, 2012. Dellinger RP, Levy MM, Rhodes A, Annane D, Gerlach H, Opal SM, Sevransky JE, Sprung CL, Douglas IS, Jaeschke R, Osborn TM, Nunnally ME, Townsend SR, Reinhart K, Kleinpell RM, Angus DC, Deutschman CS, Machado FR, Rubenfeld GD, Webb S, Beale RJ, Vincent JL, Moreno R; Surviving Sepsis Campaign Guidelines Committee including The Pediatric Subgroup*. Intensive Care Med. 2013 Feb;39(2):165-228. doi: 10.1007/s00134-012-2769-8. Epub 2013 Jan 30. Crit Care Med. 2013 Feb;41(2):580-637. doi: 10.1097/CCM.0b013e31827e83af.
  • Clark BJ, Keniston A, Douglas IS, Beresford T, Macht M, Williams A, Jones J, Burnham EL, Moss M. Healthcare utilization in medical intensive care unit survivors with alcohol withdrawal. Alcohol Clin Exp Res. 2013 Sep;37(9):1536-43. PubMed PMID: 23647435
  • Dellinger RP, Levy MM, Rhodes A, Annane D, Gerlach H, Opal SM, Sevransky JE, Sprung CL, Douglas IS, Jaeschke R, Osborn TM, Nunnally ME, Townsend SR, Reinhart K, Kleinpell RM, Angus DC, Deutschman CS, Machado FR, Rubenfeld GD, Webb S, Beale RJ, Vincent JL, Moreno R, Surviving Sepsis Campaign Guidelines Committee including The Pediatric Subgroup. Surviving Sepsis Campaign: international guidelines for management of severe sepsis and septic shock, 2012. Intensive Care Med. 2013 Feb;39(2):165-228. PubMed PMID: 23361625
  • Dellinger RP, Levy MM, Rhodes A, Annane D, Gerlach H, Opal SM, Sevransky JE, Sprung CL, Douglas IS, Jaeschke R, Osborn TM, Nunnally ME, Townsend SR, Reinhart K, Kleinpell RM, Angus DC, Deutschman CS, Machado FR, Rubenfeld GD, Webb SA, Beale RJ, Vincent JL, Moreno R, Surviving Sepsis Campaign Guidelines Committee including the Pediatric Subgroup. Surviving sepsis campaign: international guidelines for management of severe sepsis and septic shock: 2012. Crit Care Med. 2013 Feb;41(2):580-637. PubMed PMID: 23353941
  • Man M, Close SL, Shaw AD, Bernard GR, Douglas IS, Kaner RJ, Payen D, Vincent JL, Fossceco S, Janes JM, Leishman AG, O'Brien L, Williams MD, Garcia JG. Beyond single-marker analyses: mining whole genome scans for insights into treatment responses in severe sepsis. Pharmacogenomics J. 2013 Jun;13(3):218-26. PubMed PMID: 22310353
  • Lamontagne F, Quiroz Martinez H, Adhikari NK, Cook DJ, Koo KK, Lauzier F, Turgeon AF, Kho ME, Burns KE, Chant C, Fowler R, Douglas I, Poulin Y, Choong K, Ferguson ND, Meade MO. Corticosteroid use in the intensive care unit: a survey of intensivists. Can J Anaesth. 2013 Jul;60(7):652-9. PubMed PMID: 23606231
  • Park MS, He Q, Edwards MG, Sergew A, Riches DW, Albert RK, and Douglas, IS. MAP Kinase Phosphatase-1 Modulates Regional Effects of Injurious Mechanical Ventilation in Rodent Lungs. AJRCCM (Accepted)
  • Man M, Close SL, Shaw AD, Bernard GR, Douglas IS, Kaner RJ, Payen D, Vincent JL, Fossceco S, Janes JM, Leishman AG, O’Brien L, Williams MD, and Garcia JGN. Beyond single marker analyses: Mining whole genome scans for insights into treatment responses in severe sepsis. (In Press 2012, Pharmacogenomics)
  • The National Heart, Lung, and Blood Institute Acute Respiratory Distress Syndrome (ARDS) Clinical Trials Network, Rice TW, et.al. Initial trophic vs full enteral feeding in patients with acute lung injury: the EDEN randomized trial. JAMA. 2012 Feb 22;307(8):795-803. Epub 2012 Feb 5. PubMed
  • Tonelli MR, Curtis JR, Guntupalli KK, Rubenfeld GD, Arroliga AC, Brochard L, Douglas IS, Gutterman DD, Hall JR, Kavanagh BP, Mancebo J, Misak CJ, Simpson SQ, Slutsky AS, Suffredini AF, Thompson BT, Ware LB, Wheeler AP, Levy MM; on behalf of the ACCP/ATS/SCCM Working Group. An Official Multi-Society Statement: The Role of Clinical Research Results in the Practice of Critical Care Medicine. Am J Respir Crit Care Med. 2012 May 15;185(10):1117-1124.
  • The pulmonary endothelial glycocalyx regulates neutrophil adhesion and lung injury during experimental sepsis. Schmidt EP, Yang Y, Janssen WJ, Gandjeva A, Perez MJ, Barthel L, Zemans RL, Bowman JC, Koyanagi DE, Yunt ZX, Smith LP, Cheng SS, Overdier KH, Thompson KR, Geraci MW, Douglas IS, Pearse DB, Tuder RM. Nat Med. 2012 Jul 22. doi: 10.1038/nm.2843. [Epub ahead of print]
  • Drotrecogin alfa (activated) in adults with septic shock. Ranieri VM, Thompson BT, Barie PS, Dhainaut JF, Douglas IS, Finfer S, Gårdlund B, Marshall JC, Rhodes A, Artigas A, Payen D, Tenhunen J, Al-Khalidi HR, Thompson V, Janes J, Macias WL, Vangerow B, Williams MD; PROWESS-SHOCK Study Group. N Engl J Med. 2012 May 31;366(22):2055-64
  • An official multi-society statement: the role of clinical research results in the practice of critical care medicine. Tonelli MR, Curtis JR, Guntupalli KK, Rubenfeld GD, Arroliga AC, Brochard L, Douglas IS, Gutterman DD, Hall JR, Kavanagh BP, Mancebo J, Misak CJ, Simpson SQ, Slutsky AS, Suffredini AF, Thompson BT, Ware LB, Wheeler AP, Levy MM; ACCP/ATS/SCCM Working Group. Am J Respir Crit Care Med. 2012 May 15;185(10):1117-24
  • Mitogen-activated protein kinase phosphatase-1 modulates regional effects of injurious mechanical ventilation in rodent lungs. Park MS, He Q, Edwards MG, Sergew A, Riches DW, Albert RK, Douglas IS. Am J Respir Crit Care Med. 2012 Jul 1;186(1):72-81. doi: 10.1164/rccm.201109-1593OC. Epub 2012 May 10.
  • Beyond single-marker analyses: mining whole genome scans for insights into treatment responses in severe sepsis. Man M, Close SL, Shaw AD, Bernard GR, Douglas IS, Kaner RJ, Payen D, Vincent JL, Fossceco S, Janes JM, Leishman AG, O'Brien L, Williams MD, Garcia JG. Pharmacogenomics J. 2012 Feb 7
  • A multicenter mortality prediction model for patients receiving prolonged mechanical ventilation. Carson SS, Kahn JM, Hough CL, Seeley EJ, White DB, Douglas IS, Cox CE, Caldwell E, Bangdiwala SI, Garrett JM, Rubenfeld GD; ProVent Investigators. Crit Care Med. 2012 Apr;40(4):1171-6.
  • Observational study of head of bed elevation adherence using a continuous monitoring system in a medical intensive care unit. Wolken RF, Woodruff RJ, Smith J, Albert RK, Douglas IS. Respir Care. 2012 Apr;57(4):537-43.
  • Gajic O, Douglas IS, .. Malinchoc M. Early identification of patients at risk of acute lung injury: evaluation of lung injury prediction score in a multicenter cohort study. Am J Respir Crit Care Med. 2011 Feb 15;183(4):462-70.
  • Liu KD, Thompson BT, Ancukiewicz M, Steingrub JS, Douglas IS, Matthay MA, Wright P, Peterson MW, Rock P, Hyzy RC, Anzueto A, Truwit JD; National Institutes of Health National Heart, Lung, and Blood Institute Acute Respiratory Distress Syndrome Network. Acute kidney injury in patients with acute lung injury: impact of fluid accumulation on classification of acute kidney injury and associated outcomes. Crit Care Med. 2011 Dec;39 (12):2665-71.
  • Carson SS, Kahn JM, Hough CL, Seeley EJ, White DB, Douglas IS, Cox CE, Caldwell E, Bangdiwala SI, Garrett JM, Rubenfeld GD; for the ProVent Investigators. A multicenter mortality prediction model for patients receiving prolonged mechanical ventilation. Crit Care Med. 2011 Nov 10.
  • Malcolm KC, Kret JE, Young RL, Poch KR, Caceres SM, Douglas IS, Coldren CD, Burnham EL, Moss M, Nick JA. Bacteria-specific neutrophil dysfunction associated with interferon-stimulated gene expression in the acute respiratory distress syndrome. PLoS One. 2011;6(7):e21958.
  • 23. Wolken R, Woodruff R, Smith J, Albert RK, Douglas IS; Observational Study of Head of Bed Elevation Compliance Using a Continuous Monitoring System in a Medical Intensive Care Unit. Respir Care. 2011 Oct 13. [Epub ahead of print]
  • The National Heart, Lung, and Blood Institute ARDS Clinical Trials Network; Matthay MA, Brower RG, Carson S, Douglas IS, Eisner M, Hite D, Holets S, Kallet RH, Liu KD, MacIntyre N, Moss M, Schoenfeld D, Thompson BT. Randomized, Placebo-Controlled Clinical Trial of an Aerosolized Beta-2 Agonist (Albuterol) for the Treatment of Acute Lung Injury. Am J Respir Crit Care Med. 2011 Sep 1;184(5):561-8.
  • PROWESS-SHOCK Academic Steering Committee. Ranieri VM, Thompson BT, Finfer S, Barie PS, Dhainaut JF, Douglas IS, Gårdlund B, Marshall JC, Rhodes A; Unblinding plan of PROWESS-SHOCK trialIntensive Care Med. 2011 Aug;37(8):1384-5.
  • The NIH/NHLBI Acute Respiratory Distress Syndrome Network of Investigators. Enteral omega-3 fatty acid, gamma-linolenic acid, and antioxidant supplementation in acute lung injury. Rice TW, et.al. JAMA. 2011 Oct 12;306(14):1574-81.
  • Clark BJ, Smart A, House R, Douglas I, Burnham EL, Moss M. Severity of Acute Illness is Associated with Baseline Readiness to Change in Medical Intensive Care Unit Patients with Unhealthy Alcohol Use. Alcohol Clin Exp Res. 2011 Sep 26.
  • Graham BB, Keniston A, Gajic O, Alvarez CAT, Medvedev, S. Douglas IS. Diabetes Mellitus Does Not Adversely Affect Outcomes From Critical Illness. Crit. Care Med. 2010;38(1):16-24
  • Dennen P, Douglas IS, Anderson R Acute Kidney Injury in the ICU: An Update and Primer for the Intensivist. Crit. Care Med. 2010 Jan;38(1):261-75.
  • Statistical analysis plan of PROWESS SHOCK study. PROWESS SHOCK Steering Committee, Thompson BT, Ranieri VM, Finfer S, Barie PS, Dhainaut JF, Douglas IS, Gårdlund B, Marshall JC, Rhodes A. Intensive Care Med. 2010 Nov;36(11):1972-3.
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Practice Locations

Denver Health
777 Bannock St
Denver, CO 80204
303-436-6000

UCH - Anschutz Inpatient Pavilion
12605 E. 16th Ave
Aurora, CO 80045
720-848-0000

Hospital Affiliation
  • Denver Health Medical Center
  • University of Colorado Hospital

Specialty Information

Specialties
  • Internal Medicine, Board Certification (1999)
  • Pulmonary Disease, Board Certification (2000)
  • Critical Care Medicine, Board Certification (2001)
  • Fellow of the Royal College of Physicians (FRCP) UK, International Certificate (2012)
Conditions & Treatments
  • Critical Care
  • Infections - Bacterial Infections
  • Infections - Pneumonia
  • Lungs and Breathing - Lung Disease
  • Lungs and Breathing - Pulmonary Disorders
  • Infections
  • Lungs and Breathing

General Information

Medical Schools:
  • MD, University Of the Witwatersrand, Johannesburg, South Africa (1990)
Internships:
  • University of Chicago Program (1995)
  • Johannesburg General Hospital (1992)
Residency Programs:
  • University of Chicago Program, Internal Medicine (1996)
  • Johannesburg General Hospital, Critical Care Medicine (1994)
Fellowships:
  • University of Chicago Program, Pulmonary Disease and Critical Care Medicine (1999)
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Languages: English
Department: Medicine-Pulmonary Sciences & Critical Care
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