Ravi Mahalingam, PhD
Research Professor, Neurology

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Graduate Schools :
  • MS, Indian Institute of Technology (1977)
  • MS, Southern Illinois University Carbondale (1981)
  • PhD, Southern Illinois University Carbondale (1983)
Languages: English
Department: Neurology

Professional Titles

  • Research Professor

Recognition & Awards

  • Keynote speaker at IHW 2018 in Vancouver, VZV Foundation (2018)
    Each year VZV Foundation selects and expert in the field of VZV research to present their research at the International Herpesvirus Workshop

Research Interests

Currently, my laboratory is involved in identification of cell types that transport varicella to skin and ganglia during varicella. During the past 10 years, I have been characterizing the phenotype of the T-cells that respond to varicella reactivation and have been identifying signaling molecules that recruit T cells to ganglia. Because (varicella zoster virus) VZV and (simian varicella virus) SVV are highly species-specific, my laboratory is also involved in the preparation of a VZV-SVV chimeric virus to enable direct studies of VZV infection in primates and to help identify specific regions of the VZV and SVV genomes that are responsible for species specificity

Publications

  • Bubak AN, Beseler C, Como CN, Coughlan CM, Johnson NR, Hassell JE, Burnet AM, Mescher T, Schmid DS, Coleman C, Mahalingam R, Cohrs RJ, Boyd TD, Potter H, Shilleh AH, Russ HA, Nagel MA. Amylin, Aß42, and Amyloid in Varicella Zoster Virus Vasculopathy Cerebrospinal Fluid and Infected Vascular Cells. J Infect Dis. 2021 Apr 8;223(7):1284-1294. PubMed PMID: 32809013
  • Bubak AN, Beseler C, Como CN, Coughlan CM, Johnson NR, Hassell JE, Burnet AM, Mescher T, Schmid DS, Coleman C, Mahalingam R, Cohrs RJ, Boyd TD, Potter H, Shilleh AH, Russ HA, Nagel MA. Amylin, Aß42, and Amyloid in VZV Vasculopathy Cerebrospinal Fluid and Infected Vascular Cells. J Infect Dis. 2020 Aug 18. [Epub ahead of print] PubMed PMID: 32809013
  • Bubak AN, Como CN, Coughlan CM, Johnson NR, Hassell JE, Mescher T, Niemeyer CS, Mahalingam R, Cohrs RJ, Boyd TD, Potter H, Russ HA, Nagel MA. Varicella-Zoster Virus Infection of Primary Human Spinal Astrocytes Produces Intracellular Amylin, Amyloid-ß, and an Amyloidogenic Extracellular Environment. J Infect Dis. 2020 Mar 16;221(7):1088-1097. PubMed PMID: 31665341
  • Bubak AN, Traina-Dorge V, Como CN, Feia B, Pearce CM, Doyle-Meyers L, Das A, Looper J, Mahalingam R, Nagel MA. Elevated serum substance P during simian varicella virus infection in rhesus macaques: implications for chronic inflammation and adverse cerebrovascular events. J Neurovirol. 2020 Sep 22. [Epub ahead of print] PubMed PMID: 32964407
  • Mahalingam R, Gershon A, Gershon M, Cohen JI, Arvin A, Zerboni L, Zhu H, Gray W, Messaoudi I, Traina-Dorge V. Current In Vivo Models of Varicella-Zoster Virus Neurotropism. Viruses. 2019 May 31;11(6). PubMed PMID: 31159224
  • Bubak AN, Como CN, Coughlan CM, Johnson NR, Hassell JE Jr, Mescher T, Niemeyer CS, Mahalingam R, Cohrs RJ, Boyd TD, Potter H, Russ HA, Nagel MA. Varicella Zoster Virus Infection of Primary Human Spinal Astrocytes Produces Intracellular Amylin, Amyloid-beta, and an Amyloidogenic Extracellular Environment. J Infect Dis. 2019 Oct 29. [Epub ahead of print] PubMed PMID: 31665341
  • Traina-Dorge V, Mehta S, Rooney B, Crucian B, Doyle-Meyers L, Das A, Coleman C, Nagel M, Mahalingam R. Simian Varicella Virus DNA in Saliva and Buccal Cells After Experimental Acute Infection in Rhesus Macaques. Front Microbiol. 2019;10:1009. PubMed PMID: 31143167
  • Traina-Dorge V, Palmer BE, Coleman C, Hunter M, Frieman A, Gilmore A, Altrock K, Doyle-Meyers L, Nagel MA, Mahalingam R. Reactivation of Simian Varicella Virus in Rhesus Macaques after CD4 T Cell Depletion. J Virol. 2019 Feb 1;93(3). PubMed PMID: 30404798
  • Traina-Dorge V, Palmer BE, Coleman C, Hunter M, Frieman A, Gilmore A, Altrock K, Doyle-Meyers L, Nagel MA, Mahalingam R. Reactivation of Simian Varicella Virus (SVV) in Rhesus Macaques After CD4 T Cell Depletion. J Virol. 2018 Nov 7. [Epub ahead of print] PubMed PMID: 30404798
  • Ouwendijk WJD, van Veen S, Mehraban T, Mahalingam R, Verjans GMGM. Simian Varicella Virus Infects Enteric Neurons and a4ß7 Integrin-Expressing Gut-Tropic T-Cells in Nonhuman Primates. Viruses. 2018 Mar 28;10(4). PubMed PMID: 29597335
  • Ouwendijk WJD, van Veen S, Mahalingam R, Verjans GMGM. Simian varicella virus inhibits the interferon gamma signalling pathway. J Gen Virol. 2017 Sep 13. [Epub ahead of print] PubMed PMID: 28901902
  • Ouwendijk WJ, Getu S, Mahalingam R, Gilden D, Osterhaus AD, Verjans GM. Characterization of the immune response in ganglia after primary simian varicella virus infection. J Neurovirol. 2016 Jun;22(3):376-88. PubMed PMID: 26676825
  • Ouwendijk WJ, Getu S, Mahalingam R, Gilden D, Osterhaus AD, Verjans GM. Characterization of the immune response in ganglia after primary simian varicella virus infection. J Neurovirol. 2015 Dec 16. [Epub ahead of print] PubMed PMID: 26676825
  • Traina-Dorge V, Doyle-Meyers LA, Sanford R, Manfredo J, Blackmon A, Wellish M, James S, Alvarez X, Midkiff C, Palmer BE, Deharo E, Gilden D, Mahalingam R. Simian Varicella Virus Is Present in Macrophages, Dendritic Cells, and T Cells in Lymph Nodes of Rhesus Macaques after Experimental Reactivation. J Virol. 2015 Oct;89(19):9817-24. PubMed PMID: 26178993
  • Verweij MC, Wellish M, Whitmer T, Malouli D, Lapel M, Jonjic S, Haas JG, DeFilippis VR, Mahalingam R, Früh K. Varicella Viruses Inhibit Interferon-Stimulated JAK-STAT Signaling through Multiple Mechanisms. PLoS Pathog. 2015 May;11(5):e1004901. PubMed PMID: 25973608
  • Gilden D, White T, Khmeleva N, Heintzman A, Choe A, Boyer PJ, Grose C, Carpenter JE, Rempel A, Bos N, Kandasamy B, Lear-Kaul K, Holmes DB, Bennett JL, Cohrs RJ, Mahalingam R, Mandava N, Eberhart CG, Bockelman B, Poppiti RJ, Tamhankar MA, Fogt F, Amato M, Wood E, Durairaj V, Rasmussen S, Petursdottir V, Pollak L, Mendlovic S, Chatelain D, Keyvani K, Brueck W, Nagel MA. Prevalence and distribution of VZV in temporal arteries of patients with giant cell arteritis. Neurology. 2015 May 12;84(19):1948-55. PubMed PMID: 25695965
  • Gilden D, Nagel M, Cohrs R, Mahalingam R, Baird N. Varicella Zoster Virus in the Nervous System. F1000Res. 2015 Nov 26;4. PubMed PMID: 26918131
  • James SF, Traina-Dorge V, Deharo E, Wellish M, Palmer BE, Gilden D, Mahalingam R. T cells increase before zoster and PD-1 expression increases at the time of zoster in immunosuppressed nonhuman primates latently infected with simian varicella virus. J Neurovirol. 2014 Feb 19. [Epub ahead of print] PubMed PMID: 24549971
  • Traina-Dorge V, Sanford R, James S, Doyle-Meyers LA, de Haro E, Wellish M, Gilden D, Mahalingam R. Robust pro-inflammatory and lesser anti-inflammatory immune responses during primary simian varicella virus infection and reactivation in rhesus macaques. J Neurovirol. 2014 Oct;20(5):526-30. PubMed PMID: 25139181
  • Gilden D, Nagel MA, Cohrs RJ, Mahalingam R. The variegate neurological manifestations of varicella zoster virus infection. Curr Neurol Neurosci Rep. 2013 Sep;13(9):374. PubMed PMID: 23884722
  • Nagel MA, Choe A, Gilden D, Traina-Dorge V, Cohrs RJ, Mahalingam R. GeXPS multiplex PCR analysis of the simian varicella virus transcriptome in productively infected cells in culture and acutely infected ganglia. J Virol Methods. 2013 Oct;193(1):151-8. PubMed PMID: 23769859
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Professional Memberships

  • American Society of Virology, Member
  • International Society for Neurovirology, Member
  • Journal of NeurovVirology, Editorial Board Member
  • BMC Infectious Diseases, Editorial Board Member
  • Frontiers in Virology, Associate Editor

Practice Locations

Neurosciences Center - Anschutz
1635 Aurora Ct
4th Floor
Aurora, CO 80045
720-848-2080

Personal Interests
Cultural aspects of medicine including eastern traditional medicine.

Volunteer Activities
I am a member of the Honors Program Advisory Board, Metropolitan State University, Denver, CO. I am Board member in the Colorado Fine Arts Association

Public Speaking
Yes
Different aspects of Virology including Herpesviruses.

General Information

Graduate Schools:
  • MS, Indian Institute of Technology (1977)
  • MS, Southern Illinois University Carbondale (1981)
  • PhD, Southern Illinois University Carbondale (1983)
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Languages: English
Department: Neurology
Contact Us
CU Anschutz
Fitzsimons Building

13001 East 17th Place
Campus Box C290
Aurora, CO 80045

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