David Jones, PhD
Associate Professor, Pharmacology

Publications

• Anderson JW, Vaisar D, Jones DN, Pegram LM, Vigers GP, Chen H, Moffat JG, Ahn NG. Conformation Selection by ATP-competitive Inhibitors and Allosteric Communication in ERK2. bioRxiv. 2023 Nov 6. PubMed PMID: 37745518
• Smith CE, Jones DNM. NMR resonance assignment of the N-terminal GTPase domain of human Miro2 Bound to GTP. Biomol NMR Assign. 2022 Oct;16(2):349-355. PubMed PMID: 36050579
• Speidel JT, Affandi T, Jones DNM, Ferrara SE, Reyland ME. Functional proteomic analysis reveals roles for PKCd in regulation of cell survival and cell death: Implications for cancer pathogenesis and therapy. Adv Biol Regul. 2020 Dec;78:100757. PubMed PMID: 33045516
• Wang J, Murphy EJ, Nix JC, Jones DNM. Aedes aegypti Odorant Binding Protein 22 selectively binds fatty acids through a conformational change in its C-terminal tail. Sci Rep. 2020 Feb 24;10(1):3300. PubMed PMID: 32094450
• Nichols PJ, Born A, Henen MA, Strotz D, Jones DN, Delaglio F, Vögeli B. Reducing the measurement time of exact NOEs by non-uniform sampling. J Biomol NMR. 2020 Dec;74(12):717-739. PubMed PMID: 32880802
• Iverson DB, Xiao Y, Jones DN, Eisenmesser EZ, Ahn NG. Activation Loop Dynamics Are Coupled to Core Motions in Extracellular Signal-Regulated Kinase-2. Biochemistry. 2020 Jul 28;59(29):2698-2706. PubMed PMID: 32643366
• Jones DNM, Wang J, Murphy EJ. Complete NMR chemical shift assignments of odorant binding protein 22 from the yellow fever mosquito, Aedes aegypti, bound to arachidonic acid. Biomol NMR Assign. 2019 Apr;13(1):187-193. PubMed PMID: 30684234
• Singh SM, Bandi S, Jones DNM, Mallela KMG. Effect of Polysorbate 20 and Polysorbate 80 on the Higher-Order Structure of a Monoclonal Antibody and Its Fab and Fc Fragments Probed Using 2D Nuclear Magnetic Resonance Spectroscopy. J Pharm Sci. 2017 Dec;106(12):3486-3498. PubMed PMID: 28843351
• Reyland ME, Jones DN. Multifunctional roles of PKCd: Opportunities for targeted therapy in human disease. Pharmacol Ther. 2016 Sep;165:1-13. PubMed PMID: 27179744
• Lyu Q, Shi Y, Wang S, Yang Y, Han B, Liu W, Jones DN, Liu W. Structural and biochemical insights into the degradation mechanism of chitosan by chitosanase OU01. Biochim Biophys Acta. 2015 Sep;1850(9):1953-61. PubMed PMID: 26145578
• Yan C, Jones DN, Theodorescu D. Drugging the Ral GTPase. Small GTPases. 2015;6(3):157-9. PubMed PMID: 26280620
• Das C, Roy S, Namjoshi S, Malarkey CS, Jones DN, Kutateladze TG, Churchill ME, Tyler JK. Binding of the histone chaperone ASF1 to the CBP bromodomain promotes histone acetylation. Proc Natl Acad Sci U S A. 2014 Mar 10. [Epub ahead of print] PubMed PMID: 24616510
• Yan C, Liu D, Li L, Wempe MF, Guin S, Khanna M, Meier J, Hoffman B, Owens C, Wysoczynski CL, Nitz MD, Knabe WE, Ahmed M, Brautigan DL, Paschal BM, Schwartz MA, Jones DN, Ross D, Meroueh SO, Theodorescu D. Discovery and characterization of small molecules that target the GTPase Ral. Nature. 2014 Nov 20;515(7527):443-7. PubMed PMID: 25219851
• Lyu Q, Wang S, Xu W, Han B, Liu W, Jones DN, Liu W. Structural insights into the substrate-binding mechanism for a novel chitosanase. Biochem J. 2014 Jul 15;461(2):335-45. PubMed PMID: 24766439
• Chi YC, Armstrong GS, Jones DN, Eisenmesser EZ, Liu CW. Residue histidine 50 plays a key role in protecting a-synuclein from aggregation at physiological pH. J Biol Chem. 2014 May 30;289(22):15474-81. PubMed PMID: 24742669
• Das C, Roy S, Namjoshi S, Malarkey CS, Jones DN, Kutateladze TG, Churchill ME, Tyler JK. Binding of the histone chaperone ASF1 to the CBP bromodomain promotes histone acetylation. Proc Natl Acad Sci U S A. 2014 Mar 25;111(12):E1072-81. PubMed PMID: 24616510
• Nordeen SK, Bona BJ, Jones DN, Lambert JR, Jackson TA. Endocrine disrupting activities of the flavonoid nutraceuticals luteolin and quercetin. Horm Cancer. 2013 Oct;4(5):293-300. PubMed PMID: 23836117
• Murphy EJ, Booth JC, Davrazou F, Port AM, Jones DN. Interactions of Anopheles gambiae odorant-binding proteins with a human-derived repellent: implications for the mode of action of n,n-diethyl-3-methylbenzamide (DEET). J Biol Chem. 2013 Feb 8;288(6):4475-85. PubMed PMID: 23261834
• Ziemba BP, Murphy EJ, Edlin HT, Jones DN. A novel mechanism of ligand binding and release in the odorant binding protein 20 from the malaria mosquito Anopheles gambiae. Protein Sci. 2013 Jan;22(1):11-21. PubMed PMID: 23081820