Michael Graner, PhD
Research Professor, Neurosurgery

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Graduate Schools :
  • MS, University of Illinois At Urbana - Champaign (1988)
  • PhD, University of Illinois At Urbana - Champaign (1993)
Undergraduate School:
  • BA, Illinois College (IL) (1985)
Fellowships:
  • University of Arizona Program, Cancer Research (1995)
Department: Neurosurgery

Professional Titles

  • Associate Professor
  • Research Director Neurosurgery Neural Tissue Bank

Recognition & Awards

  • Immediate Past President, Society for Thermal Medicine (2019)
  • Fellow, Cell Stress Society International (2018)
  • President, Society for Thermal Medicine (2018)
  • Vice President, Society for Thermal Medicine (2017)
  • Best Presentation, International Congress on Hyperthermic Oncology (2016)
  • Vice President-Elect, Society for Thermal Medicine (2016)
  • Award Speaker, Phi Beta Kappa Annual Banquet, Illinois College Epsilon Chapter (2015)

Publications

  • Graner MW. Roles of Extracellular Vesicles in High-Grade Gliomas: Tiny Particles with Outsized Influence. Annu Rev Genomics Hum Genet. 2019 Aug 31;20:331-357. PubMed PMID: 30978305
  • Graner M. V-ATPase expression in gliomas-Not your grandparents' proton pump. EBioMedicine. 2019 Mar;41:13-14. PubMed PMID: 30808578
  • Betker JL, Angle BM, Graner MW, Anchordoquy TJ. The Potential of Exosomes From Cow Milk for Oral Delivery. J Pharm Sci. 2019 Apr;108(4):1496-1505. PubMed PMID: 30468828
  • Oushy S, Hellwinkel JE, Wang M, Nguyen GJ, Gunaydin D, Harland TA, Anchordoquy TJ, Graner MW. Glioblastoma multiforme-derived extracellular vesicles drive normal astrocytes towards a tumour-enhancing phenotype. Philos Trans R Soc Lond B Biol Sci. 2018 Jan 5;373(1737). PubMed PMID: 29158308
  • Betker JL, Angle BM, Graner MW, Anchordoquy TJ. The Potential of Exosomes From Cow Milk for Oral Delivery. J Pharm Sci. 2018 Nov 20. [Epub ahead of print] PubMed PMID: 30468828
  • Graner MW. Extracellular vesicles in cancer immune responses: roles of purinergic receptors. Semin Immunopathol. 2018 Sep 12. [Epub ahead of print] PubMed PMID: 30209547
  • Graner MW, Schnell S, Olin MR. Tumor-derived exosomes, microRNAs, and cancer immune suppression. Semin Immunopathol. 2018 Sep;40(5):505-515. PubMed PMID: 29869058
  • Oushy S, Hellwinkel JE, Wang M, Nguyen GJ, Gunaydin D, Harland TA, Anchordoquy TJ, Graner MW. Glioblastoma multiforme-derived extracellular vesicles drive normal astrocytes towards a tumour-enhancing phenotype. Philos Trans R Soc Lond B Biol Sci. 2018 Jan 5;373(1737). PubMed PMID: 29158308
  • Contreras-Zárate MJ, Ormond DR, Gillen AE, Hanna C, Day NL, Serkova NJ, Jacobsen BM, Edgerton SM, Thor AD, Borges VF, Lillehei KO, Graner MW, Kabos P, Cittelly DM. Development of Novel Patient-Derived Xenografts from Breast Cancer Brain Metastases. Front Oncol. 2017;7:252. PubMed PMID: 29164052
  • Beseler C, Vollmer T, Graner M, Yu X. The complex relationship between oligoclonal bands, lymphocytes in the cerebrospinal fluid, and immunoglobulin G antibodies in multiple sclerosis: Indication of serum contribution. PLoS One. 2017;12(10):e0186842. PubMed PMID: 29059249
  • Neudecker V, Brodsky KS, Clambey ET, Schmidt EP, Packard TA, Davenport B, Standiford TJ, Weng T, Fletcher AA, Barthel L, Masterson JC, Furuta GT, Cai C, Blackburn MR, Ginde AA, Graner MW, Janssen WJ, Zemans RL, Evans CM, Burnham EL, Homann D, Moss M, Kreth S, Zacharowski K, Henson PM, Eltzschig HK. Neutrophil transfer of miR-223 to lung epithelial cells dampens acute lung injury in mice. Sci Transl Med. 2017 Sep 20;9(408). PubMed PMID: 28931657
  • Zhou K, Spillman MA, Behbakht K, Komatsu JM, Abrahante JE, Hicks D, Schotl B, Odean E, Jones KL, Graner MW, Bemis LT. A method for extracting and characterizing RNA from urine: For downstream PCR and RNAseq analysis. Anal Biochem. 2017 Nov 1;536:8-15. PubMed PMID: 28803886
  • Ramteke A, Ting H, Agarwal C, Mateen S, Somasagara R, Hussain A, Graner M, Frederick B, Agarwal R, Deep G. Exosomes secreted under hypoxia enhance invasiveness and stemness of prostate cancer cells by targeting adherens junction molecules. Mol Carcinog. 2015 Jul;54(7):554-65. PubMed PMID: 24347249
  • Smyth T, Kullberg M, Malik N, Smith-Jones P, Graner MW, Anchordoquy TJ. Biodistribution and delivery efficiency of unmodified tumor-derived exosomes. J Control Release. 2015 Feb 10;199:145-55. PubMed PMID: 25523519
  • Yu Y, Jin D, Hu S, Zhang Y, Zheng X, Zheng J, Liao M, Chen X, Graner M, Liu H, Jin Q. A novel tuberculosis antigen identified from human tuberculosis granulomas. Mol Cell Proteomics. 2015 Apr;14(4):1093-103. PubMed PMID: 25605460
  • Yáñez-Mó M, Siljander PR, Andreu Z, Zavec AB, Borràs FE, Buzas EI, Buzas K, Casal E, Cappello F, Carvalho J, Colás E, Cordeiro-da Silva A, Fais S, Falcon-Perez JM, Ghobrial IM, Giebel B, Gimona M, Graner M, Gursel I, Gursel M, Heegaard NH, Hendrix A, Kierulf P, Kokubun K, Kosanovic M, Kralj-Iglic V, Krämer-Albers EM, Laitinen S, Lässer C, Lener T, Ligeti E, Line A, Lipps G, Llorente A, Lötvall J, Mancek-Keber M, Marcilla A, Mittelbrunn M, Nazarenko I, Nolte-'t Hoen EN, Nyman TA, O'Driscoll L, Olivan M, Oliveira C, Pállinger É, Del Portillo HA, Reventós J, Rigau M, Rohde E, Sammar M, Sánchez-Madrid F, Santarém N, Schallmoser K, Ostenfeld MS, Stoorvogel W, Stukelj R, Van der Grein SG, Vasconcelos MH, Wauben MH, De Wever O. Biological properties of extracellular vesicles and their physiological functions. J Extracell Vesicles. 2015;4:27066. PubMed PMID: 25979354
  • Schlaepfer IR, Nambiar DK, Ramteke A, Kumar R, Dhar D, Agarwal C, Bergman B, Graner M, Maroni P, Singh RP, Agarwal R, Deep G. Hypoxia induces triglycerides accumulation in prostate cancer cells and extracellular vesicles supporting growth and invasiveness following reoxygenation. Oncotarget. 2015 Sep 8;6(26):22836-56. PubMed PMID: 26087400
  • Hellwinkel JE, Redzic JS, Harland TA, Gunaydin D, Anchordoquy TJ, Graner MW. Glioma-derived extracellular vesicles selectively suppress immune responses. Neuro Oncol. 2015 Sep 18. [Epub ahead of print] PubMed PMID: 26385614
  • Kunigelis KE, Graner MW. The Dichotomy of Tumor Exosomes (TEX) in Cancer Immunity: Is It All in the ConTEXt?. Vaccines (Basel). 2015 Dec 17;3(4):1019-51. PubMed PMID: 26694473
  • Graner MW, Lillehei KO, Katsanis E. Endoplasmic reticulum chaperones and their roles in the immunogenicity of cancer vaccines. Front Oncol. 2014;4:379. PubMed PMID: 25610811
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General Information

Graduate Schools:
  • MS, University of Illinois At Urbana - Champaign (1988)
  • PhD, University of Illinois At Urbana - Champaign (1993)
Undergraduate Schools:
  • BA, Illinois College (IL) (1985)
Fellowships:
  • University of Arizona Program, Cancer Research (1995)
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Department: Neurosurgery
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